Full Text Journal Articles by
Author Michael S Saag

Advertisement

Find full text journal articles






Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

Cited: 0 times

View full text PDF listing >>



Drug and alcohol use among people living with HIV in care in the United States by geographic region.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Stephanie Ruderman, Judith I Tsui, Geetanjali Chander, Mary E McCaul, Bryan Lau, Kenneth H Mayer, D Scott Batey, Steven A Safren, Richard D Moore, Joseph J Eron, Sonia Napravnik, W Chris Mathews, Rob J Fredericksen, Andrew W Hahn, Michael J Mugavero, William B Lober, Michael S Saag, Mari M Kitahata, Joseph A C Delaney,

Substance use in the U.S. varies by geographic region. Opioid prescribing practices and marijuana, heroin, and methamphetamine availability are evolving differently across regions. We examined self-reported substance use among people living with HIV (PLWH) in care at seven sites from 2017-2019 to understand current regional substance use patterns. We calculated ... Read more >>

AIDS Care (AIDS care)
[2021, :1-8]

Cited: 0 times

View full text PDF listing >>



Advertisement

Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption.

Marcos V P Gondim, Scott Sherrill-Mix, Frederic Bibollet-Ruche, Ronnie M Russell, Stephanie Trimboli, Andrew G Smith, Yingying Li, Weimin Liu, Alexa N Avitto, Julia C DeVoto, Jesse Connell, Angharad E Fenton-May, Pierre Pellegrino, Ian Williams, Emmanouil Papasavvas, Julio C C Lorenzi, D Brenda Salantes, Felicity Mampe, M Alexandra Monroy, Yehuda Z Cohen, Sonya Heath, Michael S Saag, Luis J Montaner, Ronald G Collman, Janet M Siliciano, Robert F Siliciano, Lindsey J Plenderleith, Paul M Sharp, Marina Caskey, Michel C Nussenzweig, George M Shaw, Persephone Borrow, Katharine J Bar, Beatrice H Hahn,

Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission. However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an incomplete understanding of their antiviral activities at later stages of infection. Here, we characterized the IFN-I sensitivity of 500 clonally derived HIV-1 isolates from ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(576):]

Cited: 0 times

View full text PDF listing >>



Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science.

Michael S Saag,

JAMA (JAMA)
[2020, 324(21):2161-2162]

Cited: 0 times

View full text PDF listing >>



Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options.

Kristina L Bajema, Robin M Nance, Joseph A C Delaney, Ellen Eaton, Thibaut Davy-Mendez, Maile Y Karris, Richard D Moore, Joseph J Eron, Benigno Rodriguez, Kenneth H Mayer, Elvin Geng, Cindy Garris, Michael S Saag, Heidi M Crane, Mari M Kitahata, ,

<h4>Objective</h4>Historically, a high burden of resistance to antiretroviral therapy (ART) in heavily treatment-experienced (HTE) persons with HIV (PWH) resulted in limited treatment options (LTOs). We evaluated the prevalence, risk factors, and virologic control of HTE PWH with LTO throughout the modern ART era.<h4>Design</h4>We examined all ART-experienced PWH in care between ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(14):2051-2059]

Cited: 0 times

View full text PDF listing >>



AIDS new editor announcement.

Jay A Levy, Roel A Coutinho, Michael S Saag,

AIDS (AIDS (London, England))
[2020, 34(14):1995]

Cited: 0 times

View full text PDF listing >>



Genetic architecture of cardiometabolic risks in people living with HIV.

Haoxiang Chang, Anshuman Sewda, Carla Marquez-Luna, Sierra R White, Bridget M Whitney, Jessica Williams-Nguyen, Robin M Nance, Won Jun Lee, Mari M Kitahata, Michael S Saag, Amanda Willig, Joseph J Eron, W Christopher Mathews, Peter W Hunt, Richard D Moore, Allison Webel, Kenneth H Mayer, Joseph A Delaney, Paul K Crane, Heidi M Crane, Ke Hao, Inga Peter,

<h4>Background</h4>Advances in antiretroviral therapies have greatly improved the survival of people living with human immunodeficiency virus (HIV) infection (PLWH); yet, PLWH have a higher risk of cardiovascular disease than those without HIV. While numerous genetic loci have been linked to cardiometabolic risk in the general population, genetic predictors of the ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):288]

Cited: 0 times

View full text PDF listing >>



Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel.

