Full Text Journal Articles by
Author Michelle A Erickson

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Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction.

Takashi Fujimoto, Yoichi Morofuji, Andrej Kovac, Michelle A Erickson, Mária A Deli, Masami Niwa, William A Banks,

Statins have neuroprotective effects on neurological diseases, including a pleiotropic effect possibly related to blood-brain barrier (BBB) function. In this study, we investigated the effects of pitavastatin (PTV) on lipopolysaccharide (LPS)-induced BBB dysfunction in an in vitro BBB model comprising cocultured primary mouse brain endothelial cells, pericytes, and astrocytes. LPS ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

Cited: 0 times

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Healthy aging and the blood-brain barrier.

William A Banks, May J Reed, Aric F Logsdon, Elizabeth M Rhea, Michelle A Erickson,

The blood-brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communication between the CNS and peripheral tissues. The cells ... Read more >>

Nat Aging (Nature aging)
[2021, 1(3):243-254]

Cited: 1 time

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The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.

Elizabeth M Rhea, Aric F Logsdon, Kim M Hansen, Lindsey M Williams, May J Reed, Kristen K Baumann, Sarah J Holden, Jacob Raber, William A Banks, Michelle A Erickson,

It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in ... Read more >>

Nat Neurosci (Nature neuroscience)
[2021, 24(3):368-378]

Cited: 43 times

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The neurovascular extracellular matrix in health and disease.

Aric F Logsdon, Elizabeth M Rhea, May Reed, William A Banks, Michelle A Erickson,

The blood-brain barrier (BBB) is a vital interface that supports normal brain functions. Endothelial cells (ECs) are the main component of the BBB and are highly specialized to govern the transfer of substances into brain. The EC lumen is enmeshed with an extracellular matrix (ECM), known as the endothelial glycocalyx ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2021, 246(7):835-844]

Cited: 0 times

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In vitro modeling of blood-brain barrier and interface functions in neuroimmune communication.

Michelle A Erickson, Miranda L Wilson, William A Banks,

Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood-brain barrier (BBB) and associated cells of the neurovascular unit (NVU) serve as an important interface for immune communication between the brain and periphery through the blood. Immune functions and interactions of the ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):26]

Cited: 7 times

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Inter-alpha inhibitor proteins attenuate lipopolysaccharide-induced blood-brain barrier disruption and downregulate circulating interleukin 6 in mice.

Aric F Logsdon, Michelle A Erickson, Xiaodi Chen, Joseph Qiu, Yow-Pin Lim, Barbara S Stonestreet, William A Banks,

Circulating levels of inter-alpha inhibitor proteins change dramatically in acute inflammatory disorders, which suggest an important contribution to the immunomodulatory system. Human blood-derived inter-alpha inhibitor proteins are neuroprotective and improve survival of neonatal mice exposed to lipopolysaccharide. Lipopolysaccharide augments inflammatory conditions and disrupts the blood-brain barrier. There is a paucity ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2020, 40(5):1090-1102]

Cited: 6 times

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Age-Associated Changes in the Immune System and Blood⁻Brain Barrier Functions.

Michelle A Erickson, William A Banks,

Age is associated with altered immune functions that may affect the brain. Brain barriers, including the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB), are important interfaces for neuroimmune communication, and are affected by aging. In this review, we explore novel mechanisms by which the aging immune system alters central nervous ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(7):]

Cited: 28 times

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Commentary on the 2018 Named Series on blood-brain interfaces: Roles of neuroimmunomodulation in health and disease.

Michelle A Erickson, Joseph A Nicolazzo, William A Banks,

This year's 2018 Named Series on blood-brain interfaces highlights the importance of brain barriers as mediators of neuroimmune communication and regulators of neurological function. The term "brain interfaces" reflects our growing understanding that brain barriers such as the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) are not only gatekeepers, but ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2018, 74:3-6]

Cited: 0 times

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Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity.

