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Morehouse Choice Accountable Care Organization and Education System (MCACO-ES): Integrated Model Delivering Equitable Quality Care.

Michelle Brown, Elizabeth O Ofili, Debbie Okirie, Priscilla Pemu, Cheryl Franklin, Yoon Suk, Alexander Quarshie, Mohamed Mubasher, Charles Sow, Valerie Montgomery Rice, David Williams, Michael Brooks, Ernest Alema-Mensah, Dominic Mack, Daniel Dawes,

Accountable Care Organizations (ACOs) seek sustainable innovation through the testing of new care delivery methods that promote shared goals among value-based health care collaborators. The Morehouse Choice Accountable Care Organization and Education System (MCACO-ES), or (M-ACO) is a physician led integrated delivery model participating in the Medicare Shared Savings Program ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(17):]

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A Pilot Study of Early Storybook Reading With Babies With Hearing Loss.

Michelle I Brown, David Trembath, Marleen F Westerveld, Gail T Gillon,

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent-child eye contact, and (c) parent-child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR ... Read more >>

J. Speech Lang. Hear. Res. (Journal of speech, language, and hearing research : JSLHR)
[2019, 62(9):3397-3412]

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Syntheses and crystal structures of 2-methyl-1,1,2,3,3-penta-phenyl-2-sila-propane and 2-methyl-1,1,3,3-tetra-phenyl-2-silapropan-2-ol.

Alexandra Williams, Michelle Brown, Richard J Staples, Shannon M Biros, William R Winchester,

The sterically hindered silicon compound 2-methyl-1,1,2,3,3-penta-phenyl-2-sila-propane, C33H30Si (I), was prepared via the reaction of two equivalents of di-phenyl-methyl-lithium (benzhydryllithium) and di-chloro-methyl-phenyl-silane. This bis-benzhydryl-substituted silicon compound was then reacted with tri-fluoro-methane-sulfonic acid, followed by hydrolysis with water to give the silanol 2-methyl-1,1,3,3-tetra-phenyl-2-silapropan-2-ol, C27H26OSi (II). Key geometric features for I are the ... Read more >>

Acta Crystallogr E Crystallogr Commun (Acta crystallographica. Section E, Crystallographic communications)
[2019, 75(Pt 9):1339-1343]

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RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections.

Johann Motsch, Cláudia Murta de Oliveira, Viktor Stus, Iftihar Köksal, Olexiy Lyulko, Helen W Boucher, Keith S Kaye, Thomas M File, Michelle L Brown, Ireen Khan, Jiejun Du, Hee-Koung Joeng, Robert W Tipping, Angela Aggrey, Katherine Young, Nicholas A Kartsonis, Joan R Butterton, Amanda Paschke,

BACKGROUND:The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam for treating imipenem-nonsusceptible infections. METHODS:Randomized, controlled, double-blind, phase 3 trial. Hospitalized patients with hospital-acquired/ventilator-associated pneumonia, complicated intraabdominal infection, or complicated urinary tract infection caused by imipenem-nonsusceptible (but colistin- and imipenem/relebactam-susceptible) pathogens were randomized 2:1 to ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

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Food abundance and weather influence habitat-specific ranging patterns in forest- and savanna mosaic-dwelling red-tailed monkeys (Cercopithecus ascanius).

Edward McLester, Michelle Brown, Fiona A Stewart, Alex K Piel,

OBJECTIVES:Primates that live in predominantly forested habitats and open, savanna mosaics should exhibit behavioral responses to differing food distributions and weather. We compared ecological constraints on red-tailed monkey ranging behavior in forest and savanna mosaic environments. Intraspecific variation in adaptations to these conditions may reflect similar pressures faced by hominins ... Read more >>

Am. J. Phys. Anthropol. (American journal of physical anthropology)
[2019, 170(2):217-231]

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Evaluation of "Stop the Bleed" training among K-12 faculty and staff in Alabama.

Allison R Jones, Michelle R Brown, Amanda Esslinger, Virginia S Strickland, Jeffrey D Kerby,

OBJECTIVES:To evaluate "Stop the Bleed" (STB) training among/K12 personnel in an Alabama school system, and to assess participants' perceived readiness to train peers in STB methods. DESIGN AND SAMPLE:We performed a cross-sectional observational study with a convenience, nonprobability sample of 466 full-time personnel who received STB training. Data were collected ... Read more >>

Public Health Nurs (Public health nursing (Boston, Mass.))
[2019, 36(5):660-666]

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Achieving Health Equity with e-Healthystrides©: Patient Perspectives of a Consumer Health Information Technology Application.

