Full Text Journal Articles by
Author Mike Otto


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Intra-abdominal EWSR1/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype.

Abbas Agaimy, Robert Stoehr, Mike Otto, Jan Hinrich Bräsen, Nicole Pfarr, Björn Konukiewitz, Atsuko Kasajima, Arndt Hartmann, Günter Klöppel,

CREB family (CREB1, ATF1, and CREM) gene fusions are defining markers in diverse mesenchymal neoplasms (clear cell sarcoma, angiomatoid fibrous histiocytoma, and others). However, neoplasms harboring EWSR1-CREM/FUS-CREM fusions are rare and poorly characterized. We describe two cases (55-year-old male with 7.5 cm renal mass and 32-year-old female with 5.5 cm mesenteric mass) ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, :]

Cited: 0 times

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[Very rare cases of periprosthetic malignant neoplasms : Data from 4000 cases of endoprosthetic joint replacements from the histopathologic implant register].

Kevin Keidel, Marc Thomsen, Christian Dierkes, Holger Haas, Ingo Arnold, Karl-Dieter Heller, Vincent Krenn, Martin Liebisch, Mike Otto, Thorsten Gehrke, Veit Krenn,

BACKGROUND:In 2016, the AG 11 (work group for implant-material-intolerance) of the German society for Orthopaedics and Orthopaedic Surgery (DGOOC) created a histopathologic implant register (HIR). The goal was to conduct a retrospective data analysis based on the revised SLIM-consensus-classification, which defines eight different failure mechanisms. QUESTIONS:The analysis of 4000 cases of endoprosthetic joint replacements ... Read more >>

Orthopade (Der Orthopade)
[2020, 49(3):248-254]

Cited: 1 time

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Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters.

Friederike Hoellen, Athina Kostara, Thomas Karn, Uwe Holtrich, Ahmed El-Balat, Mike Otto, Achim Rody, Lars C Hanker,

The role of trefoil factor 3 (intestinal) (TFF3) has been analyzed in numerous cancers, such as breast and gastrointestinal cancer, and has been associated with poor prognosis. However, the role of TFF3 in ovarian cancers is not clear. Expression analysis of TFF3 in 91 ovarian cancer patients was performed by ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2016, 5(4):422-428]

Cited: 0 times

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Imaging mass spectrometry to discriminate breast from pancreatic cancer metastasis in formalin-fixed paraffin-embedded tissues.

Rita Casadonte, Mark Kriegsmann, Friederike Zweynert, Katrin Friedrich, Gustavo Baretton, Mike Otto, Sören-Oliver Deininger, Rainer Paape, Eckhard Belau, Detlev Suckau, Daniela Aust, Christian Pilarsky, Jörg Kriegsmann,

Diagnosis of the origin of metastasis is mandatory for adequate therapy. In the past, classification of tumors was based on histology (morphological expression of a complex protein pattern), while supportive immunohistochemical investigation relied only on few "tumor specific" proteins. At present, histopathological diagnosis is based on clinical information, morphology, immunohistochemistry, ... Read more >>

Proteomics (Proteomics)
[2014, 14(7-8):956-964]

Cited: 33 times

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Abdominal pseudocysts following peritoneal dialysis-associated peritonitis: a report of 3 cases.

Gernot Baer, Albrecht Wagner, Jochen Selbach, Mike Otto, Stefan M Weiner,

Common complications of peritoneal dialysis are peritonitis, leakages, hernias, catheter dislocation, and loss of ultrafiltration. We describe 3 cases of abdominal pseudocysts with progressive difficulty instilling and draining peritoneal dialysis fluid. The 3 patients had been treated with peritoneal dialysis for 1, 2, and 6 years. Two patients had experienced ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2010, 55(4):e15-9]

Cited: 1 time

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Small intestinal submucosa for pubourethral sling suspension for the treatment of stress incontinence: first histopathological results in humans.

Andreas Wiedemann, Mike Otto,

<h4>Purpose</h4>Small intestinal submucosa (SIS), a biomatrix of porcine origin, is used in pubourethral sling operations for female urinary stress incontinence, among other urological and surgical indications. To our knowledge we report the first histopathological examination of this biomatrix in human subjects.<h4>Materials and methods</h4>In a series of 15 patients with pubourethral ... Read more >>

J Urol (The Journal of urology)
[2004, 172(1):215-218]

Cited: 23 times

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Modification of human platelet adhesion on biomaterial surfaces by protein preadsorption under static and flow conditions.

Mike Otto, Arno Franzen, Torsten Hansen, Charles James Kirkpatrick,

Biomaterial-induced thrombosis remains one of the main complications of vascular implant devices. Preadsorbed proteins on the biomaterial/blood interface will modify the adhesion and activation of platelets (PTLs) during the initial contact-phase. Our results clearly show that PTL-adherence on biomaterials is influenced not only by protein preadsorption, but also by flow ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2004, 15(1):35-42]

Cited: 11 times

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Modification of human polymorphonuclear neutrophilic cell (PMN)-adhesion on biomaterial surfaces by protein preadsorption under static and flow conditions.

