Full Text Journal Articles by
Author Michela Sali

Advertisement

Find full text journal articles






COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study.

Omar Yassef Antúnez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Saráchaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Beréa de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolina Chavez, Francisco Campos, Fadia Uribe, Olguita Del Aguila, Jorge Alberto Rios Aida, Andrea Parra Buitrago, Lina Maria Betancur Londoño, León Felipe Mendoza Vega, Carolina Almeida Hernández, Michela Sali, Julian Esteban Higuita Palacio, Jessica Gomez-Vargas, Adriana Yock-Corrales, Danilo Buonsenso,

<h4>Background</h4>To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level.<h4>Methods</h4>Ambispective multicenter cohort study from 5 Latin ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e1-e6]

Cited: 0 times

View full text PDF listing >>



Guidelines for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples

Slawomir Kubik, Ana Claudia Marques, Xiaobin Xing, Janine Silvery, Claire Bertelli, Flavio De Maio, Spyros Pournaras, Tom Burr, Yannis Duffourd, Helena Siemens, Chakib Alloui, Lin Song, Yvan Wenger, Alexandra Saitta, Morgane Macheret, Ewan Smith, Philippe Menu, Marion Brayer, Lars Steinmetz, Ali Si-Mohammed, Josiane Chuisseu, Richard Stevens, Pantelis Constantoulakis, Michela Sali, Gilbert Greub, Carsten Tiemann, Vicent Pelechano, Adrian Willig, Zhenyu Xu,

<h4>Background</h4> SARS-CoV-2 genotyping has been instrumental to monitor virus evolution and transmission during the pandemic. The reliability of the information extracted from the genotyping efforts depends on a number of aspects, including the quality of the input material, applied technology and potential laboratory-specific biases. These variables must be monitored to ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Sarilumab use in severe SARS-CoV-2 pneumonia.

Elisa Gremese, Antonella Cingolani, Silvia Laura Bosello, Stefano Alivernini, Barbara Tolusso, Simone Perniola, Francesco Landi, Maurizio Pompili, Rita Murri, Angelo Santoliquido, Matteo Garcovich, Michela Sali, Gennaro De Pascale, Maurizio Gabrielli, Federico Biscetti, Massimo Montalto, Alberto Tosoni, Giovanni Gambassi, Gian Ludovico Rapaccini, Amerigo Iaconelli, Lorenzo Zileri Del Verme, Luca Petricca, Anna Laura Fedele, Marco Maria Lizzio, Enrica Tamburrini, Gerlando Natalello, Laura Gigante, Dario Bruno, Lucrezia Verardi, Eleonora Taddei, Angelo Calabrese, Francesco Lombardi, Roberto Bernabei, Roberto Cauda, Francesco Franceschi, Raffaele Landolfi, Luca Richeldi, Maurizio Sanguinetti, Massimo Fantoni, Massimo Antonelli, Antonio Gasbarrini, ,

<h4>Background</h4>Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Herein we describe the outcomes of off-label intravenous use of Sarilumab in severe SARS-CoV-2-related pneumonia.<h4>Methods</h4>53 patients with SARS-CoV-2 severe pneumonia received intravenous Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU) admission ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 27:100553]

Cited: 0 times

View full text PDF listing >>



Non tuberculous mycobacteria related spondylodiscitis: a case report and systematic literature review.

Alessandro Smimmo, Andrea Perna, Massimo Fantoni, Davide De Marco, Calogero Velluto, Luca Proietti, Michela Sali, Francesco Ciro Tamburrelli,

<h4>Purpose</h4>Mycobacterium xenopi and Non Tuberculous Mycobacteria (NTM) are rare causes of spondylodiscitis (SD). The aim of this study was to highlight the relevance of considering these pathogens in differential diagnosis of slow growing SD, obtaining the correct diagnosis and evaluating the key points of management and therapy approach.<h4>Methods</h4>A case of ... Read more >>

Infez Med (Le infezioni in medicina)
[2020, 28(3):425-435]

Cited: 0 times

View full text PDF listing >>



Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposition to adults with COVID-19: preliminary findings

danilo buonsenso, Piero Valentini, Cristina De Rose, Davide Pata, Dario Sinatti, Domenico Speziale, Rosalba Ricci, Angelo Carfi, Francesco Landi, Maurizio Sanguinetti, Michela Sali,

wheather children are easily susceptible to SARS-CoV-2 infection is still a debated question and a currently a hot topic, particularly in view of important decisions on school opening. For this reason, we decide to describe preliminary data showing the prevalence of anti-SARS-CoV-2 IgG in children with known household exposure to ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis.

