Full Text Journal Articles by
Author Michael Scheel

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Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders.

Valentin Juenger, Graham Cooper, Claudia Chien, Meera Chikermane, Frederike Cosima Oertel, Hanna Zimmermann, Klemens Ruprecht, Sven Jarius, Nadja Siebert, Joseph Kuchling, Athina Papadopoulou, Susanna Asseyer, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Michael Scheel,

OBJECTIVES:We aimed to evaluate optic chiasm (OC) measures as potential imaging marker for anterior optic pathway damage assessment in the context of neuromyelitis optica spectrum disorders (NMOSD). MATERIALS AND METHOD:This cross-sectional study included 39 patients exclusively with aquaporin 4-IgG seropositive NMOSD of which 25 patients had a history of optic ... Read more >>

Eur Radiol (European radiology)
[2020, :]

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Movement disorders after hypoxic brain injury following cardiac arrest in adults.

Franziska Scheibe, Wolf-Julian Neumann, Catharina Lange, Michael Scheel, Christian Furth, Martin Köhnlein, Philipp Mergenthaler, Jörg Schultze-Amberger, Paul Triebkorn, Petra Ritter, Andrea A Kühn, Andreas Meisel,

BACKGROUND:Posthypoxic movement disorders and chronic posthypoxic myoclonus are rare complications after cardiac arrest in adults. Our study investigates the clinical spectrum, neuroimaging results, therapy and prognosis of these debilitating posthypoxic sequelae. METHODS:This retrospective study included 72 patients from the neurological intensive care unit at a University Hospital, who were diagnosed ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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3D printing of anatomically realistic phantoms with detection tasks to assess the diagnostic performance of CT images.

Gracia Lana Ardila Pardo, Juliane Conzelmann, Ulrich Genske, Bernd Hamm, Michael Scheel, Paul Jahnke,

OBJECTIVES:Detectability experiments performed to assess the diagnostic performance of computed tomography (CT) images should represent the clinical situation realistically. The purpose was to develop anatomically realistic phantoms with low-contrast lesions for detectability experiments. METHODS:Low-contrast lesions were digitally inserted into a neck CT image of a patient. The original and the ... Read more >>

Eur Radiol (European radiology)
[2020, :]

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Cortical topological network changes following optic neuritis.

Yael Backner, Ido Ben-Shalom, Joseph Kuchling, Nadja Siebert, Michael Scheel, Klemens Ruprecht, Alexander Brandt, Friedemann Paul, Netta Levin,

OBJECTIVE:To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory-based tools to analyze functional imaging data. METHODS:Sixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 with ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial.

Christian Albert, Janine Mikolajczak, Anja Liekfeld, Sophie K Piper, Michael Scheel, Hanna G Zimmermann, Claus Nowak, Jan Dörr, Judith Bellmann-Strobl, Claudia Chien, Alexander U Brandt, Friedemann Paul, Olaf Hoffmann,

BACKGROUND:Neuroprotection and promotion of remyelination represent important therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS manifestation. Based on the presence and properties of sphingosine-1-phosphate receptors (S1PR) on astrocytes and oligodendrocytes, we hypothesized that remyelination can be enhanced by treatment with fingolimod, a S1PR modulator ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):75]

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Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS).

Priscilla Bäcker-Koduah, Judith Bellmann-Strobl, Michael Scheel, Jens Wuerfel, Klaus-Dieter Wernecke, Jan Dörr, Alexander Ulrich Brandt, Friedemann Paul,

Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients. Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:129]

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From cosmetics to compassion: A case study of goal focused positive psychotherapy.

Evelyn I Winter Plumb, Kathryn J Hawley, Collie W Conoley, Michael J Scheel,

This case study describes the progress of a client receiving goal focused positive psychotherapy over 34 sessions, capturing the subtlety and responsiveness of the theory in action. The client self-identified as a Mexican American heterosexual female in her early 20s who had experienced intense anxiety and recurring bouts of depression ... Read more >>

Psychotherapy (Chic) (Psychotherapy (Chicago, Ill.))
[2020, :]

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Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis.

