Full Text Journal Articles by
Author Miia Virta

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Persistence of Hepatitis B Immune Memory Until 6 Years of Age Following Hexavalent DTaP-IPV-HB-PRP~T Vaccination in a 3-, 5- and 11- to 12-month Schedule and Response to a Subsequent Hepatitis B Challenge Vaccination.

Miia Virta, Anu Soininen, Dhaval M Patel, Céline Petit, Cynthia Tabar, Olga Lyabis,

Anti-hepatitis B (HBs) antibody persistence and hepatitis B challenge were evaluated at 6 years of age following vaccination of fully liquid DTaP-IPV-HB-PRP~T or reconstituted DTaP-IPV-HB//PRP~T at 3, 5, 11-12 months of age. At 6 years, 53.8% and 73.5% had seroprotective anti-HBs antibodies (≥10 mIU/mL), increasing to 96.7% and 95.9% postchallenge, ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e28-e30]

Cited: 0 times

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Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants.

M Pamela Griffin, Yuan Yuan, Therese Takas, Joseph B Domachowske, Shabir A Madhi, Paolo Manzoni, Eric A F Simões, Mark T Esser, Anis A Khan, Filip Dubovsky, Tonya Villafana, John P DeVincenzo, ,

<h4>Background</h4>Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants, and a need exists for prevention of RSV in healthy infants. Nirsevimab is a monoclonal antibody with an extended half-life that is being developed to protect infants for an entire RSV season with a ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(5):415-425]

Cited: 1 time

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Immunogenicity and safety of porcine circovirus-free human rotavirus vaccine in healthy infants: a phase III, randomized trial.

Ignacio Salamanca de la Cueva, Barbara Pahud, Li-Min Huang, Michael Leonardi, José Garcia-Sicilia, Javier Céspedes, Arturo Abdelnour, Tsuyoshi Tamura, Haruo Kuroki, Nan-Chang Chiu, Miia Virta, Satu Kokko, Michael Horn, Falko Panzer, Jong-Hyun Kim, Lee Jin, Leentje Moerman, Christophe Debacq, Jose Parra, Ana Ugarte, Dan Bi, ,

BACKGROUND:Porcine circovirus type 1 (PCV-1) material was detected in the human rotavirus vaccine (HRV) in 2010. In this study (NCT02914184) we compared immunogenicity and safety of the PCV-free HRV vaccine (PCV-free HRV) with HRV. PCV-free HRV is an HRV with no detection of PCV-1 and PCV-2 according to the limit ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

Cited: 0 times

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Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controlled trial.

Kirsten P Perrett, Scott A Halperin, Terry Nolan, Cristina Martínez Pancorbo, Bruce Tapiero, Federico Martinón-Torres, Zbynek Stranak, Miia Virta, Otto G Vanderkooi, Pavel Kosina, Maria Begoña Encinas Pardilla, Ignacio Cristobal García, Gian Vincenzo Zuccotti, Lusine Kostanyan, Nadia Meyer, Maria Angeles Ceregido, Brigitte Cheuvart, Sherine O Kuriyakose, Manuel Marcos Fernández, Miguel Ángel Rodríguez Zambrano, Adrián Martín García, Juan Eloy Asenjo de la Fuente, Maria Dolores Camacho Marín, María de la Calle Fernández-Miranda, Yolanda Romero Espinar, Paola Giovanna Marchisio, Paolo Manzoni, Narcisa Mesaros,

BACKGROUND:Pertussis immunization during pregnancy is recommended in many countries. Data from large randomized controlled trials are needed to assess the immunogenicity, reactogenicity and safety of this approach. METHODS:This phase IV, observer-blind, randomized, placebo-controlled, multicenter trial assessed immunogenicity, transplacental transfer of maternal pertussis antibodies, reactogenicity and safety of a reduced-antigen-content diphtheria-tetanus-three-component ... Read more >>

Vaccine (Vaccine)
[2020, 38(8):2095-2104]

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Impact of tetanus-diphtheria-acellular pertussis immunization during pregnancy on subsequent infant immunization seroresponses: follow-up from a large randomized placebo-controlled trial.

