Full Text Journal Articles by
Author Mimoza Hoti

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Recombination and biased segregation of mitochondrial genomes during crossing and meiosis of different Schizosaccharomyces pombe strains.

Stephan Kamrad, María Rodríguez-López, Shoumit Dey, Mimoza Hoti, Henry Wallace, Markus Ralser, Jürg Bähler,

During meiosis, tethering of parental mitochondria to opposite cell poles inhibits the mixing of mitochondria with different genomes and ensures uniparental inheritance in thestandard laboratory strain of fission yeast. We here investigate mitochondrial inheritance in crosses between natural isolates using tetrad dissection and next-generation sequencing. We find that colonies grown ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Fitness Landscape of the Fission Yeast Genome.

Leanne Grech, Daniel C Jeffares, Christoph Y Sadée, María Rodríguez-López, Danny A Bitton, Mimoza Hoti, Carolina Biagosch, Dimitra Aravani, Maarten Speekenbrink, Christopher J R Illingworth, Philipp H Schiffer, Alison L Pidoux, Pin Tong, Victor A Tallada, Robin Allshire, Henry L Levin, Jürg Bähler,

The relationship between DNA sequence, biochemical function, and molecular evolution is relatively well-described for protein-coding regions of genomes, but far less clear in noncoding regions, particularly, in eukaryote genomes. In part, this is because we lack a complete description of the essential noncoding elements in a eukaryote genome. To contribute ... Read more >>

Mol Biol Evol (Molecular biology and evolution)
[2019, 36(8):1612-1623]

Cited: 1 time

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Longevity is determined by ETS transcription factors in multiple tissues and diverse species.

Adam J Dobson, Richard Boulton-McDonald, Lara Houchou, Tatiana Svermova, Ziyu Ren, Jeremie Subrini, Mireya Vazquez-Prada, Mimoza Hoti, Maria Rodriguez-Lopez, Rita Ibrahim, Afroditi Gregoriou, Alexis Gkantiragas, Jürg Bähler, Marina Ezcurra, Nazif Alic,

Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TFs) can ameliorate deleterious effects of age. Here we explore how a circuit of TFs coordinates pro-longevity transcriptional outcomes, which reveals a multi-tissue and multi-species role ... Read more >>

PLoS Genet (PLoS genetics)
[2019, 15(7):e1008212]

Cited: 4 times

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A family of transcription factors that limit lifespan: ETS factors have conserved roles in longevity

Adam Dobson, Richard Boulton-McDonald, Lara Houchou, Ziyu Ren, Mimoza Hoti, Maria Rodriguez-Lopez, Alexis Gkantiragas, Afroditi Gregoriou, Jürg Bähler, Marina Ezcurra, Nazif Alic,

<h4>ABSTRACT</h4> Increasing average population age, and the accompanying burden of ill health, is one of the public health crises of our time. Understanding the basic biology of the ageing process may help ameliorate the pathologies that characterise old age. Ageing can be modulated, often through changes in gene expression where ... Read more >>

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Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.

Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi,

[This corrects the article DOI: 10.1371/journal.pmed.1002352.]. ... Read more >>

PLoS Med (PLoS medicine)
[2018, 15(10):e1002694]

Cited: 1 time

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Fitness Landscape of the Fission Yeast Genome

Leanne Grech, Daniel Charlton Jeffares, Christoph Yves Sadée, María Rodríguez-López, Danny Asher Bitton, Mimoza Hoti, Carolina Biagosch, Dimitra Aravani, Maarten Speekenbrink, Christopher Illingworth, Philipp Schiffer, Alison Pidoux, Pin Tong, Victor Tallada, Robin Allshire, Henry Levin, Jürg Bähler,

<h4>Background</h4> Non-protein-coding regions of eukaryotic genomes remain poorly understood. Diversity studies, comparative genomics and biochemical outputs of genomic sites can be indicators of functional elements, but none produce fine-scale genome-wide descriptions of all functional elements. <h4>Results</h4> Towards the generation of a comprehensive description of functional elements in the haploid Schizosaccharomyces ... Read more >>

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Vitamin D receptor genotype influences risk of upper respiratory infection.

