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Author Micol Avenali

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Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.

Micol Avenali, Silvia Cerri, Gerardo Ongari, Cristina Ghezzi, Claudio Pacchetti, Cristina Tassorelli, Enza Maria Valente, Fabio Blandini,

<h4>Background</h4>GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression.<h4>Objective</h4>The objective of this study was to define a biochemical profile that could distinguish GBA-PD from non-mutated PD.<h4>Methods</h4>29 GBA-PD, 37 non-mutated PD, and 40 controls were recruited; α-synuclein levels in plasma, exosomes, and peripheral ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, :]

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Clinical and Electrophysiological Outcome Measures of Patients With Post-Infectious Neurological Syndromes Related to COVID-19 Treated With Intensive Neurorehabilitation.

Micol Avenali, Daniele Martinelli, Massimiliano Todisco, Isabella Canavero, Francesca Valentino, Giuseppe Micieli, Enrico Alfonsi, Cristina Tassorelli, Giuseppe Cosentino,

<b>Background:</b> The clinical spectrum of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be quite wide, including neurological symptoms. Among them, para-infectious or post-infectious neurological syndromes (PINS), caused by an inflammatory response against the central and/or peripheral nervous system, have been reported. The ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:643713]

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Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases.

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell'Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora I Perrone-Bizzozero, Raffaele A Calogero, Cristina Cereda,

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell’Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora Perrone-Bizzozero, Raffaele Calogero, Cristina Cereda,

<h4>Background</h4> Identifying robust biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common ... Read more >>

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KCTD17-related myoclonus-dystonia syndrome: clinical and electrophysiological findings of a patient with atypical late onset.

Massimiliano Todisco, Simone Gana, Giuseppe Cosentino, Edoardo Errichiello, Sebastiano Arceri, Micol Avenali, Enza Maria Valente, Enrico Alfonsi,

<h4>Introduction</h4>Myoclonus-dystonia is a rare syndrome typically occurring during childhood or adolescence, mainly due to SGCE pathogenic variants. Early-onset, atypical presentations of myoclonus-dystonia have recently been associated with KCTD17 variants. In these cases, laryngeal involvement was reported in the advanced stages.<h4>Methods</h4>We evaluated a 52-year-old man with myoclonus-dystonia and positive family history. ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 78:129-133]

Cited: 1 time

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GBA-Related Parkinson's Disease: Dissection of Genotype-Phenotype Correlates in a Large Italian Cohort.

Simona Petrucci, Monia Ginevrino, Ilaria Trezzi, Edoardo Monfrini, Lucia Ricciardi, Alberto Albanese, Micol Avenali, Paolo Barone, Anna Rita Bentivoglio, Vincenzo Bonifati, Francesco Bove, Laura Bonanni, Livia Brusa, Cristina Cereda, Giovanni Cossu, Chiara Criscuolo, Giovanna Dati, Anna De Rosa, Roberto Eleopra, Giovanni Fabbrini, Laura Fadda, Manuela Garbellini, Brigida Minafra, Marco Onofrj, Claudio Pacchetti, Ilaria Palmieri, Maria Teresa Pellecchia, Martina Petracca, Marina Picillo, Antonio Pisani, Annamaria Vallelunga, Roberta Zangaglia, Alessio Di Fonzo, Francesca Morgante, Enza Maria Valente, ,

<h4>Background</h4>Variants in GBA are the most common genetic risk factor for Parkinson's disease (PD). The impact of different variants on the PD clinical spectrum is still unclear.<h4>Objectives</h4>We determined the frequency of GBA-related PD in Italy and correlated GBA variants with motor and nonmotor features and their occurrence over time.<h4>Methods</h4>Sanger sequencing ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(11):2106-2111]

Cited: 2 times

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Reproducibility and reaction time of swallowing as markers of dysphagia in parkinsonian syndromes.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Massimiliano Todisco, Roberto De Icco, Micol Avenali, Brigida Minafra, Roberta Zangaglia, Francesca Valentino, Claudio Pacchetti, Giulia Bertino, Simone Mauramati, Mauro Fresia, Enrico Alfonsi,

<h4>Objective</h4>To investigate reproducibility and reaction time of oropharyngeal swallowing in patients with Parkinson's disease (PD) and atypical parkinsonisms (APs).<h4>Methods</h4>We enrolled 19 patients with PD, 30 with APs, and 20 healthy subjects. Presence and severity of dysphagia were assessed with clinical and fiberoptic endoscopic evaluations of swallowing. Reproducibility of the oral ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(9):2200-2208]

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Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease.