Flavio De Maio, Ettore Lo Cascio, Gabriele Babini, Michela Sali, Stefano Della Longa, Bruno Tilocca, Paola Roncada, Alessandro Arcovito, Maurizio Sanguinetti, Giovanni Scambia, Andrea Urbani,

The Envelope (E) protein of SARS-CoV-2 is the most enigmatic protein among the four structural ones. Most of its current knowledge is based on the direct comparison to the SARS E protein, initially mistakenly undervalued and subsequently proved to be a key factor in the ER-Golgi localization and in tight ... Read more >>

Microbes Infect (Microbes and infection)
[2020, 22(10):592-597]

Cited: 0 times

View full text PDF listing >>



COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study

Omar Yassef Antunez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Sarachaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Berea de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolin Chavez, Francisco Eduardo Campos, Fadia Uribe, Olguita del Aguila, JORGE ALBERTO RIOS AIDA, Andrea Parra Buitrago, Lina Maria Betancur Londono, Leon Felipe Mendoza Vega, Carolina Almeida Hernandez, Michela Sali, JULIAN HIGUITA PALACIO, Jessica Gomez-Vargas, Adriana Yock Corrales, Danilo Buonsenso,

<h4>Background: </h4> To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS C) in Latin American children, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Cytokine Profile in an Adolescent With Pediatric Multisystem Inflammatory Syndrome Temporally Related to COVID-19.

Danilo Buonsenso, Gabriele Di Sante, Michela Sali, ,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(8):e213-e215]

Cited: 0 times

View full text PDF listing >>



Children and COVID-19: Microbiological and immunological insights.

Danilo Buonsenso, Michela Sali, Davide Pata, Cristina De Rose, Maurizio Sanguinetti, Piero Valentini, Giovanni Delogu,

Since its first description in China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide being declared a pandemic by the World Health Organization. More than 10.3 million people have been infected and more than 506 000 people died. However, SARS-CoV-2 had a lower impact on the pediatric population. Only ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(10):2547-2555]

Cited: 0 times

View full text PDF listing >>



Graphene Oxide-Linezolid Combination as Potential New Anti-Tuberculosis Treatment.

Flavio De Maio, Valentina Palmieri, Giulia Santarelli, Giordano Perini, Alessandro Salustri, Ivana Palucci, Michela Sali, Jacopo Gervasoni, Aniello Primiano, Gabriele Ciasca, Maurizio Sanguinetti, Marco De Spirito, Giovanni Delogu, Massimiliano Papi,

Global pandemic management represents a serious issue for health systems. In some cases, repurposing of existing medications might help find compounds that have the unexpected potential to combat microorganisms. In the same way, changing cell-drug interaction by nanotechnology could represent an innovative strategy to fight infectious diseases. Tuberculosis (TB) remains ... Read more >>

Nanomaterials (Basel) (Nanomaterials (Basel, Switzerland))
[2020, 10(8):]

Cited: 0 times

View full text PDF listing >>



Accuracy of QuantiFERON-TB Gold Plus Test for Diagnosis of Mycobacterium tuberculosis Infection in Children.

