Full Text Journal Articles by
Author Mindie H Nguyen

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Body weight changes in treated hepatitis B patients switching to tenofovir alafenamide.

Ming-Lun Yeh, Po-Cheng Liang, Sam Trinh, Ching-I Huang, Chung-Feng Huang, Ming-Yen Hsieh, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Mindie H Nguyen, Ming-Lung Yu,

<h4>Background/purpose</h4>Switching to a tenofovir alafenamide (TAF)-containing regimen has been reported to be associated with body weight gain in human immunodeficiency virus-infected subjects. We aimed to investigate the body weight change and virological, hepatic, and renal outcomes of TAF switching among chronic hepatitis B (CHB) patients.<h4>Methods</h4>This retrospective study included 121 CHB ... Read more >>

J Formos Med Assoc (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2021, :]

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Optimal Timing of Administration of Direct-acting Antivirals for Patients With Hepatitis C-associated Hepatocellular Carcinoma Undergoing Liver Transplantation.

Michael K Turgeon, Shimul A Shah, Aaron M Delman, Benjamin V Tran, Vatche G Agopian, Joel P Wedd, Joseph F Magliocca, Ahyoung Kim, Andrew Cameron, Ali Olyaei, Susan L Orloff, Matthew P Anderson, Chandrashekhar A Kubal, Robert M Cannon, Jayme E Locke, Mary A Simpson, Mohamed E Akoad, Chelsey P Wongjirad, Juliet Emamaullee, Amika Moro, Federico Aucejo, Cyrus A Feizpour, Parsia A Vagefi, Mindie H Nguyen, Carlos O Esquivel, Kiran Dhanireddy, Vijay Subramanian, Alejandro Chavarriaga, Marwan M Kazimi, Maia S Anderson, Christopher J Sonnenday, Steven C Kim, David P Foley, Marwan Abdouljoud, Reena J Salgia, Dimitrios Moris, Debra L Sudan, Swaytha R Ganesh, Abhinav Humar, Majella Doyle, William C Chapman, Shishir K Maithel,

<h4>Objective</h4>To investigate the optimal timing of direct acting antiviral (DAA) administration in patients with hepatitis C-associated hepatocellular carcinoma (HCC) undergoing liver transplantation (LT).<h4>Summary of background data</h4>In patients with hepatitis C (HCV) associated HCC undergoing LT, the optimal timing of direct-acting antivirals (DAA) administration to achieve sustained virologic response (SVR) and ... Read more >>

Ann Surg (Annals of surgery)
[2021, 274(4):613-620]

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Letter: hepatocellular carcinoma risk in patients with non-selective beta blockers.

Daniel Q Huang, Mindie H Nguyen,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1093-1094]

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Cost-effectiveness of HCC surveillance among HCV patients after sustained virological response with direct-acting antivirals.

Daniel Q Huang, Mindie H Nguyen,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, :]

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Quantify the Risk of Severe Hepatitis B Flare in a Real World Where Cessation of Nucleos(t)ide Analog is Routinely Practiced.

Yao-Chun Hsu, Jia-Ling Wu, Mindie H Nguyen,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Substantial gaps in evaluation and treatment of patients with hepatitis B in the US.

Qing Ye, Leslie Y Kam, Yee Hui Yeo, Nolan Dang, Daniel Q Huang, Ramsey Cheung, Mindie H Nguyen,

<h4>Background & aims</h4>The occurrence of HBV-associated liver complications is reduced by antiviral therapy. However, prior studies using local institutional cohorts have suggested that evaluation and treatment are suboptimal. We aimed to determine the proportion of patients with chronic HBV infection who received adequate evaluation, were treatment eligible, and received antiviral ... Read more >>

J Hepatol (Journal of hepatology)
[2021, :]

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Systematic review with meta-analysis: prevalence of hepatic steatosis, fibrosis and associated factors in chronic hepatitis B.

