Full Text Journal Articles by
Author Michel Shamy

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Rationalisations for women-only randomised controlled trials in conditions that affect both sexes: a scoping review protocol.

Ainsley Matthewson, Olena Bereznyakova, Brian Dewar, Alexandra Davis, Mark Fedyk, Vignan Yogendrakumar, Dean A Fergusson, Sophia Gocan, Dar Dowlatshahi, Robert Fahed, Michel Shamy,

<h4>Introduction</h4>Women have historically been under-represented in randomised controlled trials (RCTs), including many landmark RCTs that established standards of care. In light of this fact, some modern researchers are calling for replication of earlier landmark trials with women only. This approach is ethically concerning, in that it would require some enrolled ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e043370]

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Advanced consent for acute stroke trials.

Michel Shamy, Brian Dewar, Naomi Niznick, Stuart Nicholls, Dar Dowlatshahi,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):170]

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Is This Contrast? Is This Blood? An Agreement Study on Post-thrombectomy Computed Tomography Scans.

Ronda Lun, Gregory B Walker, Adrien Guenego, Mohammed Kassab, Eduardo Portela, Vignan Yogendrakumar, George Medvedev, Ken Wong, Michel Shamy, Dar Dowlatshahi, Robert Fahed,

<b>Background:</b> Hemorrhagic transformation after acute ischemic stroke is a dreaded and severe complication of thrombolysis and thrombectomy. However, its detection on post-thrombectomy conventional non-contrast computed tomography (CT) scan can be complicated by the frequent (and sometimes concomitant) presence of contrast, resulting in changes in management. <b>Aims:</b> Our objective was to ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:593098]

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Prevalence and the predictive performance of the dynamic CT-angiography spot sign in an observational cohort with intracerebral hemorrhage.

Dar Dowlatshahi, Hee Sahng Chung, Michael Reaume, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Franco Momoli, Richard Aviv, Andrew M Demchuk, Santanu Chakraborty,

The CT-angiography (CTA) spot sign is a predictor of hematoma expansion (HE). We have previously reported on the use of dynamic CTA (dCTA) to detect spot sign, and to study its formation over the acquisition period. In this study, we report the frequency of dCTA spot sign in acute intracerebral ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(47):e23278]

Cited: 1 time

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Revised intracerebral hemorrhage expansion definitions: Relationship with care limitations.

Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi,

<h4>Background</h4>Hematoma expansion is an important therapeutic target in intracerebral hemorrhage. Recently proposed hematoma expansion definitions have not been validated, and no previous definition has accounted for withdrawal of care.<h4>Aims</h4>To externally validate revised definitions of hematoma expansion that incorporate intraventricular hemorrhage, and to test their validity in the context of withdrawal ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, :1747493020967255]

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Use of the ABC/2 Method to Select Patients for Thrombectomy After 6 Hours of Symptom Onset.

William Boisseau, Cyril Dargazanli, Stanislas Smajda, Jean Capron, Michel Piotin, Celina Ducroux, Michel Shamy, Dariush Dowlatshahi, Richard I Aviv, Robert Fahed,

<h4>Objective</h4>To determine whether the ABC/2 method could accurately and reliably measure infarct volume and guide thrombectomy decision in acute stroke cases presenting with late or unknown onset.<h4>Methods</h4>Four physicians who routinely use MRI for acute stroke imaging, blinded to the RAPID results, measured the diffusion-weighted imaging (DWI) infarct volume using the ... Read more >>

Neurology (Neurology)
[2021, 96(1):e10-e18]

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Advanced consent for participation in acute care randomised control trials: protocol for a scoping review.

Naomi Niznick, Ronda Lun, Brian Dewar, Dar Dowlatshahi, Michel Shamy,

<h4>Introduction</h4>Informed consent is essential to clinical research, though obtaining informed consent for participation in research for emergency conditions is challenging. Adapted consent methods include consent from a substitute-decision maker, deferral of consent and waiver of consent. A novel approach is to use advanced consent, where a potential participant provides consent ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039172]

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Physician preparedness for resource allocation decisions under pandemic conditions: A cross-sectional survey of Canadian physicians, April 2020.

Brian Dewar, Joanna E Anderson, Edmund S H Kwok, Tim Ramsay, Dar Dowlatshahi, Robert Fahed, Claire Dyason, Michel Shamy,

<h4>Background</h4>Under the pandemic conditions created by the novel coronavirus of 2019 (COVID-19), physicians have faced difficult choices allocating scarce resources, including but not limited to critical care beds and ventilators. Past experiences with severe acute respiratory syndrome (SARS) and current reports suggest that making these decisions carries a heavy emotional ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0238842]

Cited: 1 time

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Diagnosis of Transient Ischemic Attack: Sex-Specific Differences From a Retrospective Cohort Study.

