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Anesthetic Technique (Spinal vs. General Anesthesia) in Holmium Laser Enucleation of the Prostate: Retrospective Analysis of Procedural and Functional Outcomes among 1,159 Patients.

Hang Yu, Philipp Gild, Raisa S Pompe, Malte W Vetterlein, Tim A Ludwig, Armin Soave, Mara Kölker, Valentin Maurer, Phillip Marks, Andreas Becker, Mark-Andree Punke, Margit Fisch, Michael Rink, Roland Dahlem, Christian P Meyer,

<h4>Objective</h4>The aim of the study was to compare procedural efficacy, early and late functional outcomes in holmium laser enucleation of the prostate (HoLEP) under spinal anesthesia (SA) versus general anesthesia (GA).<h4>Methods</h4>We retrospectively reviewed patients undergoing HoLEP at our institution between 2012 and 2017. Standard pre-, peri-, and postoperative characteristics were ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.

Toni K Choueiri, Piotr Tomczak, Se Hoon Park, Balaji Venugopal, Thomas Ferguson, Yen-Hwa Chang, Jaroslav Hajek, Stefan N Symeonides, Jae Lyun Lee, Naveed Sarwar, Antoine Thiery-Vuillemin, Marine Gross-Goupil, Mauricio Mahave, Naomi B Haas, Piotr Sawrycki, Howard Gurney, Christine Chevreau, Bohuslav Melichar, Evgeniy Kopyltsov, Ajjai Alva, John M Burke, Gurjyot Doshi, Delphine Topart, Stephane Oudard, Hans Hammers, Hiroshi Kitamura, Jens Bedke, Rodolfo F Perini, Pingye Zhang, Kentaro Imai, Jaqueline Willemann-Rogerio, David I Quinn, Thomas Powles, ,

<h4>Background</h4>Patients with renal-cell carcinoma who undergo nephrectomy have no options for adjuvant therapy to reduce the risk of recurrence that have high levels of supporting evidence.<h4>Methods</h4>In a double-blind, phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with clear-cell renal-cell carcinoma who were at high risk for recurrence ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(8):683-694]

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Prognostic Impact of Preoperative Plasma Levels of Urokinase Plasminogen Activator Proteins on Disease Outcomes after Radical Cystectomy.

Victor M Schuettfort, Benjamin Pradere, David D'Andrea, Nico C Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Compérat, Dmitry Enikeev, Shahrokh F Shariat,

<h4>Purpose</h4>We sought to validate the association of plasma levels of urokinase-type plasminogen activator (uPA), its soluble receptor (SuPAR) and its inhibitor (PAI-one) with oncologic outcomes in a large cohort of patients treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials and methods</h4>We collected preoperative blood samples from ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001936]

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Impact of the preoperative modified glasgow prognostic score on disease outcome after radical cystectomy for urothelial carcinoma of the bladder.

Victor M Schuettfort, Kilian Gust, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Background</h4>To investigate the predictive and prognostic value of the preoperative modified Glasgow Prognostic Score (mGPS) in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Methods</h4>We conducted a retrospective analysis of an established multicenter database consisting of 4,335 patients who were treated with RC +/- adjuvant chemotherapy ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Quality indicators for the management of high-risk upper tract urothelial carcinoma requiring radical nephroureterectomy.

Frederik König, Shahrokh F Shariat, Pierre I Karakiewicz, Dong-Ho Mun, Michael Rink, Benjamin Pradere,

<h4>Purpose of review</h4>The purpose of this article was to identify quality indicators for an optimized management of high-risk upper tract urothelial carcinoma (UTUC) requiring radical nephroureterectomy (RNU).<h4>Recent findings</h4>RNU with bladder cuff resection is the standard treatment of high-risk UTUC. For the bladder cuff resection, two main approaches are accepted: transvesical ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):291-296]

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Impact of preoperative plasma levels of interleukin 6 and interleukin 6 soluble receptor on disease outcomes after radical cystectomy for bladder cancer.

Victor M Schuettfort, Benjamin Pradere, Quoc-Dien Trinh, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Michael Rink, Pierre I Karakiewicz, Piotr Chlosta, Jeremy Yuen-Chun Teoh, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Marco Moschini, Shahrokh F Shariat,

<h4>Background</h4>Preoperative plasma levels of Interleukin 6 (IL6) and its soluble receptor (IL6sR) have previously been associated with oncologic outcomes in urothelial carcinoma of the bladder (UCB); however, external validation in patients treated with radical cystectomy (RC) for UCB is missing.<h4>Patients/methods</h4>We prospectively collected preoperative plasma from 1,036 consecutive patients at two ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2021, :]

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Chiara Lonati, Philipp Baumeister, Paola Irene Ornaghi, Ettore Di Trapani, Ottavio De Cobelli, Michael Rink, Robert Jeffrey Karnes, Cédric Poyet, Giuseppe Simone, Luca Afferi, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Wojciech Krajewski, Alessandro Antonelli, Maria Angela Cerruto, Stefania Zamboni, Claudio Simeone, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.<h4>Objective</h4>To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.<h4>Design, setting, and participants</h4>We retrospectively analyzed 1881 BCa patients who underwent TURB and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer.