Priscilla Pemu, Robina Josiah Willock, Ernest Alema-Mensa, Latrice Rollins, Michelle Brown, Bethany Saint Clair, Elizabeth Olorundare, Atuarra McCaslin, Tabia Henry Akintobi, Alexander Quarshie, Elizabeth Ofili,

Objective:We describe the implementation, clinical outcomes and participant perspectives for e-Healthystrides©. Setting:Three independent ambulatory clinics and an historic African American (AA) church. Participants:Adults with diagnosed diabetes mellitus type 2. Intervention:e-Healthystrides© health coach facilitated intervention. Primary outcome:Acquisition of three new self-management behaviors. Secondary outcomes:Blood pressure, blood glucose, A1c, attrition rate and ... Read more >>

Ethn Dis (Ethnicity & disease)
[2019, 29(Suppl 2):393-404]

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The effect of firefighter personal protective equipment on static and dynamic balance.

Michelle Nicole Brown, Rachel Michelle Mei Ling Char, Shawn O Henry, Jenna Tanigawa, Shelyce Yasui,

Firefighters work in unpredictable conditions, necessitating the use of personal protective equipment (PPE). However, the additional weight from the PPE and self-contained breathing apparatus (SCBA) alters their centre of mass (COM), restricts movement and limits vision (face mask) contributing to a firefighters' challenge of maintaining balance. Thus, the purpose of ... Read more >>

Ergonomics (Ergonomics)
[2019, 62(9):1193-1201]

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Preliminary evaluation of Thermo Fisher TaqMan® Triplex q-PCR kit for simultaneous detection of chikungunya, dengue, and Zika viruses in mosquitoes.

Taylor Lura, Tianyun Su, Michelle Q Brown,

J. Vector Ecol. (Journal of vector ecology : journal of the Society for Vector Ecology)
[2019, 44(1):205-209]

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Susceptibility Profile of Aedes aegypti L. (Diptera: Culicidae) from Montclair, California, to Commonly Used Pesticides, With Note on Resistance to Pyriproxyfen.

Tianyun Su, Jennifer Thieme, Taylor Lura, Min-Lee Cheng, Michelle Q Brown,

The peridomestic anthropophilic Aedes aegypti L. (Diptera: Culicidae) is originated from the wild zoophilic subspecies Aedes aegypti formosus in sub-Saharan Africa, and currently has a broad distribution in human-modified environments of the tropics and subtropics worldwide. In California, breeding populations were initially detected in 2013 in the cities of Fresno, ... Read more >>

J. Med. Entomol. (Journal of medical entomology)
[2019, 56(4):1047-1054]

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The Centers for Medicare & Medicaid Services Oncology Care Model Halfway Through - Perspectives from Diverse Participants.

Ronald M Kline, Michelle Brown, Nikolas Buescher, John Cox, Elizabeth Horenkamp, Russell Hoverman, Marcus Neubauer, Randall Oyer, Anne Marie Fraley Rainey, Larisa Strawbridge,

The Oncology Care Model (OCM) is a 5-year model developed and tested by the Centers for Medicare & Medicaid Services that uses an episode-based payment model triggered by the receipt of chemotherapy to test if changing payment mechanisms, in conjunction with a requirement for enhanced patient services, can generate clinical ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, :]

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Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification.

Tyler J Loftus, Michelle P Brown, John H Slish, Martin D Rosenthal,

Preoperative risk stratification has long been developed as a strategy to predict postoperative outcomes and potentially alter or optimize comorbidities and modifiable risk. Malnutrition is among the most common potentially modifiable risk factors and the strongest predictor of poor postsurgical outcomes. Historically, malnutrition has been difficult to address for healthcare ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2019, 34(3):340-348]

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High Resistance to Bacillus sphaericus and Susceptibility to Other Common Pesticides in Culex pipiens (Diptera: Culicidae) from Salt Lake City, UT.

