Full Text Journal Articles by
Author Michaella Reif

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Nox4 mediates skeletal muscle metabolic responses to exercise.

Kalyn S Specht, Shashi Kant, Adele K Addington, Ryan P McMillan, Matthew W Hulver, Heather Learnard, Maura Campbell, Sarah R Donnelly, Amada D Caliz, Yongmei Pei, Michaella M Reif, Jacob M Bond, Anthony DeMarco, Branch Craige, John F Keaney, Siobhan M Craige,

<h4>Objective</h4>The immediate signals that couple exercise to metabolic adaptations are incompletely understood. Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) produces reactive oxygen species (ROS) and plays a significant role in metabolic and vascular adaptation during stress conditions. Our objective was to determine the role of Nox4 in exercise-induced skeletal muscle ... Read more >>

Mol Metab (Molecular metabolism)
[2021, 45:101160]

Cited: 1 time

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Impact of Preoperative Platelet Count on Bleeding Risk and Allogeneic Transfusion in Multilevel Spine Surgery.

Jonathan H Chow, Zackary Chancer, Michael A Mazzeffi, John S McNeil, Michael J Sokolow, Tyler M Gaines, Michaella M Reif, Anthony T Trinh, Ian J Wellington, Jael E Camacho, Jacob J Bruckner, Kenichi A Tanaka, Steven Ludwig,

<h4>Study design</h4>This was an observational cohort study of patients receiving multilevel thoracic and lumbar spine surgery.<h4>Objective</h4>The aim of this study was to identify which patients are at high risk for allogeneic transfusion which may allow for better preoperative planning and employment of specific blood management strategies.<h4>Summary of background data</h4>Multilevel posterior ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, 46(1):E65-E72]

Cited: 0 times

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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.

Shashi Kant, Siobhan M Craige, Kai Chen, Michaella M Reif, Heather Learnard, Mark Kelly, Amada D Caliz, Khanh-Van Tran, Kasmir Ramo, Owen M Peters, Marc Freeman, Roger J Davis, John F Keaney,

Diseases related to impaired blood flow such as peripheral artery disease (PAD) impact nearly 10 million people in the United States alone, yet patients with clinical manifestations of PAD (e.g., claudication and limb ischemia) have limited treatment options. In ischemic tissues, stress kinases such as c-Jun N-terminal kinases (JNKs), are ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):4223]

Cited: 6 times

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Considerations beyond Stenosis for Carotid Endarterectomy in Treating Free-Floating Thrombus of the Carotid Artery.

Besher Tolaymat, Karen Irizarry, Michaella Reif, Charles B Drucker, Brittany O Aicher, Rajabrata Sarkar, Shahab Toursavadkohi, Thomas S Monahan,

<h4>Background</h4>Free-floating thrombus (FFT) of the carotid artery is an uncommon condition that can present with neurologic symptoms, often in the setting of ischemic stroke. The literature pertaining to the incidence and optimal treatment of this condition is limited. Herein, we report our contemporary experience with FFT across a range of ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2019, 60:221-228]

Cited: 2 times

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Faces and Senses.

Besher Tolaymat, Michaella M Reif,

Obstet Gynecol (Obstetrics and gynecology)
[2019, 133(2):372]

Cited: 0 times

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Iliofemoral deep venous thrombosis in kidney transplant patients can cause graft dysfunction.

Ali Khalifeh, Michaella Reif, Besher Tolayamat, Janet Karanja, Rajabrata Sarkar, Shahab Toursavadkohi,

We present a series of kidney transplant dysfunction secondary to lower extremity deep venous thrombosis (DVT). A 70-year-old man underwent living unrelated kidney transplantation and presented 2 months postoperatively with acute kidney injury (AKI) secondary to external iliac vein thrombosis. Graft function improved after endovascular intervention. A 43-year-old man underwent living unrelated kidney ... Read more >>

J Vasc Surg Cases Innov Tech (Journal of vascular surgery cases and innovative techniques)
[2019, 5(1):7-11]

Cited: 0 times

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Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states.

Siobhan M Craige, Michaella M Reif, Shashi Kant,

Mixed lineage kinases, or MLKs, are members of the MAP kinase kinase kinase (MAP3K) family, which were originally identified among the activators of the major stress-dependent mitogen activated protein kinases (MAPKs), JNK and p38. During stress, the activation of JNK and p38 kinases targets several essential downstream substrates that react ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2016, 1862(9):1581-1586]

Cited: 10 times

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Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.

Chunying Li, Michaella M Reif, Siobhan M Craige, Shashi Kant, John F Keaney,

Metabolic stress sensors like AMP-activated protein kinase (AMPK) are known to confer stress adaptation and promote longevity in lower organisms. This study demonstrates that activating the metabolic stress sensor AMP-activated protein kinase (AMPK) in endothelial cells helps maintain normal cellular function by promoting mitochondrial biogenesis and stress adaptation. To better ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2016, 55-56:45-53]

Cited: 11 times

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Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions.

Siobhan M Craige, Shashi Kant, Michaella Reif, Kai Chen, Yongmei Pei, Rebecca Angoff, Koichi Sugamura, Timothy Fitzgibbons, John F Keaney,

Vascular reactive oxygen species (ROS) are known to be involved in atherosclerosis development and progression. NADPH oxidase 4 (Nox4) is a constitutively active ROS-producing enzyme that is highly expressed in the vascular endothelium. Nox4 is unique in its biology and has been implicated in vascular repair, however, the role of ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2015, 89:1-7]

Cited: 34 times

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