Micol Avenali, Fabio Blandini, Silvia Cerri,

Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), occur in a considerable percentage of all patients with sporadic Parkinson's disease (PD), varying between 8% and 12% across the world. Genome wide association studies have confirmed the strong correlation between PD and GBA1 mutations, pointing to this ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:97]

Cited: 2 times

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Proprioceptive Focal Stimulation (Equistasi®) May Improve the Quality of Gait in Middle-Moderate Parkinson's Disease Patients. Double-Blind, Double-Dummy, Randomized, Crossover, Italian Multicentric Study.

Antonella Peppe, Stefano Paravati, Maria Giulia Baldassarre, Leila Bakdounes, Fabiola Spolaor, Annamaria Guiotto, Davide Pavan, Zimi Sawacha, Sonia Bottino, Daniela Clerici, Nicola Cau, Alessandro Mauro, Giovanni Albani, Micol Avenali, Giorgio Sandrini, Cristina Tassorelli, Daniele Volpe,

Objective: The object of the study was to evaluate the efficacy of Proprioceptive Focal Stimulation on Gait in middle-advanced Parkinson (PD) patients by a crossover, randomized, double Blind double dummy study using Equistasi®, a nano-technological device of the dimension of a plaster which generates High Frequency Vibration (FV). Background: The ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:998]

Cited: 1 time

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Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study.

Micol Avenali, Marco Toffoli, Stephen Mullin, Alisdair McNeil, Derralynn A Hughes, A Mehta, Fabio Blandini, Anthony H V Schapira,

<h4>Objectives</h4><i>GBA1</i> mutations are a frequent risk factor for Parkinson disease (PD). The aim of this study is to evaluate clinical features in a group of <i>GBA1</i> mutation-positive individuals over a 6-year follow-up.<h4>Methods</h4>This is a longitudinal study on a cohort of <i>GBA1</i>-positive carriers. We enrolled 31 patients with Gaucher disease type ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(10):1091-1097]

Cited: 8 times

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Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project.

Sara Bottiroli, Marta Allena, Grazia Sances, Roberto De Icco, Micol Avenali, Ricardo Fadic, Zaza Katsarava, Miguel Ja Lainez, Maria Teresa Goicochea, Lars Bendtsen, Rigmor Højland Jensen, Giuseppe Nappi, Cristina Tassorelli, ,

<h4>Aim</h4>To identify factors that may be predictors of the outcome of a detoxification treatment in medication-overuse headache.<h4>Methods</h4>Consecutive patients entering a detoxification program in six centres in Europe and Latin America were evaluated and followed up for 6 months. We evaluated anxious and depressive symptomatology (though patients with severe psychiatric comorbidity ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2019, 39(1):135-147]

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Pain in focal dystonias - A focused review to address an important component of the disease.

Micol Avenali, R De Icco, M Tinazzi, G Defazio, L Tronconi, G Sandrini, C Tassorelli,

Focal dystonia is characterized by involuntary muscle contractions that cause abnormal postures and/or twisting movements in a segment of the body. Motor symptoms have a major impact on disability in this condition, but the presence of pain represents an additional source of impairment and poor quality of life. Notwithstanding that ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2018, 54:17-24]

Cited: 3 times

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Body Weight Support Combined With Treadmill in the Rehabilitation of Parkinsonian Gait: A Review of Literature and New Data From a Controlled Study.

