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Author Miguel Silva

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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Criss-cross heart three-dimensional printed models in medical education: A multi-center study on their value as a supporting tool to conventional imaging.

Israel Valverde, Gorka Gomez, Nick Byrne, Shafkat Anwar, Miguel Angel Silva, Maria Martin Talavera, Kuberan Pushparajah, Maria Nieves Velasco Forte,

The utility of three-dimensional (3D) printed models for medical education in complex congenital heart disease (CHD) is sparse and limited. The purpose of this study was to evaluate the utility of 3D-printed models for medical education in criss-cross hearts covering a wide range of participants with different levels of knowledge ... Read more >>

Anat Sci Educ (Anatomical sciences education)
[2021, :]

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Distal Biceps Reconstruction With an Alternative Technique for Tendon Tensioning and Fixation: A Case Report.

Maria João Leite, Miguel Relvas Silva, António Sousa, Alberto Vieira, Nuno Neves, Manuel Ribeiro da Silva,

<h4>Case</h4>A 41-year-old right-handed male patient presented to our institution with a chronic distal biceps rupture after failed primary surgery 6 months previously. We performed a reconstruction with semitendinosus autograft fixed proximally with a Pulvertaft weave and distally with a cortical button plus interference screw. The patient showed complete pain resolution ... Read more >>

JBJS Case Connect (JBJS case connector)
[2021, 11(2):]

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Design of Kinematic Connectors for Microstructured Materials Produced by Additive Manufacturing.

Miguel R Silva, João A Dias-de-Oliveira, António M Pereira, Nuno M Alves, Álvaro M Sampaio, António J Pontes,

The main characteristic of materials with a functional gradient is the progressive composition or the structure variation across its geometry. This results in the properties variation in one or more specific directions, according to the functional application requirements. Cellular structure flexibility in tailoring properties is employed frequently to design functionally-graded ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(9):]

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Assessment of the Dimensional and Geometric Precision of Micro-Details Produced by Material Jetting.

Miguel R Silva, António M Pereira, Álvaro M Sampaio, António J Pontes,

Additive Manufacturing (AM) technology has been increasing its penetration not only for the production of prototypes and validation models, but also for final parts. This technology allows producing parts with almost no geometry restrictions, even on a micro-scale. However, the micro-Detail (mD) measurement of complex parts remains an open field ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(8):]

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Serum potassium levels provide prognostic information in symptomatic heart failure beyond traditional clinical variables.

Camila Cristiane Toledo, Pedro Vellosa Schwartzmann, Luis Miguel Silva, Gabriel da Silva Ferreira, Fernando Bianchini Cardoso, Vinicius Citelli Ribeiro, Layde Rosane Paim, Lígia M Antunes-Correa, Andrei Carvalho Sposito, Jose Roberto Matos Souza, Rodrigo Modolo, Wilson Nadruz, Luis Sergio Fernandes de Carvalho, Otávio R Coelho-Filho,

<h4>Aims</h4>Despite of recent advances in the pharmacological treatment, heart failure (HF) maintains significant morbidity and mortality rates. While serum potassium disorders are common and associated with adverse outcomes, the exact recommended potassium level for patients with HF are not entirely established. We aimed to investigate the prognostic role of potassium ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(3):2133-2143]

Cited: 1 time

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iEC7871 Quercus suber model: the first multi-tissue diel cycle genome-scale metabolic model of a woody tree

Emanuel Cunha, Miguel Silva, Ines Chaves, Huseyin Demirci, Davide Lagoa, Diogo Lima, Miguel Rocha, Isabel Rocha, Oscar Dias,

In the last decade, genome-scale metabolic models have been increasingly used to study plant metabolic behaviour at the tissue and multi-tissue level in different environmental conditions. Quercus suber ( Q. suber ), also known as the cork oak tree, is one of the most important forest communities of the Mediterranean/Iberian ... Read more >>

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Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.

