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Preclinical and exploratory human studies of novel 68Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers.

Xiaobo Wang, Ming Zhou, Bei Chen, Huanhuan Liu, Jianyang Fang, Shijun Xiang, Shuo Hu, Xianzhong Zhang,

<h4>Purpose</h4>While TIGIT has been propelled as a next-generation target in cancer immunotherapy, anti-TIGIT therapy seems to be promising for a fraction of patients in clinical trials. Therefore, patient stratification is critical for this therapy, which could benefit from a whole-body, non-invasive, and quantitative evaluation of TIGIT expression in cancers. In ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2022, :]

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Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge.

Wouter Bulten, Kimmo Kartasalo, Po-Hsuan Cameron Chen, Peter Ström, Hans Pinckaers, Kunal Nagpal, Yuannan Cai, David F Steiner, Hester van Boven, Robert Vink, Christina Hulsbergen-van de Kaa, Jeroen van der Laak, Mahul B Amin, Andrew J Evans, Theodorus van der Kwast, Robert Allan, Peter A Humphrey, Henrik Grönberg, Hemamali Samaratunga, Brett Delahunt, Toyonori Tsuzuki, Tomi Häkkinen, Lars Egevad, Maggie Demkin, Sohier Dane, Fraser Tan, Masi Valkonen, Greg S Corrado, Lily Peng, Craig H Mermel, Pekka Ruusuvuori, Geert Litjens, Martin Eklund, ,

Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions have been shown to be accelerators for medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this ... Read more >>

Nat Med (Nature medicine)
[2022, :]

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The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis.

Ming Zhou, Ceyda Coruh, Guanghui Xu, Laura M Martins, Clara Bourbousse, Alice Lambolez, Julie A Law,

DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in regulating gene expression, and ensures transposon silencing. As is evidenced by the numerous defects associated with aberrant DNA methylation landscapes, establishing proper tissue-specific methylation patterns is critical. Yet, how such differences arise remains a largely open question ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):244]

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A Flexible Microfluidic Chip-Based Universal Fully Integrated Nanoelectronic System with Point-of-Care Raw Sweat, Tears, or Saliva Glucose Monitoring for Potential Noninvasive Glucose Management.

Mimi Sun, Xinyi Pei, Tong Xin, Jian Liu, Chongbo Ma, Mengzhu Cao, Ming Zhou,

By combining the distinctive noninvasive feature with the peculiar complete functional implementation trait, fully integrated raw noninvasive biofluid glucose biosensors offer active and remote glucose monitoring while posing minimal harm or infection risks compared to the traditional invasive manner. However, each previously reported fully integrated raw noninvasive biofluid glucose biosensor ... Read more >>

Anal Chem (Analytical chemistry)
[2022, :]

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Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters.

Lunzhi Yuan, Ming Zhou, Jian Ma, Xuan Liu, Peiwen Chen, Huachen Zhu, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia,

Cell Mol Immunol (Cellular & molecular immunology)
[2022, :]

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Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with 18F-SynVesT-1 positron emission tomography imaging.

Yongxiang Tang, Jie Yu, Ming Zhou, Jian Li, Tingting Long, Yulai Li, Li Feng, Dengming Chen, Zhiquan Yang, Yiyun Huang, Shuo Hu,

<h4>Purpose</h4>The loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia type II (FCD II), but this has not been directly tested in vivo. In this positron emission tomography (PET) study with the new tracer <sup>18</sup>F-SynVesT-1, we evaluated SV2A abnormalities ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2022, :]

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Alternative transcription and feedback regulation suggest that SlIDI1 is involved in tomato carotenoid synthesis in a complex way.

Ming Zhou, Lei Deng, Shaogui Guo, Guoliang Yuan, Chuanyou Li, Changbao Li,

Carotenoid pigments confer photoprotection and visual attraction and serve as precursors for many important signaling molecules. Herein, the orange-fruited phenotype of a tomato elite inbred line resulting from sharply reduced carotenoid levels and an increased β-carotene-to-lycopene ratio in fruit was shown to be controlled by a single recessive gene, oft3. ... Read more >>

Hortic Res (Horticulture research)
[2022, 9:]

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High-Normal Thyroid Function Predicts Incident Nonalcoholic Fatty Liver Disease Among Middle-Aged and Older Euthyroid Subjects.