Eliana Berra, Roberto De Icco, Micol Avenali, Carlotta Dagna, Silvano Cristina, Claudio Pacchetti, Mauro Fresia, Giorgio Sandrini, Cristina Tassorelli,

<b>Background:</b> Gait disorders represent disabling symptoms in Parkinson's Disease (PD). The effectiveness of rehabilitation treatment with Body Weight Support Treadmill Training (BWSTT) has been demonstrated in patients with stroke and spinal cord injuries, but limited data is available in PD. <b>Aims:</b> The aim of the study is to investigate the ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:1066]

Cited: 2 times

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Botulinum toxin for chronic migraine: Clinical trials and technical aspects.

Cristina Tassorelli, Grazia Sances, Micol Avenali, Roberto De Icco, Daniele Martinelli, Vito Bitetto, Giuseppe Nappi, Giorgio Sandrini,

OnabotulinumtoxinA has been approved for the prophylaxis of chronic migraine following the demonstration of efficacy in two large controlled trials. Data collected from pragmatic studies in the real-life setting have contributed important additional information useful for the management of this group of extremely disabled and challenging patients. The main findings ... Read more >>

Toxicon (Toxicon : official journal of the International Society on Toxinology)
[2018, 147:111-115]

Cited: 1 time

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Pain processing in atypical Parkinsonisms and Parkinson disease: A comparative neurophysiological study.

Micol Avenali, Cristina Tassorelli, Roberto De Icco, Armando Perrotta, Mariano Serrao, Mauro Fresia, Claudio Pacchetti, Giorgio Sandrini,

<h4>Objective</h4>Pain is a frequent non-motor feature in Parkinsonism but mechanistic data on the alteration of pain processing are insufficient to understand the possible causes and to define specifically-targeted treatments.<h4>Methods</h4>we investigated spinal nociception through the neurophysiological measure of the threshold (TR) of nociceptive withdrawal reflex (NWR) and its temporal summation threshold ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2017, 128(10):1978-1984]

Cited: 2 times

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Changes in anxiety and depression symptoms associated to the outcome of MOH: A post-hoc analysis of the Comoestas Project.

Sara Bottiroli, Marta Allena, Grazia Sances, Roberto De Icco, Micol Avenali, Ricardo Fadic, Zaza Katsarava, Miguel Ja Lainez, Maria Teresa Goicochea, Rigmor Højland Jensen, Giuseppe Nappi, Cristina Tassorelli, ,

Aims To evaluate the impact of treatment success on depression and anxiety symptoms in medication-overuse headache (MOH) and whether depression and anxiety can be predictors of treatment outcome. Methods All consecutive patients entering the detoxification program were analysed in a prospective, non-randomised fashion over a six-month period. Depression and anxiety ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2018, 38(4):646-654]

Cited: 5 times

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Time for a Consensus Conference on pain in neurorehabilitation.

Giorgio Sandrini, Stefano Tamburin, Stefano Paolucci, Paolo Boldrini, Vincenzo M Saraceni, Nicola Smania, ,

Eur J Phys Rehabil Med (European journal of physical and rehabilitation medicine)
[2016, 52(5):714-716]

Cited: 1 time

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Assessing and treating pain in movement disorders, amyotrophic lateral sclerosis, severe acquired brain injury, disorders of consciousness, dementia, oncology and neuroinfectivology. Evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation.

Michelangelo Bartolo, Adriano Chiò, Sergio Ferrari, Cristina Tassorelli, Stefano Tamburin, Micol Avenali, Eva Azicnuda, Andrea Calvo, Augusto T Caraceni, Giovanni Defazio, Roberto DE Icco, Rita Formisano, Simone Franzoni, Elena Greco, Iwona Jedrychowska, Francesca Magrinelli, Umberto Manera, Enrico Marchioni, Sara Mariotto, Salvatore Monaco, Andrea Pace, Donatella Saviola, Isabella Springhetti, Michele Tinazzi, Antonio DE Tanti, ,

Pain is an important non-motor symptom in several neurological diseases, such as Parkinson's disease, cervical dystonia, amyotrophic lateral sclerosis, severe acquired brain injury, disorders of consciousness and dementia, as well as in oncology and neuroinfectivology. To overcome the lack of evidence-based data on pain management in these diseases, the Italian ... Read more >>

Eur J Phys Rehabil Med (European journal of physical and rehabilitation medicine)
[2016, 52(6):841-854]

Cited: 5 times

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