Mike Otto, Björn Wahn, Charles James Kirkpatrick,

Biomaterials induce a specific reaction after implantation in the human body. This reaction depends on the chemical and physico-chemical properties of the material as well as on the site and type of implantation. We have used a dynamic model, the parallel-plate flow-chamber, to examine the interactions of different biomaterials with ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2003, 14(3):263-270]

Cited: 10 times

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Myocardial angiogenesis resulting in functional communications with the left cavity induced by intramyocardial high-frequency ablation: histomorphology of immediate and long-term effects in pigs.

Ulrich Dietz, Georg Horstick, Tobias Manke, Mike Otto, Olaf Eick, C James Kirkpatrick, Jürgen Meyer, Harald Darius,

A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). ... Read more >>

Cardiology (Cardiology)
[2003, 99(1):32-38]

Cited: 8 times

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Discrimination of early/intermediate and advanced/complicated coronary plaque types by radiofrequency intravascular ultrasound analysis.

Peter M Stähr, Tobias Höfflinghaus, Thomas Voigtländer, Brian K Courtney, Anja Victor, Mike Otto, Paul G Yock, Rüdiger Brennecke, Peter J Fitzgerald,

Radiofrequency intravascular ultrasound (IVUS-RF) analysis, as an extension of conventional IVUS imaging, may provide more accurate plaque discrimination. Thirty-two autopsy atherosclerotic coronary arteries were investigated. Corresponding sectors in different plaques were matched by histologic and RF analysis. Histologic analysis utilized the American Heart Association plaque classification. The backscattered ultrasound RF ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2002, 90(1):19-23]

Cited: 25 times

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Impact of vessel curvature on the accuracy of three-dimensional intravascular ultrasound: validation by phantoms and coronary segments.

Peter Stähr, Thomas Voigtländer, Hans-Jürgen Rupprecht, Patrick Aschenbrücker, Hayraet Mamtimin, Rüdiger Brennecke, Mike Otto, Peter J Fitzgerald, Jürgen Meyer,

<h4>Background</h4>Three-dimensional intravascular ultrasound (IVUS) is used for volumetric assessment of arteriosclerotic plaque burden and restenotic tissue at follow-up after coronary interventions. However, the accuracy of these measurements, especially in tortuous vessels, is unclear.<h4>Methods</h4>A commercially available electrocardiogram (ECG)-gated 3-dimensional-IVUS system was tested in volume-validated straight and curved hydrocolloid phantoms and in ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2002, 15(8):823-830]

Cited: 1 time

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Software-supported image quantification of angiogenesis in an in vitro culture system: application to studies of biocompatibility.

Kirsten Peters, Harald Schmidt, Ronald E Unger, Mike Otto, Günter Kamp, C James Kirkpatrick,

Healing of soft tissue trauma and bone discontinuities following implantation involves acute inflammatory reactions and the formation of blood vessels (angiogenesis). During angiogenesis new capillary vessels arise from the existing vasculature. Endothelial cells (EC) are the major cell type involved in angiogenesis. Corrosion of orthopaedic metallic implant materials (e.g. CoCr ... Read more >>

Biomaterials (Biomaterials)
[2002, 23(16):3413-3419]

Cited: 36 times

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Reduction of myocardial infarct size with sCR1sLe(x), an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing sialyl Lewis x.

K Zacharowski, M Otto, G Hafner, H C Marsh, C Thiemermann,

1 This study investigated the effects of soluble complement receptor type 1 (sCR1) or sCR1sLex, agents which function as a complement inhibitor or as a combined complement inhibitor and selectin adhesion molecule antagonist, respectively, on the infarct size and cardiac troponin T (cTnT) release caused by regional myocardial ischaemia and ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[1999, 128(5):945-952]

Cited: 24 times

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Biomaterial-induced sarcoma: A novel model to study preneoplastic change.

C J Kirkpatrick, A Alves, H Köhler, J Kriegsmann, F Bittinger, M Otto, D F Williams, R Eloy,

In the study of carcinogenesis most interest has focused on carcinomas, as they represent the majority of human cancers. The recognition of the adenoma-carcinoma sequence both in humans and in animal experimental models has given the field of basic oncology the opportunity to elucidate individual mechanisms in the multistep development ... Read more >>

Am J Pathol (The American journal of pathology)
[2000, 156(4):1455-1467]

Cited: 53 times

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Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat.

K Zacharowski, A Olbrich, M Otto, G Hafner, C Thiemermann,

1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat. 2. One hundred and sixty-seven, male Wistar rats were anaesthetized (thiopentone, 120 mg kg(-1) i.p.), ventilated (8-10 ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[1999, 126(4):849-858]

Cited: 25 times

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