Full Text Journal Articles by
Author Michael Shields

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How We Teach Children with Asthma to Use Their Inhaler: A Scoping Review

Patrick McCrossan, Orla Mallon, Michael Shields, Catherine Russell, Lesley Kennedy, Dara O’Donoghue,

<h4>Background: </h4> One reason that asthma remains poorly controlled in children is poor inhaler technique. Guidelines recommend checking inhaler technique at each clinical visit. However, they do not specify how best to train children to mastery of correct inhaler technique. Many children are simply shown how to use inhalers which ... Read more >>

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Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review.

Lauren Alexandra Quinn, Michael D Shields, Ian Sinha, Helen E Groves,

<h4>Background</h4>Acute bronchiolitis caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and asthma. However, it is unclear whether this association is causal. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, but the longer-term follow-up has given conflicting evidence for ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):269]

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Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: a prospective multicentre cohort study protocol.

Michael Corr, Sharon Christie, Chris Watson, Julieann Maney, Derek Fairley, Shamez N Ladhani, Mark David Lyttle, Lisa McFetridge, Hannah Mitchell, Michael David Shields, Claire McGinn, James McKenna, Peter Mallett, Kathryn Ferris, Gala Rowe-Setz, Rebecca Moore, Steven Foster, Jennifer Evans, Tom Waterfield,

<h4>Background</h4>A novel coronavirus SARS-CoV-2 has been responsible for a worldwide pandemic. Children typically have very mild, or no, symptoms of infection. This makes estimations of seroprevalence in children difficult. Research is therefore required to determine the seroprevalence of SARS-CoV-2 antibodies in children. The primary objective of this study is to ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e041661]

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Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review

Lauren Quinn, Michael Shields, Ian Sinha, Helen Groves,

<h4>Background: </h4> Acute bronchiolitis caused by Respiratory Syncytial Virus (RSV) has been associated with greater risk of recurrent wheezing and asthma. However, it is unclear whether this association is causal. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, but the longer term follow-up has given ... Read more >>

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Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): a prospective, multicentre cohort study.

Thomas Waterfield, Juli-Ann Maney, Derek Fairley, Mark D Lyttle, James P McKenna, Damian Roland, Michael Corr, Lisa McFetridge, Hannah Mitchell, Kerry Woolfall, Fiona Lynn, Bethany Patenall, Michael D Shields, ,

<h4>Background</h4>No previous studies have validated current clinical practice guidelines for the management of non-blanching rashes in children who have received meningococcal B and C vaccinations. The aim of this study was to evaluate the performance of existing clinical practice guidelines in the diagnosis of invasive meningococcal disease in children presenting ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.

Thomas Waterfield, Julie-Ann Maney, Mark D Lyttle, James P McKenna, Damian Roland, Michael Corr, Bethany Patenall, Michael D Shields, Kerry Woolfall, Derek Fairley, ,

<h4>Background</h4>The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):487]

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Characteristics of Reported Pediatric Medication Errors in Northern Ireland and Use in Quality Improvement.

Richard L Conn, Mary P Tully, Michael D Shields, Angela Carrington, Tim Dornan,

BACKGROUND:To protect children from harm, clinicians, educators, and patient safety champions need information to direct improvement efforts. Critical incident data could provide this but are often disregarded as a source of evidence because under-reporting makes them an inaccurate measure of error rates. OBJECTIVE:Our aim was to identify key targets for ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(5):551-560]

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Diagnostic Value of Mid-regional Pro-adrenomedullin (MR-proADM) as a Biomarker of Invasive Bacterial Infection in Children: A Systematic Review.

Michael Corr, Derek Fairley, James McKenna, Michael Shields, Thomas Waterfield,

<h4>Background: </h4> In children differentiating between the early stages of an invasive bacterial infection (IBI) and a benign self-limiting viral infection remains clinically challenging. This often leads to an over-use of antimicrobial drugs with resultant antimicrobial resistance due to the concern of not detecting a deteriorating child. Hence research into ... Read more >>

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How we teach children with asthma to use their inhaler: a scoping review protocol.

Patrick McCrossan, Orla Mallon, Michael D Shields, Dara O'Donoghue,

BACKGROUND:One reason that asthma remains poorly controlled in children is poor inhaler technique. Current guidelines recommend checking inhaler technique at each clinical visit. However, they do not specify how best to train children to mastery of correct inhaler technique. Currently, many children are simply shown how to use inhalers (brief ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):178]

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Use of oximetry to screen for paediatric obstructive sleep apnoea: is one night enough and is 6 hours too much?