Qi Zheng, Biyao Zou, Yuankai Wu, Yeehui Yeo, Huizhen Wu, Christopher D Stave, Ramsey C Cheung, Mindie H Nguyen,

<h4>Background</h4>As the prevalence of hepatitis steatosis (HS) increases, the prevalence of HS among those with chronic hepatitis B (CHB) may also be increasing but data on the effect of HS on CHB disease progression are lacking.<h4>Aims</h4>To determine the prevalence of HS in CHB and associated factors, prevalence of fibrosis and ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1100-1109]

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ALT levels in Treatment-Naïve, Chronic Hepatitis B Patients with Concurrent Fatty Liver Disease: A U.S. Nationwide Study.

Christine Y Chang, Leslie Kam, Nolan Dang, Ramsey Cheung, Mindie H Nguyen,

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, :]

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Incorporating fatty liver disease in multidisciplinary care and novel clinical trial designs for patients with metabolic diseases.

Mohammed Eslam, Aijaz Ahmed, Jean-Pierre Després, Vivekanand Jha, Jason C G Halford, Jack Tan Wei Chieh, David C H Harris, Masaomi Nangaku, Stephen Colagiuri, Giovanni Targher, Shashank Joshi, Christopher D Byrne, Kamlesh Khunti, Mindie H Nguyen, Robert G Gish, Jacob George,

With the global epidemics of obesity and associated conditions, including type 2 diabetes, metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension, stroke, cardiovascular disease, osteoporosis, cancer, and cognitive changes, the prevalence of multimorbidity is rapidly increasing worldwide. In this Review, a panel of international experts from across the spectrum ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(9):743-753]

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Evaluation of ethnic influence in the application of a hepatocellular carcinoma predictive model for chronic hepatitis C.

Mike T Wei, Michael H Le, Charles Landis, Huy Trinh, Grace Wong, An Le, Jian Zhang, Ramsey Cheung, Mindie H Nguyen,

Currently, there is no well-established algorithm predicting hepatocellular carcinoma (HCC) development in untreated hepatitis C virus (HCV) patients. We aimed to validate an algorithm (risk evaluation of viral load elevation and associated liver disease/HCV [REVEAL-HCV]: age, AST, ALT, HCV RNA, HCV genotype, and cirrhosis) developed in Taiwanese patients. We analyzed ... Read more >>

J Med Virol (Journal of medical virology)
[2021, 93(11):6257-6266]

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Letter to the Editor: Hepatocellular Carcinoma Surveillance in Cirrhosis Patients: Is the Real-World Situation Even Worse Than Reported?

Daniel Q Huang, Yee Hui Yeo, Mindie H Nguyen,

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(3):1714-1715]

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Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

Jiyoon Park, An K Le, Tai-Chung Tseng, Ming-Lun Yeh, Dae Won Jun, Huy Trinh, Grace L H Wong, Chien-Hung Chen, Cheng-Yuan Peng, Sung Eun Kim, Hyunwoo Oh, Min-Sun Kwak, Ka Shing Cheung, Hidenori Toyoda, Yao-Chun Hsu, Jae Yoon Jeong, Eileen L Yoon, Teerapat Ungtrakul, Jian Zhang, Qing Xie, Sang Bong Ahn, Masaru Enomoto, Jae-Jun Shim, Chris Cunningham, Soung Won Jeong, Yong Kyun Cho, Eiichi Ogawa, Rui Huang, Dong-Hyun Lee, Hirokazu Takahashi, Pei-Chien Tsai, Chung-Feng Huang, Chia-Yen Dai, Cheng-Hao Tseng, Satoshi Yasuda, Ritsuzo Kozuka, Jiayi Li, Christopher Wong, Clifford C Wong, Changqing Zhao, Joseph Hoang, Yuichiro Eguchi, Chao Wu, Yasuhito Tanaka, Ed Gane, Tawesak Tanwandee, Ramsey Cheung, Man-Fung Yuen, Hyo-Suk Lee, Ming-Lung Yu, Jia-Horng Kao, Hwai-I Yang, Mindie H Nguyen,

<h4>Background & aims</h4>Antiviral treatment criteria are based on disease progression risk, and hepatocellular carcinoma (HCC) surveillance recommendations for patients with chronic hepatitis B (CHB) without cirrhosis is based on an annual incidence threshold of 0.2%. However, accurate and precise disease progression estimate data are limited. Thus, we aimed to determine ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Genomic Analysis of Vascular Invasion in HCC Reveals Molecular Drivers and Predictive Biomarkers.

