Full Text Journal Articles by
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Sensemaking in the Time of COVID‐19

Marlys K. Christianson, Michelle A. Barton,

(Journal of Management Studies)
[2020, :]

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Update on congenital cytomegalovirus infection: Prenatal prevention, newborn diagnosis, and management.

Michelle Barton, A Michael Forrester, Jane McDonald,

Cytomegalovirus (CMV) is the leading cause of congenital infection and the most common cause of non-genetic sensorineural hearing loss (SNHL) in childhood. Although most infected infants are asymptomatic at birth, the risk for SNHL and other neurodevelopmental morbidity makes congenital CMV (cCMV) a disease of significance. Adherence to hygienic measures ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2020, 25(6):395-396]

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Predictive value of repeated cerebrospinal fluid parameters in the outcomes of bacterial meningitis in infants <90 days of age.

Joseph Y Ting, Ashley Roberts, Sarah Khan, Ari Bitnun, Michael Hawkes, Michelle Barton, Jennifer Bowes, Jason Brophy, Lynda Ouchenir, Christian Renaud, Andrée-Anne Boisvert, Jane McDonald, Joan L Robinson,

BACKGROUND:There are variations in recommendations from different guidelines regarding the indications for repeat lumbar puncture (LP) in young infants with the diagnosis of bacterial meningitis. OBJECTIVE:To evaluate the frequency of repeat LPs and the characteristics of cerebrospinal fluid (CSF) parameters in repeated sampling and their predictive values for adverse outcomes ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0238056]

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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.

Amanda R Wasylishen, Chang Sun, Sydney M Moyer, Yuan Qi, Gilda P Chau, Neeraj K Aryal, Florencia McAllister, Michael P Kim, Michelle C Barton, Jeannelyn S Estrella, Xiaoping Su, Guillermina Lozano,

Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in DAXX, which encodes a chaperone for the histone 3.3 variant, occur in 25% of pancreatic neuroendocrine tumors (PanNETs). To advance our understanding of physiological functions of Daxx, we developed a conditional Daxx allele ... Read more >>

Sci Adv (Science advances)
[2020, 6(32):eaba8415]

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Enteroviral and Herpes Simplex Virus  Central Nervous System Infections in Infants <90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

Abstract Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. Methods: In this cross-sectional retrospective study, seven centers from the Pediatric ... Read more >>

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.

Youn-Sang Jung, Sabrina A Stratton, Sung Ho Lee, Moon-Jong Kim, Sohee Jun, Jie Zhang, Biyun Zheng, Christopher L Cervantes, Jong-Ho Cha, Michelle C Barton, Jae-Il Park,

BACKGROUND AND AIMS:How Wnt signaling is orchestrated in liver regeneration and tumorigenesis remains elusive. Recently, we identified transmembrane protein 9 (TMEM9) as a Wnt signaling amplifier. APPROACH AND RESULTS:TMEM9 facilitates v-ATPase assembly for vesicular acidification and lysosomal protein degradation. TMEM9 is highly expressed in regenerating liver and hepatocellular carcinoma (HCC) ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

Cited: 1 time

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COVID- 19 Infection in Children: Estimating Pediatric Morbidity and Mortality

Michelle Barton Forbes, Kayur Mehta, Kriti Kumar, Jielin Lu, Nicole Le Saux, Margaret Sampson, Joan Robinson,

BACKGROUND: Estimates of pediatric morbidity and mortality from COVID-19 are vital for planning optimal use of human and material resources throughout this pandemic. METHODS: Government websites from countries with minimum 1000 cases in adults and children on April 13, 2020 were searched to find the number of cases confirmed in ... Read more >>

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KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells.

Janani Kumar, Gundeep Kaur, Ren Ren, Yue Lu, Kevin Lin, Jia Li, Yun Huang, Anamika Patel, Michelle C Barton, Todd Macfarlan, Xing Zhang, Xiaodong Cheng,

Interactions of KRAB (Krüppel-associated box)-associated protein KAP1 [also known as TRIM28 (tripartite motif containing protein 28)] with DNA-binding KRAB zinc finger (KRAB-ZF) proteins silence many transposable elements during embryogenesis. However, in some cancers, TRIM28 is upregulated and interacts with different partners, many of which are transcription regulators such as EZH2 in ... Read more >>

NAR Cancer (NAR cancer)
[2020, 2(2):zcaa007]

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Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.