Michael S Saag, Rajesh T Gandhi, Jennifer F Hoy, Raphael J Landovitz, Melanie A Thompson, Paul E Sax, Davey M Smith, Constance A Benson, Susan P Buchbinder, Carlos Del Rio, Joseph J Eron, Gerd Fätkenheuer, Huldrych F Günthard, Jean-Michel Molina, Donna M Jacobsen, Paul A Volberding,

<h4>Importance</h4>Data on the use of antiretroviral drugs, including new drugs and formulations, for the treatment and prevention of HIV infection continue to guide optimal practices.<h4>Objective</h4>To evaluate new data and incorporate them into current recommendations for initiating HIV therapy, monitoring individuals starting on therapy, changing regimens, preventing HIV infection for those ... Read more >>

JAMA (JAMA)
[2020, 324(16):1651-1669]

Cited: 0 times

View full text PDF listing >>



Risk of Incident Diabetes Mellitus, Weight Gain, and their Relationships with Integrase Inhibitor-based Initial Antiretroviral Therapy Among Persons with HIV in the US and Canada.

Peter F Rebeiro, Cathy A Jenkins, Aihua Bian, Jordan E Lake, Kassem Bourgi, Richard D Moore, Michael A Horberg, W Christopher Matthews, Michael J Silverberg, Jennifer Thorne, Angel M Mayor, Viviane D Lima, Frank J Palella, Michael S Saag, Keri N Althoff, M John Gill, Cherise Wong, Marina B Klein, Heidi M Crane, Vincent C Marconi, Bryan E Shepherd, Timothy R Sterling, John R Koethe,

<h4>Background</h4>Integrase strand transfer inhibitor (INSTI)-based combination antiretroviral therapy (cART) is associated with greater weight gain among persons with HIV, though the metabolic consequences, such as diabetes mellitus (DM), are unclear. We examined the impact of initial cART regimen and weight on incident DM in a large North American HIV cohort ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Hepatitis C Among High-Risk Alabamians: Disease Burden and Screening Effectiveness.

Anthony B Lee, Sandra Karumberia, Ashley Gilmore, Ebony Williams, Nichole Bruner, Edgar Turner Overton, Michael S Saag, Ricardo A Franco,

<h4>Background</h4>The effectiveness of hepatitis C testing and linkage-to-care (LTC) is poorly characterized in low-resource jurisdictions facing gaps in harm reduction, including illegality of syringe exchange services. Effectiveness of a community-based test/LTC program was evaluated in Alabama.<h4>Methods</h4>In 2016-2018, shelters, drug treatment centers (DTCs), AIDS organizations, and Federally Qualified Health Centers (FQHCs) ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(Supplement_5):S365-S375]

Cited: 0 times

View full text PDF listing >>



Timing of Antiretroviral Therapy Initiation and Risk of Cancer among Persons Living with HIV.

Michael J Silverberg, Wendy Leyden, Raúl U Hernández-Ramírez, Li Qin, Haiqun Lin, Amy C Justice, Nancy A Hessol, Chad J Achenbach, Gypsyamber D'Souza, Eric A Engels, Keri N Althoff, Angel M Mayor, Timothy R Sterling, Mari M Kitahata, Ronald J Bosch, Michael S Saag, Charles S Rabkin, Michael A Horberg, M John Gill, Surbhi Grover, W Christopher Mathews, Jun Li, Heidi M Crane, Stephen J Gange, Bryan Lau, Richard D Moore, Robert Dubrow, Romain S Neugebauer, ,

BACKGROUND:Persons living with HIV (PLWH) experience a high burden of cancer. It remains unknown which cancer types are reduced in PLWH with earlier initiation of antiretroviral therapy (ART). METHODS:We evaluated AIDS-free, ART-naive PLWH during 1996-2014 from 22 cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

View full text PDF listing >>



What's All This Fuss I Hear About Viral "Blips"?

Michael S Saag,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(12):2710-2711]

Cited: 0 times

View full text PDF listing >>



Association Between Chronic Hepatitis C Virus Infection and Myocardial Infarction Among People Living With HIV in the United States.

Jessica Williams-Nguyen, Stephen E Hawes, Robin M Nance, Sara Lindström, Susan R Heckbert, H Nina Kim, W Chris Mathews, Edward R Cachay, Matt Budoff, Christopher B Hurt, Peter W Hunt, Elvin Geng, Richard D Moore, Michael J Mugavero, Inga Peter, Mari M Kitahata, Michael S Saag, Heidi M Crane, Joseph A Delaney,

Hepatitis C virus (HCV) infection is common among people living with human immunodeficiency virus (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic of active research. MI is classified into types, predominantly atheroembolic type 1 MI (T1MI) and supply-demand mismatch type 2 MI (T2MI). We examined the ... Read more >>

Am J Epidemiol (American journal of epidemiology)
[2020, 189(6):554-563]

Cited: 0 times

View full text PDF listing >>



The PROSPER-HIV Study: A Research Protocol to Examine Relationships Among Physical Activity, Diet Intake, and Symptoms in Adults Living With HIV.

