Full Text Journal Articles by
Author Michael Wurm

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry.

Sascha René Tittel, Désirée Dunstheimer, Dörte Hilgard, Burkhild Knauth, Elke Fröhlich-Reiterer, Angela Galler, Michael Wurm, Reinhard Walter Holl, ,

<h4>Aims</h4>To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D).<h4>Methods</h4>We included 79,067 T1D patients aged 6-20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. ... Read more >>

Acta Diabetol (Acta diabetologica)
[2021, 58(5):623-631]

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[Satellite data for recording health-relevant environmental conditions: examples and interdisciplinary potential].

Hannes Taubenböck, Patrick Schmich, Thilo Erbertseder, Inken Müller, Julia Tenikl, Matthias Weigand, Jeroen Staab, Michael Wurm,

Environmental conditions influence human health and interact with other factors such as DNA, lifestyle, or the social environment. Earth observations from space provide data on the most diverse manifestations of these environmental conditions and make it possible to quantify them spatially. Using two examples - the availability of open and ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(8):936-944]

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Elevated Plasma Vitamin B12 in Patients with Hepatic Glycogen Storage Diseases.

Julia Hinkel, Johannes Schmitt, Michael Wurm, Stefanie Rosenbaum-Fabian, Karl Otfried Schwab, Donald W Jacobsen, Ute Spiekerkoetter, Sergey N Fedosov, Luciana Hannibal, Sarah C Grünert,

<i>Background</i>: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B<sub>12</sub> status in a large cohort of hepatic GSD patients. <i>Methods</i>: Plasma vitamin B<sub>12</sub>, total plasma homocysteine (tHcy) and methylmalonic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(8):]

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Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study.

Stefan Groeneweg, Ferdy S van Geest, Ayhan Abacı, Alberto Alcantud, Gautem P Ambegaonkar, Christine M Armour, Priyanka Bakhtiani, Diana Barca, Enrico S Bertini, Ingrid M van Beynum, Nicola Brunetti-Pierri, Marianna Bugiani, Marco Cappa, Gerarda Cappuccio, Barbara Castellotti, Claudia Castiglioni, Krishna Chatterjee, Irenaeus F M de Coo, Régis Coutant, Dana Craiu, Patricia Crock, Christian DeGoede, Korcan Demir, Alice Dica, Paul Dimitri, Anna Dolcetta-Capuzzo, Marjolein H G Dremmen, Rachana Dubey, Anina Enderli, Jan Fairchild, Jonathan Gallichan, Belinda George, Evelien F Gevers, Annette Hackenberg, Zita Halász, Bianka Heinrich, Tony Huynh, Anna Kłosowska, Marjo S van der Knaap, Marieke M van der Knoop, Daniel Konrad, David A Koolen, Heiko Krude, Amy Lawson-Yuen, Jan Lebl, Michaela Linder-Lucht, Cláudia F Lorea, Charles M Lourenço, Roelineke J Lunsing, Greta Lyons, Jana Malikova, Edna E Mancilla, Anne McGowan, Veronica Mericq, Felipe M Lora, Carla Moran, Katalin E Müller, Isabelle Oliver-Petit, Laura Paone, Praveen G Paul, Michel Polak, Francesco Porta, Fabiano O Poswar, Christina Reinauer, Klara Rozenkova, Tuba S Menevse, Peter Simm, Anna Simon, Yogen Singh, Marco Spada, Jet van der Spek, Milou A M Stals, Athanasia Stoupa, Gopinath M Subramanian, Davide Tonduti, Serap Turan, Corstiaan A den Uil, Joel Vanderniet, Adri van der Walt, Jean-Louis Wémeau, Jolante Wierzba, Marie-Claire Y de Wit, Nicole I Wolf, Michael Wurm, Federica Zibordi, Amnon Zung, Nitash Zwaveling-Soonawala, W Edward Visser,

<h4>Background</h4>Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor disability resulting from cerebral hypothyroidism and chronic peripheral thyrotoxicosis. We sought to systematically assess the phenotypic characteristics and natural history of patients with MCT8 deficiency.<h4>Methods</h4>We did an international, ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2020, 8(7):594-605]

Cited: 2 times

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Diabetes management in Wolcott-Rallison syndrome: analysis from the German/Austrian DPV database.

