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Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study.

Katja M Gist, Andrew Misfeldt, Rashmi D Sahay, Stephen M Gorga, David J Askenazi, Brian C Bridges, Matthew L Paden, Michael Zappitelli, Jason Gien, Rajit K Basu, Jennifer G Jetton, Heidi J Murphy, Eileen King, Geoffrey M Fleming, David T Selewski, David S Cooper,

Acute kidney injury (AKI) and fluid overload (FO) are common complications of extracorporeal membrane oxygenation (ECMO). The purpose of this study was to characterize AKI and FO in children receiving extracorporeal cardiopulmonary resuscitation (eCPR). We performed a multicenter retrospective study of children who received eCPR. AKI was assessed during ECMO ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1912-1922]

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Implementing a fluid volume management program to decrease intra-dialytic hypotensive events in a paediatric in-centre haemodialysis unit: a quality improvement project.

Evelien Snauwaert, Stéphanie Wagner, Natasha A Jawa, Valentina Bruno, Ashlene McKay, Amrit Kirpalani, Rosaleen Nemec, Chia Wei Teoh, Elizabeth A Harvey, Michael Zappitelli, Christoph Licht, Damien G Noone,

<h4>Background</h4>Intra-dialytic hypotension (IDH) is the most common serious adverse event in paediatric haemodialysis (HD). Repeated IDH results in chronic multi-organ damage and increased mortality. At the Hospital for Sick Children, Toronto, retrospective data from all in-centre HD sessions revealed frequently occurring IDH events (16.5 ± 5.6% of HD sessions per week). Based ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, :]

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Peritoneal dialysis-related peritonitis caused by Gordonia bronchialis: first pediatric report.

Valentina Bruno, James Tjon, Sandy Lin, Helen Groves, Kescha Kazmi, Michael Zappitelli, Elizabeth Harvey,

<h4>Introduction</h4>Gordonia species, aerobic, weakly acid-fast, Gram-positive bacilli, are a rare cause of peritonitis in patients undergoing peritoneal dialysis (PD). We report the first pediatric case of PD-related peritonitis caused by Gordonia bronchialis.<h4>Case presentation</h4>A 13-year-old girl with chronic kidney disease (CKD) stage 5D, on continuous cycling PD (CCPD) for 8 years, ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, :]

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Authors' Reply.

Cal H Robinson, Nivethika Jeyakumar, Ron Wald, Michael Zappitelli, Rahul Chanchlani,

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, 32(10):2681-2682]

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Acute kidney injury in critically Ill children and young adults with suspected SARS-CoV2 infection.

Rajit K Basu, Erica C Bjornstad, Katja M Gist, Michelle Starr, Paras Khandhar, Rahul Chanchlani, Kelli A Krallman, Michael Zappitelli, David Askenazi, Stuart L Goldstein, ,

<h4>Background</h4>We aimed to study the association of suspected versus confirmed infection with the novel SARS-CoV2 virus with the prevalence of acute kidney injury (AKI) in critically ill children.<h4>Methods</h4>Sequential point-prevalence study of children and young adults aged 7 days to 25 years admitted to intensive care units under investigation for SARS-CoV2 ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study.

Helen L MacLaughlin, Mindy Pike, Nicholas M Selby, Edward Siew, Vernon M Chinchilli, Andrew Guide, Thomas G Stewart, Jonathan Himmelfarb, Alan S Go, Chirag R Parikh, Nasrollah Ghahramani, James Kaufman, T Alp Ikizler, Cassianne Robinson-Cohen, ,

<h4>Background</h4>Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI.<h4>Methods</h4>This prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event ... Read more >>

BMC Nephrol (BMC nephrology)
[2021, 22(1):200]

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Patient and caregiver perspectives on blood pressure in children with chronic kidney disease.

