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Author Mikio Mikami

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Clinicopathological Demographics of Malignant Melanoma of the Vulva and Vagina in Japan

Dai Ogata, Shin Nishio, Naohito Hatta, Tatsuya Kaji, Kazuyasu Fujii, Mikio Mikami, Yoshio Kiyohara, Takayuki Enomoto,

<h4>Objective: </h4> Malignant melanomas of the vulva (VuM) and vagina (VaM) represent a unique subgroup of rare malignant melanomas with critical biological properties and treatment differing from that of other cancers. In Japan, adequate surveys on these have not been performed. The objective of this study was to elucidate the ... Read more >>

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Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan.

Tsuyoshi Ohta, Satoru Nagase, Yosuke Okui, Takayuki Enomoto, Wataru Yamagami, Mikio Mikami, Hideki Tokunaga, Kazuhiko Ino, Kimio Ushijima, Makio Shozu, Hironori Tashiro, Masaki Mandai, Shingo Miyamoto, Ken-Ichirou Morishige, Yoshio Yoshida, Kiyoshi Yoshino, Toshiaki Saito, Eiji Kobayashi, Hiroaki Kobayashi, Munetaka Takekuma, Yoshito Terai, Takuma Fujii, Hiroyuki Kanao, Daisuke Aoki, Hidetaka Katabuchi, Nobuo Yaegashi,

<h4>Objective</h4>The purpose of our study was to conduct a detailed survey of radical hysterectomy in Japanese patients with early-stage cervical cancer, and to compare oncologic outcomes between open and minimally invasive radical hysterectomy.<h4>Methods</h4>In Japan during 2015, the medical records of 929 patients with FIGO stage IB1 and IIA disease treated ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Clinicopathological characteristics and prognostic factors of ovarian granulosa cell tumors: A JSGO-JSOG joint study.

Yasuhiko Ebina, Wataru Yamagami, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami,

<h4>Objectives</h4>The aim of this study was to elucidate the clinicopathological features of ovarian granulosa cell tumors (GCTs) and to identify the prognostic factors.<h4>Methods</h4>The Japanese Society of Gynecologic Oncology (JSGO) conducted an observational retrospective cohort study of women with GCTs enrolled in the Gynecological Tumor Registry of the Japan Society of ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Intraoperative Rupture of the Ovarian Capsule in Early-Stage Ovarian Cancer: A Meta-analysis.

Shayan Dioun, Jenny Wu, Ling Chen, Samantha Kaplan, Yongmei Huang, Alexander Melamed, Allison Gockley, Caryn M St Clair, June Y Hou, Ana I Tergas, Fady Khoury-Collado, Hiroko Machida, Mikio Mikami, Koji Matsuo, Dawn L Hershman, Jason D Wright,

<h4>Objective</h4>To examine the effects of intraoperative ovarian capsule rupture on progression-free survival and overall survival in women who are undergoing surgery for early-stage ovarian cancer.<h4>Data sources</h4>MEDLINE using PubMed, EMBASE (Elsevier), ClinicalTrials.gov, and Scopus (Elsevier) were searched from inception until August 11, 2020.<h4>Methods of study selection</h4>High-quality studies reporting survival outcomes comparing ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, 138(2):261-271]

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Pyogenic Spondylitis in Multidisciplinary Therapies of Gynecologic Malignancies: Three Cases Reports.

Masae Ikeda, Miwa Yasaka, Tetsuji Iida, Masako Shida, Hiroshi Yoshida, Takeshi Hirasawa, Mikio Mikami,

Both during and after cancer treatment, pyogenic spondylitis is an uncommon but serious complication. Because pyogenic spondylitis is often recognized as a complication of a distant process causing bacteremia, it initially may be misdiagnosed the primary infection such as urinary tract infection. Consequently, a considerable delay in diagnosis frequently occurs. ... Read more >>

Tokai J Exp Clin Med (The Tokai journal of experimental and clinical medicine)
[2021, 46(2):118-122]

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Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.