Sophia Gocan, Tess Fitzpatrick, Chu Qi Wang, Monica Taljaard, Wei Cheng, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Background and purpose</h4>Research suggests that women and men may present with different transient ischemic attack (TIA) and stroke symptoms. We aimed to explore symptoms and features associated with a definite TIA/stroke diagnosis and whether those associations differed by sex.<h4>Methods</h4>We completed a retrospective cohort study of patients referred to The Ottawa ... Read more >>

Stroke (Stroke)
[2020, 51(11):3371-3374]

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Recurrence of cervical artery dissection: protocol for a systematic review.

Elizabeth Lounsbury, Brian Dewar, Alexandra Davis, Dean A Fergusson, Dar Dowlatshahi, Michel Shamy,

<h4>Introduction</h4>Cervical artery dissection, including carotid and vertebral artery dissection, is an important cause of stroke in the young. Risk of developing cervical artery dissection has been associated with physical activity in various forms and has been presumed to be related to minor trauma and mechanical stretching of the cervical arteries. ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e037124]

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Prevalence of non-contrast CT abnormalities in adults with reversible cerebral vasoconstriction syndrome: protocol for a systematic review and meta-analysis.

Ryan Daniel Gotesman, Naomi Niznick, Brian Dewar, Dean A Fergusson, Risa Shorr, Michel Shamy, Dar Dowlatshahi,

<h4>Introduction</h4>Reversible cerebral vasoconstriction syndrome (RCVS) is characterised by severe, recurrent thunderclap headaches (TCHs) and vasoconstriction of cerebral arteries that resolve within 3 months. Abnormalities on non-contrast CT (NCCT) such as ischaemic strokes, intracerebral haemorrhage and subarachnoid haemorrhages are frequently observed on brain imaging of patients with RCVS though their prevalence ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e041776]

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Decreased Stroke Presentation Rates at a Comprehensive Stroke Center during COVID-19.

Dar Dowlatshahi, Grant Stotts, Aline Bourgoin, Sophia Gocan, Laura Dunn, Jodi Powell, Frank L Silver, Greg Walker, Vignan Yogendrakumar, Robert Fahed, Dylan Blacquiere, Michel Shamy,

We reviewed stroke care delivery during the COVID-19 pandemic at our stroke center and provincial telestroke system. We counted referrals to our prevention clinic, code strokes, thrombolysis, endovascular thrombectomies, and activations of a provincial telestroke system from February to April of 2017-2020. In April 2020, there was 28% reduction in ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2021, 48(1):118-121]

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Distribution and predictive performance of the temporal phase of dynamic spot sign appearance in acute intracerebral hemorrhage.

Hee Sahng Chung, Santanu Chakraborty, Michael Reaume, Vignan Yogendrakumar, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Richard I Aviv, Dar Dowlatshahi,

<h4>Background</h4>Dynamic CT angiography (dCTA) contrast extravasation, known as the "dynamic spot sign", can predict hematoma expansion (HE) in intracerebral hemorrhage (ICH). Recent reports suggest the phase of spot sign appearance is related to the magnitude of HE. We used dCTA to explore the association between the phase of spot sign ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0236196]

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Variability Predictors of Vasospasm in Subarachnoid Hemorrhage: A Feasibility Study.

Rosendo A Rodriguez, Christophe L Herry, Shane W English, Tim Ramsay, Andrew J E Seely, Glen P Kenny, Michel Shamy,

<h4>Background</h4>Mean cerebral blood flow velocity (mean-CBFV) obtained from Transcranial Doppler (TCD) poorly predicts cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Variability descriptors of mean-CBFV obtained during extended TCD recordings may improve this prediction. We assessed the feasibility of generating reliable linear and non-linear descriptors of mean-CBFV variability using ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, :1-7]

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Natural history of recovery after intracerebral haemorrhage: a scoping review protocol.

Sara Massicotte, Ronda Lun, Vignan Yogendrakumar, Brian Dewar, Alexandra Davies, Dean A Fergusson, Michel Shamy, Dar Dowlatshahi,

<h4>Introduction</h4>Clinical trials for intracerebral haemorrhage typically measure outcomes in the same way and at the same time points as trials for ischaemic stroke. However, there is growing evidence that the trajectory of recovery following intracerebral haemorrhage may differ significantly from that following ischaemic stroke. A better understanding of current approaches ... Read more >>

BMJ Open (BMJ open)
[2020, 10(8):e039460]

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Different meanings of equipoise and the four quadrants of uncertainty.