Justin Guang-Ao Wu, Allison Tong, Nicole Evangelidis, Karine E Manera, Camilla S Hanson, Amanda Baumgart, Noa Amir, Aditi Sinha, Allison Dart, Allison A Eddy, Chandana Guha, Debbie S Gipson, Detlef Bockenhauer, Hui-Kim Yap, Jaap Groothoff, Michael Zappitelli, Stephen I Alexander, Susan L Furth, Susan Samuel, Simon A Carter, Amanda Walker, Joshua Kausman, David Martinez-Martin, Talia Gutman, Jonathan C Craig,

<h4>Background</h4>Over 50% of children with chronic kidney disease (CKD) have uncontrolled hypertension, increasing their long-term risk of cardiovascular disease and progression to kidney failure. Children receiving medications or dialysis may also experience acute blood pressure fluctuations accompanied by debilitating symptoms. We aimed to describe the perspectives of children with CKD ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2021, :]

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Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group.

Stephen M Gorga, Lisa Lima, David J Askenazi, Brian C Bridges, David S Cooper, Matthew L Paden, Michael Zappitelli, Katja M Gist, Jason Gien, Jennifer G Jetton, Heidi J Murphy, Geoffrey M Fleming, David T Selewski, Rajit K Basu,

Fluid overload (FO) and acute kidney injury (AKI) occur commonly in children supported with extracorporeal membrane oxygenation (ECMO). Continuous renal replacement therapy (CRRT) may be used to manage AKI and FO in children on ECMO. In 2012, our group surveyed ECMO centers to begin to understand the practice patterns around ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Association of Urine Platinum With Acute Kidney Injury in Children Treated With Cisplatin for Cancer.

Asaf Lebel, Hayton Chui, Kelly R McMahon, Yong Jin Lim, Joseph Macri, Stella Wang, Prasad Devarajan, Tom D Blydt-Hansen, Michael Zappitelli, Bradley L Urquhart,

Cisplatin is a chemotherapeutic agent highly excreted in urine and known to cause acute kidney injury (AKI). As AKI diagnosis by serum creatinine (SCr) is usually delayed, endeavors for finding early AKI biomarkers continue. This study aims to determine if urine platinum (UP) concentration 24 hours after cisplatin infusion is ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2021, 61(7):871-880]

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Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study.

Cal H Robinson, Nivethika Jeyakumar, Bin Luo, Ron Wald, Amit X Garg, Danielle M Nash, Eric McArthur, Jason H Greenberg, David Askenazi, Cherry Mammen, Lehana Thabane, Stuart Goldstein, Rulan S Parekh, Michael Zappitelli, Rahul Chanchlani,

<h4>Background</h4>AKI is common during pediatric hospitalizations and associated with adverse short-term outcomes. However, long-term outcomes among survivors of pediatric AKI who received dialysis remain uncertain.<h4>Methods</h4>To determine the long-term risk of kidney failure (defined as receipt of chronic dialysis or kidney transplant) or death over a 22-year period for pediatric survivors ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, 32(8):2005-2019]

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Relationship of patent ductus arteriosus management with neonatal AKI.

Ronnie Guillet, David T Selewski, Russell Griffin, Shantanu Rastogi, David J Askenazi, Carl T D'Angio, ,

<h4>Objective</h4>Investigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates.<h4>Study design</h4>Retrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 - 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, 41(6):1441-1447]

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Association of pediatric cardiac surgery-associated acute kidney injury with post-discharge healthcare utilization, mortality and kidney outcomes.

Sophia Nunes, Erin Hessey, Marc Dorais, Sylvie Perreault, Philippe Jouvet, Véronique Phan, Jacques Lacroix, Jean-Philippe Lafrance, Susan Samuel, Michael Zappitelli,

<h4>Background</h4>Acute kidney Injury (AKI) in children undergoing cardiac surgery (CS) is strongly associated with hospital morbidity. Post-discharge CS AKI outcomes are less clear. We evaluated associations between AKI and post-discharge (a) healthcare utilization, (b) chronic kidney disease (CKD) or hypertension and (c) mortality.<h4>Methods</h4>This is a retrospective two-centre cohort study of ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(9):2865-2874]

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Acute kidney injury in the pediatric intensive care unit: outpatient follow-up.