Carla Calçada, Miguel Silva, Vitória Baptista, Vandana Thathy, Rita Silva-Pedrosa, Diana Granja, Pedro Eduardo Ferreira, José Pedro Gil, David A Fidock, Maria Isabel Veiga,

Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia. The <i>Plasmodium falciparum</i> multidrug resistance protein 1 (PfMDR1) transporter plays a central role in parasite resistance to ACT partner ... Read more >>

mBio (mBio)
[2020, 11(6):]

Cited: 1 time

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Velocity Determinants in Spastic Patients after Stroke-A Gait Analysis Study.

Miguel Reis E Silva, Jorge Jacinto,

<h4>Introduction</h4>Gait velocity in spastic patients after stroke is both a life quality and mortality predictor. However, the precise biomechanical events that impair a faster velocity in this population are not defined. This study goal is to find out which are the gait parameters associated with a higher velocity in stroke ... Read more >>

Neurol Int (Neurology international)
[2020, 12(3):48-54]

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Deep gluteal space anatomy and its relationship with deep gluteal pain syndromes.

Maria J Leite, André R Pinho, Miguel R Silva, João C Lixa, Maria D Madeira, Pedro G Pereira,

<h4>Introduction</h4>Increasing interest has been seen in understanding the anatomy and biomechanics involved in the Deep Gluteal Syndrome, therefore the main objective of our paper was to define the anatomy of the deep gluteal space concerning the important osseous, muscular and neurological structures.<h4>Methods</h4>12 cadaveric models (24 hemipelvises) were used. We proceeded ... Read more >>

Hip Int (Hip international : the journal of clinical and experimental research on hip pathology and therapy)
[2020, :1120700020966255]

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Patent Cliffs in the Era of Complex Therapies and Biologics.

Marco T Sabatini, Miguel Silva,

<h4>Introduction</h4>The rise of new product classes such as biologics and complex molecules over the past two decades have brought to light some of the unique market dynamics that such products face. While we have seen and experienced the inception, growth and expansion phase of such products, the ongoing incumbent decline ... Read more >>

Pharmaceut Med (Pharmaceutical medicine)
[2020, 34(4):271-278]

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Coracoid morphology and humeral version as risk factors for subscapularis tears.

Maria J Leite, André R Pinho, Márcia C Sá, Miguel R Silva, António N Sousa, João M Torres,

<h4>Background</h4>The pathophysiology of subscapularis (SS) lesions is still relatively unknown despite recent interest in predictive factors for SS tears. Our goal was to determine the influence of the coracoid morphology and humeral version on SS tears.<h4>Methods</h4>This was a retrospective, controlled, single-blinded study. We analyzed 232 shoulders with SS lesions confirmed ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2020, 29(9):1804-1810]

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Brazilian Cardiovascular Rehabilitation Guideline - 2020.

Tales de Carvalho, Mauricio Milani, Almir Sergio Ferraz, Anderson Donelli da Silveira, Artur Haddad Herdy, Carlos Alberto Cordeiro Hossri, Christina Grüne Souza E Silva, Claudio Gil Soares de Araújo, Eneas Antonio Rocco, José Antonio Caldas Teixeira, Luciana Oliveira Cascaes Dourado, Luciana Diniz Nagem Janot de Matos, Luiz Gustavo Marin Emed, Luiz Eduardo Fonteles Ritt, Marconi Gomes da Silva, Mauro Augusto Dos Santos, Miguel Morita Fernandes da Silva, Odilon Gariglio Alvarenga de Freitas, Pablo Marino Corrêa Nascimento, Ricardo Stein, Romeu Sergio Meneghelo, Salvador Manoel Serra,

Arq Bras Cardiol (Arquivos brasileiros de cardiologia)
[2020, 114(5):943-987]

Cited: 6 times

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Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma.

Moritz Jesinghaus, Katja Steiger, Fabian Stögbauer, Bernhard Haller, Andreas Kolk, Ulrich Straßen, Anja Pickhard, Markus Wirth, Miguel Silva, Jan Budczies, Aaron Becker von Rose, Björn Konukiewitz, Peer Kuhn, Konrad Klinghammer, Hendrik Dapper, Stefan Münch, Stephanie E Combs, Wilko Weichert, Melanie Boxberg,

<h4>Background</h4>Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading is irrelevant due to its lack of prognostic impact. Recently, a novel grading termed Cellular Dissociation Grade (CDG) based on Tumour Budding and Cell Nest Size was ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 122(6):835-846]

Cited: 1 time

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Quinoa (Chenopodium quinoa Willd.): An Overview of the Potentials of the "Golden Grain" and Socio-Economic and Environmental Aspects of Its Cultivation and Marketization.