Maya S Krishnan, Anand Rajan Kd, Jangho Park, Vinodhini Arjunan, Fernando Jose Garcia Marques, Abel Bermudez, Olivia A Girvan, Nam S Hoang, Jun Yin, Mindie H Nguyen, Nishita Kothary, Sharon Pitteri, Dean W Felsher, Renumathy Dhanasekaran,

<h4>Background and aims</h4>Vascular invasion (VI) is a critical risk factor for HCC recurrence and poor survival. The molecular drivers of vascular invasion in HCC are open for investigation. Deciphering the molecular landscape of invasive HCC will help identify therapeutic targets and noninvasive biomarkers.<h4>Approach and results</h4>To this end, we undertook this ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 73(6):2342-2360]

Cited: 4 times

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Differential Clinical Characteristics and Mortality Outcomes in Persons With NAFLD and/or MAFLD.

Vy H Nguyen, Michael H Le, Ramsey C Cheung, Mindie H Nguyen,

<h4>Background & aims</h4>Metabolic dysfunction-associated fatty liver disease (MAFLD) establishes new criteria for diagnosing fatty liver disease independent of alcohol intake and concomitant viral hepatitis infection. However, the long-term outcomes of patients with MAFLD are sparse. We aimed to describe the characteristics and long-term survival of persons meeting criteria for nonalcoholic ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(10):2172-2181.e6]

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Surveillance of patients with cirrhosis remains suboptimal in the United States.

Yee Hui Yeo, Jungyun Hwang, Donghak Jeong, Nolan Dang, Leslie Y Kam, Linda Henry, Haesuk Park, Ramsey Cheung, Mindie H Nguyen,

<h4>Background & aims</h4>Regular monitoring/surveillance for liver complications is crucial to reduce morbidity and mortality in patients with cirrhosis. Recommendations from professional societies are available but adherence is not well studied, especially outside of academic centers. We aimed to determine the frequencies and factors associated with laboratory monitoring, and hepatocellular carcinoma ... Read more >>

J Hepatol (Journal of hepatology)
[2021, 75(4):856-864]

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Treatment and Renal Outcomes Up to 96 Weeks After Tenofovir Alafenamide Switch From Tenofovir Disoproxil Fumarate in Routine Practice.

Hidenori Toyoda, Jennifer Leong, Charles Landis, Masanori Atsukawa, Tsunamasa Watanabe, Daniel Q Huang, Joanne Liu, Sabrina Xin Zi Quek, Toru Ishikawa, Taeang Arai, Keisuke Yokohama, Makoto Chuma, Koichi Takaguchi, Haruki Uojima, Tomonori Senoo, Hansen Dang, Mayumi Maeda, Joseph Hoang, Richard H Le, Satoshi Yasuda, Khin N Thin, Sally Tran, Nicholas Chien, Linda Henry, Akira Asai, Shinya Fukunishi, Ramsey Cheung, Seng Gee Lim, Huy N Trinh, Mindie H Nguyen,

<h4>Background and aims</h4>Real-world data for treatment effectiveness and renal outcomes in chronic hepatitis B (CHB) patients who were switched to the new and safer prodrug tenofovir alafenamide (TAF) from tenofovir disoproxil fumarate (TDF) are limited. Therefore, we aimed to evaluate treatment and renal outcomes of this population.<h4>Approach and results</h4>We analyzed ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(2):656-666]

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Resubclassification and clinical management for Barcelona Clinic Liver Cancer Stage C hepatocellular carcinoma.

Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Tsung-Chin Wu, Jen-Hao Yeh, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Lewis Roberts, Dae Won Jun, Hidenori Toyoda, Satoshi Yasuda, Mindie H Nguyen, Ming-Lung Yu,

<h4>Background</h4>Patients with Barcelona Clinic Liver Cancer Stage C (BCLC-C) hepatocellular carcinoma (HCC) can be markedly heterogeneous with varying prognosis. This study aims to establish a new subclassification system for BCLC-C HCC to better predict overall survival (OS) and to tailor therapy.<h4>Methods</h4>We retrospectively studied 1856 BCLC-C HCC patients between 2006 and ... Read more >>

Hepatol Int (Hepatology international)
[2021, 15(4):946-956]

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A population-based US study of hepatitis C diagnosis rate.