Shin Nishio, Koji Matsuo, Shinya Matsuzaki, Tomoyasu Kato, Shoji Kamiura, Hiroshi Adachi, Masao Okadome, Toshiaki Nakamura, Mikio Mikami, Takayuki Enomoto,

<h4>Objective</h4>Studies on vulvar adenocarcinoma are lacking. Thus, we aimed to compare the characteristics and survival outcomes between vulvar adenocarcinoma and squamous cell carcinoma (SCC).<h4>Methods</h4>This was a preplanned sub-analysis of a previously organized nationwide retrospective observational study in Japan conducted between 2001 and 2010 (JGOG-1075S). Surgically treated women with stage I-IV ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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Association of menopause, aging and treatment procedures with positive margins after therapeutic cervical conization for CIN 3: a retrospective study of 8,856 patients by the Japan Society of Obstetrics and Gynecology.

Masae Ikeda, Mikio Mikami, Miwa Yasaka, Takayuki Enomoto, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Hidetaka Katabuchi,

<h4>Objective</h4>The Japan Society of Obstetrics and Gynecology conducted a retrospective multi-institutional survey of patients who underwent cervical conization in Japan. This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(5):e68]

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Clinico-pathological characteristics of patients with stage IB1-IB2 (FIGO 2018) uterine cervical cancer: a nationwide study in Japan.

Keita Tsuji, Muneaki Shimada, Fumiaki Takahashi, Hideki Tokunaga, Imari Deura, Satoshi Yamaguchi, Toru Nakanishi, Koji Matsuo, Nobuo Yaegashi, Mikio Mikami,

<h4>Objective</h4>The aim of this retrospective analysis is to reveal clinicopathological findings and clinical outcome of patients with stage IB1/IB2 (FIGO 2018) uterine cervical cancer.<h4>Methods</h4>Based on the database of the Japanese Gynecologic Oncology Group, 2194 patients with stage IB1/IB2 (FIGO 2018), who underwent radical hysterectomy between 1/1/2004-12/31/2008, were identified as eligible ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(8):1541-1552]

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

Masae Ikeda, Masako Shida, Shogo Shigeta, Satoru Nagase, Fumiaki Takahashi, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.<h4>Methods</h4>This analysis ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e44]

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A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy.

Kensuke Sakai, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>To clarify the role of radiotherapy for endometrial cancer.<h4>Methods</h4>Data were analyzed for 39 247 patients with endometrial cancer registered with the Gynecologic Cancer Registry of the Japan Society of Obstetrics and Gynecology from 2004 to 2011.<h4>Results</h4>The rates of 5-year overall survival (5y-OS) in the radiotherapy and surgery groups were 53.6% and ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Wait-time for adjuvant radiotherapy and oncologic outcome in early-stage cervical cancer: A treatment implication during the coronavirus pandemic.

Koji Matsuo, Muneaki Shimada, Shinya Matsuzaki, Takayuki Enomoto, Mikio Mikami,

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 148:117-120]

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A randomized phase III trial of adjuvant chemotherapy versus concurrent chemoradiotherapy for postoperative cervical cancer: Japanese Gynecologic Oncology Group study (JGOG1082).

Akiko Furusawa, Munetaka Takekuma, Keita Mori, Tomoka Usami, Eiji Kondo, Shin Nishio, Koji Nishino, Yuichiro Miyamoto, Ryoichi Yoshimura, Miho Watanabe, Mikio Mikami, Takayuki Enomoto,

<h4>Background</h4>The standard treatment for stage IB-IIB cervical cancer is radiotherapy or radical hysterectomy; after radical hysterectomy, adjuvant concurrent chemoradiotherapy is recommended for patients with high risk factors. However, adjuvant concurrent chemoradiotherapy can cause severe gastrointestinal and urinary toxicity.<h4>Primary objective</h4>To assess whether postoperative adjuvant chemotherapy is not inferior to adjuvant concurrent ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(4):623-626]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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A retrospective assessment of the safety and efficacy of laparoscopic radical hysterectomy in Japan during the early years following its introduction: a Japanese Gynecologic Oncology Group study (JGOG1081S).