Niamh Catherine Galway, Barbara Maxwell, Michael Shields, Dara O'Donoghue,

<h4>Introduction</h4>Nocturnal pulse oximetry can be used to screen for obstructive sleep apnoea (OSA) using the McGill Oximetry Score (MOS). The MOS has a time threshold for a technically adequate study of 6 hours. It has been suggested that one night of oximetry is sufficient to screen for OSA using the ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, 106(1):58-61]

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How we teach children with asthma to use their inhaler: A scoping review protocol

Patrick McCrossan, Orla Mallon, Michael Shields, Dara O'Donoghue,

<h4>Background: </h4> One reason that asthma remains poorly controlled in children is poor inhaler technique. Current guidelines recommend checking inhaler technique at each clinical visit. However, they do not specify how best to train children to mastery of correct inhaler technique. Currently many children are simply shown how to use ... Read more >>

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Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children.

Thomas Waterfield, Mark D Lyttle, James McKenna, Julie-Ann Maney, Damian Roland, Michael Corr, Kerry Woolfall, Bethany Patenall, Michael Shields, Derek Fairley, ,

<h4>Background</h4>Rapid molecular diagnostic testing has the potential to improve the early recognition of meningococcal disease (MD). The aim of this study was to report on the diagnostic test accuracy of point-of-care loop-mediated isothermal amplification (LAMP) in the diagnosis of MD.<h4>Design</h4>Data were collected prospectively from three UK emergency departments (ED) between ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(12):1151-1156]

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Geochemical and Stable Fe Isotopic Analysis of Dissimilatory Microbial Iron Reduction in Chocolate Pots Hot Spring, Yellowstone National Park.

Nathaniel W Fortney, Brian L Beard, Jack A Hutchings, Michael R Shields, Thomas S Bianchi, Eric S Boyd, Clark M Johnson, Eric E Roden,

Chocolate Pots hot spring (CP) is an Fe-rich, circumneutral-pH geothermal spring in Yellowstone National Park. Relic hydrothermal systems have been identified on Mars, and modern hydrothermal environments such as CP are useful for gaining insight into potential pathways for generation of biosignatures of ancient microbial life on Earth and Mars. ... Read more >>

Astrobiology (Astrobiology)
[2021, 21(1):83-102]

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Aerosol Therapy in Asthma-Why We Are Failing Our Patients and How We Can Do Better.

Robert W Morton, Heather E Elphick, Vanessa Craven, Michael D Shields, Lesley Kennedy,

In order for inhaled corticosteroids to be delivered adequately to the airways they require patients to take them regularly using an effective technique. Patients often have a poor inhaler technique, and this has been shown to result in sub-optimal asthma control. It is important for all clinicians prescribing inhaled medication ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:305]

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The ERS approach to e-cigarettes is entirely rational.

Andrew Bush, Jayesh Mahendra Bhatt, Will Carroll, Frances Child, Gary Connett, Iolo Doull, Francis Gilchrist, Jonathan Grigg, Simon Langton-Hewer, Julian Legg, Warren Lenney, James Paton, Michael Shields, Ian Sinha,

Eur Respir J (The European respiratory journal)
[2020, 55(5):]

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A protocol for a systematic review and meta-analysis of the diagnostic accuracy of mid-regional pro-adrenomedullin in predicting invasive bacterial infection in children.

Michael Corr, Thomas Waterfield, Derek Fairley, James McKenna, Michael D Shields,

<h4>Background</h4>The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limiting viral infection. These challenges mandate a cautious approach resulting in the overuse of antimicrobial drugs with resultant antimicrobial resistance. ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):69]

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Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media.

Lindsay Broadbent, Sheerien Manzoor, Maria C Zarcone, Judit Barabas, Michael D Shields, Sejal Saglani, Claire M Lloyd, Andrew Bush, Adnan Custovic, Peter Ghazal, Mindy Gore, Ben Marsland, Graham Roberts, Jurgen Schwarze, Steve Turner, Ultan F Power,

The culture of differentiated human airway epithelial cells allows the study of pathogen-host interactions and innate immune responses in a physiologically relevant in vitro model. As the use of primary cell culture has gained popularity the availability of the reagents needed to generate these cultures has increased. In this study ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0228229]

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Exposure and attitudes to adolescent health amongst Paediatric trainees in Northern Ireland: a mixed-methods study.