Jiyong Liang, Lulu Wang, Chao Wang, Jianfeng Shen, Bojin Su, Anantha L Marisetty, Dexing Fang, Cynthia Kassab, Kang Jin Jeong, Wei Zhao, Yiling Lu, Abhinav K Jain, Zhicheng Zhou, Han Liang, Shao-Cong Sun, Changming Lu, Zhi-Xiang Xu, Qinghua Yu, Shan Shao, XiaoHua Chen, Meng Gao, Francois X Claret, Zhiyong Ding, Jian Chen, Pingsheng Chen, Michelle C Barton, Guang Peng, Gordon B Mills, Amy B Heimberger,

Programmed cell death 1 ligand 1 (PD-L1) is a key driver of tumor-mediated immune suppression, and targeting it with antibodies can induce therapeutic responses. Given the costs and associated toxicity of PD-L1 blockade, alternative therapeutic strategies are needed. Using reverse-phase protein arrays to assess drugs in use or likely to ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, 8(7):952-965]

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Clinical Pathology in the Foal.

Michelle Henry Barton, Kelsey A Hart,

The dynamic physiologic changes and unique diet during the neonatal period contribute to key differences in clinicopathologic test results of healthy foals relative to healthy adult horses. When reporting results, most diagnostic laboratories only provide reference intervals for mature horses. Thus, failure to recognize the unique differences that occur in ... Read more >>

Vet Clin North Am Equine Pract (The Veterinary clinics of North America. Equine practice)
[2020, 36(1):73-85]

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Mesoscopic Liquid Clusters Represent a Distinct Condensate of Mutant p53

David Yang, Arash Saeedi, Aram Davtyan, Mohsen Fathi, Mohammad Safari, Alena Klindziuk, Michelle Barton, Navin Varadarajan, Anatoly Kolomeisky, Peter Vekilov,

Abstract The oncogenic properties of mutant p53 have been ascribed to destabilization of the p53 conformation, followed by aggregation into insoluble fibrils. Here we combine immunofluorescent 3D confocal microscopy of breast cancer cells expressing the p53 mutant Arg248Gln (R248Q) with light scattering from solutions of the purified protein and molecular ... Read more >>

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Lyme disease in children: Data from the Canadian Paediatric Surveillance Program.

Nicholas H Ogden, Salima Gasmi, Jules K Koffi, Michelle Barton, L Robbin Lindsay, Joanne M Langley,

BACKGROUND:Lyme disease (LD) is an infectious disease that is emerging in eastern and central Canada associated with the spread of the tick vector Ixodes scapularis. National surveillance shows that children are an at-risk age group. OBJECTIVES:To study the epidemiology of LD in Canadian children using the Canadian Paediatric Surveillance Program ... Read more >>

Ticks Tick Borne Dis (Ticks and tick-borne diseases)
[2020, 11(2):101347]

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ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Roxsan Manshouri, Etienne Coyaud, Samrat T Kundu, David H Peng, Sabrina A Stratton, Kendra Alton, Rakhee Bajaj, Jared J Fradette, Rosalba Minelli, Michael D Peoples, Alessandro Carugo, Fengju Chen, Christopher Bristow, Jeffrey J Kovacs, Michelle C Barton, Tim Heffernan, Chad J Creighton, Brian Raught, Don L Gibbons,

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of metastasis. During EMT cell-cell adhesion is reduced allowing cells to dissociate and invade. Of ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5125]

Cited: 6 times

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Posttransplant Lymphoproliferative Disorder in Pediatric Patients: Characteristics of Disease in EBV-seropositive Recipients.

Arnaud G L'Huillier, Anne I Dipchand, Vicky L Ng, Diane Hebert, Yaron Avitzur, Melinda Solomon, Bo-Yee Ngan, Simon Yeung, Derek Stephens, Angela S Punnett, Michelle Barton, Upton D Allen,

BACKGROUND:Patients at greatest risk of posttransplant lymphoproliferative disorder (PTLD) are those who acquire primary Epstein-Barr virus (EBV) infection after solid organ transplantation. The incidence of PTLD among patients who are EBV-seropositive before transplant is lower, and little is known about the differences in presentation and outcome of this population. We ... Read more >>

Transplantation (Transplantation)
[2019, 103(11):e369-e374]

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1143. Measuring Up! Benchmarking Antimicrobial Use in Canadian Children’s Hospitals.

Julie Blackburn, Jennifer Bowes, Mary-Ann Harrison, Nick Barrowman, Hélène Roy, Michelle Science, Kathryn E Timberlake, Alena Tse-Chang, Ashley Roberts, Vanessa C Paquette, Natasha Kwan, Joseph V Vayalumkal, Cora Constantinescu, Deonne Dersch-Mills, Dominik Mertz, Sarah Khan, Yameen Al Matawah, Roseline Thibeault, Louise Gosselin, Marie-Astrid Lefebvre, Sergio Fanella, Ashley N Walus, Michelle Barton, Venita Harris, Jeannette L Comeau, Kathryn Slayter, Cheryl Foo, Athena McConnell, Blair Seifert, Kirk Leifso, Isabelle Viel-Thériault, Nicole Le Saux,

AbstractBackgroundInappropriate antimicrobial use (AU) is recognized as a leading cause of antimicrobial resistance. However, quantifying AU in hospitals is challenging due to variability in information systems. Point prevalence surveys (PPS) provide a means to quantify AU in a cross-sectional manner within and between institutions. The aim of the study was ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S407-S407]

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856. Invasive Haemophilus influenzae Disease in Children: A Canadian MultiCenter Study on Emerging Serotypes.