Danilo Buonsenso, Giovanni Delogu, Clelia Perricone, Roberta Grossi, Angela Careddu, Flavio De Maio, Ivana Palucci, Maurizio Sanguinetti, Piero Valentini, Michela Sali,

Compared to its predecessor QuantiFERON-TB Gold In Tube (QFT-IT), QuantiFERON-TB Gold Plus (QFT-Plus) contains an additional antigen tube (TB2), stimulating both CD4<sup>+</sup> and CD8<sup>+</sup> T cells. The ability to discriminate CD4<sup>+</sup> and CD8<sup>+</sup> responses is suggested to be useful in differentiating stages of <i>Mycobacterium tuberculosis</i> infection. While QFT-Plus has already ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2020, 58(6):]

Cited: 0 times

View full text PDF listing >>



Enhanced binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis

Flavio De Maio, Ettore Lo Cascio, Gabriele Babini, Michela Sali, Stefano Della Longa, Bruno Tilocca, Paola Roncada, Alessandro Arcovito, Maurizio Sanguinetti, Giovanni Scambia, Andrea Urbani,

<h4>Background: </h4> The Envelope (E) protein of SARS-CoV-2 is the most enigmatic protein among the four structural ones on the viral genome. Most of the current knowledge on the E protein is based on the direct comparison to the SARS E protein, initially mistakenly undervalued and subsequently proved to be ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Sarilumab use in severe SARS-CoV-2 pneumonia

Elisa Gremese, Antonella Cingolani, Silvia Laura Bosello, Stefano Alivernini, Barbara Tolusso, Simone Perniola, Francesco Landi, Maurizio Pompili, Rita Murri, Angelo Santoliquido, Matteo Garcovich, Michela Sali, Gennaro De Pascale, Maurizio Gabrielli, Federico Biscetti, Massimo Montalto, Alberto Tosoni, Giovanni Gambassi, Gian Ludovico Rapaccini, Amerigo Iaconelli, Lorenzo Zileri Dal Verme, Luca Petricca, Anna Laura Fedele, Marco Maria Lizzio, Enrica Tamburrini, Gerlando Natalello, Laura Gigante, Dario Bruno, Lucrezia Verardi, Manuela Taddeo, Angelo Calabrese, Francesco Lombardi, Roberto Bernabei, Roberto Cauda, Francesco Franceschi, Raffaele Landolfi, Luca Richeldi, Maurizio Sanguinetti, Massimo Fantoni, Massimo Antonelli, Antonio Gasbarrini,

Importance: Interleukin-6 signal blockade has shown preliminary beneficial effects in treating aberrant host inflammatory response against SARS-CoV-2 leading to severe respiratory distress. <h4>Objective:</h4> to describe the effect of off-label intravenous use of Sarilumab in patients with severe SARS-CoV-2-related pneumonia. <h4>Design:</h4> Observational clinical cohort study. <h4>Setting:</h4> Fondazione Policlinico Universitario A. Gemelli ... Read more >>

()
[, :]

Cited: 1 time

View full text PDF listing >>



Case Report: Multifocal Tubercular Osteomyelitis of the Spine and Bilateral Dactylitis.

Francesco Taccari, Gianmaria Baldin, Arianna Emiliozzi, Lara Campana, Enrica Tamburrini, Edoardo Leone, Giovanni Delogu, Michela Sali, Roberto Cauda, Antonio Leone, Federico Pallavicini,

We report a case of a 13-year-old immunocompetent male with multifocal tubercular osteomyelitis involving several spinal segments, small bones of the hands, and the scalp, who started with progressively back pain and enlarging painful swelling on the palms of hands, fatigue, and irregular fever. All the hand lesions were firm, ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2019, 101(3):494-497]

Cited: 0 times

View full text PDF listing >>



IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay.

Ivana Palucci, Basem Battah, Alessandro Salustri, Flavio De Maio, Linda Petrone, Fabiola Ciccosanti, Michela Sali, Vincent Bondet, Darragh Duffy, Gian Maria Fimia, Delia Goletti, Giovanni Delogu,

Interferon-γ inducible protein 10 (IP-10), is a potent chemoattractant that promotes migration of monocytes and activated T-cells to inflammation foci. IP-10 is elevated in serum of patients with chronic hepatitis C virus (HCV) and tuberculosis (TB) infections, although it remains to be determined the contribution of IP-10 in restricting Mycobacterium ... Read more >>

Int J Med Microbiol (International journal of medical microbiology : IJMM)
[2019, 309(5):299-306]

Cited: 1 time

View full text PDF listing >>



Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis.

