Full Text Journal Articles by
Author Michele Ciccarelli

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Osteochondral allograft transplantation for complex distal humeral fractures assisted by 3D computer planning and printing technology: technical note.

Raffaele Russo, Antonio Guastafierro, Giuseppe Della Rotonda, Stefano Viglione, Michele Ciccarelli, Fabrizio Fiorentino, Paolo Minopoli, Marco Mortellaro, Livia Renata Pietroluongo, Francesco Langella,

<h4>Purpose</h4>The surgical treatment of comminuted distal humeral articular fractures (DHF) is challenging and is jeopardized by the high rate of complications. The study aims to describe the application of osteochondral allograft (OCA) transplantation for the treatment of complex DHF assisted with a 3D printed specific instrumentation.<h4>Methods</h4>Retrospective study. Inclusion criteria were ... Read more >>

Eur J Orthop Surg Traumatol (European journal of orthopaedic surgery & traumatology : orthopedie traumatologie)
[2021, :]

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The Role of Glycemic Variability in Cardiovascular Disorders.

Valentina Alfieri, Veronika A Myasoedova, Maria Cristina Vinci, Maurizio Rondinelli, Paola Songia, Ilaria Massaiu, Nicola Cosentino, Donato Moschetta, Vincenza Valerio, Michele Ciccarelli, Giancarlo Marenzi, Stefano Genovese, Paolo Poggio,

Diabetes mellitus (DM) is one of the most common and costly disorders that affect humans around the world. Recently, clinicians and scientists have focused their studies on the effects of glycemic variability (GV), which is especially associated with cardiovascular diseases. In healthy subjects, glycemia is a very stable parameter, while ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(16):]

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Vascular and metabolic effects of SGLT2i and GLP-1 in heart failure patients.

Michele Correale, Olga Lamacchia, Michele Ciccarelli, Giuseppe Dattilo, Lucia Tricarico, Natale Daniele Brunetti,

Alterations of endothelial function, inflammatory activation, and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway are involved in the pathophysiology of heart failure. Metabolic alterations have been studied in the myocardium of heart failure (HF) patients; alterations in ketone body and amino acid/protein metabolism have been described in patients affected by HF, ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Healthberry 865® and Its Related, Specific, Single Anthocyanins Exert a Direct Vascular Action, Modulating Both Endothelial Function and Oxidative Stress.

Albino Carrizzo, Rosario Lizio, Paola Di Pietro, Michele Ciccarelli, Antonio Damato, Eleonora Venturini, Patrizia Iannece, Eduardo Sommella, Pietro Campiglia, Philipp Ockermann, Carmine Vecchione,

In recent years, epidemiological studies have identified a relationship between diet and cerebro-cardiovascular disease (CVD). In this regard, there is a promising dietary group for cardiovascular protection are polyphenols, especially anthocyanins. Vascular reactivity studies were performed using Healthberry 865<sup>®</sup> and constituent single anthocyanins to characterize vasomotor responses; immunofluorescence analysis with ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(8):]

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Predictors of complications in initially haemodynamically stable patients admitted in a modern coronary care unit.

Alfonso Campanile, Michele Ciccarelli, Gennaro Galasso, Ferruccio Dell'Aquila, Vincenza Procaccini, Francesco Vigorito, Carmine Vecchione, Amelia Ravera,

<h4>Aims</h4>Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed availability, understanding, which patients will really benefit from in a such a critical care setting, is of ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(7):553-559]

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Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19.

Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J Iwashyna, Margaret S Herridge, Maurizio Cecconi, ,

<h4>Background</h4>Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, physical function and prevalence of post-traumatic stress symptoms of invasively ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):91]

Cited: 1 time

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Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study.

Alessandro Pizzocaro, Paolo Colombo, Walter Vena, Salvatore Ariano, Paola Magnoni, Francesco Reggiani, Giuseppe Favacchio, Marco Mirani, Elisabetta Lavezzi, Antonio Voza, Marta Calatroni, Gherardo Mazziotti, Andrea Lania, ,

<h4>Purpose</h4>To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis.<h4>Methods</h4>This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43-85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up ... Read more >>

Endocrine (Endocrine)
[2021, 73(2):255-260]

Cited: 1 time

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Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases.

Marcello Izzo, Albino Carrizzo, Carmine Izzo, Enrico Cappello, Domenico Cecere, Michele Ciccarelli, Patrizia Iannece, Antonio Damato, Carmine Vecchione, Francesco Pompeo,

Vitamin D is the first item of drug expenditure for the treatment of osteoporosis. Its deficiency is a condition that affects not only older individuals but also young people. Recently, the scientific community has focused its attention on the possible role of vitamin D in the development of several chronic ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(5):]

Cited: 1 time

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Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy.