Eiji Kobayashi, Hiroyuki Kanao, Munetaka Takekuma, Shin Nishio, Atsumi Kojima-Chiba, Akiko Tozawa, Satoshi Yamaguchi, Nobuhiro Takeshima, Eiji Nakatani, Mikio Mikami,

<h4>Objective</h4>To evaluate the safety and efficacy of laparoscopic radical hysterectomy (LRH) for cervical cancer, in terms of morbidity and short-term oncologic outcome following LRH's introduction into Japan.<h4>Methods</h4>We conducted a retrospective analysis of patients with early-stage cervical cancer (FIGO staging IA2, IB1, and IIA1) who underwent LRH from Dec 2014 to ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(2):417-428]

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Surgical margin status and recurrence pattern in invasive vulvar Paget's disease: A Japanese Gynecologic Oncology Group study.

Koji Matsuo, Shin Nishio, Shinya Matsuzaki, Haruko Iwase, Seiji Kagami, Shu Soeda, Hirokazu Usui, Ryutaro Nishikawa, Mikio Mikami, Takayuki Enomoto,

<h4>Objective</h4>To examine the association between surgical margin status and recurrence pattern in invasive vulvar Paget's disease.<h4>Methods</h4>This is a preplanned secondary analysis of a previously organized nationwide retrospective study in Japan (JGOG-1075S). Women with stage I-IV invasive vulvar Paget's disease who received surgical treatment from 2001-2010 were examined (n=139). Multivariable analysis ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(3):748-754]

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The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer.

Takashi Iwata, Hiroko Machida, Koji Matsuo, Kaoru Okugawa, Tsuyoshi Saito, Kyoko Tanaka, Kenichiro Morishige, Hiroaki Kobayashi, Kiyoshi Yoshino, Hideki Tokunaga, Tomoaki Ikeda, Makio Shozu, Nobuo Yaegashi, Takayuki Enomoto, Mikio Mikami,

<h4>Objective</h4>To evaluate timing and a prediction model for pregnancy in early-stage cervical cancer patients who underwent fertility-sparing trachelectomy.<h4>Design</h4>Retrospective cohort.<h4>Setting</h4>Academic multicenter.<h4>Patient(s)</h4>Women ages <45 years with clinical stage I-II cervical cancer were enrolled between 2009 and 2013 (n = 393).<h4>Intervention(s)</h4>Planned fertility-sparing trachelectomy.<h4>Main outcome measure(s)</h4>Cumulative incidences and clinicopathological characteristics of those who developed ... Read more >>

Fertil Steril (Fertility and sterility)
[2021, 115(5):1250-1258]

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Small Cell Neuroendocrine Carcinoma of the Endometrium with Difficulty Identifying the Original Site in the Uterus.

Tetsuji Iida, Toshinari Muramatsu, Hiroshi Kajiwara, Nobuaki Kato, Hitoshi Itoh, Tomoaki Narayama, Hiroko Machida, Masae Ikeda, Masako Shida, Takeshi Hirasawa, Mikio Mikami,

Diagnosis of malignant uterine tumor with continuous lesions from the uterine body to the cervix, i.e., endometrial or cervical cancer, depends on the main site of the lesions. However, it may be difficult to differentiate advanced cancer that is widespread in the uterus. We experienced a patient who was diagnosed ... Read more >>

Tokai J Exp Clin Med (The Tokai journal of experimental and clinical medicine)
[2020, 45(4):156-161]

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Hospital volume-outcome relationship in vulvar cancer treatment: a Japanese Gynecologic Oncology Group study.

Koji Matsuo, Shin Nishio, Shinya Matsuzaki, Hiroko Machida, Mikio Mikami,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e24]

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Hypoxia-inducible Factor-1α Suppression in Ovarian Clear-cell Carcinoma Cells by Silibinin Administration.

Mariko Miyazawa, Masanori Yasuda, Masaki Miyazawa, Naoki Ogane, Tomomi Katoh, Mitsutake Yano, Takeshi Hirasawa, Mikio Mikami, Hitoshi Ishimoto,

<h4>Background/aim</h4>Advanced ovarian clear-cell carcinoma (CCC) fails to respond to standard chemotherapy, and has a poor prognosis. Since hypoxia-inducible factor-1 (HIF-1) stimulates various genes involved in cancer, we aimed to examine the efficacy of silibinin, an active component of milk thistle belonging to Asteraceae, in suppressing HIF-1 activity, and elucidate the ... Read more >>

Anticancer Res (Anticancer research)
[2020, 40(12):6791-6798]

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Impact of lymphadenectomy on the treatment of endometrial cancer using data from the JSOG cancer registry.

