Full Text Journal Articles by
Author Michelle Done

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones,

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0192499]

Cited: 3 times

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Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial.

N Jewel Samadder, Deborah W Neklason, Kenneth M Boucher, Kathryn R Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V Tavtigian, Michelle W Done, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Rian Davis, Matthew K Topham, Patrick Lynch, Elena Strait, Wendy McKinnon, Randall W Burt, Scott K Kuwada,

Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal polyps and cancer. Surgical and endoscopic management of duodenal neoplasia is difficult and chemoprevention has not been successful.To evaluate the effect of a combination of sulindac and erlotinib on duodenal adenoma regression in patients with FAP.Double-blind, randomized, ... Read more >>

JAMA (JAMA)
[2016, 315(12):1266-1275]

Cited: 39 times

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Activating mutation in MET oncogene in familial colorectal cancer.

Deborah W Neklason, Michelle W Done, Nykole R Sargent, Ann G Schwartz, Hoda Anton-Culver, Constance A Griffin, Dennis J Ahnen, Joellen M Schildkraut, Gail E Tomlinson, Louise C Strong, Alexander R Miller, Jill E Stopfer, Randall W Burt,

In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherited colon ... Read more >>

BMC Cancer (BMC cancer)
[2011, 11:424]

Cited: 23 times

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Shortcuts to genetic characterization of polyposis patients in a high-risk registry.

Michelle W Done, Deborah Neklason, Randall Burt, Thérèse Tuohy,

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2011, 9(Suppl 1):O8-O8]

Cited: 0 times

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Deciphering the molecular pathways disrupted in normal and neoplastic colonic tissue in inherited colorectal cancer syndromes.

Deborah W Neklason, Michelle W Done, Brett Milash, Lewis Frey, Nykole Sargent, Thérèse M Tuohy, Randall W Burt,

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2011, 9(Suppl 1):O6-O6]

Cited: 0 times

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Large intron 14 rearrangement in APC results in splice defect and attenuated FAP.

Thérèse M F Tuohy, Michelle W Done, Michelle S Lewandowski, Patricia M Shires, Devki S Saraiya, Sherry C Huang, Deborah W Neklason, Randall W Burt,

Familial adenomatous polyposis [FAP (OMIM 175100)] is an autosomal dominant colorectal cancer predisposition syndrome characterized by hundreds to thousands of colonic polyps and, if untreated by a combination of screening and/or surgical intervention, an approximately 99% lifetime risk of colorectal cancer. A subset of FAP patients develop an attenuated form ... Read more >>

Hum Genet (Human genetics)
[2010, 127(3):359-369]

Cited: 9 times

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