Katharina Möller, Christoph Fraune, Niclas C Blessin, Maximilian Lennartz, Martina Kluth, Claudia Hube-Magg, Linnea Lindhorst, Roland Dahlem, Margit Fisch, Till Eichenauer, Silke Riechardt, Ronald Simon, Guido Sauter, Franziska Büscheck, Wolfgang Höppner, Cord Matthies, Ousman Doh, Till Krech, Andreas H Marx, Henrik Zecha, Michael Rink, Stefan Steurer, Till S Clauditz,

<h4>Background</h4>PD-L1 expression predicts response to immune checkpoint inhibitors in renal cell carcinomas (RCC), but has also been suggested to be linked to poor patient outcome.<h4>Methods</h4>We analyzed PD-L1 in > 1400 RCC in a tissue microarray format by immunohistochemistry. Results were compared with histological tumor type, parameters of cancer aggressiveness, and intratumoral CD8<sup>+</sup> cytotoxic ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, :]

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Napsin A Expression in Human Tumors and Normal Tissues.

Sören Weidemann, Jan Lukas Böhle, Hendrina Contreras, Andreas M Luebke, Martina Kluth, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Katharina Möller, Christoph Fraune, Christian Bernreuther, Michael Rink, Ronald Simon, Anne Menz, Andrea Hinsch, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Sarah Minner,

<b>Background:</b> Novel aspartic proteinase of the pepsin family A (Napsin A, TAO1/TAO2) is a functional aspartic proteinase which is involved in the maturation of prosurfactant protein B in type II pneumocytes and the lysosomal protein catabolism in renal cells. Napsin A is highly expressed in adenocarcinomas of the lung and ... Read more >>

Pathol Oncol Res (Pathology oncology research : POR)
[2021, 27:613099]

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Real-world outcomes in patients with metastatic renal cell carcinoma according to risk factors: the STAR-TOR registry.

Arne Strauss, Marianne Schmid, Michael Rink, Michael Moran, Stephan Bernhardt, Marcus Hubbe, Lothar Bergmann, Katrin Schlack, Martin Boegemann,

<b>Aim:</b> Examine outcomes in sunitinib-treated patients by International Metastatic RCC Database Consortium (IMDC) or Memorial Sloan-Kettering Cancer Center (MSKCC) risk factors. <b>Patients & methods:</b> Patients enrolled in STAR-TOR registry (n = 327). End points included overall survival, progression-free survival and objective response rate. <b>Results:</b> Overall survival was similar for IMDC 0 versus 1 (p = 0.238) or ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, 17(18):2325-2338]

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A panel of systemic inflammatory response biomarkers for outcome prediction in patients treated with radical cystectomy for urothelial carcinoma.

Victor M Schuettfort, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Frederik König, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Objectives</h4>To determine the predictive and prognostic value of a panel of systemic inflammatory response (SIR) biomarkers relative to established clinicopathological variables in order to improve patient selection and facilitate more efficient delivery of peri-operative systemic therapy.<h4>Materials and methods</h4>The preoperative serum levels of a panel of SIR biomarkers, including albumin-globulin ratio, ... Read more >>

BJU Int (BJU international)
[2021, :]

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Mismatch repair deficiency occurs very rarely in seminomas.

David Dum, Stefan Steurer, Ronald Simon, Pia Victoria Zimmermann, Eike Burandt, Till Sebastian Clauditz, Margit Fisch, Michael Rink, Roland Dahlem, Wolfgang Höppner, Henrik Zecha, Ousman Doh, Cord Matthies, Waldemar Wilczak, Guido Sauter, Christoph Fraune,

<h4>Background</h4>Dense tumor-associated lymphocyte infiltration is linked to mismatch repair (MMR) deficiency in colorectal and endometrial cancer. MMR deficiency is of high clinical importance as MMR deficient cancers tend to react favorably to treatment with immune checkpoint inhibitors. Strong lymphocytic infiltration is a morphological hallmark of seminomas. We thus asked whether ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(3):1048-1055]

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A Comparison of BTA stat and NMP 22 as Non-Invasive Screening Methods for Bladder Cancer. A Systematic Review.

Sara Lezon, Michael Rink, Christine Gräfin zu Eulenburg, Kai Joachim Buhling,

<h4>Background: </h4> The purpose of this study was to systematically review the effects of bladder tumor antigen (BTA) stat and nuclear matrix protein (NMP) 22 as a screening method in an asymptomatic population. <h4>Methods: </h4> We evaluated 381 international studies by selecting randomized controlled trials (RCTs). We descriptively evaluated and ... Read more >>

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Predictive value of De Ritis ratio in metastatic renal cell carcinoma treated with tyrosine-kinase inhibitors.