Yeqing Gu, Xiaohui Wu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu,

<h4>Background</h4>Thyroid hormones (THs) influence hepatic lipid homeostasis through multiple pathways, suggesting that THs may predict the risk of nonalcoholic fatty liver disease (NAFLD). However, prospective studies on the association between THs levels and incident NAFLD in euthyroid subjects are limited. This prospective cohort study aimed to explore whether THs were ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2022, 77(1):197-203]

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Towards Integration of Domain Knowledge-Guided Feature Engineering and Deep Feature Learning in Surface Electromyography-Based Hand Movement Recognition.

Wentao Wei, Xuhui Hu, Hua Liu, Ming Zhou, Yan Song,

As a machine-learning-driven decision-making problem, the surface electromyography (sEMG)-based hand movement recognition is one of the key issues in robust control of noninvasive neural interfaces such as myoelectric prosthesis and rehabilitation robot. Despite the recent success in sEMG-based hand movement recognition using end-to-end deep feature learning technologies based on deep ... Read more >>

Comput Intell Neurosci (Computational intelligence and neuroscience)
[2021, 2021:4454648]

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G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis.

Wei Liu, Yaping Yang, Zonghui Zeng, Yuling Tian, Qiong Wu, Ming Zhou, Zhen F Fu, Ling Zhao,

Rabies, caused by rabies virus (RABV), is an ancient zoonotic disease that significantly affects human and animal health throughout the world. RABV causes acute encephalitis in mammals with a high fatality rate in developing countries. G protein-coupled receptor 17 (GPR17) is a vital gene in the central nervous system (CNS) ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 265:109326]

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Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.

Hanli Ruan, Ying Gao, Ruihua Mao, Ye Liu, Ming Zhou,

Two new cytochalasans with a rare 6/6/5/5/7 pentacyclic ring system, named chaetoconvosins C-D (1-2), together with two known congeners (3-4), were isolated from the fermentation of an endophytic fungus, Chaetomium sp. SG-01, harbored in the fibrous roots of Schisandra glaucescens Diels. Their structures including the absolute configuration were elucidated by ... Read more >>

Planta Med (Planta medica)
[2021, :]

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Enhanced interfacial polarization of biomass-derived porous carbon with a low radar cross-section.

Jialing Wang, Ming Zhou, Zhengchan Xie, Xingyu Hao, Shaolong Tang, Jingwen Wang, Zhongqiu Zou, Guangbin Ji,

Ultra-thin microwave absorbers have been urgently demanded for electromagnetic applications in recent years. Herein, porous carbon with a "flower cluster" microstructure was synthesized from biomass waste (mango seeds) by a facile activation and carbonization method. The novel structure reduced the density and also improved the impedance matching, dipole polarization, and ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2021, 612:146-155]

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Electron relay via diffusible and protein-bound flavin cofactor in human six-transmembrane epithelial antigen of the prostate (STEAP)

Kehan Chen, Lie Wang, Jiemin Shen, Ah-lim Tsai, Ming Zhou, Gang Wu,

Six transmembrane epithelial antigen of the prostate (STEAP) is a family of membrane-embedded metal ion reductases that transfer electrons across the cell membranes. STEAPs are unique to mammals and implicated in metabolic and inflammatory responses and are significantly upregulated in many types of cancer cells. There are four members in ... Read more >>

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Insight into the mechanism of H+-coupled nucleobase transport

Jun Weng, Xiaoming Zhou, Pattama Wiriyasermkul, Zhenning Ren, Xiuwen Yan, Kehan Chen, Eva Gil Iturbe, Ming Zhou, Matthias Quick,

Members of the nucleobase/ascorbic acid transporter (NAT) gene family are found in all kingdoms of life. In mammals, the concentrative uptake of ascorbic acid (vitamin C) by members of the NAT family is driven by the Na + gradient, while the uptake of nucleobases in bacteria is powered by the ... Read more >>

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Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry.