Nelly Blindenbacher, Eveline Brunner, Susanna Asseyer, Michael Scheel, Nadja Siebert, Ludwig Rasche, Judith Bellmann-Strobl, Alexander Brandt, Klemens Ruprecht, Dominik Meier, Jens Wuerfel, Friedemann Paul, Tim Sinnecker,

Background:Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging. Objective:The purpose of this study was to study the evolution and prognostic relevance of susceptibility weighted imaging hypointense lesions in clinically isolated syndrome and early multiple sclerosis. Methods:Sixty-six early multiple sclerosis and clinically ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2020, 6(1):2055217320915480]

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Scout-guided needle placement-a technical approach for dose reduction in CT-guided periradicular infiltration.

Maximilian Nunninger, Victor Paul Bela Braun, Marco Ziegert, Felix Benjamin Schwarz, Bernd Hamm, Michael Scheel, Paul Jahnke,

PURPOSE:To develop and evaluate a technical approach for CT-guided periradicular infiltration using quantitative needle access and guidance parameters extracted from CT scout images. METHODS:Five 3D-printed phantoms of the abdomen mimicking different patients were used to develop a technical approach for scout-guided periradicular infiltration. The needle access point, puncture depth, and ... Read more >>

Neuroradiology (Neuroradiology)
[2020, 62(3):341-346]

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Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease.

Andreas Horn, Gregor Wenzel, Friederike Irmen, Julius Huebl, Ningfei Li, Wolf-Julian Neumann, Patricia Krause, Georg Bohner, Michael Scheel, Andrea A Kühn,

Neuroimaging has seen a paradigm shift away from a formal description of local activity patterns towards studying distributed brain networks. The recently defined framework of the 'human connectome' enables global analysis of parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(10):3129-3143]

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Intrathecal IgM production is a strong risk factor for early conversion to multiple sclerosis.

Catherina Pfuhl, Ulrike Grittner, René M Gieß, Michael Scheel, Janina R Behrens, Ludwig Rasche, Florence C Pache, Rüdiger Wenzel, Alexander U Brandt, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht, Johanna Oechtering,

OBJECTIVES:To evaluate intrathecal immunoglobulin M (IgM) production, as compared to previously established risk factors, as risk factor for conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and to explore the association of intrathecal IgM production with onset age and radiologic and CSF findings in CIS/early MS. METHODS:Comprehensive CSF ... Read more >>

Neurology (Neurology)
[2019, 93(15):e1439-e1451]

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Uncovering convolutional neural network decisions for diagnosing multiple sclerosis on conventional MRI using layer-wise relevance propagation.

Fabian Eitel, Emily Soehler, Judith Bellmann-Strobl, Alexander U Brandt, Klemens Ruprecht, René M Giess, Joseph Kuchling, Susanna Asseyer, Martin Weygandt, John-Dylan Haynes, Michael Scheel, Friedemann Paul, Kerstin Ritter,

Machine learning-based imaging diagnostics has recently reached or even surpassed the level of clinical experts in several clinical domains. However, classification decisions of a trained machine learning system are typically non-transparent, a major hindrance for clinical integration, error tracking or knowledge discovery. In this study, we present a transparent deep ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:102003]

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Timing of brain computed tomography and accuracy of outcome prediction after cardiac arrest.

Kaspar Josche Streitberger, Christian Endisch, Christoph J Ploner, Robert Stevens, Michael Scheel, Martin Kenda, Christian Storm, Christoph Leithner,

AIM:Gray-white-matter ratio (GWR) calculated from head CT is a radiologic index of tissue changes associated with hypoxic-ischemic encephalopathy after cardiac arrest (CA). Evidence from previous studies indicates high specificity for poor outcome prediction at GWR thresholds of 1.10-1.20. We aimed to determine the relationship between accuracy of neurologic prognostication by ... Read more >>

Resuscitation (Resuscitation)
[2019, 145:8-14]

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Attack-related damage of thalamic nuclei in neuromyelitis optica spectrum disorders.