Florian Janisch, Thomas Klotzbücher, Phillip Marks, Christina Kienapfel, Christian P Meyer, Hang Yu, Constantin Fühner, Tobias Hillemacher, Keiichiro Mori, Hadi Mostafei, Shahrokh F Shariat, Margit Fisch, Roland Dahlem, Michael Rink,

<h4>Background</h4>Predictive markers can help tailor treatment to the individual in metastatic renal cell carcinoma (mRCC). De Ritis ratio (DRR) is associated with oncologic outcomes in various solid tumors.<h4>Objective</h4>To assess the value of DRR in prognosticating survival in mRCC patients treated with tyrosine-kinase inhibitors (TKI).<h4>Methods</h4>Overall, 220 mRCC patients treated with TKI ... Read more >>

World J Urol (World journal of urology)
[2021, 39(8):2977-2985]

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Assessing the Outcome of Holmium Laser Enucleation of the Prostate by Age, Prostate Volume, and a History of Blood Thinning Agents: Report from a Single-Center Series of >1800 Consecutive Cases.

Philipp Gild, Lukas Lenke, Raisa S Pompe, Malte W Vetterlein, Tim A Ludwig, Armin Soave, Felix K-H Chun, Sascha Ahyai, Roland Dahlem, Margit Fisch, Michael Rink, Christian P Meyer, Andreas Becker,

<b><i>Purpose:</i></b> To assess perioperative outcomes of holmium laser enucleation of the prostate (HoLEP) in a real-world scenario and with a focus on demanding patient factors, such as large prostate size, advanced patient age, and anticoagulation therapy (AT). <b><i>Materials and Methods:</i></b> We retrospectively analyzed HoLEP procedures at our institution between 2010 ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(5):639-646]

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Y-chromosome loss is frequent in male renal tumors.

Franziska Büscheck, Christoph Fraune, Seyedehmina Garmestani, Ronald Simon, Martina Kluth, Claudia Hube-Magg, Kathrin Ketterer, Christian Eichelberg, Doris Höflmayer, Frank Jacobsen, Corinna Wittmer, Waldemar Wilczak, Guido Sauter, Margit Fisch, Till Eichenauer, Michael Rink,

<h4>Background</h4>Loss of the Y-chromosome is a common event in different tumor types but its prevalence and clinical relevance in renal cell tumors is still not understood.<h4>Methods</h4>It was the aim of this study to estimate the frequency and clinical relevance of Y-loss in kidney neoplasms. A cohort of 1,252 male renal ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(3):209]

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Prognostic value of albumin to globulin ratio in non-muscle-invasive bladder cancer.

Fahad Quhal, Benjamin Pradere, Ekaterina Laukhtina, Reza Sari Motlagh, Hadi Mostafaei, Keiichiro Mori, Victor M Schuettfort, Pierre I Karakiewicz, Morgan Rouprêt, Dmitry Enikeev, Michael Rink, Mohammad Abufaraj, Shahrokh F Shariat,

<h4>Purpose</h4>To investigate the prognostic value of preoperative serum albumin to globulin ratio (AGR) in patients with non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of bladder tumor (TURB) with or without intravesical therapy (IVT).<h4>Materials and methods</h4>We retrospectively reviewed 1,096 consecutive patients with NMIBC. Levels of albumin and globulin were obtained ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors.

Stefan Steurer, Claudia Riemann, Franziska Büscheck, Andreas M Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Anne Menz, Margit Fisch, Michael Rink, Christian Bernreuther, Patrick Lebok, Till S Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, David Dum, Ronald Simon, Sarah Minner, Eike Burandt, Rainer Krech, Till Krech, Andreas H Marx,

<h4>Background</h4>Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.<h4>Methods</h4>To comprehensively catalogue p63 expression, tissue microarrays (TMAs) containing 12,620 tissue ... Read more >>

Biomark Res (Biomarker research)
[2021, 9(1):7]

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A Systematic Review and Scoping Analysis of Smoking Cessation after a Urological Cancer Diagnosis.

Calvin Zhao, Marc A Bjurlin, Timothy Roberts, Michael Rink, Shahrokh F Shariat, Richard S Matulewicz,

<h4>Purpose</h4>Smoking cessation after a urological cancer diagnosis significantly benefits patients. It is not well known how often patients quit after diagnosis or how urologists intervene to support patients' smoking cessation efforts. We examined rates of smoking cessation after diagnosis among patients with urological cancers, and assessed how often patients are ... Read more >>

J Urol (The Journal of urology)
[2021, 205(5):1275-1285]

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Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy.

