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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Feasibility, Utility, and Safety of Fully Incorporating Transesophageal Echocardiography into an Emergency Medicine Practice.

Robert F Reardon, Elliott Chinn, Dave Plummer, Andrew Laudenbach, Andie Rowland Fisher, Will Smoot, Daniel Lee, Joseph Novik, Barrett Wagner, Chris Kaczmarczyk, Johanna Moore, Emily Thompson, Craig Tschautscher, Teresa Dunphy, Thomas Pahl, Michael A Puskarich, James R Miner,

<h4>Introduction</h4>Transthoracic echocardiography (TTE) is a standard procedure for emergency physicians (EPs). Transesophageal echocardiography (TEE) is known to have great utility in patients who are critically ill or in cardiac arrest, and has been used by some EPs with specialized ultrasound training, but it is generally considered outside the reach of ... Read more >>

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, :]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Effect of losartan on hospitalized patients with COVID-19-induced lung injury: A randomized clinical trial

Michael Puskarich, Nicholas Ingraham, Lisa Merck, Brian Driver, David Wacker, Lauren Page Black, Alan Jones, Courtney Fletcher, Andrew South, Andrew Nelson, Thomas Murray, Christopher Tignanelli, Christopher Lewandowski, Joseph Farhat, Justin Benoit, Dana Byrne, Alex Hall, Ronald Reilkoff, Michelle Biros, Kartik Cherabuddi, Jeffrey Chipman, Timothy Schacker, Tyler Bold, Kenneth Beckman, Ryan Langlois, Matthew Aliota, Faheem Guirgis, James Galbriath, Margaret Beyer, Chas Salmen, Brian Roberts, David Wright, Helen Voelker, Joseph Koopmeiners,

<h4>Background</h4> SARS-CoV-2 viral entry may disrupt angiotensin II (Ang II) homeostasis in part via ACE2 downregulation, potentially contributing to COVID-19 induced lung injury. Preclinical models of viral pneumonias that utilize ACE2 demonstrate Ang II type 1 receptor (AT1R) blockade mitigates lung injury, though observational COVID-19 data addressing the effect of ... Read more >>

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Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.

Brandon P Verdoorn, Tamara K Evans, Gregory J Hanson, Yi Zhu, Larissa G P Langhi Prata, Robert J Pignolo, Elizabeth J Atkinson, Erin O Wissler-Gerdes, George A Kuchel, Joan B Mannick, Stephen B Kritchevsky, Sundeep Khosla, Stacey A Rizza, Jeremy D Walston, Nicolas Musi, Lewis A Lipsitz, Douglas P Kiel, Raymond Yung, Nathan K LeBrasseur, Ravinder J Singh, Teresa McCarthy, Michael A Puskarich, Laura J Niedernhofer, Paul D Robbins, Matthew Sorenson, Tamara Tchkonia, James L Kirkland,

The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults and those with chronic diseases. These individuals are also at the greatest risk for morbidity and mortality from SARS-CoV-2 infection. SARS-CoV-2 complications include cytokine storm ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, :]

Cited: 1 time

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 17 times

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 23 times

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Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit.

Sherehan Ibrahim, Jamie R Lowe, Carolyn T Bramante, Surbhi Shah, Nichole R Klatt, Nancy Sherwood, Louis Aronne, Michael Puskarich, Leonardo Tamariz, Ana Palacio, Eric Bomberg, Michael Usher, Samantha King, Brad Benson, Deneen Vojta, Chris Tignanelli, Nicholas Ingraham,

Metformin is the first-line medication for type 2 diabetes, but it also has a long history of improved outcomes in infectious diseases, such as influenza, hepatitis C, and <i>in-vitro</i> assays of zika. In the current Covid-19 pandemic, which has rapidly spread throughout the world, 4 observational studies have been published ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:587801]

Cited: 0 times

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A fast, resource efficient, and reliable rule-based system for COVID-19 symptom identification.

Himanshu S Sahoo, Greg M Silverman, Nicholas E Ingraham, Monica I Lupei, Michael A Puskarich, Raymond L Finzel, John Sartori, Rui Zhang, Benjamin C Knoll, Sijia Liu, Hongfang Liu, Genevieve B Melton, Christopher J Tignanelli, Serguei V S Pakhomov,

<h4>Objective</h4>With COVID-19, there was a need for a rapidly scalable annotation system that facilitated real-time integration with clinical decision support systems (CDS). Current annotation systems suffer from a high-resource utilization and poor scalability limiting real-world integration with CDS. A potential solution to mitigate these issues is to use the rule-based ... Read more >>

JAMIA Open (JAMIA open)
[2021, 4(3):ooab070]

Cited: 0 times

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Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic.