Alexia F Bertuzzi, Michele Ciccarelli, Andrea Marrari, Nicolò Gennaro, Andrea Dipasquale, Laura Giordano, Umberto Cariboni, Vittorio Lorenzo Quagliuolo, Marco Alloisio, Armando Santoro,

<h4>Background</h4>The impact of active cancer in COVID-19 patients is poorly defined; however, most studies showed a poorer outcome in cancer patients compared to the general population.<h4>Methods</h4>We analysed clinical data from 557 consecutive COVID-19 patients. Uni-multivariable analysis was performed to identify prognostic factors of COVID-19 survival; propensity score matching was used ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 125(3):358-365]

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The effect of COVID-19 epidemic on vital signs in hospitalized patients: a pre-post heat-map study from a large teaching hospital.

Pier Francesco Caruso, Giovanni Angelotti, Massimiliano Greco, Marco Albini, Victor Savevski, Elena Azzolini, Martina Briani, Michele Ciccarelli, Alessio Aghemo, Hayato Kurihara, Antonio Voza, Salvatore Badalamenti, Michele Lagioia, Maurizio Cecconi, ,

The Lombardy SARS-CoV-2 outbreak in February 2020 represented the beginning of COVID-19 epidemic in Italy. Hospitals were flooded by thousands of patients with bilateral pneumonia and severe respiratory, and vital sign derangements compared to the standard hospital population. We propose a new visual analysis technique using heat maps to describe ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, :]

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Critical Care Outreach Team During COVID-19: Ventilatory Support in the Ward and Outcomes.

Antonio Messina, Andrea Pradella, Valeria Alicino, Maxim Neganov, Giacomo De Mattei, Giacomo Coppalini, Katerina Negri, Elena Costantini, Alessandro Protti, Elena Azzolini, Michele Ciccarelli, Alessio Aghemo, Antonio Voza, Massimiliano Greco, Michele Lagioia, Maurizio Cecconi,

<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) outbreak, a critical care outreach team was implemented in our hospital to guarantee multidisciplinary patient assessment at admission and prompt ICU support in medical wards. In this paper, we report the activity plan results and describe the baseline characteristics of the referred subjects.<h4>Methods</h4>We retrospectively ... Read more >>

Respir Care (Respiratory care)
[2021, 66(6):928-935]

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A risk score based on baseline risk factors for predicting mortality in COVID-19 patients.

Ze Chen, Jing Chen, Jianghua Zhou, Fang Lei, Feng Zhou, Juan-Juan Qin, Xiao-Jing Zhang, Lihua Zhu, Ye-Mao Liu, Haitao Wang, Ming-Ming Chen, Yan-Ci Zhao, Jing Xie, Lijun Shen, Xiaohui Song, Xingyuan Zhang, Chengzhang Yang, Weifang Liu, Xiao Zhang, Deliang Guo, Youqin Yan, Mingyu Liu, Weiming Mao, Liming Liu, Ping Ye, Bing Xiao, Pengcheng Luo, Zixiong Zhang, Zhigang Lu, Junhai Wang, Haofeng Lu, Xigang Xia, Daihong Wang, Xiaofeng Liao, Gang Peng, Liang Liang, Jun Yang, Guohua Chen, Elena Azzolini, Alessio Aghemo, Michele Ciccarelli, Gianluigi Condorelli, Giulio G Stefanini, Xiang Wei, Bing-Hong Zhang, Xiaodong Huang, Jiahong Xia, Yufeng Yuan, Zhi-Gang She, Jiao Guo, Yibin Wang, Peng Zhang, Hongliang Li,

<h4>Background</h4>To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources.<h4>Methods</h4>6415 patients from seven hospitals in Wuhan city were assigned to the training ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, 37(6):917-927]

Cited: 1 time

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Bronchoalveolar lavage in suspected COVID-19 cases with a negative nasopharyngeal swab: a retrospective cross-sectional study in a high-impact Northern Italy area.