Nicholas W Bateman, Christopher M Tarney, Tamara S Abulez, Brian L Hood, Kelly A Conrads, Ming Zhou, Anthony R Soltis, Pang-Ning Teng, Amanda Jackson, Chunqiao Tian, Clifton L Dalgard, Matthew D Wilkerson, Michael D Kessler, Zachary Goecker, Jeremy Loffredo, Craig D Shriver, Hai Hu, Michele Cote, Glendon J Parker, James Segars, Ayman Al-Hendy, John I Risinger, Neil T Phippen, Yovanni Casablanca, Kathleen M Darcy, G Larry Maxwell, Thomas P Conrads, Timothy D O'Connor,

Characterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with disease pathogenesis. Nonsynonymous single-nucleotide polymorphisms encoding missense substitutions within tryptic peptides exhibiting high allele frequencies in European, African, and East Asian populations, termed peptide ancestry informative markers (pAIMs), were prioritized from 1000 ... Read more >>

iScience (iScience)
[2022, 25(1):103665]

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Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients.

Talia L Fuchs, Fiona Maclean, John Turchini, A Cristina Vargas, Selina Bhattarai, Abbas Agaimy, Arndt Hartmann, Chia-Sui Kao, Carla Ellis, Michael Bonert, Xavier Leroy, Lakshmi P Kunju, Lauren Schwartz, Admire Matsika, Sean R Williamson, Priya Rao, Mukul Divatia, Rosa Guarch, Ferran Algaba, Marcelo L Balancin, Ming Zhou, Hemamali Samaratunga, Isabela Werneck da Cunha, Fadi Brimo, Andrew Ryan, David Clouston, Manju Aron, Marie O'Donnell, Emily Chan, Michelle S Hirsch, Holger Moch, Chun-Yin Pang, Cheuk Wah, Weihua Yin, Joanna Perry-Keene, Asli Yilmaz, Angela Chou, Adele Clarkson, Gerhard van der Westhuizen, Ella Morrison, Jonathan Zwi, Ondrej Hes, Kiril Trpkov, Anthony J Gill,

Most succinate dehydrogenase (SDH)-deficient renal cell carcinomas (RCCs) demonstrate stereotypical morphology characterized by bland eosinophilic cells with frequent intracytoplasmic inclusions. However, variant morphologic features have been increasingly recognized. We therefore sought to investigate the incidence and characteristics of SDH-deficient RCC with variant morphologies. We studied a multi-institutional cohort of 62 ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Loculations and Associated Risk Factors of Childhood Pleural Tuberculosis.

Jun-Li Wang, Ming Zhou, Yan-An Zhang, Mao-Shui Wang,

<b>Background:</b> Pleural loculation in childhood pleural tuberculosis (TB) remains a problem in practice, it is usually associated with failure drainage. Therefore, to improve the management of childhood pleural TB, a retrospective study was conducted to identify the risk factors associated with loculated effusion in childhood pleural TB. <b>Methods:</b> Between January ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:781042]

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Adherence to a vegetable dietary pattern attenuates the risk of non-alcoholic fatty liver disease in incident type 2 diabetes: The TCLSIH cohort study.

Yang Xia, Limin Cao, Qing Zhang, Li Liu, Shunming Zhang, Ge Meng, Hongmei Wu, Yeqing Gu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Qijun Wu, Kaijun Niu, Yuhong Zhao,

<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is a strong risk factor for type 2 diabetes. However, no study has investigated whether dietary intake can modify this effect. Therefore, we aimed to investigate the effect of dietary pattern modification on the association between NAFLD and type 2 diabetes.<h4>Methods</h4>A large prospective cohort study ... Read more >>

J Intern Med (Journal of internal medicine)
[2021, :]

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Comprehensive analysis of protein acetylation and glucose metabolism inmouse brains infected with rabies virus.

