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Association between inflammatory bowel diseases and Parkinson's disease: systematic review and meta-analysis.

Yu Zhu, Min Yuan, Yue Liu, Fang Yang, Wen-Zhi Chen, Zhen-Zhen Xu, Zheng-Bing Xiang, Ren-Shi Xu,

Growing evidence suggests that there are similar pathological mechanisms and closely related pathogenic risk factors for inflammatory bowel disease (IBD) and Parkinson's disease (PD). However, the epidemiological features of these two diseases are different. This review systematically evaluated the relationship between inflammatory bowel diseases and Parkinson's disease risk. We searched ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):344-353]

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy.

Huan He, Qibin Liao, Chen Zhao, Cuisong Zhu, Meiqi Feng, Zhuoqun Liu, Lang Jiang, Linxia Zhang, Xiangqing Ding, Min Yuan, Xiaoyan Zhang, Jianqing Xu,

<h4>Background</h4>Hypoxia is a striking feature of most solid tumors and could be used to discriminate tumors from normoxic tissues. Therefore, the design of hypoxia-conditioned Chimeric Antigen Receptor (CAR) T cells is a promising strategy to reduce on-target off-tumor toxicity in adoptive cell therapy. However, existing hypoxia-conditioned CAR-T designs have been ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(10):]

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Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

Benjamin Stein, John Ferrarone, Eric Gardner, Jae Won Chang, David Wu, Qiuying Chen, Pablo Hollstein, Min Yuan, Roger Liang, John Coukos, Miriam Sindelar, Bryan Ngo, Steven Gross, Reuben Shaw, John Asara, Raymond Moellering, Harold Varmus, Lewis Cantley,

KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD) and activating mutations in KRAS frequently co-occur with loss-of-function mutations in the tumor suppressor genes, TP53 or STK11/LKB1 . However, mutation of all three genes is rarely observed in hLUAD, even though engineered mutations of all three genes ... Read more >>

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Firmicutes and Blautia in Gut Microbiota Lessened in Chronic Liver Diseases and Hepatocellular Carcinoma Patients: A Pilot Study.

Tianyou Chen, Rongrong Ding, Xiaorong Chen, Yunfei Lu, Jia Shi, Ying Lü, Bozong Tang, Wensi Zhang, Chen Ye, Min Yuan, Zongguo Yang,

The gut microbiota system plays vital role in liver diseases. This study aimed to address the diversity of gut microbiota and its correlations with clinical parameters in healthy individuals, chronic liver disease (CLD), and hepatocellular carcinoma (HCC) patients. Fecal specimens of 9 healthy individuals, 11 CLD, and 21 HCC were ... Read more >>

Bioengineered (Bioengineered)
[2021, :]

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Fast and efficient correction for population stratification in multi-locus genome-wide association studies.

Rui Liu, Min Yuan, Xu Steven Xu, Yaning Yang,

Reducing false discoveries caused by population stratification (PS) has always been a challenge in genome-wide association studies (GWAS). The current literature established several single marker approaches including genomic control (GC), EIGENSTRAT and generalized linear mixed model association test (GMMAT) and multi-marker methods such as LASSO mixed model (LASSOMM). However, the ... Read more >>

Genetica (Genetica)
[2021, :]

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Comparative Untargeted Metabolomic Profiling of Induced Mitochondrial Fusion in Pancreatic Cancer.

Nicholas D Nguyen, Meifang Yu, Vinit Y Reddy, Ariana C Acevedo-Diaz, Enzo C Mesarick, Joseph Abi Jaoude, Min Yuan, John M Asara, Cullen M Taniguchi,

Mitochondria are dynamic organelles that constantly alter their shape through the recruitment of specialized proteins, like mitofusin-2 (Mfn2) and dynamin-related protein 1 (Drp1). Mfn2 induces the fusion of nearby mitochondria, while Drp1 mediates mitochondrial fission. We previously found that the genetic or pharmacological activation of mitochondrial fusion was tumor suppressive ... Read more >>

Metabolites (Metabolites)
[2021, 11(9):]

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Basic Reproduction Number of the 2019 Novel Coronavirus Disease in the Major Endemic Areas of China: A Latent Profile Analysis.