Tianyun Su, Jennifer Thieme, Gregory S White, Taylor Lura, Nadja Mayerle, Ary Faraji, Min-Lee Cheng, Michelle Q Brown,

Biorational mosquito larvicides based on microbial organisms and insect growth regulators (IGRs) have played a vital role in integrated mosquito control, particularly since the invasion of West Nile virus to the United States in 1999. Products that are formulated with technical powder of the bacterium, Bacillus sphaericus Neide (recently Lysinibacillus ... Read more >>

J. Med. Entomol. (Journal of medical entomology)
[2019, 56(2):506-513]

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1339. Results for the Supplemental Microbiological Modified Intent-to-Treat (SmMITT) Population of the RESTORE-IMI 1 Trial of Imipenem/Cilastatin/Relebactam (IMI/REL) vs. Imipenem/Cilastatin Plus Colistin (IMI+CST) in Patients with Imipenem-Nonsusceptible (NS) Bacterial Infections.

Keith Kaye, Thomas File, Helen W Boucher, Michelle Brown, Angela Aggrey, Ireen Khan, Hee-Koung Joeng, Robert Tipping, Jiejun Du, Katherine Young, Joan Butterton, Nicholas A Kartsonis, Amanda Paschke,

AbstractBackgroundClinical trials of new antibacterial agents in patients with carbapenem-resistant infections are critical but challenging to conduct. One challenge is identifying the study population by microbiological (micro) criteria; patients need to be identified locally to initiate effective treatment rapidly, but data standardization requires central laboratory confirmation. REL is a novel ... Read more >>

Open Forum Infect Dis (Open Forum Infectious Diseases)
[2018, 5(Suppl 1):S409-S409]

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Simplification of Imipenem Dosing by Removal of Weight-Based Adjustments.

Mallika Lala, Michelle Brown, Bhavna Kantesaria, Brittany Walker, Amanda Paschke, Matthew L Rizk,

In patients with renal insufficiency, dose adjustments based on creatinine clearance and body weight have been a component of imipenem dosage instructions. The objective of the current analysis was to provide revised dosing recommendations by evaluating the impact of creatinine clearance and body weight on the pharmacokinetics of imipenem. A ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2019, 59(5):646-653]

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1951. Nephrotoxicity Associated With Imipenem/Cilastatin/Relebactam (IMI/REL) vs. Imipenem/Cilastatin Plus Colistin (IMI+CST) in Patients With Imipenem-Nonsusceptible (NS) Bacterial Infections.

Michelle Brown, Johann Motsch, Keith Kaye, Thomas File, Helen W Boucher, Neika Vendetti, Angela Aggrey, Hee-Koung Joeng, Robert Tipping, Jiejun Du, Daryl D Depestel, Joan Butterton, Nicholas A Kartsonis, Amanda Paschke,

AbstractBackgroundNephrotoxicity is a common complication of CST-based therapy, limiting its use to treat carbapenem-resistant bacterial infections. REL is a novel β-lactamase inhibitor that restores imipenem activity against many imipenem-NS strains of Gram-negative pathogens. IMI/REL was shown to be as effective but better tolerated than IMI+CST in the phase 3 RESTORE-IMI ... Read more >>

Open Forum Infect Dis (Open Forum Infectious Diseases)
[2018, 5(Suppl 1):S563-S563]

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Group movements in response to competitors' calls indicate conflicts of interest between male and female grey-cheeked mangabeys.

Michelle Brown, Peter M Waser,

Long-distance vocalizations mediate spacing patterns by allowing groups to choose whether to draw close enough to a neighbor to initiate a short-range interaction. It is unclear, however, whether the patterning of calls and the resulting movements are invariant or change in response to social and ecological variables. In this study, ... Read more >>

Am. J. Primatol. (American journal of primatology)
[2018, 80(11):e22918]

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Group-level competition influences urinary steroid hormones among wild red-tailed monkeys, indicating energetic costs.

Adrian V Jaeggi, Benjamin C Trumble, Michelle Brown,

Various theories emphasize that intergroup competition should affect intragroup cooperation and social relationships, especially if the cost of intergroup competition outweighs that of intragroup competition. This cost of intergroup competition may be quantified by changes in physiological status, such as in the steroid hormones cortisol (C) and testosterone (T), which ... Read more >>

Am. J. Primatol. (American journal of primatology)
[2018, :e22757]

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Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.