Michelle A Erickson, W Sandy Liang, Elizabeth G Fernandez, Kristin M Bullock, Jarl A Thysell, William A Banks,

Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the brain's response to a systemic inflammatory insult. ... Read more >>

PLoS One (PloS one)
[2018, 13(10):e0205769]

Cited: 8 times

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The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain.

May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Michelle A Erickson, William A Banks, Robert B Vernon,

The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised largely of hyaluronan (HA) and HA-associated members of the lectican family of chondroitin sulfate proteoglycans (CSPGs). We examined regional differences in microvascular density, neuronal and glial markers, ... Read more >>

J Histochem Cytochem (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society)
[2018, 66(10):697-707]

Cited: 5 times

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Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions.

Michelle A Erickson, William A Banks,

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status of the brain, and are also important regulators of neuroimmune communication. It is increasingly appreciated that communication between the brain and immune system contributes to physiologic processes, adaptive responses, and disease states. In this review, we discuss the highly specialized ... Read more >>

Pharmacol Rev (Pharmacological reviews)
[2018, 70(2):278-314]

Cited: 54 times

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Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation.

Slava Rom, Viviana Zuluaga-Ramirez, Nancy L Reichenbach, Michelle A Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L Jordan-Sciutto, Yuri Persidsky,

<h4>Background</h4>Secoisolariciresinol diglucoside (SDG), the main lignan in flaxseed, is known for its beneficial effects in inflammation, oxidative stress, heart disease, tumor progression, atherosclerosis, and diabetes. SDG might be an attractive natural compound that protects against neuroinflammation. Yet, there are no comprehensive studies to date investigating the effects of SDG on ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2018, 15(1):25]

Cited: 10 times

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Gut reactions: How the blood-brain barrier connects the microbiome and the brain.

Aric F Logsdon, Michelle A Erickson, Elizabeth M Rhea, Therese S Salameh, William A Banks,

A growing body of evidence indicates that the microbiome interacts with the central nervous system (CNS) and can regulate many of its functions. One mechanism for this interaction is at the level of the blood-brain barriers (BBBs). In this minireview, we examine the several ways the microbiome is known to ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2018, 243(2):159-165]

Cited: 30 times

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Erratum.

Michelle A Erickson, Joseph Jude, Hengjiang Zhao, Elizabeth M Rhea, Therese S Salameh, William Jester, Shelley Pu, Jenna Harowitz, Ngan Nguyen, William A Banks, Reynold A Panettieri, Kelly L Jordan-Sciutto,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(1):535]

Cited: 0 times

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Blood-Brain Barriers in Obesity.

Elizabeth M Rhea, Therese S Salameh, Aric F Logsdon, Angela J Hanson, Michelle A Erickson, William A Banks,

After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden. Obesity is associated with serious negative health outcomes such ... Read more >>

AAPS J (The AAPS journal)
[2017, 19(4):921-930]

Cited: 25 times

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HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Patrick J Gannon, Cagla Akay-Espinoza, Alan C Yee, Lisa A Briand, Michelle A Erickson, Benjamin B Gelman, Yan Gao, Norman J Haughey, M Christine Zink, Janice E Clements, Nicholas S Kim, Gabriel Van De Walle, Brigid K Jensen, Robert Vassar, R Christopher Pierce, Alexander J Gill, Dennis L Kolson, J Alan Diehl, Joseph L Mankowski, Kelly L Jordan-Sciutto,

Mounting evidence implicates antiretroviral (ARV) drugs as potential contributors to the persistence and evolution of clinical and pathological presentation of HIV-associated neurocognitive disorders in the post-ARV era. Based on their ability to induce endoplasmic reticulum (ER) stress in various cell types, we hypothesized that ARV-mediated ER stress in the central ... Read more >>

Am J Pathol (The American journal of pathology)
[2017, 187(1):91-109]

Cited: 14 times

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Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Brigid K Jensen, Hubert Monnerie, Maggie V Mannell, Patrick J Gannon, Cagla Akay Espinoza, Michelle A Erickson, Annadora J Bruce-Keller, Benjamin B Gelman, Lisa A Briand, R Christopher Pierce, Kelly L Jordan-Sciutto, Judith B Grinspan,

Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antiretroviral-treated patients have revealed persistent white matter abnormalities including diffuse myelin pallor, diminished white matter tracts, and decreased myelin protein mRNAs. Loss of myelin can contribute to neurocognitive dysfunction ... Read more >>

J Neuropathol Exp Neurol (Journal of neuropathology and experimental neurology)
[2015, 74(11):1093-1118]

Cited: 21 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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Alpha synuclein is transported into and out of the brain by the blood-brain barrier.