Honglv Xu, Yi Zhang, Min Yuan, Liya Ma, Meng Liu, Hong Gan, Wenwen Liu, Gillian Gianna Anne Lum, Fangbiao Tao,

<b>Objective:</b> The aim of this study is to analyze the latent class of basic reproduction number (<i>R</i> <sub>0</sub>) trends of the 2019 novel coronavirus disease (COVID-19) in the major endemic areas of China. <b>Methods:</b> The provinces that reported more than 500 cases of COVID-19 till February 18, 2020 were selected ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:575315]

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An aptasensor for the detection of Pb2+ based on photoinduced electron transfer between a G-quadruplex-hemin complex and a fluorophore.

Ya Wang, Tai Ye, Min Yuan, Hui Cao, Jingsong Yu, Fengqin Yin, Xiuxiu Wu, Liling Hao, Fei Xu,

Due to the threat to health of heavy metal contamination, simple and rapid detection methods for heavy metals are an urgent needed in environment protection and food safety. In this work, we have developed a fluorescent aptasensor for the 'turn-off' model detection of Pb<sup>2+</sup> . The key feature of the ... Read more >>

Luminescence (Luminescence : the journal of biological and chemical luminescence)
[2021, :]

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Considerations on the concept, definition, and diagnosis of amyotrophic lateral sclerosis.

Ren-Shi Xu, Min Yuan,

The concept, definition, and diagnosis of amyotrophic lateral sclerosis (ALS) currently present some problems. This article systematically reviews the literature on the history, current concepts, definition, and diagnosis of ALS, and discloses the present problems based on the retrieved literature and the authors' clinical experience. The current concepts and definitions ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1723-1729]

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Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model.

Min Yuan, Guoqing Jing, Qian Kong, Tingqian Ming, Xuemin Song, Xiaojing Wu,

The aim of the present study was to investigate the effect of penehyclidine hydrochloride (PHC) pretreatment on mice with lipopolysaccharide (LPS)‑induced acute lung injury (ALI) and its possible underlying mechanisms. Mice were randomly separated into six groups: i) Sham group; ii) LPS group; iii) LPS + PHC group; iv) tumor necrosis factor a‑induced protein 8‑like protein ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 24(5):]

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Antimicrobial Resistance and Molecular Characterization of Citrobacter spp. Causing Extraintestinal Infections.

Liyun Liu, Ling Zhang, Haijian Zhou, Min Yuan, Dalong Hu, Yonglu Wang, Hui Sun, Jianguo Xu, Ruiting Lan,

<h4>Objectives</h4>This prospective study was carried out to investigate molecular characteristics and antimicrobial susceptibility patterns of <i>Citrobacter</i> spp. from extraintestinal infections.<h4>Methods</h4>Forty-six clinical <i>Citrobacter</i> spp. isolates were isolated from hospital patients with extraintestinal infections and analyzed by multilocus sequence typing (MLST) using seven housekeeping genes. Antimicrobial susceptibility testing was performed by disk ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2021, 11:737636]

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Comparative untargeted metabolomic profiling of induced mitochondrial fusion in pancreatic cancer

Nicholas Nguyen, Meifang Yu, Vinit Reddy, Ariana Acevedo-Diaz, Enzo Mesarick, Joseph Abi Jaoude, Min Yuan, John Asara, Cullen Taniguchi,

Mitochondria are dynamic organelles that constantly alter their shape through the recruitment of specialized proteins, like mitofusin-2 (Mfn2) and dynamin-related protein 1 (Drp1). Mfn2 induces the fusion of nearby mitochondria, while Drp1 mediates mitochondrial fission. We previously found that the genetic or pharmacological activation of mitochondrial fusion was tumor suppressive ... Read more >>

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Safety Analysis of Apatinib Combined with Chemotherapy in the Treatment of Advanced Gastric Carcinoma: A Randomised Controlled Trial.