Kusum S Mathews, Kevin P Seitz, Kelly C Vranas, Abhijit Duggal, Thomas S Valley, Bo Zhao, Stephanie Gundel, Michael O Harhay, Steven Y Chang, Catherine L Hough, ,

<h4>Objectives</h4>The coronavirus disease 2019 pandemic has strained many healthcare systems. In response, U.S. hospitals altered their care delivery systems, but there are few data regarding specific structural changes. Understanding these changes is important to guide interpretation of outcomes and inform pandemic preparedness. We sought to characterize emergency responses across hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1038-1048]

Cited: 1 time

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Serum Levels of Branched Chain Amino Acids Predict Duration of Cardiovascular Organ Failure in Septic Shock.

Michael A Puskarich, Cora McHugh, Thomas L Flott, Alla Karnovsky, Alan E Jones, Kathleen A Stringer, ,

<h4>Background</h4>Sepsis shifts cardiac metabolic fuel preference and this disruption may have implications for cardiovascular function. A greater understanding of the role of metabolism in the development and persistence of cardiovascular failure in sepsis could serve to identify novel pharmacotherapeutic approaches.<h4>Methods</h4>Secondary analysis of prospective quantitative proton nuclear magnetic resonance (1H-NMR) metabolomic ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(1):65-72]

Cited: 1 time

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Pharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock.

Michael A Puskarich, Theodore S Jennaro, Christopher E Gillies, Charles R Evans, Alla Karnovsky, Cora E McHugh, Thomas L Flott, Alan E Jones, Kathleen A Stringer, ,

Sepsis-induced metabolic dysfunction contributes to organ failure and death. L-carnitine has shown promise for septic shock, but a recent phase II study of patients with vasopressor-dependent septic shock demonstrated a non-significant reduction in mortality. We undertook a pharmacometabolomics study of these patients (n = 250) to identify metabolic profiles predictive of a ... Read more >>

Clin Transl Sci (Clinical and translational science)
[2021, :]

Cited: 0 times

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Group IIA secretory phospholipase 2 independently predicts mortality and positive blood culture in emergency department sepsis patients.

Utsav Nandi, Alan E Jones, Michael A Puskarich,

<h4>Objective</h4>The IIA isoform of phospholipase A2 is an acute phase reactant that increases in sepsis, although data regarding its prognostic value are limited. We hypothesized that group IIA secretory phospholipase A2 (sPLA2-IIA) predicts sepsis mortality and positive cultures and sought to compare its predictive characteristics to lactate and procalcitonin.<h4>Methods</h4>sPLA2-IIA and ... Read more >>

J Am Coll Emerg Physicians Open (Journal of the American College of Emergency Physicians open)
[2021, 2(3):e12460]

Cited: 0 times

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A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19.

Michael A Puskarich, Nathan W Cummins, Nicholas E Ingraham, David A Wacker, Ronald A Reilkoff, Brian E Driver, Michelle H Biros, Fernanda Bellolio, Jeffrey G Chipman, Andrew C Nelson, Kenneth Beckman, Ryan Langlois, Tyler Bold, Matthew T Aliota, Timothy W Schacker, Helen T Voelker, Thomas A Murray, Joseph S Koopmeiners, Christopher J Tignanelli,

<h4>Background</h4>The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. Treatment with angiotensin receptor blockers (ARBs), such as losartan, may mitigate these effects, though induction of ACE2 could increase viral entry, replication, and worsen disease.<h4>Methods</h4>This study represents a placebo-controlled blinded randomized ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 37:100957]

Cited: 1 time

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Association of hospital closures with changes in Medicare-covered ambulance trips among rural emergency medical services agencies.

Sayeh Nikpay, Craig Tschautscher, Nathaniel L Scott, Michael Puskarich,

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, 28(9):1070-1072]

Cited: 0 times

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Most emergency department patients meeting sepsis criteria are not diagnosed with sepsis at discharge.

John M Litell, Faheem Guirgis, Brian Driver, Alan E Jones, Michael A Puskarich,

<h4>Objectives</h4>Effective sepsis resuscitation depends on useful criteria for prompt identification of eligible patients. These criteria should reliably predict a discharge diagnosis of sepsis, ensuring that interventions are triggered for those who need it while avoiding potentially harmful interventions in those who do not. We sought to determine the proportion of ... Read more >>

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, 28(7):745-752]

Cited: 0 times

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Implementation and Evaluation of a Novel COVID-19 Prognostic Score for Patients with Suspected COVID-19

Monica Lupei, Danni Li, Nicholas Ingraham, Karyn Baum, Bradley Benson, Michael Puskarich, David Milbrandt, Genevieve Melton, Daren Scheppmann, Michael Usher, Christopher Tignanelli,

<h4>Background: </h4> Patient safety and optimal resource allocation are essential during the COVID-19 pandemic. We present a COVID-19 prognostic algorithm implemented in real-time as a clinical decision support structure for symptomatic persons under investigation (PUI) for COVID-19 in the emergency department (ED). <h4>Methods: </h4>: The training data included 1,469 patients ... Read more >>

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Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021.