Michel Shamy, Brian Dewar, Mark Fedyk,

J Clin Epidemiol (Journal of clinical epidemiology)
[2020, 127:248-249]

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Original and Modified Graeb Score Correlation With Intraventricular Hemorrhage and Clinical Outcome Prediction in Hyperacute Intracranial Hemorrhage.

Daniel-Alexandre Bisson, Mathew L Flaherty, Anwar S Shatil, David Gladstone, Dar Dowlatshahi, Janice Carrozzella, Liying Zhang, Michael D Hill, Andrew Demchuck, Richard I Aviv, ,

Background and Purpose- The Graeb score is a visual rating scale of intraventricular hemorrhage (IVH) on noncontrast head CT. Little data exist in the hyperacute (<6 hour) period for reliability and predictive value of the modified Graeb Score (mGS) or the original Graeb Score (oGS) for clinical outcomes or their ... Read more >>

Stroke (Stroke)
[2020, 51(6):1696-1702]

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Clinical Reasoning: Recurrent strokes secondary to unknown vasculopathy.

Ronda Lun, Naomi Niznick, Ruth Padmore, Jonathan Mack, Michel Shamy, Grant Stotts, Dylan Blacquiere,

Neurology (Neurology)
[2020, 94(22):e2396-e2401]

Cited: 0 times

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Early Dabigatran Treatment After Transient Ischemic Attack and Minor Ischemic Stroke Does Not Result in Hemorrhagic Transformation.

Anas Alrohimi, Kelvin Ng, Dar Dowlatshahi, Brian Buck, Grant Stotts, Sibi Thirunavukkarasu, Michel Shamy, Hayrapet Kalashyan, Leka Sivakumar, Ashfaq Shuaib, Mike Sharma, Ken Butcher,

<b>Objectives: </b>The optimal timing of anticoagulation after ischemic stroke in atrial fibrillation (AF) patients is unknown. Our aim was to demonstrate the feasibility and safety of initiating dabigatran therapy within 14 days of transient ischemic attack (TIA) or minor stroke in AF patients.<br><br><b>Patients and methods: </b>A prospective, multi-center registry (NCT02415855) ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(5):604-611]

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"It's About How Hard You Can Get Hit and Keep Moving Forward": How to Survive Rejection and Get Your Research Published.

Robert Fahed, Michel Shamy, Dar Dowlatshahi,

Stroke (Stroke)
[2020, 51(5):e74-e77]

Cited: 0 times

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Reader response: Prognostic value of "tissue-based" definitions of TIA and minor stroke: Population-based study.

Sophia Gocan, Tess Fitzpatrick, Michel Shamy,

Neurology (Neurology)
[2020, 94(15):679]

Cited: 0 times

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Spotlight on Consent:  Lessons from the SPOTLIGHT Trial for Acute Intracerebral Hemorrhage

Tess Fitzpatrick, Michel Shamy, Brian Dewar, Julie Spence, Andrew Demchuk, Michael Hill, Matthew Flaherty, David Gladstone,

<h4>Background: </h4> SPOTLIGHT was a Canadian multicentre, placebo-controlled, randomized trial of emergency treatment with recombinant Factor VIIa for patients with acute intracerebral hemorrhage that enrolled a subset of eligible patients via deferral of consent. We investigated attitudes towards deferral of consent among participants and their legally-authorized representatives (LARs). Methods All ... Read more >>

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Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack.

Tess Fitzpatrick, Sophia Gocan, Chu Qi Wang, Aline Bourgoin, Monica Taljaard, Wei Cheng, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Background and purpose</h4>The diagnosis of transient ischemic attack (TIA) is largely dependent on a process of clinical decision-making that remains poorly characterized in the absence of a validated and accessible biomarker or imaging test. We performed a retrospective chart review to identify variables associated with a final neurologist diagnosis of ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2020, 10(4):245-249]

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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel Cr Rohr, Daniela Iancu, Demetrios J Sahlas, Amy Y X Yu, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce C V Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, ,

BACKGROUND:Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke. ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10227):878-887]

Cited: 30 times

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Overcoming Neurophobia With the Help of Peruvian Talking Bears.

Brian Dewar, Gregory S Day, Michel C F Shamy,

JAMA Neurol (JAMA neurology)
[2020, 77(3):291-292]

Cited: 0 times

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