Min Yuan, Zhaohui Wang, Yibo Zhang, Liying Chen, Yuting Liu, Cui Cui, Bo Sun,

<h4>Objective</h4>To study the safety of apatinib combined with chemotherapy in the treatment of advanced gastric carcinoma (GCA).<h4>Methods</h4>74 patients with advanced GCA treated in the oncology department of Weifang People's Hospital (January 2019-January 2020) were enrolled in this study and equally split into study group (SG) and reference group (RG) according ... Read more >>

J Oncol (Journal of oncology)
[2021, 2021:5177140]

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Survey of Adherence with COVID-19 Prevention Behaviors During the 2020 Thanksgiving and Winter Holidays Among Members of the COVID-19 Community Research Partnership.

James E Peacock, David M Herrington, Sharon L Edelstein, Austin L Seals, Ian D Plumb, Sharon Saydah, William H Lagarde, Michael S Runyon, Patrick D Maguire, Adolfo Correa, William S Weintraub, Thomas F Wierzba, John W Sanders, ,

Prevention behaviors represent important public health tools to limit spread of SARS-CoV-2. Adherence with recommended public health prevention behaviors among 20000 + members of a COVID-19 syndromic surveillance cohort from the mid-Atlantic and southeastern United States was assessed via electronic survey following the 2020 Thanksgiving and winter holiday (WH) seasons. Respondents were ... Read more >>

J Community Health (Journal of community health)
[2021, :]

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Iron Cycle Tuned by Outer-Membrane Cytochromes of Dissimilatory Metal-Reducing Bacteria: Interfacial Dynamics and Mechanisms In Vitro.

Sheng-Song Yu, Jie-Jie Chen, Rui-Fen Cheng, Yuan Min, Han-Qing Yu,

The biogeochemical cycle of iron is of great importance to living organisms on Earth, and dissimilatory metal-reducing bacteria (DMRB) with the capability of reducing hematite (α-Fe<sub>2</sub>O<sub>3</sub>) by outer-membrane (OM) cytochromes play a great role in the iron cycle. However, the dynamic binding of cytochromes to α-Fe<sub>2</sub>O<sub>3</sub> at the molecular level ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, :]

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Instance elimination strategy for non-convex multiple-instance learning using sparse positive bags.

Min Yuan, Yitian Xu, Renxiu Feng, Zongmin Liu,

In some multiple instance learning (MIL) applications, positive bags are sparse (i.e. containing only a small fraction of positive instances). To deal with the imbalanced data caused by these situations, we present a novel MIL method based on a small sphere and large margin approach (SSLM-MIL). Due to the introduction ... Read more >>

Neural Netw (Neural networks : the official journal of the International Neural Network Society)
[2021, 142:509-521]

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Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5-Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection.

Shirron Carter, Joann Miller, Gwendolyn Cramer, Min Yuan, Stacy Guzman, Mary E Putt, Keith A Cengel, Gary M Freedman, Theresa M Busch,

Treatment de-escalation is sought in the management of precursor lesions of early stage breast cancer, driving the appeal of adjuvant modalities to lumpectomy that reduce toxicity and minimally detract from patient quality of life. We investigate photodynamic therapy (PDT), with the photosensitizing prodrug, 5-aminolevulinic acid (ALA), as adjuvant therapy to ... Read more >>

Photochem Photobiol (Photochemistry and photobiology)
[2021, :]

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A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity.

Min Yuan, Xu-Jiang Yuan, Miguel Pineda, Ze-Yu Liang, Jian He, Sheng-Wei Sun, Tian-Ling Pan, Kun-Ping Li,

Among different types, Chinese propolis (ChPs) and Brazilian green propolis (BrGPs) have been shown to contain multi-functional properties. Despite extensive research in the field, reports comparing propolis from different geographical areas are still limited, compromising our current understanding of the potential therapeutic effect associated with propolis and its derived compounds. ... Read more >>

Food Funct (Food & function)
[2020, 11(3):2368-2379]

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Downregulation of miR-98-5p expression induces interleukin-6 expression in rheumatoid fibroblast-like synoviocytes.

