Full Text Journal Articles by
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Color-related chlorophyll and carotenoid concentrations of Chinese kale can be altered through CRISPR/Cas9 targeted editing of the carotenoid isomerase gene BoaCRTISO.

Bo Sun, Min Jiang, Hao Zheng, Yue Jian, Wen-Li Huang, Qiao Yuan, Ai-Hong Zheng, Qing Chen, Yun-Ting Zhang, Yuan-Xiu Lin, Yan Wang, Xiao-Rong Wang, Qiao-Mei Wang, Fen Zhang, Hao-Ru Tang,

The carotenoid isomerase gene (BoaCRTISO) of Chinese kale was targeted and edited using the CRISPR/Cas9 system in the present study. The results showed a high mutation rate (81.25%), and 13 crtiso mutants were obtained. Only two types of mutations, insertions and replacements, were found. Both the total and individual carotenoid ... Read more >>

Hortic Res (Horticulture research)
[2020, 7:161]

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Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer.

Jiajia Chen, Rong Wu, Ying Xuan, Min Jiang, Yuecan Zeng,

BACKGROUND:Despite the prominent development of medical technology in recent years, the prognosis of non-small cell lung cancer (NSCLC) is still not optimistic. It is crucial to identify more reliable diagnostic biomarkers for the early diagnosis and personalized therapy of NSCLC and clarify the molecular mechanisms underlying NSCLC progression. METHODS:In the ... Read more >>

Biosci Rep (Bioscience reports)
[2020, 40(10):]

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Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages.

Chun-Ying Qiao, Ying Li, Yue Shang, Min Jiang, Jian Liu, Zi-Ying Zhan, Huan Ye, Yong-Ce Lin, Jing-Ya Jiao, Rong-Hui Sun, Zhi-Hong Zhang, Mei-Hua Piao, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian,

Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation. Treated with lipopolysaccharide (LPS) plus MSU, both mouse peritoneal ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1481-1493]

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Meta-Analysis Treatment Hyperphosphatemia Chronic Renal Failure Based on Nano Lanthanum Hydroxide.

Min Jiang, Hengheng Zheng, Chengliang Xu, Ye Wang, Tingxin Wan,

In this study, our aim is to investigate the effect of lanthanum carbonate in chronic treatment renal failure complicated with hyperphosphatemia. Using methods with lanthanum carbonate, hyperphosphatemia, placebos, calcium carbonate, end-stage renal disease as keywords, we searched the Chinese Journal Full-text Database, Chinese sci-tech journal database, Wanfang Data knowledge service ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(10):6555-6560]

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A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation

Min Jiang, Lixian Liu, Ruiwu Liu, Kit Lam, Nancy Lane, Wei Yao,

Abstract Aims. Currently, there are no effective medications that reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatment of mesenchymal stromal cell (MSC), in the treatment of bone loss secondary to PD. Materials and Methods. ... Read more >>

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Metabolic engineering of Pichia pastoris for malic acid production from methanol.

Feng Guo, Zhongxue Dai, Wenfang Peng, Shangjie Zhang, Jie Zhou, Jiangfeng Ma, Weiliang Dong, Fengxue Xin, Wenming Zhang, Min Jiang,

The application of rational design in reallocating metabolic flux to accumulate desired chemicals is always restricted by the native regulatory network. In this study, recombinant Pichia pastoris was constructed for malic acid production from sole methanol through rational redistribution of metabolic flux. Different malic acid accumulation modules were systematically evaluated ... Read more >>

Biotechnol Bioeng (Biotechnology and bioengineering)
[2020, :]

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eRNAs and Superenhancer lncRNAs Are Functional in Human Prostate Cancer.

Xiaona Zhang, Panpan Pang, Min Jiang, Qunfa Cao, Huili Li, Yi Xu, Yao Li, Xue Chen, Junsong Han,

Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. lncRNAs (long noncoding RNAs) play a significant role in the occurrence and development of PCa. eRNAs (enhancer RNAs) and SE-lncRNAs (superenhancer lncRNAs) are important elements of lncRNAs, but the role of eRNAs and SE-lncRNAs in PCa ... Read more >>

Dis Markers (Disease markers)
[2020, 2020:8847986]

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Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism.

Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian,

ETHNOPHARMACOLOGICAL RELEVANCE:As the largest genus of Gentianaceae family, the Gentiana genus harbors over 400 species, widely distributed in the alpine areas of temperate regions worldwide. Plants from Gentiana genus are traditionally used to treat a wide variety of diseases including easing pain dispelling rheumatism, and treating liver jaundice, chronic pharyngitis ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 264:113391]

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Individual-Based Transfer Learning for Dynamic Multiobjective Optimization.

Min Jiang, Zhenzhong Wang, Shihui Guo, Xing Gao, Kay Chen Tan,

Dynamic multiobjective optimization problems (DMOPs) are characterized by optimization functions that change over time in varying environments. The DMOP is challenging because it requires the varying Pareto-optimal sets (POSs) to be tracked quickly and accurately during the optimization process. In recent years, transfer learning has been proven to be one ... Read more >>

IEEE Trans Cybern (IEEE transactions on cybernetics)
[2020, PP:]

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Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population.