Armin Soave, Lan Kluwe, Hang Yu, Michael Rink, Philipp Gild, Malte W Vetterlein, Philipp Marks, Guido Sauter, Margit Fisch, Christian P Meyer, Tim Ludwig, Roland Dahlem, Sarah Minner, Klaus Pantel, Bettina Steinbach, Heidi Schwarzenbach,

The aim of the present study was to analyze copy number variations (CNV) of multiple oncogenes and tumor suppressor genes in genomic DNA from primary tumor tissue, lymph node metastasis and cell-free DNA (cfDNA) from serum of 72 urothelial carcinoma of bladder (UCB) patients treated with radical cystectomy (RC), using ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21562]

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Impact of preoperative serum albumin-globulin ratio on disease outcome after radical cystectomy for urothelial carcinoma of the bladder.

Victor M Schuettfort, David D Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Piotr Chlosta, Marko Babjuk, Marina Deuker, Marco Moschini, Shahrokh F Shariat, Benjamin Pradere,

<h4>Introduction</h4>The Albumin-Globulin Ratio (AGR; albumin/total protein - albumin) has been associated with oncological outcome in various malignancies. However, its role in urothelial carcinoma of the bladder (UCB) has not been clearly established. In this study, we assessed the association of preoperative AGR (pAGR) with survival in patients who underwent radical cystectomy (RC) ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(4):235.e5-235.e14]

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Learning benefits of live surgery and semi-live surgery in urology-informing the debate with results from the International Meeting of Reconstructive Urology (IMORU) VIII.

Victor M Schuettfort, Tim A Ludwig, Phillip Marks, Malte W Vetterlein, Valentin Maurer, Constantin Fuehner, Florian Janisch, Armin Soave, Michael Rink, Silke Riechardt, Oliver Engel, Margit Fisch, Roland Dahlem, Christian P Meyer,

<h4>Purpose</h4>To analyze the perceived learning opportunities of participants of the International Meeting on Reconstructive Urology (IMORU) VIII for both live surgery demonstrations (LSD) and semi-live surgery demonstrations (SLSD). Safety and educational efficacy of LSD and SLSD at live surgery events (LSE) have been debated extensively, however, objective data comparing learning ... Read more >>

World J Urol (World journal of urology)
[2021, 39(7):2801-2807]

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Impact of Smoking Habit on Perioperative Morbidity in Patients Treated with Radical Cystectomy for Urothelial Bladder Cancer: A Systematic Review and Meta-analysis.

Riccardo Tellini, Andrea Mari, Gianluca Muto, Giovanni Enrico Cacciamani, Matteo Ferro, Judith Stangl-Kremser, Riccardo Campi, Francesco Soria, Michael Rink, Evanguelos Xylinas, Andrea Minervini, Alberto Briganti, Francesco Montorsi, Morgan Roupret, Shahrokh F Shariat, Marco Moschini, ,

<h4>Context</h4>Smoking habit at the time of surgery is associated with higher perioperative complications and mortality across different types of surgeries. In recent years, several studies have attempted to explore the influence of smoking on perioperative outcomes following radical cystectomy (RC) for urothelial bladder cancer (UBC) with contradictory results.<h4>Objective</h4>To systematically investigate ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(4):580-593]

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The Impact of Circulating Tumor Cells on Venous Thromboembolism and Cardiovascular Events in Bladder Cancer Patients Treated with Radical Cystectomy.

Michael Rink, Sabine Riethdorf, Hang Yu, Mara Kölker, Malte W Vetterlein, Roland Dahlem, Margit Fisch, Klaus Pantel, Armin Soave,

<h4>Background</h4>Cancer is a relevant risk factor for venous thromboembolism (VTE). Circulating tumor cells (CTC) are associated with an increased risk of VTE in breast cancer. In addition, circulating cell-free nucleic acids have been associated with cardiovascular events (CVE).<h4>Objective</h4>To investigate the association of CTC status and the risk of VTE as ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Postoperative Chemotherapy Bladder Instillation After Radical Nephroureterectomy: Results of a European Survey from the Young Academic Urologist Urothelial Cancer Group.

Tom-Régis Dobé, Gianluigi Califano, Friedrich-Carl von Rundstedt, Idir Ouzaid, Simone Albisinni, Atiqullah Aziz, Ettore Di Trapani, Kees Hendricksen, Wojciech Krajewski, Andrea Mari, Marco Moschini, Andrea Necchi, Aidan P Noon, Cedric Poyet, Benjamin Pradère, Michael Rink, Florian Roghmann, Paul Sargos, Roland Seiler, Francesco Soria, Malte W Vetterlein, Evanguelos Xylinas,

<h4>Background</h4>Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk.<h4>Objective</h4>The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues.<h4>Design setting and ... Read more >>

Eur Urol Open Sci (European urology open science)
[2020, 22:45-50]

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