Alena Welters, Thomas Meissner, Katja Konrad, Clemens Freiberg, Katharina Warncke, Sylvia Judmaier, Olga Kordonouri, Michael Wurm, Matthias Papsch, Gisela Fitzke, Silke Christina Schmidt, Sascha R Tittel, Reinhard W Holl,

<h4>Background</h4>Wolcott-Rallison syndrome (WRS) is characterized by permanent early-onset diabetes, skeletal dysplasia and several additional features, e.g. recurrent liver failure. This is the first multicentre approach that focuses on diabetes management in WRS. We searched the German/Austrian Diabetes-Patienten-Verlaufsdokumentation (DPV) registry and studied anthropometric characteristics, diabetes treatment, glycaemic control and occurrence of ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):100]

Cited: 1 time

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Short-Term Effects of Growth Hormone on Lipolysis, Glucose and Amino Acid Metabolism Assessed in Serum and Microdialysate of Healthy Young Men.

Andreas Krebs, Andreas Baum, Jürgen Doerfer, Klaus Gempel, Michael Wurm, Corinna Brichta, Jörn Oliver Sass, Karl Winkler, Karl Otfried Schwab,

<b>Objective: </b>We investigated direct effects of a therapeutic growth hormone dose on lipolysis, glucose and amino acid metabolism.<br><br><b>Methods: </b>This crossover microdialysis trial involved six healthy male volunteers receiving single subcutaneous injections of both growth hormone (0.035 mg/kg) and placebo (0.9% sodium chloride). The investigation comprised three test days with standard diet. ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2020, 128(12):819-826]

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Using the Lifeworld Approach to Improve HIV Testing.

Michael Wurm, Anja Neumann, Jürgen Wasem, Janine Biermann-Stallwitz,

Major guidelines for HIV recommend that testing should be provided in a way that is adapted to the lifeworld of groups at risk. However, precise definitions as to what adaption to the lifeworld means are missing. Therefore, this research project evaluated how the lifeworld approach can be operationalized in regard ... Read more >>

Soc Work Public Health (Social work in public health)
[2019, 34(6):542-555]

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Start low, go slowly - mental abnormalities in young prolactinoma patients under cabergoline therapy.

Corinna Melanie Brichta, Michael Wurm, Andreas Krebs, Karl Otfried Schwab, Natascha van der Werf-Grohmann,

Background Prolactin-secreting pituitary adenomas in childhood and adolescence are rare. First-line therapy consists of dopamine agonists (DAs) like cabergoline. Experience in treating prolactinomas in paediatric and adolescent patients is limited. Methods This study was a retrospective analysis of clinical data, laboratory data, radiological findings and medical treatment of paediatric and ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(9):969-977]

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Evaluating the four most important salivary sex steroids during male puberty: testosterone best characterizes pubertal development.

Andreas Krebs, Karoline Dickhuth, Rebekka Mumm, Bernhard Stier, Jürgen Doerfer, Dirk Grueninger, Michael Wurm, Corinna Brichta, Karl Otfried Schwab,

Background During pubertal development in healthy boys, increased levels of different sex steroids occur which are responsible for sexual maturation and physical changes. However, relationships between various sex hormones and pubertal development stages have not been sufficiently studied. Methods The investigation included 165 normal boys (mean age 12.7±2.8 years, mean ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(3):287-294]

Cited: 1 time

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Hemoglobin A1c and retinal arteriolar narrowing in children with type 1 diabetes: the diagnostics of early atherosclerosis risk in kids study.