Jie Pei, Yueming Yuan, Dayong Tian, Fei Huang, Chengguang Zhang, Caiqian Wang, Ming Zhou, Huanchun Chen, Zhenfang Fu, Ling Zhao,

Rabies, caused by rabies virus (RABV), is a widespread zoonosis that is nearly 100% fatal. Alteration of the metabolic environment affects viral replication and the immune response during viral infection. In this study, glucose uptake was increased in mouse brains at the late stage of infection with different RABV strains ... Read more >>

J Virol (Journal of virology)
[2021, :JVI0194221]

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Identification and Validation of N6-methyladenosine-related Biomarkers for Bladder Cancer: Implications for Immunotherapy

Hongyu Deng, Faqing Tang, Ming Zhou, Dongyong Shan, Xingyu Chen, Ke Cao,

N6-methyladenosine (m6A) has emerged as one of the most important modifications of RNA. Based on the expression of 23 kinds of m 6 A regulatory factors, we identified three different m 6 A modification patterns in bladder cancer. The effects of the three kinds of m 6 A modification modes ... Read more >>

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[Relationship between Muscle Mass of Limbs and aGVHD in Patients with Allogeneic Hematopoietic Stem Cell Transplantation].

Wen-Jian Zhang, Rui-Qing Zhou, Ling-Fu Ma, Zhi-Min Wang, Wen-Jian Mo, Ming Zhou, Xiao-Ming Quan,

<h4>Objective</h4>To explore the correlation of limb muscle mass and acute graft-versus-host disease.<h4>Methods</h4>Clinical data from 144 patients treated by allo-HSCT in Guangzhou First People's Hospital were collected and analyzed retrospectively. The age, sex, diagnosis, donor age, sex of the donors, preparative regimen, ATG dose, HLA match, graft source, and number of ... Read more >>

Zhongguo Shi Yan Xue Ye Xue Za Zhi (Zhongguo shi yan xue ye xue za zhi)
[2021, 29(6):1950-1956]

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Mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia.

Yuling Zhang, Yumiao Li, Liangliang Wu, Ming Zhou, Caixia Wang, Wenjian Mo, Xiaowei Chen, Shilin Xu, Ruiqing Zhou, Shunqing Wang, Yuping Zhang,

A retrospective study on 287 patients with SAA who underwent allo-HSCT between October 2012 and January 2020 was conducted to explore the outcomes, risk factors and treatment options for MC. Among 287 AA patients who excluded Fanconi anemia (FA), Congenital dyskeratosis (DKC), Paroxysmal nocturnal hemoglobinuria (PNH), etc.112 underwent matched sibling ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):435-443]

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Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis.

Shan Mao, Shuning Tian, Xianghong Luo, Ming Zhou, Zheng Cao, Ji Li,

Myocardial cell injury caused by myocardial ischemia and reperfusion is one of the main causes of the occurrence and development of heart disease. Recent study has shown that inducing mitophagy of cardiomyocytes is a crucial method to alleviate ischemia-reperfusion injury. While, Polo-like kinase 1 (PLK1) can induce the mitophagy of breast cancer cells. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2676-2687]

Cited: 2 times

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The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein.

Xinde Zhao, Ming Zhou, Yong Yang, Minjie Luo,

The ubiquitin hydrolase OTUB1 has been elucidated to be highly expressed in tumors, however, its roles in glioma progression are still confusing. Here, via analyzing several online datasets, OTUB1 expression was shown to be remarkably increased in glioma tissues compared to that in the adjacent tissues, and predicted a poor ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):12636-12645]

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Relationship Between Dietary Patterns and Carotid Atherosclerosis Among People Aged 50 Years or Older: A Population-Based Study in China.

Yunyun Liu, Xuena Wang, Qing Zhang, Ge Meng, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Magdalena J Górska, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Liping Tan, Kaijun Niu,

<b>Background:</b> The relationship between dietary patterns and atherosclerosis is inconclusive. Usually, diets vary greatly among different regions due to cultural differences and lifestyles. Few studies to date based on a Chinese population have investigated the relationship between dietary patterns and the formation of atherosclerosis in carotid arteries. We aimed to ... Read more >>

Front Nutr (Frontiers in nutrition)
[2021, 8:723726]

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