Allison R Webel, Dustin Long, Benigno Rodriguez, Christine Horvat Davey, Thomas W Buford, Heidi M Crane, Kenneth Mayer, Michael S Saag, Amanda L Willig,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(3):346-352]

Cited: 0 times

View full text PDF listing >>



Antiretroviral drug class and anaemia risk in the current treatment era among people living with HIV in the USA: a clinical cohort study.

Barbara N Harding, Bridget M Whitney, Robin M Nance, Heidi M Crane, Greer Burkholder, Richard D Moore, W Christopher Mathews, Joseph J Eron, Peter W Hunt, Paul Volberding, Benigno Rodriguez, Kenneth Mayer, Michael S Saag, Mari M Kitahata, Susan R Heckbert, Joseph A C Delaney,

OBJECTIVE:Anaemia is common among people living with HIV (PLWH) and has been associated with certain, often older, antiretroviral medications. Information on current antiretroviral therapy (ART) and anaemia is limited. The objective was to compare the associations between anaemia incidence or haemoglobin change with core ART classes in the current ART ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e031487]

Cited: 0 times

View full text PDF listing >>



Association of Immunosuppression and Human Immunodeficiency Virus (HIV) Viremia With Anal Cancer Risk in Persons Living With HIV in the United States and Canada.

Raúl U Hernández-Ramírez, Li Qin, Haiqun Lin, Wendy Leyden, Romain S Neugebauer, Keri N Althoff, Nancy A Hessol, Chad J Achenbach, John T Brooks, M John Gill, Surbhi Grover, Michael A Horberg, Jun Li, W Christopher Mathews, Angel M Mayor, Pragna Patel, Charles S Rabkin, Anita Rachlis, Amy C Justice, Richard D Moore, Eric A Engels, Michael J Silverberg, Robert Dubrow, ,

<h4>Background</h4>People living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1176-1185]

Cited: 1 time

View full text PDF listing >>



Impact of Abstinence and of Reducing Illicit Drug Use Without Abstinence on Human Immunodeficiency Virus Viral Load.

Robin M Nance, Maria Esther Perez Trejo, Bridget M Whitney, Joseph A C Delaney, Fredrick L Altice, Curt G Beckwith, Geetanjali Chander, Redonna Chandler, Katerina Christopoulous, Chinazo Cunningham, William E Cunningham, Carlos Del Rio, Dennis Donovan, Joseph J Eron, Rob J Fredericksen, Shoshana Kahana, Mari M Kitahata, Richard Kronmal, Irene Kuo, Ann Kurth, W Chris Mathews, Kenneth H Mayer, Richard D Moore, Michael J Mugavero, Lawrence J Ouellet, Vu M Quan, Michael S Saag, Jane M Simoni, Sandra Springer, Lauren Strand, Faye Taxman, Jeremy D Young, Heidi M Crane,

<h4>Background</h4>Substance use is common among people living with human immunodeficiency virus (PLWH) and a barrier to achieving viral suppression. Among PLWH who report illicit drug use, we evaluated associations between HIV viral load (VL) and reduced use of illicit opioids, methamphetamine/crystal, cocaine/crack, and marijuana, regardless of whether or not abstinence ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(5):867-874]

Cited: 0 times

View full text PDF listing >>



Obesity Affects the Association of Bioelectrical Impedance Phase Angle With Mortality in People Living With HIV.

Viola Cogliandro, Donna Yester, Andrew O Westfall, James L Raper, Michael S Saag, German Henostroza, E Turner Overton, Amanda L Willig,

Bioelectrical impedance analysis phase angle (BIA-PA) is a valid indicator of mortality risk in people living with HIV; however, it is not known whether BIA-PA is valid for people living with HIV who are overweight or obese. We assessed whether BIA-PA differentially predicted mortality by body mass index category in ... Read more >>

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(1):51-59]

Cited: 0 times

View full text PDF listing >>



Déjà vu all over again.

Michael S Saag, Julie B Dumond,

AIDS (AIDS (London, England))
[2019, 33(13):2097-2098]

Cited: 0 times

View full text PDF listing >>



HIV 101: fundamentals of antiretroviral therapy.

Michael S Saag,

Antiretroviral therapy (ART) should be started as soon as possible after HIV diagnosis. Recommended starting ART regimens in patients with any baseline viral load include ictegravir plus tenofovir alafenamide (TAF)/emtricitabine (FTC), dolutegravir (DTG) plus abacavir/lamivudine, DTG plus TAF (or TDF)/FTC, or DTG plus 3TC. Initial laboratory evaluation includes CD4+ cell ... Read more >>

Top Antivir Med (Topics in antiviral medicine)
[2019, 27(3):123-127]

Cited: 0 times

View full text PDF listing >>



Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS).