Michael Wurm, Leonie Kühnemund, Lisa Maier, Mi Xia, Kai Lichte, Kristiane Hallermann, Alexandra Krause, Andreas Krebs, Henner Hanssen, Peter Deibert, Karl Otfried Schwab,

<h4>Background/objective</h4>Microvascular alterations play a key role in the development of diabetes complications. Retinal vessel analysis is a unique method to examine microvascular changes in brain-derived vessels.<h4>Methods</h4>Sixty-seven pediatric and adolescent type 1 diabetes patients and 58 healthy control persons (mean age 12.4 ± 2.9 years) underwent non-mydriatic retinal photography of both eyes. Central retinal ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2019, 20(5):622-628]

Cited: 1 time

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[Barriers to Accessing HIV Testing Services - A Systematic Literature Review].

Michael Wurm, Anja Neumann, Jürgen Wasem, Janine Biermann-Stallwitz,

<h4>Objective</h4>In Germany there are 3,100 new HIV infections per year (2016), mainly homosexual men and intravenous drug users. According to experts from Robert Koch Institute, about 30 % of people with HIV are diagnosed late, well past the optimal moment to start the antiretroviral therapy. The high rate of late ... Read more >>

Gesundheitswesen (Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)))
[2019, 81(3):e43-e57]

Cited: 1 time

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Transfer of Topical Testosterone to Subcutaneous Microdialysate, Blood and Saliva in Healthy Young Men.

Andreas Krebs, Hans-Willi Clement, Jutta Zimmerer, Eberhard Schulz, Jürgen Doerfer, Michael Wurm, Corinna Brichta, Natascha van der Werf-Grohmann, Karl Otfried Schwab,

<h4>Objective</h4>We evaluated percutaneous penetration of topical testosterone and subsequent transfer to subcutaneous tissue, blood and saliva.<h4>Methods</h4>This microdialysis trial involved eight healthy male volunteers. Five participants received a single dose of 50 mg testosterone gel on the abdominal skin and three untreated participants served as controls. Two microdialysis probes were inserted percutaneously ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(5):289-294]

Cited: 0 times

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Semiparametric Generalized Linear Models with the gldrm Package.

Michael J Wurm, Paul J Rathouz,

This paper introduces a new algorithm to estimate and perform inferences on a recently proposed and developed semiparametric generalized linear model (glm). Rather than selecting a particular parametric exponential family model, such as the Poisson distribution, this semiparametric glm assumes that the response is drawn from the more general exponential ... Read more >>

R J (The R journal)
[2018, 10(1):288-307]

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Slum mapping in polarimetric SAR data using spatial features

Michael Wurm, Andreas Schmitt, Hannes Taubenböck, Matthias Weigand,

Driven by massive urbanization processes, particularly in developing countries, people flock into the cities resulting in an evolution of large slum areas. Mapping and monitoring of slum areas have become an invaluable source for decision-making processes to implement policies related to improve living conditions. Space-borne remotely sensed data has been ... Read more >>

(Remote sensing of environment.)
[2017, 194:190-204]

Cited: 1 time

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COBA-Cohort: a prospective cohort of HIV-negative men who have sex with men, attending community-based HIV testing services in five European countries (a study protocol).

Nicolas Lorente, Laura Fernàndez-López, Ricardo Fuertes, Daniela Rojas Castro, François Pichon, Bojan Cigan, Sophocles Chanos, Paula Meireles, Raquel Lucas, Stéphane Morel, Per Slaaen Kaye, Cristina Agustí, Irena Klavs, Tom Platteau, Jordi Casabona, ,

<h4>Introduction</h4>Community-based voluntary counselling and testing (CBVCT) services for men who have sex with men (MSM) can reach those most-at-risk and provide an environment for gay men that is likely to be non-stigmatising. Longitudinal data on the behaviour of HIV-negative MSM are scarce in Europe. The aim of this protocol, developed ... Read more >>

BMJ Open (BMJ open)
[2016, 6(7):e011314]

Cited: 3 times

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Decrease of small dense LDL and lipoprotein-associated phospholipase A2 due to human growth hormone treatment in short children with growth hormone deficiency and small for gestational age status.