Viktória Angeli, Pedro Miguel Silva, Danilo Crispim Massuela, Muhammad Waleed Khan, Alicia Hamar, Forough Khajehei, Simone Graeff-Hönninger, Cinzia Piatti,

Quinoa (Chenopodium quinoa Willd.) is native to the Andean region and has attracted a global growing interest due its unique nutritional value. The protein content of quinoa grains is higher than other cereals while it has better distribution of essential amino acids. It can be used as an alternative to ... Read more >>

Foods (Foods (Basel, Switzerland))
[2020, 9(2):]

Cited: 4 times

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Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum.

Miguel Silva, Carla Calçada, Miguel Teixeira, Maria Isabel Veiga, Pedro Eduardo Ferreira,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(1):26-27]

Cited: 5 times

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Cost and Safety Evaluation of Simultaneous Bilateral Total Knee Arthroplasty versus Unilateral Knee.

José Humberto de Souza Borges, Paulo Lobo Júnior, Darlan Malba Dias, Miguel Fernando Ferreira da Silva, Anderson Freitas, Thaiane Araújo,

<b>Objective</b>  To measure the cost of simultaneous total knee arthroplasty, as well as the costs of total and intensive care unit (ICU) length of stay, perioperative complications and need for blood transfusion compared to the costs of unilateral procedure in a referral hospital, in Federal District, Brazil. <b>Method</b>  The present ... Read more >>

Rev Bras Ortop (Sao Paulo) (Revista brasileira de ortopedia)
[2019, 54(6):709-713]

Cited: 1 time

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Genotyping of Sea Anemone during Early Development.

Miguel A P Silva, Nagayasu Nakanishi,

Described here is a PCR-based protocol to genotype the gastrula stage embryo of the anthozoan cnidarian Nematostella vectensis without sacrificing the life of the animal. Following in vitro fertilization and de-jellying, zygotes are allowed to develop for 24 h at room temperature to reach the early- to mid-gastrula stage. The ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (147):]

Cited: 0 times

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Sulfite concentration and the occurrence of headache in young adults: a prospective study.

Miguel Silva, Jorge Gama, Nuno Pinto, Glaucia Pivi, Hugo Brancal, Lurdes Carvalho, Virgílio Loureiro, Maria Vaz Patto,

<h4>Background/objectives</h4>Sulfites are additives commonly used in food and wine industries that are associated to adverse clinical effects such as headaches. The objective of this study is to investigate the possible association between sulfite concentration in wine and the occurrence of headaches in young adults.<h4>Subjects/methods</h4>Eighty volunteers, aged between 18 and 25 ... Read more >>

Eur J Clin Nutr (European journal of clinical nutrition)
[2019, 73(9):1316-1322]

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Skin Rash and Fever of Unknown Origin A Diagnostic Challenge.

Albina Moreira, Miguel Borges Silva, Ana Afonso, Cristina Rodrigues,

We report a clinical case of adult-onset Still's disease. In addition to the imaging features of the case, the following aspects are also briefly described: clinical presentation (prolonged fever associated with migratory polyarthritis and skin rash), treatment performed (resort to anti-inflammatory and corticoid), and clinical evolution of the patient after ... Read more >>

Eur J Case Rep Intern Med (European journal of case reports in internal medicine)
[2019, 6(1):001023]

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Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda.