Matthew J Feinstein, Robin M Nance, J A Chris Delaney, Susan R Heckbert, Matthew J Budoff, Daniel R Drozd, Greer A Burkholder, James H Willig, Michael J Mugavero, William C Mathews, Richard D Moore, Joseph J Eron, Sonia Napravnik, Peter W Hunt, Elvin Geng, Priscilla Hsue, Inga Peter, William B Lober, Kristina Crothers, Carl Grunfeld, Michael S Saag, Mari M Kitahata, Donald M Lloyd-Jones, Heidi M Crane,

<h4>Background</h4>Persons with human immunodeficiency virus (HIV) have higher risks for myocardial infarction (MI) than the general population. This is driven in part by higher type 2 MI (T2MI, due to coronary supply-demand mismatch) rates among persons with HIV (PWH). In the general population, T2MI has higher mortality than type 1 ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):149]

Cited: 3 times

View full text PDF listing >>



Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States.

Heidi M Crane, Robin M Nance, Susan R Heckbert, Corey Ritchings, Lisa Rosenblatt, Matthew Budoff, Brian R Wood, David L Tirschwell, H Nina Kim, William C Mathews, Elvin Geng, Richard D Moore, Peter W Hunt, Joseph J Eron, Greer A Burkholder, Daniel R Drozd, Felicia C Chow, Kyra J Becker, Joseph R Zunt, Emily L Ho, Rizwan Kalani, Andrew Huffer, Bridget M Whitney, Michael S Saag, Mari M Kitahata, Joseph A C Delaney,

<h4>Objective</h4>Bilirubin is an antioxidant that may suppress lipid oxidation. Elevated bilirubin is associated with decreased cardiovascular events in HIV-uninfected populations. We examined these associations in people living with HIV (PLWH).<h4>Methods</h4>Potential myocardial infarctions (MIs) and strokes were centrally adjudicated. We examined MI types: type 1 MI (T1MI) from atherosclerotic plaque instability ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(5):e141-e147]

Cited: 1 time

View full text PDF listing >>



Virologic Failure Among People Living With HIV Initiating Dolutegravir-Based Versus Other Recommended Regimens in Real-World Clinical Care Settings.

Robin M Nance, Vani Vannappagari, Kimberly Smith, Catherine B Johannes, Brian Calingaert, Catherine W Saltus, Kenneth H Mayer, Bridget M Whitney, Benigno Rodriguez, Richard D Moore, Joseph J Eron, Elvin Geng, William Christopher Mathews, Michael J Mugavero, Michael S Saag, Mari M Kitahata, Joseph A C Delaney, Heidi M Crane,

<h4>Background</h4>Guidelines for initial antiretroviral treatment (ART) regimens have evolved, with integrase strand transfer inhibitors (INSTIs) increasingly prominent. Research on virologic failure (VF) with INSTI therapy is predominantly from clinical trials not care settings, especially for recently approved medications including dolutegravir. We compared outcomes among people living with HIV (PLWH) who ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(5):572-577]

Cited: 4 times

View full text PDF listing >>



Antiretroviral Activity of AMD11070 (An Orally Administered CXCR4 Entry Inhibitor): Results of NIH/NIAID AIDS Clinical Trials Group Protocol A5210.

Victoria A Johnson, Yoninah S Cramer, Susan L Rosenkranz, Stephen Becker, Karin L Klingman, Beatrice Kallungal, Eoin Coakley, Edward P Acosta, Gary Calandra, Michael S Saag, ,

AMD11070 binds to the chemokine receptor CXCR4, with anti-HIV-1 activity <i>in vitro</i> and <i>in vivo</i>. We conducted a phase IB/IIA proof-of-concept dose-escalating, open-label study to determine safety and antiviral activity of AMD11070 administered over 10 days to HIV-1-infected participants who harbored CXCR4-tropic virus. Primary endpoints were ≥1 log<sub>10</sub> rlu (relative ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2019, 35(8):691-697]

Cited: 1 time

View full text PDF listing >>



Marijuana Use Is Not Associated With Changes in Opioid Prescriptions or Pain Severity Among People Living With HIV and Chronic Pain.

Jessica S Merlin, Dustin Long, William C Becker, Edward R Cachay, Katerina A Christopolous, Kasey R Claborn, Heidi M Crane, Eva Jennifer Edelman, Travis I Lovejoy, William Christopher Mathews, Benjamin J Morasco, Sonia Napravnik, Connall OʼCleirigh, Michael S Saag, Joanna L Starrels, Robert Gross, Jane M Liebschutz,

<h4>Background</h4>People living with HIV (PLWH) commonly report marijuana use for chronic pain, although there is limited empirical evidence to support its use. There is hope that marijuana may reduce prescription opioid use. Our objective was to investigate whether marijuana use among PLWH who have chronic pain is associated with changes ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(2):231-237]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
1.1761 s