David A Jolliffe, Claire L Greiller, Charles A Mein, Mimoza Hoti, Eteri Bakhsoliani, Aurica G Telcian, Angela Simpson, Neil C Barnes, John A Curtin, Adnan Custovic, Sebastian L Johnston, Christopher J Griffiths, Robert T Walton, Adrian R Martineau,

SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections. The influence of genetic variation in the vitamin D pathway resulting in susceptibility to upper respiratory infections (URI) has not been investigated. We evaluated the influence of thirty-three SNP in eleven vitamin D pathway ... Read more >>

Br J Nutr (The British journal of nutrition)
[2018, 120(8):891-900]

Cited: 9 times

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A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast

María Rodríguez-López, Cristina Cotobal, Oscar Fernández-Sánchez, Natalia Borbarán Bravo, Risky Oktriani, Heike Abendroth, Dardan Uka, Mimoza Hoti, Jin Wang, Mikel Zaratiegui, Jürg Bähler,

In the fission yeast Schizosaccharomyces pombe the prevailing approach for gene manipulations is based on homologous recombination of a PCR product that contains genomic target sequences and a selectable marker. The CRISPR/Cas9 system has recently been implemented in fission yeast, which allows for seamless genome editing without integration of a ... Read more >>

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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.

Daniel C Jeffares, Clemency Jolly, Mimoza Hoti, Doug Speed, Liam Shaw, Charalampos Rallis, Francois Balloux, Christophe Dessimoz, Jürg Bähler, Fritz J Sedlazeck,

Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic diversity and evolution. We analyse the effects of SVs on gene expression, quantitative traits and intrinsic reproductive isolation in the yeast Schizosaccharomyces pombe. We establish a high-quality curated catalogue ... Read more >>

Nat Commun (Nature communications)
[2017, 8:14061]

Cited: 99 times

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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast

Daniel Jeffares, Clemency Jolly, Mimoza Hoti, Doug Speed, Liam Shaw, Charalampos Rallis, Francois Balloux, Christophe Dessimoz, Jürg Bähler, Fritz Sedlazeck,

Large structural variations (SVs) in the genome are harder to identify than smaller genetic variants but may substantially contribute to phenotypic diversity and evolution. Here we analyze the effects of SVs on gene expression, quantitative traits, and intrinsic reproductive isolation in the yeast Schizosaccharomyces pombe . We establish a high-quality ... Read more >>

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A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast.

María Rodríguez-López, Cristina Cotobal, Oscar Fernández-Sánchez, Natalia Borbarán Bravo, Risky Oktriani, Heike Abendroth, Dardan Uka, Mimoza Hoti, Jin Wang, Mikel Zaratiegui, Jürg Bähler,

In the fission yeast <i>Schizosaccharomyces pombe</i> the prevailing approach for gene manipulations is based on homologous recombination of a PCR product that contains genomic target sequences and a selectable marker. The CRISPR/Cas9 system has recently been implemented in fission yeast, which allows for seamless genome editing without integration of a ... Read more >>

Wellcome Open Res (Wellcome open research)
[2016, 1:19]

Cited: 10 times

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Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs).

Adrian R Martineau, Beverley D MacLaughlin, Richard L Hooper, Neil C Barnes, David A Jolliffe, Claire L Greiller, Kate Kilpin, David McLaughlin, Gareth Fletcher, Charles A Mein, Mimoza Hoti, Robert Walton, Jonathan Grigg, Peter M Timms, Raj K Rajakulasingam, Angshu Bhowmik, Marion Rowe, Timothy R Venton, Aklak B Choudhury, David E Simcock, Zia Sadique, William R Monteiro, Christopher J Corrigan, Catherine M Hawrylowicz, Christopher J Griffiths,

<h4>Rationale</h4>Asthma exacerbations are commonly precipitated by viral upper respiratory infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with asthma. Trials of vitamin D in adults with asthma with incidence of exacerbation and URI as primary outcome are lacking.<h4>Objective</h4>To conduct a randomised controlled trial of vitamin D3 ... Read more >>

Thorax (Thorax)
[2015, 70(5):451-457]

Cited: 41 times

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Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson, Morris Brown, Nilesh J Samani, Anna F Dominiczak, John M Connell, G Mark Lathrop, Jaspal Kooner, John Chambers, Paul Elliott, Robert Clarke, Rory Collins, Maris Laan, Elin Org, Elin Org, Peeter Juhanson, Gudrun Veldre, Margus Viigimaa, Susana Eyheramendy, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Meena Kumari, Michael Marmot, Eric Brunner, Mark Caulfield, Patricia B Munroe,

WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WNK1 variation in HapMap, we aimed to replicate our ... Read more >>

PLoS One (PloS one)
[2009, 4(4):e5003]

Cited: 32 times

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