S Claiborne Johnston, J Donald Easton, Mary Farrant, William Barsan, Robin A Conwit, Jordan J Elm, Anthony S Kim, Anne S Lindblad, Yuko Y Palesch, ,

BACKGROUND:Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2018, 379(3):215-225]

Cited: 30 times

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Innovative Methods for Designing Actionable Program Evaluation.

Brandon Nesbit, Marci Hertz, Sally Thigpen, Ted Castellanos, Michelle Brown, Jamila Porter, Amber Williams,

CONTEXT:For most programs, whether funded through governmental agencies or nongovernmental organizations, demonstrating the impact of implemented activities is vital to ensuring continued funding and support. OBJECTIVE:Program evaluation is a critical tool that serves the dual purpose of describing impact and identifying areas for program improvement. From a funder's perspective, describing ... Read more >>

J Public Health Manag Pract (Journal of public health management and practice : JPHMP)
[2018, 24 Suppl 1 Suppl, Injury and Violence Prevention:S12-S22]

Cited: 3 times

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Promoting language and social communication development in babies through an early storybook reading intervention.

Michelle I Brown, Marleen F Westerveld, David Trembath, Gail T Gillon,

PURPOSE:This study examined the effectiveness of low- and high-intensity early storybook reading (ESR) intervention workshops delivered to parents for promoting their babies language and social communication development. These workshops educated parents on how to provide a stimulating home reading environment and engage in parent-child interactions during ESR. METHOD:Parent-child dyads (n = 32); ... Read more >>

Int J Speech Lang Pathol (International journal of speech-language pathology)
[2018, 20(3):337-349]

Cited: 3 times

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Early Timing of Thyroidectomy for Hyperthyroidism in Graves' Disease Improves Biochemical Recovery.

Domenic Vital, Grégoire B Morand, Grégoire B Morand, Christian Meerwein, Roman D Laske, Hans C Steinert, Christoph Schmid, Michelle L Brown, Gerhard F Huber,

The role of thyroidectomy as an early treatment for hyperthyroidism has been poorly investigated. Our aim was to examine its success rates, particularly focusing on thyroidectomy as an early treatment.Patients with thyroidectomy for hyperthyroidism between February 2008 and October 2014 were included. They were divided into two groups (early and ... Read more >>

World J Surg (World journal of surgery)
[2017, 41(10):2545-2550]

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From Donor to Recipient: Considerations for Blood Transfusion Outcomes Research.

Allison R Jones, Michelle R Brown, David E Vance,

Donated blood can be broken down into blood components for use in patient care. This article focuses primarily on packed red blood cells (PRBCs), as they experience breakdown during storage that may adversely impact patient outcomes. Patients require PRBC transfusions for a number of clinical reasons. Although transfusions of PRBCs ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2017, 19(5):491-498]

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Evaluation of OneStep Dengue NS1 RapiDip™ InstaTest and OneStep Dengue Fever IgG/IgM RapiCard™ InstaTest during the course of a dengue type 1 epidemic.

Ivan Vickers, Kevin Harvey, Kereann Nelson, Michelle Brown, Marion Bullock-DuCasse, John Lindo,

We determined the diagnostic performance of the OneStep NS1 and the OneStep IgG/IgM RDT kits against a panel of samples which comprised of 174 dengue positive and 165 dengue negative sera characterized by three reference enzyme-linked immunosorbent assays (ELISAs). The diagnostic sensitivities of the OneStep kits for the detection of ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2017, 89(4):271-275]

Cited: 1 time

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Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections.

Matthew Sims, Valeri Mariyanovski, Patrick McLeroth, Wayne Akers, Yu-Chieh Lee, Michelle L Brown, Jiejun Du, Alison Pedley, Nicholas A Kartsonis, Amanda Paschke,

Objectives:The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem non-susceptible pathogens. Methods:To explore relebactam's safety, tolerability and efficacy, we conducted a randomized (1:1:1), controlled, Phase 2 trial comparing imipenem/cilastatin+relebactam 250 mg, imipenem/cilastatin+relebactam 125 mg and imipenem/cilastatin alone in adults with complicated urinary tract infections (cUTI) or acute pyelonephritis, regardless of baseline ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2017, 72(9):2616-2626]

Cited: 21 times

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