Stephen Mullen, Michael D Shields, Dara O'Donoghue,

Aims:To determine the exposure and attitudes of paediatric trainees towards adolescent medicine. Methods:All paediatric trainees in the Northern Ireland deanery (n=107) were invited to participate in an online survey in March 2016. The questionnaire was based on the 'Modified Perceptions of Adolescent Issues and Resources: Care of Adolescents' questionnaire. The ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2020, 4(1):e000563]

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Comparative Therapeutic Potential of ALX-0171 and Palivizumab against Respiratory Syncytial Virus Clinical Isolate Infection of Well-Differentiated Primary Pediatric Bronchial Epithelial Cell Cultures.

Lindsay Broadbent, Hong Guo Parke, Lyndsey J Ferguson, Andrena Millar, Michael D Shields, Laurent Detalle, Ultan F Power,

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in young infants. There are no RSV-specific treatments available. Ablynx has been developing an anti-RSV F-specific nanobody, ALX-0171. To characterize the therapeutic potential of ALX-0171, we exploited our well-differentiated primary pediatric bronchial epithelial cell (WD-PBEC)/RSV infection model, which replicates several ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(2):]

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The causal effect of education on chronic health conditions in the UK.

Katharina Janke, David W Johnston, Carol Propper, Michael A Shields,

We study the causal impact of education on chronic health conditions by exploitng two UK education policy reforms. The first reform raised the minimum school leaving age in 1972 and affected the lower end of the educational attainment distribution. The second reform is a combination of several policy changes that ... Read more >>

J Health Econ (Journal of health economics)
[2020, 70:102252]

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Proptosis, Orbital Pain, and Long-Standing Monocular Vision Loss Resolved by Surgical Resection of Intraosseous Spheno-Orbital Meningioma: A Case Report and Literature Review.

Jonathan M Parish, Michael Shields, Mackenzie Jones, Scott D Wait, Vinay R Deshmukh,

Background and Importance  We present a case of a patient with a residual intraosseous sphenoid wing meningioma presenting with proptosis, orbital pain, and monocular vision loss for 8 months who underwent decompression of the optic canal, orbital contents, and orbital reconstruction resulting in significant improvement in her vision loss with ... Read more >>

J Neurol Surg Rep (Journal of neurological surgery reports)
[2020, 81(1):e28-e32]

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Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a protocol for a systematic review.

Lauren Alexandra Quinn, Michael D Shields, Helen E Groves,

<h4>Background</h4>Lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and subsequent asthma. However, it is still unclear whether this association is causal or not. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, i.e. those ... Read more >>

Syst Rev (Systematic reviews)
[2019, 8(1):333]

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Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Fernando M de Benedictis, Ines Carloni, Pasquale Comberiati, Michael D Shields, Andrew Bush, Anne B Chang,

The causes of chronic cough in children are mainly dependent on the setting and age of the child. Protracted bacterial bronchitis is a frequent cause of morbidity in childhood, and antibiotic treatment is beneficial. Prompt recognition and early treatment is important both to prevent inappropriate use of asthma medications and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:459]

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Comparative therapeutic potential of ALX-0171 and palivizumab against RSV clinical isolate infection of well-differentiated primary pediatric bronchial epithelial cell cultures

Lindsay Broadbent, Hong Guo Parke, Lyndsey Ferguson, Andrena Miller, Michael Shields, Laurent Detalle, Ultan Power,

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in young infants. There are no RSV-specific treatments available. Ablynx has been developing an anti-RSV F-specific Nanobody®, ALX-0171. To characterise the therapeutic potential of ALX-0171 we exploited our well-differentiated primary pediatric bronchial epithelial cell (WD-PBEC)/RSV infection model, which replicates several ... Read more >>

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Fifteen-minute consultation: Symptoms and signs of meningococcal disease.

Michael Corr, Thomas Waterfield, Michael Shields,

Meningococcal disease remains a leading cause of meningitis, sepsis and death in children worldwide and in the UK. Successful vaccination programmes in the UK have, however, significantly reduced the burden of disease in children. Unfortunately, despite vaccination, a significant number of children are still diagnosed with invasive meningococcal disease each ... Read more >>

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, 105(4):200-203]

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