Kirsten P Perrett, Scott A Halperin, Terry Nolan, Alfonso Carmona Martínez, Federico Martinón-Torres, Jose García-Sicilia, Miia Virta, Otto G Vanderkooi, Gian Vincenzo Zuccotti, Paolo Manzoni, Lusine Kostanyan, Nadia Meyer, Maria Angeles Ceregido, Brigitte Cheuvart, Sherine O Kuriyakose, Zbynek Stranak, Jose M Merino Arribas, María José Cilleruelo Ortega, Mariano Miranda-Valdivieso, Begoña Arias Novas, Jose Tomas Ramos Amador, Felix Omeñaca, Manuel Baca, Paola Giovanna Marchisio, Narcisa Mesaros,

BACKGROUND:Pertussis immunization during pregnancy results in high pertussis antibody concentrations in young infants but may interfere with infant immune responses to post-natal immunization. METHODS:This phase IV, multi-country, open-label study assessed the immunogenicity and safety of infant primary vaccination with DTaP-HepB-IPV/Hib and 13-valent pneumococcal conjugate vaccine (PCV13). Enrolled infants (6-14 weeks old) ... Read more >>

Vaccine (Vaccine)
[2020, 38(8):2105-2114]

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2855. Respiratory Syncytial Virus Neutralizing Antibodies in Cord Blood and Serum from Infants up to 2 Years of Age in a Multinational Prospective Study.

Joseph B Domachowske, Veronique Bianco, Ana Ceballos, Luis Cousin, Ulises D’Andrea, Ilse Dieussaert, Janet A Englund, Sanjay Gandhi, Gerco Haars, Lisa Jose, Nicola Klein, Joanne Marie. Langley, Amanda Leach, Shabir A Madhi, Koen Maleux, Thi Lien-Anh Nguyen, Thanyawee Puthanakit, Peter Silas, Sonia K Stoszek, Auchara Tangsathapornpong, Jamaree Teeratakulpisarn, Miia Virta, Khalequ Zaman,

AbstractBackgroundRespiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) during infancy worldwide. High cord blood (CB) concentrations of anti-RSV neutralizing antibody (nAb) may attenuate, delay, or prevent infant infection. We report RSV A and B nAb concentrations in CB and serum from a birth ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S74-S75]

Cited: 0 times

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Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma.

Petri Koponen, Kirsi Nuolivirta, Miia Virta, Merja Helminen, Mikko Hurme, Matti Korppi,

Viral bronchiolitis is a major cause of hospitalization in infancy, with increased asthma risk in later childhood. However, the principal mechanisms behind post-bronchiolitic asthma have remained unclear. Previously, different cytokine polymorphisms have been associated with asthma occurrence, but no previous follow-up study has investigated cytokine polymorphisms in relation to post-bronchiolitic ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2014, 49(8):800-806]

Cited: 8 times

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IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants.

Merja Helminen, Kirsi Nuolivirta, Miia Virta, Anne Halkosalo, Matti Korppi, Timo Vesikari, Mikko Hurme,

We analyzed polymorphisms of IL-10 -1082 G/A, IL-18 -137 G/C, TLR4 +896 A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2008, 43(4):391-395]

Cited: 42 times

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Childhood cat exposure-related tolerance is associated with IL1A and IL10 polymorphisms.

Jussi Karjalainen, Miia Virta, Tanja Pessi, Janne Hulkkonen, Markku M Nieminen, Mikko Hurme,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2005, 116(1):223-225]

Cited: 5 times

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Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures.

Miia Virta, Mikko Hurme, Merja Helminen,

Febrile seizures can be the first sign of epilepsy. In a recent study, patients with temporal lobe epilepsy were reported to carry the interleukin-1beta allele 2 at position -511 more often than healthy control subjects. Because pro-inflammatory cytokines, such as interleukin-1, are well-known inducers of fever and therefore could play ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2002, 26(3):192-195]

Cited: 74 times

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Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures.

Miia Virta, Mikko Hurme, Merja Helminen,

<h4>Purpose</h4>Pro- and antiinflammatory cytokines regulate the febrile response during infection. Febrile seizures (FSs) conversely are associated with rapid onset of high fever. Activation of the cytokine network has been shown in previous studies of FSs and cytokines. In this study, the association between cytokines and FSs was further investigated.<h4>Methods</h4>Interleukin-1beta (IL-1beta), ... Read more >>

Epilepsia (Epilepsia)
[2002, 43(8):920-923]

Cited: 82 times

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