Athina Papadopoulou, Frederike Cosima Oertel, Laura Gaetano, Joseph Kuchling, Hanna Zimmermann, Claudia Chien, Nadja Siebert, Susanna Asseyer, Judith Bellmann-Strobl, Klemens Ruprecht, M Mallar Chakravarty, Michael Scheel, Stefano Magon, Jens Wuerfel, Friedemann Paul, Alexander Ulrich Brandt,

OBJECTIVES:In neuromyelitis optica spectrum disorders (NMOSD) thalamic damage is controversial, but thalamic nuclei were never studied separately. We aimed at assessing volume loss of thalamic nuclei in NMOSD. We hypothesised that only specific nuclei are damaged, by attacks affecting structures from which they receive afferences: the lateral geniculate nucleus (LGN), ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(10):1156-1164]

Cited: 1 time

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Vision and Vision-Related Measures in Progressive Multiple Sclerosis.

Yael Backner, Panayiota Petrou, Haya Glick-Shames, Noa Raz, Hanna Zimmermann, Rebecca Jost, Michael Scheel, Friedemann Paul, Dimitrios Karussis, Netta Levin,

Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:455]

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Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.

Svetlana Lublinsky, Sebastian Major, Vasilis Kola, Viktor Horst, Edgar Santos, Johannes Platz, Oliver Sakowitz, Michael Scheel, Christian Dohmen, Rudolf Graf, Hartmut Vatter, Stefan Wolf, Peter Vajkoczy, Ilan Shelef, Johannes Woitzik, Peter Martus, Jens P Dreier, Alon Friedman,

BACKGROUND:Disease progression and delayed neurological complications are common after aneurysmal subarachnoid hemorrhage (aSAH). We explored the potential of quantitative blood-brain barrier (BBB) imaging to predict disease progression and neurological outcome. METHODS:Data were collected as part of the Co-Operative Studies of Brain Injury Depolarizations (COSBID). We analyzed retrospectively, blinded and semi-automatically ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 43:460-472]

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The meaning of therapists' hope for their clients: A phenomenological study.

Theodore T Bartholomew, Brittany E Gundel, Huaying Li, Eileen E Joy, Ellice Kang, Michael J Scheel,

Hope is often identified as a central process in psychotherapy, with researchers supporting links between clients' hope, symptom distress, and process variables. However, this body of literature is yet to specifically ask what it means for psychotherapists to have hope for their clients. Our purpose, with this descriptive phenomenological study, ... Read more >>

J Couns Psychol (Journal of counseling psychology)
[2019, 66(4):496-507]

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Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis.

Graham Cooper, Carsten Finke, Claudia Chien, Alexander U Brandt, Susanna Asseyer, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Michael Scheel,

Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS) and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a measure of white matter integrity, has previously shown reduced intensity values in MS NAWM. We evaluate the validity of a standardized ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:334]

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Early focal brain injury after subarachnoid hemorrhage correlates with spreading depolarizations.

Nina Eriksen, Egill Rostrup, Martin Fabricius, Michael Scheel, Sebastian Major, Maren K L Winkler, Georg Bohner, Edgar Santos, Oliver W Sakowitz, Vasilis Kola, Clemens Reiffurth, Jed A Hartings, Peter Vajkoczy, Johannes Woitzik, Peter Martus, Martin Lauritzen, Bente Pakkenberg, Jens P Dreier,

OBJECTIVE:To investigate whether spreading depolarization (SD)-related variables at 2 different time windows (days 1-4 and 5-8) after aneurysmal subarachnoid hemorrhage (aSAH) correlate with the stereologically determined volume of early focal brain injury on the preinterventional CT scan. METHODS:In this observational multicenter study of 54 patients, volumes of unaffected brain tissue, ... Read more >>

Neurology (Neurology)
[2019, 92(4):e326-e341]

Cited: 4 times

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A case report of delayed cortical infarction adjacent to sulcal clots after traumatic subarachnoid hemorrhage in the absence of proximal vasospasm.