Jing Jing, Dan Xu, Zheng Li, Min Jiang, Jing Wang, Jian Zhang,

BACKGROUND:Chronic obstructive pulmonary disease (COPD) is the result of interaction between genetic and environmental factors. In this study, we aimed to explore whether MIR2113 and MIR129-LEP polymorphisms confer susceptibility to COPD. METHODS:We selected five polymorphisms of two genes (MIR2113: rs2505059 and rs9320913; MIR129-LEP: rs7778167, rs791595 and rs4731420) based on previous ... Read more >>

Pulm Pharmacol Ther (Pulmonary pharmacology & therapeutics)
[2020, 64:101945]

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Learning From Weakly Labeled Data Based on Manifold Regularized Sparse Model.

Jia Zhang, Shaozi Li, Min Jiang, Kay Chen Tan,

In multilabel learning, each training example is represented by a single instance, which is relevant to multiple class labels simultaneously. Generally, all relevant labels are considered to be available for labeled data. However, instances with a full label set are difficult to obtain in real-world applications, thus leading to the ... Read more >>

IEEE Trans Cybern (IEEE transactions on cybernetics)
[2020, PP:]

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[Advance of extracorporeal membrane oxygenation therapy in cardiac arrest caused by acute poisoning].

Min Jiang, Jun Wang, Fei He,

Acute poisoning induced cardiac arrest (APCA) is an acute circulatory failure caused by severe poisoning, which is characterized by complicated mechanisms, limited treatment methods and poor prognosis. Recently, emerging evidence has demonstrated that extracorporeal membrane oxygenation (ECMO) could be a promising tool that may benefit the patients with APCA refractory ... Read more >>

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (Zhonghua wei zhong bing ji jiu yi xue)
[2020, 32(9):1145-1148]

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Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study.

Sonali Pechlivanis, Nils Lehmann, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Raimund Erbel, Susanne Moebus,

BACKGROUND:A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a CAD genetic risk score is superior to the measurement of coronary artery calcification (CAC) for CHD risk assessment and ii) the CHD risk ... Read more >>

BMC Med Genet (BMC medical genetics)
[2020, 21(1):178]

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Systematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity.

Hongling Yang, Ruochun Guo, Shaochuan Li, Fang Liang, Cheng Tian, Xueqin Zhao, Yan Long, Fei Liu, Min Jiang, Yu Zhang, Jun Ma, Mengni Peng, Siyi Zhang, Weitao Ye, Qiangsheng Gan, Fangling Zeng, Shanliang Mao, Qihua Liang, Xiaodong Ma, Mengru Han, Fei Gao, Rentao Yang, Cheng Zhang, Lulu Xiao, Junjie Qin, Shenghui Li, Chunyan Zhu,

The woman's gut microbiota during pregnancy may support nutrient acquisition, is associated with diseases, and has been linked to infant health. However, there is limited information on gut microbial characteristics and dependence in pregnant women. In this study, we provide a comprehensive overview of the gut microbial characteristics of 1479 ... Read more >>

NPJ Biofilms Microbiomes (NPJ biofilms and microbiomes)
[2020, 6(1):32]

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The value of lymphocyte count in determining the severity of COVID-19 and estimating the time for nucleic acid test results to turn negative.

Yuanchao Li, Tuoyun Yang, Sicong Wang, Junbo Zheng, Jing Zhou, Min Jiang, Tong Zhou, Yang Cao, Hongliang Wang,

Peripheral blood lymphocyte count is shown to be decreased in patients with COVID-19 in the early stage of the disease. The degree of lymphocyte count reduction is related to COVID-19 severity and could be used as an indicator to reflect the disease severity. Our aim was to investigate the value ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Identification of osteogenic progenitor cell-targeted peptides that augment bone formation.

Min Jiang, Ruiwu Liu, Lixian Liu, Alexander Kot, Xueping Liu, Wenwu Xiao, Junjing Jia, Yuanpei Li, Kit S Lam, Wei Yao,

Activation and migration of endogenous mesenchymal stromal cells (MSCs) are critical for bone regeneration. Here, we report a combinational peptide screening strategy for rapid discovery of ligands that not only bind strongly to osteogenic progenitor cells (OPCs) but also stimulate osteogenic cell Akt signaling in those OPCs. Two lead compounds ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4278]

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Perspiration During Exercise in Patients With Stable Chronic Obstructive Pulmonary Disease

Zheng Li, Yanxin Zhang, Jing Wang, Dan Xu, Jing Jing, Min Jiang, Fengsen Li,

Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common progressive respiratory condition. Chills in the back region with excessive sweating are common symptoms in COPD patients. The aim of our study was to identify factors associated with increased rates of perspiration in COPD patients. Methods: We performed a prospective ... Read more >>

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Impact of supervisory behavior on sustainable employee performance: Mediation of conflict management strategies using PLS-SEM.