Cal Robinson, Erin Hessey, Sophia Nunes, Marc Dorais, Rahul Chanchlani, Jacques Lacroix, Philippe Jouvet, Veronique Phan, Michael Zappitelli,

<h4>Background</h4>Few studies have characterized follow-up after pediatric acute kidney injury (AKI). Our aim was to describe outpatient AKI follow-up after pediatric intensive care unit (PICU) admission.<h4>Methods</h4>Two-center retrospective cohort study (0-18 years; PICU survivors (2003-2005); noncardiac surgery; and no baseline kidney disease). Provincial administrative databases were used to determine outcomes.<h4>Exposure</h4>AKI (KDIGO ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

Cited: 1 time

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Serum Creatinine Monitoring After Acute Kidney Injury in the PICU.

Cal Robinson, Kelly Benisty, Vedran Cockovski, Ari R Joffe, Daniel Garros, Teodora Riglea, Michael Pizzi, Ana Palijan, Rahul Chanchlani, Catherine Morgan, Michael Zappitelli,

<h4>Objectives</h4>It is unknown whether children with acute kidney injury during PICU admission have kidney function monitored after discharge. Objectives: 1) describe postdischarge serum creatinine monitoring after PICU acute kidney injury and 2) determine factors associated with postdischarge serum creatinine monitoring.<h4>Design</h4>Secondary analysis of longitudinal cohort study data.<h4>Setting</h4>Two PICUs in Montreal and ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(4):412-425]

Cited: 1 time

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Long-term Risk of Hypertension After Surgical Repair of Congenital Heart Disease in Children.

Jason H Greenberg, Eric McArthur, Heather Thiessen-Philbrook, Michael Zappitelli, Ron Wald, Sunjay Kaushal, Derek K Ng, Allen D Everett, Rahul Chanchlani, Amit X Garg, Chirag R Parikh,

<h4>Importance</h4>The long-term risk of hypertension in children after surgery for congenital heart disease (CHD) is unclear.<h4>Objective</h4>To assess the incidence of hypertension after cardiac surgery in children with CHD.<h4>Design, setting, and participants</h4>A multicenter retrospective matched cohort study was conducted in Ontario, Canada, using administrative databases. A total of 3600 children with ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(4):e215237]

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Canadian Association of Paediatric Nephrologists COVID-19 Rapid Response: Guidelines for Management of Acute Kidney Injury in Children.

Abdullah Alabbas, Amrit Kirpalani, Catherine Morgan, Cherry Mammen, Christoph Licht, Veronique Phan, Andrew Wade, Elizabeth Harvey, Michael Zappitelli, Edward G Clark, Swapnil Hiremath, Steven D Soroka, Ron Wald, Matthew A Weir, Rahul Chanchlani, Mathieu Lemaire,

<h4>Purpose</h4>This article provides guidance on managing acute kidney injury (AKI) and kidney replacement therapy (KRT) in pediatrics during the COVID-19 pandemic in the Canadian context. It is adapted from recently published rapid guidelines on the management of AKI and KRT in adults, from the Canadian Society of Nephrology (CSN). The ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2021, 8:2054358121990135]

Cited: 1 time

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Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately.

Heidi J Murphy, Jason Gien, Rashmi Sahay, Eileen King, David T Selewski, Brian C Bridges, David S Cooper, Geoffrey M Fleming, Matthew L Paden, Michael Zappitelli, Katja M Gist, Rajit K Basu, Jennifer G Jetton, David Askenazi,

<h4>Introduction</h4>We aimed to characterize acute kidney injury (AKI), fluid overload (FO), and renal replacement therapy (RRT) utilization by diagnostic categories and examine associations between these complications and mortality by category.<h4>Methods</h4>To test our hypotheses, we conducted a retrospective multicenter, cohort study including 446 neonates (categories: 209 with cardiac disease, 114 with ... Read more >>

Blood Purif (Blood purification)
[2021, 50(6):808-817]

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Quality improvement goals for pediatric acute kidney injury: pediatric applications of the 22nd Acute Disease Quality Initiative (ADQI) conference.