Christian Schinke, Viktor Horst, Ludwig Schlemm, Matthias Wawra, Michael Scheel, Jed A Hartings, Jens P Dreier,

BACKGROUND:Cortical ischemic lesions represent the predominant pathomorphological pattern of focal lesions after aneurysmal subarachnoid hemorrhage (aSAH). Autopsy studies suggest that they occur adjacent to subarachnoid blood and are related to spasm of small cortical rather than proximal arteries. Recent clinical monitoring studies showed that cortical spreading depolarizations, which induce cortical ... Read more >>

BMC Neurol (BMC neurology)
[2018, 18(1):210]

Cited: 1 time

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Modulating the human functional connectome using deep brain stimulation

Andreas Horn, Gregor Wenzel, Friederike Irmen, Julius Hübl, Ningfei Li, Wolf-Julian Neumann, Patricia Krause, Georg Bohner, Michael Scheel, Andrea Kühn,

Abstract Neuroimaging has seen a paradigm shift from a formal description of local activity patterns toward studying distributed brain networks. The recently defined framework of the ‘human connectome’ allows to globally analyse parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with ... Read more >>

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Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

Maureen A Mealy, Sarah E Mossburg, Su-Hyun Kim, Silvia Messina, Nadja Borisow, Reydmar Lopez-Gonzalez, Juan Pablo Ospina, Michael Scheel, Anusha K Yeshokumar, Amine Awad, M Isabel Leite, JorgeA Jimenez Arango, Friedemann Paul, Jacqueline Palace, Ho Jin Kim, Michael Levy,

BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of life in those with NMOSD. ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 28:64-68]

Cited: 2 times

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Correction to: Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout.

Torsten Diekhoff, Michael Scheel, Sandra Hermann, Jürgen Mews, Bernd Hamm, Kay Geert A Hermann,

The name of Kay Geert A. Hermann is incorrectly captured in the original article and is now corrected in this paper. ... Read more >>

Skeletal Radiol. (Skeletal radiology)
[2018, 47(12):1719]

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Spinal cord lesions and atrophy in NMOSD with AQP4-IgG and MOG-IgG associated autoimmunity.

Claudia Chien, Michael Scheel, Tanja Schmitz-Hübsch, Nadja Borisow, Klemens Ruprecht, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt,

BACKGROUND:Spinal cord (SC) affection is a hallmark symptom of neuromyelitis optica spectrum disorders (NMOSD). Patients with aquaporin-4 (AQP4-IgG+) or myelin oligodendrocyte glycoprotein (MOG-IgG+) antibody seropositivity show this overlapping clinical phenotype. OBJECTIVE:Quantitative comparison of SC lesions and atrophy in AQP4-IgG+ and MOG-IgG+ NMOSD. METHODS:AQP4-IgG+ (n = 38), MOG-IgG+ (n = 15) NMOSD patients and healthy ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, 25(14):1926-1936]

Cited: 3 times

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Diagnosis and Treatment of NMO Spectrum Disorder and MOG-Encephalomyelitis.

Nadja Borisow, Masahiro Mori, Satoshi Kuwabara, Michael Scheel, Friedemann Paul,

Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead to recurrent attacks of optic neuritis, myelitis and/or brainstem syndromes. In some patients with symptoms of NMOSD, no AQP4-Abs but Abs against myelin-oligodendrocyte-glycoprotein (MOG) are detectable. These clinical syndromes are ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:888]

Cited: 11 times

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