Caterina Barberi, Elena Castelnuovo, Andrea Dipasquale, Federica Mrakic Sposta, Giulia Vatteroni, Lorenzo Maria Canziani, Marco Alloisio, Michele Ciccarelli, Carlo Selmi, Giorgio Maria Ferraroli,

COVID-19 diagnosis relies on molecular testing for SARS-CoV-2 via nasopharyngeal swab in the presence of suggestive clinical, radiological and laboratory findings. Since bronchoalveolar lavage liquid (BAL) collected during fibrobronchoscopy may increase test sensitivity compared to nasopharyngeal swabs, it was performed during the 2020 pandemic in clinically or radiologically suspected cases. ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2021, :]

Cited: 3 times

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Safety and efficacy of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: systematic review and meta-analysis of 22 studies and 440 281 patients.

Angelo Silverio, Marco Di Maio, Costantina Prota, Elena De Angelis, Ilaria Radano, Rodolfo Citro, Albino Carrizzo, Michele Ciccarelli, Carmine Vecchione, Davide Capodanno, Gennaro Galasso,

<h4>Aims</h4>The aim of the present meta-analysis was to evaluate the efficacy and safety of non-vitamin K oral antagonists (NOACs) vs. vitamin K antagonists (VKAs) in elderly patients with atrial fibrillation (AF) and indirectly compare NOACs in this population.<h4>Methods and results</h4>MEDLINE, Cochrane, ISI Web of Sciences, and SCOPUS were searched for ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, 7(FI1):f20-f29]

Cited: 6 times

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A Novel Vasoactive Peptide "PG1" from Buffalo Ice-Cream Protects from Angiotensin-Evoked High Blood Pressure.

Albino Carrizzo, Manuela Giovanna Basilicata, Giacomo Pepe, Kasper K Sørensen, Michele Ciccarelli, Veronica Di Sarno, Antonio Damato, Eleonora Venturini, Anna Borrelli, Simona Musella, Mario Abate, Paola Di Pietro, Carmine Ostacolo, Pietro Campiglia, Carmine Vecchione,

<h4>Background</h4>Arterial hypertension is the most important risk factor for cardiovascular diseases, myocardial infarction, heart failure, renal failure and peripheral vascular disease. In the last decade, milk-derived bioactive peptides have attracted attention for their beneficial cardiovascular properties.<h4>Methods</h4>Here, we combined in vitro chemical assay such as LC-MS/MS analysis of buffalo ice cream, ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(3):]

Cited: 2 times

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Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art.

Mariaconsiglia Calabrese, Marina Garofano, Roberta Palumbo, Paola Di Pietro, Carmine Izzo, Antonio Damato, Eleonora Venturini, Severino Iesu, Nicola Virtuoso, Andrea Strianese, Michele Ciccarelli, Gennaro Galasso, Carmine Vecchione,

Recent scientific literature has investigated the cardiovascular implications of COVID-19. The mechanisms of cardiovascular damage seem to involve the protein angiotensin-converting enzyme 2 (ACE2), to which severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) binds to penetrate cells and other mechanisms, most of which are still under study. Cardiovascular sequelae of ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

Cited: 3 times

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Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial.

François-Xavier Lescure, Hitoshi Honda, Robert A Fowler, Jennifer Sloane Lazar, Genming Shi, Peter Wung, Naimish Patel, Owen Hagino, ,

<h4>Background</h4>Elevated proinflammatory cytokines are associated with greater COVID-19 severity. We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical (requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.<h4>Methods</h4>We did a 60-day, ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(5):522-532]

Cited: 23 times

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Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study.

Martina Sollini, Silvia Morbelli, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Silvia Chiola, Fabrizia Gelardi, Arturo Chiti,

<h4>Purpose</h4>The present study hypothesised that whole-body [18F]FDG-PET/CT might provide insight into the pathophysiology of long COVID.<h4>Methods</h4>We prospectively enrolled 13 adult long COVID patients who complained for at least one persistent symptom for >30 days after infection recovery. A group of 26 melanoma patients with negative PET/CT matched for sex/age was used ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(10):3187-3197]

Cited: 9 times

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Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study

Martina Sollini, Silvia Morbelli, Michele Ciccarelli, Maurizio Cecconi, Alessio Aghemo, Paola Morelli, Silvia Chiola, Fabrizia Gelardi, Arturo Chiti,

<h4>Purpose</h4> The present study hypothesised that whole-body [18F]FDG-PET/CT might provide insight into the pathophysiology of long COVID. <h4>Methods</h4> We prospectively enrolled 13 adult long COVID patients who complained for at least one persistent symptom for >30 days after infection recovery. A group of 26 melanoma patients with negative PET/CT matched for ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :1-11]

Cited: 0 times

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Reciprocal organ interactions during heart failure-a position paper from the ESC working group on myocardial function.