, Luis Eduardo Paim Rohde, Marcelo Westerlund Montera, Edimar Alcides Bocchi, Nadine Oliveira Clausell, Denilson Campos de Albuquerque, Salvador Rassi, Alexandre Siciliano Colafranceschi, Aguinaldo Figueiredo de Freitas, Almir Sergio Ferraz, Andreia Biolo, Antonio C. Pereira Barretto, Antonio Luiz Pinho Ribeiro, Carisi Anne Polanczyk, Danielle Menosi Gualandro, Dirceu Rodrigues Almeida, Eneida Rejane Rabelo da Silva, Estêvão Lanna Figueiredo, Evandro Tinoco Mesquita, Fabiana G. Marcondes-Braga, Fátima das Dores da Cruz, Felix José Alvarez Ramires, Fernando Antibas Atik, Fernando Bacal, Germano Emilio Conceição Souza, Gustavo Luiz Gouvêa de Almeida, Gustavo Calado de Aguiar Ribeiro, Humberto Villacorta, Jefferson Luís Vieira, João David de Souza, João Manoel Rossi, Jose Albuquerque de Figueiredo, Lidia Ana Zytynsky Moura, Livia Adams Goldraich, Luis Beck-da-Silva, Luiz Claudio Danzmann, Manoel Fernandes Canesin, Marcelo Imbroinise Bittencourt, Marcelo Iorio Garcia, Marcely Gimenes Bonatto, Marcus Vinícius Simões, Maria da Consolação Vieira Moreira, Miguel Morita Fernandes da Silva, Mucio Tavares de Olivera, Odilson Marcos Silvestre, Pedro Vellosa Schwartzmann, Reinaldo Bulgarelli Bestetti, Ricardo Mourilhe Rocha, Ricardo Simões, Sabrina Bernardez Pereira, Sandrigo Mangini, Sílvia Marinho Martins Alves, Silvia Moreira Ayub Ferreira, Victor Sarli Issa, Vitor Salvatore Barzilai, Wolney de Andrade Martins,

Arq Bras Cardiol (Arquivos brasileiros de cardiologia)
[2018, 111(3):436-539]

Cited: 21 times

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Rotational Instability after Anterior Talofibular and Calcaneofibular Ligament Section: The Experimental Basis for the Ankle Pivot Test.

Francisco Guerra-Pinto, Nuno Côrte-Real, Tiago Mota Gomes, Miguel Duarte Silva, José Guimarães Consciência, Mariano Monzo, Xavier Martin Oliva,

The clinical diagnosis of the anterior talofibular ligament (ATFL) rupture is based on the findings from the medical history and the anterior drawer test, a maneuver that allegedly pushes the talus and rearfoot anteriorly, although with great variability in its sensitivity. We consider that an ATFL rupture is best evaluated ... Read more >>

J Foot Ankle Surg (The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons)
[2018, 57(6):1087-1091]

Cited: 3 times

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Plasmodium falciparum Plasmepsin 2 Duplications, West Africa.

Juliana Inoue, Miguel Silva, Bakary Fofana, Kassim Sanogo, Andreas Mårtensson, Issaka Sagara, Anders Björkman, Maria Isabel Veiga, Pedro Eduardo Ferreira, Abdoulaye Djimde, José Pedro Gil,

Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(8):]

Cited: 6 times

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On a "Columbus' Egg": Modeling the shape of asymptomatic, dysplastic and impinged hip joints.

Daniel Simões Lopes, Sara M Pires, Vasco V Mascarenhas, Miguel T Silva, Joaquim A Jorge,

Understanding morphological features that characterize normal hip joint is critical and necessary for a more comprehensive definition of pathological presentations, such as femoroacetabular impingement and hip dysplasia. Based on anatomical observations that articular surfaces of synovial joints are better represented by ovoidal shapes than by spheres, the aim of this ... Read more >>

Med Eng Phys (Medical engineering & physics)
[2018, 59:50-55]

Cited: 1 time

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[Aphasia Rapid Test: Translation, Adaptation and Validation Studies for the Portuguese Population].

Miguel Tábuas-Pereira, Sandra Freitas, José Beato-Coelho, Joana Ribeiro, Joana Parra, Cristina Martins, Miguel Silva, Maria Assunção Matos, Ana Rita Nogueira, Fernando Silva, João Sargento-Freitas, Gustavo Cordeiro, Luís Cunha, Isabel Santana,

<h4>Introduction</h4>Classical aphasia evaluation scales are too long to use in the context of acute stroke or as a monitoring tool. The Aphasia Rapid Test is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in less than 3 minutes. We aimed to adapt ... Read more >>

Acta Med Port (Acta medica portuguesa)
[2018, 31(5):265-271]

Cited: 0 times

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