Jiang Min, Shuja Iqbal, Muhammad Aamir Shafique Khan, Shamim Akhtar, Farooq Anwar, Sikandar Ali Qalati,

This study investigates the relationship between supervisory behavior, conflict management strategies, and sustainable employee performance and inquires the mediating effect of conflict management strategies. Data were collected from the SMEs of the manufacturing industry of Pakistan. The significance of the model was assessed using the PLS-SEM (structural equation modeling). The ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0236650]

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[Rapid identification of 15 common S. enterica Salmonella serovars by multiplex real-time PCR].

Le Zuo, Yixiang Jiang, Min Wan, Min Jiang, Xiaolu Shi, Yinghui Li, Yaqun Qiu, Yiman Lin, Qinghua Hu,

OBJECTIVE:Multiplex real-time PCR for the identification of 15 Salmonella serovars was developed. METHODS:Through the Salmonella genome comparison, 12 membrane proteins STM4497 gene can be used to identify 15 Salmonella serovars, and these 12 genes were respectively listed as A-L genes. Then primers were designed according to A-L gene conserved sequences, ... Read more >>

Wei Sheng Yan Jiu (Wei sheng yan jiu = Journal of hygiene research)
[2020, 49(5):823-858]

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Rapid evaluation of neutralizing antibodies in COVID-19 patients

Pingping Zhang, Baisheng Li, Wei Min, Xiaohui Wang, Zhencui Li, Yong Zhao, Huan Zhang, Min Jiang, Huanying Zheng, Chao Yang, Wei Zhang, Le Zuo, Qi Gao, Zhengrong Yang, Yanzhao Li, Tiejian Feng, Changqing Lin, Qinghua Hu, Tie Song, Ruifu Yang,

The ongoing coronavirus disease 2019 (COVID-19) pandemic calls for a method to rapidly and conveniently evaluate neutralizing antibody (NAb) activity in patients. Here, an up-conversion phosphor technology-based point-of-care testing (UPT-POCT) and a microneutralization assay were employed to detect total antibodies against the receptor-binding domain of severe acute respiratory syndrome coronavirus ... Read more >>

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Hydrolysis of Corncob Hemicellulose by Solid Acid Sulfated Zirconia and Its Evaluation in Xylitol Production.

Lijun Wan, Zhen Gao, Bin Wu, Fei Cao, Min Jiang, Ping Wei, Honghua Jia,

Corncob is an abundant agricultural residue containing high content of hemicellulose. In this paper, the hemicellulosic hydrolysate was prepared from the hydrolysis of corncob using the solid acid sulfated zirconia as a catalyst. According to response surface analysis experiments, the optimum conditions for preparing hemicellulosic hydrolysate catalyzed by sulfated zirconia ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2020, :]

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Network Pharmacology to Identify the Pharmacological Mechanisms of a Traditional Chinese Medicine Derived from Trachelospermum jasminoides in Patients with Rheumatoid Arthritis.

Tao Jiang, Bo Kong, Wei Yan, Changgui Wu, Min Jiang, Xing Xu, Xiaobing Xi,

BACKGROUND This study used a network pharmacology approach to identify the pharmacological mechanisms of a traditional Chinese medicine derived from Trachelospermum jasminoides (Lindl.) Lem. in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS Known compounds of T. jasminoides were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, the ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e922639]

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Number of Stent Retriever Passes Associated with Clinical Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke.

Zongjie Shi, Shunyuan Guo, Sujie Zheng, Jiang Yong Min, Yu Geng,

OBJECTIVE:To evaluate the association between the number of stent retriever (SR) passes and clinical outcome after mechanical thrombectomy (MT) in patients with acute ischemic stroke(AIS). METHODS:We retrospectively analyze data collected from consecutive patients with large vessel occlusion (LVO) in anterior circulation treated with MT. Baseline characteristics, number of SR passes, symptomatic ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(11):105199]

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Metabolic engineering of Escherichia coli for L-malate production anaerobically.

Youming Jiang, Tianwen Zheng, Xiaohan Ye, Fengxue Xin, Wenming Zhang, Weiliang Dong, Jiangfeng Ma, Min Jiang,

BACKGROUND:L-malate is one of the most important platform chemicals widely used in food, metal cleaning, textile finishing, pharmaceuticals, and synthesis of various fine chemicals. Recently, the development of biotechnological routes to produce L-malate from renewable resources has attracted significant attention. RESULTS:A potential L-malate producing strain E. coli BA040 was obtained ... Read more >>

Microb. Cell Fact. (Microbial cell factories)
[2020, 19(1):165]

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Sitting-induced hemodynamic changes and association with sitting intolerance in children and adolescents: a cross-sectional study.

Chunyan Tao, Zhenhui Han, Yongqiang Yan, Zhitao Pan, Hanwen Zhu, Xueying Li, Hongxia Li, Yuanyuan Wang, Ping Liu, Yuli Wang, Min Jiang, Chaoshu Tang, Hongfang Jin, Junbao Du,

Hemodynamic alteration with postural change from supine to sitting has been unclear in the young. In the cross-sectional study, 686 participants (371 boys and 315 girls, aged 6-18 years) were recruited from 4 schools in Kaifeng city, the central area of China. The active sitting test was performed to obtain heart ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13921]

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