Jeffrey A Kline, Carlos A Camargo, D Mark Courtney, Christopher Kabrhel, Kristen E Nordenholz, Thomas Aufderheide, Joshua J Baugh, David G Beiser, Christopher L Bennett, Joseph Bledsoe, Edward Castillo, Makini Chisolm-Straker, Elizabeth M Goldberg, Hans House, Stacey House, Timothy Jang, Stephen C Lim, Troy E Madsen, Danielle M McCarthy, Andrew Meltzer, Stephen Moore, Craig Newgard, Justine Pagenhardt, Katherine L Pettit, Michael S Pulia, Michael A Puskarich, Lauren T Southerland, Scott Sparks, Danielle Turner-Lawrence, Marie Vrablik, Alfred Wang, Anthony J Weekes, Lauren Westafer, John Wilburn,

<h4>Objectives</h4>Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the severe acute respiratory syndrome (SARS-CoV-2) and associated disease (COVID-19) remain an urgent unmet need, especially in emergency care. The objective was to derive and validate a clinical prediction score for SARS-CoV-2 infection ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0248438]

Cited: 2 times

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Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock

Michael Puskarich, Theodore Jennaro, Christopher Gillies, Charles Evans, Alla Karnovsky, Cora McHugh, Thomas Flott, Alan Jones, Kathleen Stringer,

<h4>Background</h4> Sepsis-induced metabolic dysfunction contributes to organ failure and death. L-carnitine has shown promise for septic shock, but a recent study demonstrated a non-significant reduction in mortality. <h4>Methods</h4> A pharmacometabolomics study of patients (n=250) in a Phase II trial of L-carnitine to identify metabolic profiles predictive of a 90-day mortality ... Read more >>

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Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments

Jeffrey Kline, Carlos Camargo, Mark Courtney, Christopher Kabrhel, Kristen Nordenholz, Thomas Aufderheide, Joshua Baugh, David Beiser, Christopher Bennett, Joseph Bledsoe, Edward Castillo, Makini Chisholm-Straker, Elizabeth Goldberg, Hans House, Stacey House, Timothy Jang, Chris Kabrhel, Stephen Lim, Troy Madsen, Danielle McCarthy, Andrew Meltzer, Stephen Moore, Craig Newgard, Justine Pagenhardt, Katherine Pettit, Michael Pulia, Michael Puskarich, Lauren Southerland, Scott Sparks, Danielle Turner-Lawrence, Marie Vrablik, Alfred Wang, Anthony Weekes, Lauren Westafer, John Wilburn,

<h4>Objectives</h4> Accurate and reliable criteria to rapidly estimate the probability of infection with the novel coronavirus-2 that causes the severe acute respiratory syndrome (SARS-CoV-2) and associated disease (COVID-19) remain an urgent unmet need, especially in emergency care. The objective was to derive and validate a clinical prediction rule for SARS-CoV-2 ... Read more >>

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mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses.

Basil S Karam, Rachel S Morris, Carolyn T Bramante, Michael Puskarich, Emily J Zolfaghari, Sahar Lotfi-Emran, Nicholas E Ingraham, Anthony Charles, David J Odde, Christopher J Tignanelli,

In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of ... Read more >>

J Med Virol (Journal of medical virology)
[2021, 93(4):1843-1846]

Cited: 9 times

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The Use of Electronic Consent for COVID-19 Clinical Trials: Lessons for Emergency Care Research During a Pandemic and Beyond.

Eric Jaton, Jamie Stang, Michelle Biros, Abbey Staugaitis, Julie Scherber, Florian Merkle, Nicholas M Mohr, Christopher Streib, Lauren Klein, Michael A Puskarich,

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2020, 27(11):1183-1186]

Cited: 1 time

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Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity.

Yuzi Tian, Rachel M Russo, Yongqing Li, Monita Karmakar, Baoling Liu, Michael A Puskarich, Alan E Jones, Kathleen A Stringer, Theodore J Standiford, Hasan B Alam,

<h4>Purpose</h4>Microbial infection stimulates neutrophil/macrophage/monocyte extracellular trap formation, which leads to the release of citrullinated histone H3 (CitH3) catalyzed by peptidylarginine deiminase (PAD) 2 and 4. Understanding these molecular mechanisms in the pathogenesis of septic shock will be an important next step for developing novel diagnostic and treatment modalities. We sought ... Read more >>

Infection (Infection)
[2021, 49(1):83-93]

Cited: 3 times

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Using l-Carnitine as a Pharmacologic Probe of the Interpatient and Metabolic Variability of Sepsis.

Theodore S Jennaro, Michael A Puskarich, Marc R McCann, Christopher E Gillies, Manjunath P Pai, Alla Karnovsky, Charles R Evans, Alan E Jones, Kathleen A Stringer,

<h4>Objective</h4>The objective of this review is to discuss the therapeutic use and differential treatment response to Levo-carnitine (l-carnitine) treatment in septic shock, and to demonstrate common lessons learned that are important to the advancement of precision medicine approaches to sepsis. We propose that significant interpatient variability in the metabolic response ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2020, 40(9):913-923]

Cited: 1 time

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