Keiko Saotome, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>Regional lymph node (LN) dissection is a standard surgical procedure for endometrial cancer, but there is currently no clear consensus on its therapeutic significance. We aimed to determine the impact of regional LN dissection on the outcome of endometrial cancer.<h4>Methods</h4>Study subjects comprised 36,813 patients who were registered in the gynecological ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2021, 64(1):80-89]

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The Role of Hypertension and Renin-angiotensin-aldosterone System Inhibitors in Bleomycin-induced Lung Injury.

Ryujiro Hara, Makoto Onizuka, Sawako Shiraiwa, Kaito Harada, Yasuyuki Aoyama, Daisuke Ogiya, Masako Toyosaki, Rikio Suzuki, Sinichiro Machida, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Shigeki Watanabe, Akira Miyajima, Ryota Masuda, Masayuki Iwazaki, Mikio Mikami, Takashi Koike, Hiroyuki Mochizuki, Kiyoshi Ando,

<h4>Introduction</h4>The risk factors for bleomycin-induced lung injury (BLI), a fatal complication of cancer chemotherapy, are not well-established. The renin-angiotensin-aldosterone system (RAAS) has recently been suggested to play a role in the development of lung injury. This study clarified the impact of hypertension (HTN) and the administration of RAAS inhibitors on ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2021, 21(4):e321-e327]

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Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan.

Isao Murakami, Akiko Ohno, Masae Ikeda, Hiroshi Yamashita, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi,

<h4>Objective</h4>With increased screening, more patients with precancerous or early cervical cancer are now being identified. Age at pregnancy, and thus number of patients requiring fertility preservation, have also increased, resulting in more diagnostic and therapeutic cervical conization (conization) procedures. We here investigated the pathological and clinical characteristics of patients undergoing ... Read more >>

Heliyon (Heliyon)
[2020, 6(10):e05193]

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Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis.

Tatsuyuki Chiyoda, Manabu Sakurai, Toyomi Satoh, Satoru Nagase, Mikio Mikami, Hidetaka Katabuchi, Daisuke Aoki,

<h4>Objective</h4>To assess the effectiveness of lymphadenectomy at primary debulking surgery (PDS) on the survival of patients with epithelial ovarian cancer (EOC).<h4>Methods</h4>We searched PubMed, Ichushi, and the Cochrane Library. Randomized controlled trials (RCTs) and retrospective cohort studies comparing survival of women with EOC undergoing lymphadenectomy at PDS with that of women ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(5):e67]

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Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project.

Shogo Shigeta, Masako Shida, Satoru Nagase, Masae Ikeda, Fumiaki Takahashi, Takeo Shibata, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published its first clinical guidelines for uterine cervical cancer in 2007 which has been revised twice in 2011 and 2017. The aim of this study was to investigate the influence of the first guideline publication on the therapeutic trend and patient outcome by analyzing ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):248-255]

Cited: 2 times

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Investigation of clinicopathological features of vulvar cancer in 1068 patients: A Japanese Gynecologic Oncology Group (JGOG) nationwide survey study.

Shin Nishio, Kenta Murotani, Sari Nakao, Motoki Takenaka, Shiro Suzuki, Yoichi Aoki, Yukiharu Todo, Masayoshi Hosaka, Hidekatsu Nakai, Hidetaka Katabuchi, Hirotaka Nishi, Munetaka Takekuma, Mikio Mikami, Takayuki Enomoto,

<h4>Objective</h4>Vulvar cancer is a rare malignancy in the aging population, and optimizing treatment strategies requires large-scale investigation of the clinicopathological features of this disease. In Japan, no such surveys have been conducted in the past 30 years. This large-scale retrospective multi-center study aimed to examine the clinicopathological features of vulvar cancer ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(2):449-455]

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