Yee Hui Yeo, Leslie Y Kam, Michael H Le, Donghak Jeong, Nolan Dang, Linda Henry, Ramsey Cheung, Mindie H Nguyen,

<h4>Background</h4>Underdiagnosis of HCV infection may hinder the obtainment of 2030 elimination goal.<h4>Objective</h4>To estimate the pre-DAA HCV diagnosis rate to inform future public health effort.<h4>Methods</h4>Data were obtained from three nationwide databases (Truven Health MarketScan Research Database 2007-2014, US Census Bureau 2012-2016 and NHANES 2007-2014). HCV diagnosis was defined with either one ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, :]

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Characteristics and healthcare costs in the aging hepatitis B population of Japan: A nationwide real-world analysis.

Hiroshi Yotsuyanagi, Masayuki Kurosaki, Hiroshi Yatsuhashi, I-Heng Lee, Alvin Ng, Craig Brooks-Rooney, Mindie H Nguyen,

<h4>Introduction</h4>Advancing age, comorbidity, and financial burden have been observed in chronic hepatitis B (CHB) patients globally. As Japan is leading the world in aging demographics, similar real-world data are urgently needed for its CHB population to inform all stakeholders.<h4>Methods</h4>This cross-sectional study characterized the demographics, comorbidities, and healthcare costs of a ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, :]

Cited: 1 time

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Fatty Liver Index and Development of Cardiovascular Disease: Findings from the UK Biobank.

Biyao Zou, Yee Hui Yeo, Ramsey Cheung, Erik Ingelsson, Mindie H Nguyen,

<h4>Background</h4>Nonalcoholic fatty liver disease is common and is associated with rising morbidity and mortality in the UK. Cardiovascular disease is the main cause of death in people with nonalcoholic fatty liver disease.<h4>Aims</h4>To determine the association between baseline cardiovascular risk factors with fatty liver index, and to investigate the association between ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(6):2092-2100]

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Twelve-month post-treatment parameters are superior in predicting hepatocellular carcinoma in patients with chronic hepatitis B.

Sang Bong Ahn, Jun Choi, Dae Won Jun, Hyunwoo Oh, Eileen L Yoon, Hyoung Su Kim, Soung Won Jeong, Sung Eun Kim, Jae-Jun Shim, Yong Kyun Cho, Hyo Young Lee, Sung Won Han, Mindie H Nguyen, ,

<h4>Background & aims</h4>There are currently several prediction models for hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) receiving oral antiviral therapy. However, most models are based on pre-treatment clinical parameters. The current study aimed to develop a novel and practical prediction model for HCC by using both pre- and post-treatment ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(7):1652-1661]

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Chronic hepatitis, osteoporosis, and men: under-recognised and underdiagnosed.

Debi Prasad, Mindie H Nguyen,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2021, 9(3):141]

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Defining Age-Related Thresholds for ALT and the Risk of Confounders.

Daniel Q Huang, Mindie H Nguyen,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Epidemiology, pathogenesis, diagnosis, surveillance, and management of hepatocellular carcinoma associated with vascular liver disease.

Debi Prasad, Mindie H Nguyen,

Vascular liver disease (VLD) presents special challenges in the diagnosis, surveillance, and treatment of hepatocellular carcinoma (HCC). HCC arising in the setting of vascular liver disease is often thought to be due to elevated hepatic arterial blood flow, rather than progressive fibrosis from chronic inflammation as with other chronic liver ... Read more >>

Kaohsiung J Med Sci (The Kaohsiung journal of medical sciences)
[2021, 37(5):355-360]

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Treatment eligibility in hepatitis B: a call for better linkage to optimal care.

Daniel Q Huang, Mindie H Nguyen,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(3):160]

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