Ivana Palucci, Giuseppe Maulucci, Flavio De Maio, Michela Sali, Alessandra Romagnoli, Linda Petrone, Gian Maria Fimia, Maurizio Sanguinetti, Delia Goletti, Marco De Spirito, Mauro Piacentini, Giovanni Delogu,

Host-directed therapies (HDTs) are emerging as a potential valid support in the treatment of drug-resistant tuberculosis (TB). Following our recent report indicating that genetic and pharmacological inhibition of transglutaminase 2 (TG2) restricts Mycobacterium tuberculosis (Mtb) replication in macrophages, we aimed to investigate the potentials of the TG2 inhibitors cystamine and ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:3042]

Cited: 2 times

View full text PDF listing >>



Combined use of Quantiferon and HBHA-based IGRA supports tuberculosis diagnosis and therapy management in children.

Michela Sali, Danilo Buonsenso, Pamela D'Alfonso, Flavio De Maio, Manuela Ceccarelli, Basem Battah, Ivana Palucci, Teresa Chiacchio, Delia Goletti, Maurizio Sanguinetti, Piero Valentini, Giovanni Delogu,

<h4>Objectives</h4>Interferon-γ release assays (IGRA) are designed for diagnosis of tuberculosis (TB) infection, and do not discriminate latent TB infection (LTBI) from active TB. Heparin-binding hemagglutinin antigen (HBHA) emerged as a promising antigen for TB diagnosis when used in IGRA format. Aim of this study was to prospectively evaluate the performance ... Read more >>

J Infect (The Journal of infection)
[2018, 77(6):526-533]

Cited: 5 times

View full text PDF listing >>



PE_PGRS3 of Mycobacterium tuberculosis is specifically expressed at low phosphate concentration, and its arginine-rich C-terminal domain mediates adhesion and persistence in host tissues when expressed in Mycobacterium smegmatis.

Flavio De Maio, Basem Battah, Valentina Palmieri, Linda Petrone, Francesco Corrente, Alessandro Salustri, Ivana Palucci, Silvia Bellesi, Massimiliano Papi, Salvatore Rubino, Michela Sali, Delia Goletti, Maurizio Sanguinetti, Riccardo Manganelli, Marco De Spirito, Giovanni Delogu,

PE_PGRSs of Mycobacterium tuberculosis (Mtb) represent a family of complex and peculiar proteins whose role and function remain elusive. In this study, we investigated PE_PGRS3 and PE_PGRS4, two highly homologous PE_PGRSs encoded by two contiguous genes in the Mtb genome. Using a gene-reporter system in Mycobacterium smegmatis (Ms) and transcriptional ... Read more >>

Cell Microbiol (Cellular microbiology)
[2018, 20(12):e12952]

Cited: 4 times

View full text PDF listing >>



Vitamin D Levels in Active TB, Latent TB, Non-TB Pneumonia and Healthy Children: A Prospective Observational Study.

Danilo Buonsenso, Michela Sali, Davide Pata, Enrico Masiello, Gilda Salerno, Manuela Ceccarelli, Giovanni Delogu, Piero Valentini,

<h4>Background</h4>Growing evidence suggests that vitamin D deficiency might be implicated in the development of active tuberculosis (TB). We evaluated vitamin D levels in children with active TB compared to children with latent TB infection (LTBI), non-TB pneumonia (NTBP) and healthy controls to determine if there was a difference.<h4>Methods</h4>In this prospective ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2018, 37(5):337-347]

Cited: 2 times

View full text PDF listing >>



Rapid and safe one-step extraction method for the identification of Brucella strains at genus and species level by MALDI-TOF mass spectrometry.