David T Selewski, David J Askenazi, Kianoush Kashani, Rajit K Basu, Katja M Gist, Matthew W Harer, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Claudio Ronco, Stuart L Goldstein, Theresa Ann Mottes,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(4):733-746]

Cited: 2 times

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24-hour ambulatory blood pressure monitoring 9 years after pediatric cardiac surgery: a pilot and feasibility study.

Daniel Fredric, Jason H Greenberg, Chirag R Parikh, Prasad Devarajan, Hayton Chui, Vedran Cockovski, Michael Pizzi, Ana Palijan, Erin Hessey, Yaqi Jia, Heather R Thiessen-Philbrook, Michael Zappitelli,

<h4>Background</h4>Children undergoing cardiac surgery are at risk of high blood pressure (BP), a risk factor for cardiovascular and kidney disease. Twenty-four-hour ambulatory BP monitoring (ABPM) is a reference standard hypertension (HTN) test. Little data exist on ABPM abnormalities in children several years post cardiac surgery. This study aimed to (a) ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(6):1533-1541]

Cited: 0 times

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Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury.

Sandeep Brar, Kathleen D Liu, Alan S Go, Raymond K Hsu, Vernon M Chinchilli, Steven G Coca, Amit X Garg, Jonathan Himmelfarb, T Alp Ikizler, James Kaufman, Paul L Kimmel, Chirag R Parikh, Edward D Siew, Lorraine B Ware, Hui Zeng, Chi-Yuan Hsu, , ,

<h4>Background and objectives</h4>The risk-benefit ratio of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy after AKI may be altered due to concerns regarding recurrent AKI. We evaluated, in a prospective cohort, the association between use (versus nonuse) of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and the subsequent risk of AKI and ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 16(1):26-36]

Cited: 1 time

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Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis.

Erica C Bjornstad, Kelli A Krallman, David Askenazi, Michael Zappitelli, Stuart L Goldstein, Rajit K Basu, ,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(3):446-448]

Cited: 10 times

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Acute Kidney Injury and Risk of CKD and Hypertension after Pediatric Cardiac Surgery.

Michael Zappitelli, Chirag R Parikh, James S Kaufman, Alan S Go, Paul L Kimmel, Chi-Yuan Hsu, Steven G Coca, Vernon M Chinchilli, Jason H Greenberg, Marva M Moxey-Mims, T Alp Ikizler, Vedran Cockovski, Anne-Marie Dyer, Prasad Devarajan, ,

<h4>Background and objectives</h4>The association of AKI after pediatric cardiac surgery with long-term CKD and hypertension development is unclear. The study objectives were to determine whether AKI after pediatric cardiac surgery is associated with incident CKD and hypertension.<h4>Design, setting, participants, & measurements</h4>This was a prospective cohort study of children of 1 ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 15(10):1403-1412]

Cited: 5 times

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Agreement Between Administrative Database and Medical Chart Review for the Prediction of Chronic Kidney Disease G category.

Louise Roy, Michael Zappitelli, Brian White-Guay, Jean-Philippe Lafrance, Marc Dorais, Sylvie Perreault,

<h4>Background</h4>Chronic kidney disease (CKD) is a major health issue and cardiovascular risk factor. Validity assessment of administrative data for the detection of CKD in research for drug benefit and risk using real-world data is important. Existing algorithms have limitations and we need to develop new algorithms using administrative data, giving ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358120959908]

Cited: 1 time

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Improving the quality of neonatal acute kidney injury care: neonatal-specific response to the 22nd Acute Disease Quality Initiative (ADQI) conference.

Matthew W Harer, David T Selewski, Kianoush Kashani, Rajit K Basu, Katja M Gist, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Stuart L Goldstein, Theresa Ann Mottes, David J Askenazi,

With the adoption of standardized neonatal acute kidney injury (AKI) definitions over the past decade and the concomitant surge in research studies, the epidemiology of and risk factors for neonatal AKI have become much better understood. Thus, there is now a need to focus on strategies designed to improve AKI ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, 41(2):185-195]

Cited: 2 times

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