Craig Frankel, Mohammad Alghounaim, Jane McDonald, John Gunawan, Joan Robinson, Sarah Khan, Jacqueline K Wong, Alison Lopez, Sergio Fanella, Jeannette L Comeau, Jennifer Bowes, Robert Slinger, Angela Kalia, Ashley Roberts, Kirk Leifso, Michelle Barton,

AbstractBackgroundOur objective was to describe the serotype distribution and clinical spectrum of invasive Haemophilus influenza (Hi) disease in children admitted to participating centers within the Paediatric Investigator’s Collaborative Network on Infections in Canada (PICNIC).MethodsAll cases of Hi bacteremia were identified from the PICNIC Database of Gram-negative bacteremia (2013–2017). Disease was ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S19-S19]

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44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundHerpes simplex virus (HSV) and enterovirus (EV) are important causes of central nervous system (CNS) infections in young infants. Though long-term morbidity has been linked to HSV, there is still limited data on outcomes of other viral CNS infections in young infants.Objectives1) Conduct a descriptive analysis of viral CNS infections ... Read more >>

(Paediatrics & child health)
[2019, 24(Suppl 2):e18-e18]

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Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.

Rama Soundararajan, Jared J Fradette, Jessica M Konen, Stacy Moulder, Xiang Zhang, Don L Gibbons, Navin Varadarajan, Ignacio I Wistuba, Debasish Tripathy, Chantale Bernatchez, Lauren A Byers, Jeffrey T Chang, Alejandro Contreras, Bora Lim, Edwin Roger Parra, Emily B Roarty, Jing Wang, Fei Yang, Michelle Barton, Jeffrey M Rosen, Sendurai A Mani,

Over the last decade, both early diagnosis and targeted therapy have improved the survival rates of many cancer patients. Most recently, immunotherapy has revolutionized the treatment options for cancers such as melanoma. Unfortunately, a significant portion of cancers (including lung and breast cancers) do not respond to immunotherapy, and many ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(5):]

Cited: 7 times

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Posttransplant lymphoproliferative disorder in pediatric patients: Survival rates according to primary sites of occurrence and a proposed clinical categorization.

Arnaud G L'Huillier, Anne I Dipchand, Vicky L Ng, Diane Hebert, Yaron Avitzur, Melinda Solomon, Bo-Yee Ngan, Derek Stephens, Angela S Punnett, Michelle Barton, Upton D Allen,

Posttransplant lymphoproliferative disorder (PTLD) is a devastating complication of organ transplant. In a hospital-based registry, we identified biopsy-proven cases of PTLD among children during a 15-year period and reviewed trends in PTLD rates, the sites of involvement, and the associated survival rates. Cases that were included had at least 1 year ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2019, 19(10):2764-2774]

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Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013.

Jennifer Tam, Jesse Papenburg, Sergio Fanella, Sandra Asner, Michelle Barton, Cybele Bergeron, Shalini Desai, Charles Hui, Cheryl Foo, Joanne M Langley, Kirk Leifso, My-Linh Ma, Jeffrey Pernica, Joan Robinson, Roopi Singh, Bruce Tapiero, Upton Allen,

Background:Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are <0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(1):113-119]

Cited: 3 times

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2342. Treatment Implications of Herpes Simplex Virus Central Nervous System Infection in Canadian Infants <90 Days Old: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason C Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane Mcdonald, André-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundIn the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy and long-term prophylaxis improve outcomes, clinicians need to be able to clinically detect young infants most likely to have HSV to facilitate early initiation of therapy. Limited data exist ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S696-S696]

Cited: 0 times

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Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review.

Monika Wojtera, Horace Cheng, Kyle Fiorini, Kevin Coughlin, Michelle Barton, Julie E Strychowsky,

BACKGROUND:There is no consensus regarding approaches to infantile group B streptococcal (GBS) head and neck cellulitis and necrotizing fasciitis. We present a case of GBS necrotizing cellulitis and summarize the literature regarding the presentation and management of infantile head and neck GBS cellulitis and necrotizing fasciitis. METHODS:The literature was searched ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(9):e241-e245]

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Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Ayala Tovy, Adam Spiro, Ryan McCarthy, Zohar Shipony, Yael Aylon, Kendra Allton, Elena Ainbinder, Noa Furth, Amos Tanay, Michelle Barton, Moshe Oren,

Genes Dev. (Genes & development)
[2018, 32(19-20):1358]

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