Shujun Wang, Qin Geng, Hongju Zhang, Qing Du, Qiaofeng Wei, Yanhui Cui, Xiuying Zhang, Min Yuan,

<h4>Aim</h4>The increased level of interleukin-6 (IL-6) plays a significant role in the pathogenesis of rheumatoid arthritis (RA). Specific blockade of IL-6 or its receptor has been used successfully in treating RA. MicroRNAs can regulate gene expression and act as regulators of target genes. Manipulation of specific microRNAs provides a novel ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2021, 24(8):1024-1031]

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NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells.

Natalia I Rubtsova, Michael C Hart, Alejandro D Arroyo, Sofya A Osharovich, Benjamin K Liebov, Joann Miller, Min Yuan, Jeffrey M Cochran, Sanghoon Chong, Arjun G Yodh, Theresa M Busch, E James Delikatny, Nadia Anikeeva, Anatoliy V Popov,

New exogenous probes are needed for both imaging diagnostics and therapeutics. Here, we introduce a novel nanocomposite near-infrared (NIR) fluorescent imaging probe and test its potency as a photosensitizing agent for photodynamic therapy (PDT) against triple-negative breast cancer cells. The active component in the nanocomposite is a small molecule, pyropheophorbide ... Read more >>

Bioconjug Chem (Bioconjugate chemistry)
[2021, 32(8):1852-1863]

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Bipolar disorder and the risk for stroke incidence and mortality: a meta-analysis.

Min Yuan, Zhi-Long Xiao, Huang-Yan Zhou, Wei Rao, Gang Huang, Hong-Bing Nie, Wen-Feng Cao, Ren-Shi Xu,

<h4>Objective</h4>Bipolar disorder (BD) may be associated with an increased risk of stroke, but to date, the results of the studies are still controversial. This study aimed to assess the association of BD with stroke incidence and mortality by a meta-analysis.<h4>Method</h4>PubMed, EMBASE, the Cochrane library databases, and Web of Science databases ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, :]

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Extraction of Pb(II) from wheat samples via dual-frequency ultrasound-assisted enzymatic digestion and the mechanisms of its interactions with wheat proteins.

Hui Cao, Denghui Meng, Xutao Liu, Tai Ye, Min Yuan, Jinsong Yu, Xiuxiu Wu, Yan Li, Fengqin Yin, Fei Xu,

A novel dual-frequency ultrasound-assisted enzymatic digestion (DUED) technique was used to extract Pb(II) from certified reference materials (CRMs) of wheat flour. Following this, the interactions of Pb(II) with wheat proteins were investigated to provide evidence for the selection of enzyme species. The results showed that the simultaneous use of α-amylase ... Read more >>

Food Chem (Food chemistry)
[2021, 363:130247]

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Synthesis and evaluation of mesoporous silica/mesoporous molecularly imprinted nanoparticles as adsorbents for detection and selective removal of imidacloprid in food samples.

Fengqin Yin, Feng Xu, Kun Zhang, Min Yuan, Hui Cao, Tai Ye, Xiuxiu Wu, Fei Xu,

The double-mesoporous-layer imprinted polymer of mesoporous silica/mesoporous molecularly imprinted nanoparticles (MIP), with high specific surface area, rich porosity, excellent mass transfer rate and selectivity, were synthesized using imidacloprid (IDP) as a template. Under the optimal conditions of pH, contact time, concentration and temperature, MIP showed high adsorption capacity of 13.86 μg·mg<sup>-1</sup> ... Read more >>

Food Chem (Food chemistry)
[2021, 364:130216]

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SCEBE: an efficient and scalable algorithm for genome-wide association studies on longitudinal outcomes with mixed-effects modeling.

Min Yuan, Xu Steven Xu, Yaning Yang, Yinsheng Zhou, Yi Li, Jinfeng Xu, Jose Pinheiro, ,

Genome-wide association studies (GWAS) using longitudinal phenotypes collected over time is appealing due to the improvement of power. However, computation burden has been a challenge because of the complex algorithms for modeling the longitudinal data. Approximation methods based on empirical Bayesian estimates (EBEs) from mixed-effects modeling have been developed to ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, 22(3):]

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