Michele Ciccarelli, Dana Dawson, Inês Falcao-Pires, Mauro Giacca, Nazha Hamdani, Stéphane Heymans, Astrid Hooghiemstra, Annebet Leeuwis, Dorien Hermkens, Carlo Gabriele Tocchetti, Jolanda van der Velden, Serena Zacchigna, Thomas Thum,

Heart failure-either with reduced or preserved ejection fraction (HFrEF/HFpEF)-is a clinical syndrome of multifactorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body's needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, :]

Cited: 0 times

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Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.

Detmar Kolijn, Steffen Pabel, Yanna Tian, Mária Lódi, Melissa Herwig, Albino Carrizzo, Saltanat Zhazykbayeva, Árpád Kovács, Gábor Á Fülöp, Inês Falcão-Pires, Peter H Reusch, Sophie Van Linthout, Zoltán Papp, Loek van Heerebeek, Carmine Vecchione, Lars S Maier, Michele Ciccarelli, Carsten Tschöpe, Andreas Mügge, Zsolt Bagi, Samuel Sossalla, Nazha Hamdani,

<h4>Aims</h4>Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular outcomes, but the underlying mechanisms are still elusive. This study investigated the mechanisms of empagliflozin in human and murine heart failure with preserved ejection fraction (HFpEF).<h4>Methods and results</h4>The acute mechanisms of empagliflozin were investigated in human myocardium from patients with HFpEF and murine ZDF obese ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(2):495-507]

Cited: 14 times

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The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.

Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino,

Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore ... Read more >>

Cells (Cells)
[2021, 10(1):]

Cited: 0 times

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Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients.

Angelo Silverio, Marco Di Maio, Rodolfo Citro, Luca Esposito, Giuseppe Iuliano, Michele Bellino, Cesare Baldi, Giuseppe De Luca, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso,

<h4>Background</h4>A high prevalence of cardiovascular risk factors including age, male sex, hypertension, diabetes, and tobacco use, has been reported in patients with Coronavirus disease 2019 (COVID-19) who experienced adverse outcome. The aim of this study was to investigate the relationship between cardiovascular risk factors and in-hospital mortality in patients with ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):23]

Cited: 10 times

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Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients.

Hui Liu, Jing Chen, Qin Yang, Fang Lei, Changjiang Zhang, Juan-Juan Qin, Ze Chen, Lihua Zhu, Xiaohui Song, Liangjie Bai, Xuewei Huang, Weifang Liu, Feng Zhou, Ming-Ming Chen, Yan-Ci Zhao, Xiao-Jing Zhang, Zhi-Gang She, Qingbo Xu, Xinliang Ma, Peng Zhang, Yan-Xiao Ji, Xin Zhang, Juan Yang, Jing Xie, Ping Ye, Elena Azzolini, Alessio Aghemo, Michele Ciccarelli, Gianluigi Condorelli, Giulio G Stefanini, Jiahong Xia, Bing-Hong Zhang, Yufeng Yuan, Xiang Wei, Yibin Wang, Jingjing Cai, Hongliang Li,

<h4>Background</h4>To develop a sensitive risk score predicting the risk of mortality in patients with coronavirus disease 2019 (COVID-19) using complete blood count (CBC).<h4>Methods</h4>We performed a retrospective cohort study from a total of 13,138 inpatients with COVID-19 in Hubei, China, and Milan, Italy. Among them, 9,810 patients with <b>≥</b>2 CBC records ... Read more >>

Med (N Y) (Med (New York, N.Y.))
[2021, 2(4):435-447.e4]

Cited: 2 times

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Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function.

Serena Zacchigna, Alessia Paldino, Inês Falcão-Pires, Evangelos P Daskalopoulos, Matteo Dal Ferro, Simone Vodret, Pierluigi Lesizza, Antonio Cannatà, Daniela Miranda-Silva, André P Lourenço, Bruno Pinamonti, Gianfranco Sinagra, Florian Weinberger, Thomas Eschenhagen, Lucie Carrier, Izhak Kehat, Carlo G Tocchetti, Michele Russo, Alessandra Ghigo, James Cimino, Emilio Hirsch, Dana Dawson, Michele Ciccarelli, Marco Oliveti, Wolfgang A Linke, Ilona Cuijpers, Stephane Heymans, Nazha Hamdani, Martine de Boer, Dirk J Duncker, Diederik Kuster, Jolanda van der Velden, Christophe Beauloye, Luc Bertrand, Manuel Mayr, Mauro Giacca, Florian Leuschner, Johannes Backs, Thomas Thum,

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(1):43-59]

Cited: 7 times

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