Michela Sali, Flavio De Maio, Michela Tarantino, Giuliano Garofolo, Manuela Tittarelli, Lorena Sacchini, Katiuscia Zilli, Paolo Pasquali, Paola Petrucci, Cinzia Marianelli, Massimiliano Francia, Maurizio Sanguinetti, Rosanna Adone,

Brucellosis is essentially a disease of domesticated livestock; however, humans can also be infected via the consumption of contaminated meat or dairy products, underlying the need for rapid and accurate identification methods. Procedures for microbiological identification and typing of Brucella spp. are expensive, time-consuming, and must be conducted in biohazard ... Read more >>

PLoS One (PloS one)
[2018, 13(6):e0197864]

Cited: 5 times

View full text PDF listing >>



Genetic Diversity of Mycobacterium tuberculosis Isolates in the Metropolitan Area of Rome.

Angela Cannas, Serena Camassa, Michela Sali, Ornella Butera, Antonio Mazzarelli, Maurizio Sanguinetti, Antonino Di Caro, Giovanni Delogu, Enrico Girardi,

<h4>Background</h4>The presence in a geographic area of Mycobacterium tuberculosis (Mtb) strains belonging to different phylogeographic lineages and showing different drug susceptibility patterns may suggest recent transmission, with implications in terms of patient clinical management and disease control. The aim of this study was to carry out a preliminary epidemiological investigation ... Read more >>

Chemotherapy (Chemotherapy)
[2018, 63(3):148-154]

Cited: 0 times

View full text PDF listing >>



Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1β-induced autophagy.

Alessandra Romagnoli, Elisa Petruccioli, Ivana Palucci, Serena Camassa, Elisabetta Carata, Linda Petrone, Stefania Mariano, Michela Sali, Luciana Dini, Enrico Girardi, Giovanni Delogu, Delia Goletti, Gian Maria Fimia,

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has infected over 1.7 billion people worldwide and causes 1.4 million deaths annually. Recently, genome sequence analysis has allowed the reconstruction of Mycobacterium tuberculosis complex (MTBC) evolution, with the identification of seven phylogeographic lineages: four referred to as evolutionarily "ancient", and ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(6):624]

Cited: 8 times

View full text PDF listing >>



Evaluation of PE_PGRS33 as a potential surface target for humoral responses against Mycobacterium tuberculosis.

Mariachiara Minerva, Flavio De Maio, Serena Camassa, Basem Battah, Palucci Ivana, Riccardo Manganelli, Maurizio Sanguinetti, Michela Sali, Giovanni Delogu,

Mycobacterium tuberculosis (Mtb) PE_PGRS33 is a surface-exposed protein that was shown to interact with Toll-like receptor 2 on host macrophages to induce inflammatory signals and promote entry in macrophages. In this study, we investigated PE_PGRS33 as a potential target of a humoral response aimed at hampering key processes in tuberculosis ... Read more >>

Pathog Dis (Pathogens and disease)
[2017, 75(8):]

Cited: 2 times

View full text PDF listing >>



Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.

Serena Camassa, Ivana Palucci, Raffaella Iantomasi, Tiziana Cubeddu, Mariachiara Minerva, Flavio De Maio, Samuel Jouny, Elisa Petruccioli, Delia Goletti, Francesco Ria, Michela Sali, Maurizio Sanguinetti, Riccardo Manganelli, Stefano Rocca, Priscille Brodin, Giovanni Delogu,

PE_PGRS33 is a surface-exposed protein of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) which exerts its role in macrophages entry and immunomodulation. In this study, we aimed to investigate the polymorphisms in the <i>pe_pgrs33</i> gene of <i>Mtb</i> clinical isolates and evaluate their impact on protein functions. We sequenced <i>pe_pgrs33</i> in a collection of 135 ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2017, 7:137]

Cited: 4 times

View full text PDF listing >>



Understanding cutaneous tuberculosis: two clinical cases.

Flavio De Maio, Enrico Maria Trecarichi, Elena Visconti, Maurizio Sanguinetti, Giovanni Delogu, Michela Sali,

Tuberculosis (TB) is an ancient human disease and remains today one of the most important public health problems and the second most frequent cause of death from an infectious disease worldwide. While pulmonary TB is the most common form, extra-pulmonary TB is on the rise due to the increase in ... Read more >>

JMM Case Rep (JMM case reports)
[2016, 3(6):e005070]

Cited: 2 times

View full text PDF listing >>



Advertisement

Disclaimer
8.9358 s