Andreas Krebs, Thomas Kratzin, Jürgen Doerfer, Karl Winkler, Michael Wurm, Natascha von der Werf-Grohmann, Alexandra Krause, Karl Otfried Schwab,

Growth hormone deficiency (GHD) and small for gestational age (SGA) status are associated with cardiovascular risks. We therefore, investigated antiatherogenic effects of growth hormone (GH).Subfractions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL), lipoprotein-associated phospholipase A2 (Lp-PLA2), and high-sensitivity C-reactive protein (hsCRP) were measured at baseline, after 8 and 52 ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2016, 29(2):203-208]

Cited: 2 times

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Rayleigh scattering of linear alkylbenzene in large liquid scintillator detectors.

Xiang Zhou, Qian Liu, Michael Wurm, Qingmin Zhang, Yayun Ding, Zhenyu Zhang, Yangheng Zheng, Li Zhou, Jun Cao, Yifang Wang,

Rayleigh scattering poses an intrinsic limit for the transparency of organic liquid scintillators. This work focuses on the Rayleigh scattering length of linear alkylbenzene (LAB), which will be used as the solvent of the liquid scintillator in the central detector of the Jiangmen Underground Neutrino Observatory. We investigate the anisotropy ... Read more >>

Rev Sci Instrum (The Review of scientific instruments)
[2015, 86(7):073310]

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A standardized clinical and radiological follow-up of patients with chronic non-bacterial osteomyelitis treated with pamidronate.

Christine Hofmann, Michael Wurm, Tobias Schwarz, Henning Neubauer, Meinrad Beer, Hermann Girschick, Henner Morbach,

<h4>Objectives</h4>Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system. Treatment with NSAIDs is generally effective in the majority of patients, however, a sizeable proportion of patients have persistent disease and subsequent treatment strategies are required. The aim of this study was to characterise the clinical and radiological ... Read more >>

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2014, 32(4):604-609]

Cited: 13 times

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Early onset of polyglandular failure is associated with HLA-DRB1*03.

Manuela Dittmar, Maximilian Ide, Michael Wurm, George J Kahaly,

<h4>Objectives</h4>Polyglandular failure or autoimmunity (PGA) involves at least two endocrine diseases. Several genes may play a role in its etiology. This study analyzed 1) whether HLA-DRB1, HLA-DQB1, and MHC class I chain-related gene A (MICA) polymorphisms are associated in PGA and 2) whether PGA patients display stronger associations with these ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2008, 159(1):55-60]

Cited: 15 times

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[Polymorphisms of MICA microsatellites in thyroidal autoimmunity].

Maximilian Ide, Manuela Dittmar, Michael Wurm, Michael Kanitz, George J Kahaly,

<h4>Background</h4>The autoimmune thyropathies Graves' disease (GD) and Hashimoto's thyroiditis (HT) have multiple genetic and environmental backgrounds. Allele alterations of immune genes might contribute to the development of autoimmunity.<h4>Patients and methods</h4>This study determined a triplet short tandem repeat (STR) polymorphism in the transmembrane region of the major histocompatibility complex (MHC) class ... Read more >>

Med Klin (Munich) (Medizinische Klinik (Munich, Germany : 1983))
[2007, 102(1):11-15]

Cited: 3 times

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The fate of the distal aorta after repair of acute type A aortic dissection.

James C Halstead, Matthias Meier, Christian Etz, David Spielvogel, Carol Bodian, Michael Wurm, Rohit Shahani, Randall B Griepp,

<h4>Objectives</h4>The residual aorta's behavior after repair of acute type A dissection is incompletely understood. We analyzed segmental growth rates, distal reoperation, and factors influencing long-term survival.<h4>Methods</h4>One hundred seventy-nine consecutive patients (70% male; mean age, 60 years) with acute type A dissection underwent aggressive resection of the intimal tear and open ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2007, 133(1):127-135]

Cited: 130 times

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