Yu-Ting Sui, Kristin M Bullock, Michelle A Erickson, Jing Zhang, W A Banks,

Alpha-synuclein (α-Syn), a small protein with multiple physiological and pathological functions, is one of the dominant proteins found in Lewy Bodies, a pathological hallmark of Lewy body disorders, including Parkinson's disease (PD). More recently, α-Syn has been found in body fluids, including blood and cerebrospinal fluid, and is likely produced ... Read more >>

Peptides (Peptides)
[2014, 62:197-202]

Cited: 51 times

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Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

Kenji Dohi, Brian C Kraemer, Michelle A Erickson, Pamela J McMillan, Andrej Kovac, Zuzana Flachbartova, Kim M Hansen, Gul N Shah, Nader Sheibani, Therese Salameh, William A Banks,

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined ... Read more >>

PLoS One (PloS one)
[2014, 9(9):e108034]

Cited: 18 times

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Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells.

Michelle A Erickson, Yoichi Morofuji, Joshua B Owen, William A Banks,

Increased blood levels of the eotaxin chemokine C-C motif ligand 11 (CCL11) in aging were recently shown to negatively regulate adult hippocampal neurogenesis. How circulating CCL11 could affect the central nervous system (CNS) is not clear, but one possibility is that it can cross the blood-brain barrier (BBB). Here, we ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2014, 349(3):497-507]

Cited: 36 times

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Central and peripheral administration of antisense oligonucleotide targeting amyloid-β protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AβPPswe) mice.

Susan A Farr, Michelle A Erickson, Michael L Niehoff, William A Banks, John E Morley,

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Currently, there are no therapies to stop or reverse the symptoms of AD. We have developed an antisense oligonucleotide (OL-1) against the amyloid-β protein precursor (AβPP) that can decrease AβPP expression and amyloid-β protein (Aβ) production. This antisense rapidly crosses the blood-brain ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2014, 40(4):1005-1016]

Cited: 18 times

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Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype.

Bryce C Rhodehouse, Michelle A Erickson, William A Banks, Shawn E Bearden,

Hyperhomocysteinemia (HHcy) is associated with cognitive impairment and Alzheimer's disease. Whether this association is mechanistic remains unclear. Here, we used a mouse model to test the hypothesis that HHcy increases levels of amyloid-β (Aβ) transporters in microvessels that form the blood-brain barrier, elevates Aβ content (Aβ40 and Aβ42) in the ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2013, 35(1):59-66]

Cited: 7 times

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Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine.

Michelle A Erickson, Kim Hansen, William A Banks,

Impairment in two blood-brain barrier (BBB) efflux transporters, p-glycoprotein (Pgp) and low-density lipoprotein receptor-related protein-1 (LRP-1) are thought to contribute to the progression of Alzheimer's disease (AD) by resulting in the brain accumulation of their substrate amyloid beta peptide (Aβ). The initial cause of impaired efflux, however, is unknown. We ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2012, 26(7):1085-1094]

Cited: 45 times

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Insulin in the brain: there and back again.

William A Banks, Joshua B Owen, Michelle A Erickson,

Insulin performs unique functions within the CNS. Produced nearly exclusively by the pancreas, insulin crosses the blood-brain barrier (BBB) using a saturable transporter, affecting feeding and cognition through CNS mechanisms largely independent of glucose utilization. Whereas peripheral insulin acts primarily as a metabolic regulatory hormone, CNS insulin has an array ... Read more >>

Pharmacol Ther (Pharmacology & therapeutics)
[2012, 136(1):82-93]

Cited: 199 times

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