Full Text Journal Articles by
Author Michael Kreuter

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The Diagnosis and Treatment of Pulmonary Fibrosis.

Michael Kreuter, Ulf Müller Ladner, Ulrich Costabel, Danny Jonigk, Claus Peter Heussel,

<h4>Background</h4>The different types of pulmonary fibrosis are a subgroup of the interstitial lung diseases (ILDs). They are associated with a chronic and often progressive course.<h4>Methods</h4>This review is based on pertinent publications retrieved by a selective search in the EMBASE and PubMed databases, with an emphasis on articles published from 2000 ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Prognostic Value of Oxygenated Hemoglobin Assessed during Acute Exacerbations of Chronic Pulmonary Disease.

Clemens F Hinke, Rudolf A Jörres, Peter Alter, Robert Bals, Florian Bornitz, Michael Kreuter, Felix J F Herth, Kathrin Kahnert, Christina Kellerer, Henrik Watz, Stephan Budweiser, Franziska C Trudzinski,

<h4>Background</h4>Oxygenated hemoglobin(OxyHem) is a simple-to-measure marker of oxygen content capable of predicting all-cause mortality in stable chronic obstructive pulmonary disease (COPD).<h4>Objectives</h4>We aimed to analyze its predictive value during acute exacerbations of COPD (AECOPD).<h4>Methods</h4>In this retrospective study, data from 227 patients discharged after severe AECOPD at RoMed Clinical Center Rosenheim, Germany, ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-8]

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Reply to Althuwaybi et al.: Hospitalization Outcomes for COVID-19 in Patients with Interstitial Lung Disease: A Potential Role for Aerodigestive Pathophysiology?

Nazia Chaudhuri, Peter M George, Michael Kreuter, Maria Molina-Molina, Pilar Rivera-Ortega, Giulia M Stella, Iain Stewart, Lisa G Spencer, Athol U Wells, R Gisli Jenkins,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(4):522-524]

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S2K Guideline for Diagnosis of Idiopathic Pulmonary Fibrosis.

Jürgen Behr, Andreas Günther, Francesco Bonella, Julien Dinkel, Ludger Fink, Thomas Geiser, Klaus Geissler, Sven Gläser, Sabin Handzhiev, Danny Jonigk, Dirk Koschel, Michael Kreuter, Gabriela Leuschner, Philipp Markart, Antje Prasse, Nicolas Schönfeld, Jonas Christian Schupp, Helmut Sitter, Joachim Müller-Quernheim, Ulrich Costabel,

Idiopathic pulmonary fibrosis (IPF) is a severe and often fatal disease. Diagnosis of IPF requires considerable expertise and experience. Since the publication of the international IPF guideline in the year 2011 and the update 2018 several studies and technical advances have occurred, which made a new assessment of the diagnostic ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-34]

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Residual symptoms and lower lung function in patients recovering from SARS-CoV-2 infection.

Frederik Trinkmann, Michael Müller, Alexandra Reif, Nicolas Kahn, Michael Kreuter, Franziska Trudzinski, Monika Eichinger, Claus-Peter Heussel, Felix J F Herth, ,

Eur Respir J (The European respiratory journal)
[2021, :]

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The DIAMORFOSIS (DIAgnosis and Management Of lung canceR and FibrOSIS) survey: international survey and call for consensus.

Argyris Tzouvelekis, Katerina Antoniou, Michael Kreuter, Matthew Evison, Torsten G Blum, Venerino Poletti, Bogdan Grigoriu, Carlo Vancheri, Paolo Spagnolo, Theodoros Karampitsakos, Francesco Bonella, Athol Wells, Ganesh Raghu, Maria Molina-Molina, Daniel A Culver, Elisabeth Bendstrup, Nesrin Mogulkoc, Stefano Elia, Jacques Cadranel, Demosthenes Bouros,

<h4>Background</h4>Currently there is major lack of agreement on the diagnostic and therapeutic management of patients with idiopathic pulmonary fibrosis (IPF) and lung cancer. Our aim was to identify variations in diagnostic and management strategies across different institutions and provide rationale for a consensus statement on this issue.<h4>Methods</h4>This was a joint-survey ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(1):]

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Monocyte Count as a Prognostic Biomarker in Patients with Idiopathic Pulmonary Fibrosis.

Michael Kreuter, Sarah J Bradley, Joyce S Lee, Argyrios Tzouvelekis, Justin M Oldham, Philip L Molyneaux, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler, Toby M Maher,

<b>Rationale:</b> There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count. <b>Objectives:</b> We used pooled data from pirfenidone and interferon gamma-1b trials to explore the association between monocyte count and prognosis in patients with IPF. <b>Methods:</b> This retrospective ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, :]

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Suggestions for improving clinical utility of future guidelines for diagnosis and management of IPF - results of a Delphi survey.

Manuela Funke-Chambour, Carlo Albera, Elisabeth Bendstrup, Ulrich Costabel, Jan C Grutters, Sergio Harari, Kerri A Johannson, Michael Kreuter, Irina Strambu, Carlo Vancheri, Francesco Varone, Patrizio Vitulo, Wim A Wuyts, Fernando Martinez, Ganesh Raghu, ,

Eur Respir J (The European respiratory journal)
[2021, :]

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A New Tool to Assess Quality of life in Patients with Idiopathic Pulmonary Fibrosis or Non-Specific Interstitial Pneumonia *

Detlef Kirsten, Ulrike de Vries, Ulrich Costabel, Dirk Koschel, Francesco Bonella, Andreas Günther, Jürgen Behr, Martin Claussen, Stefan Schwarz, Antje Prasse, Michael Kreuter,

<h4>Background: </h4> Quality of life (QoL) is significantly impaired in patients with pulmonary fibrosis, however reliable tools to assess QoL are still missing. We thus aimed to develop a new questionnaire called QPF to measure QoL in patients with fibrotic idiopathic interstitial pneumonias (IIP) . <h4>Methods:</h4> As part of a ... Read more >>

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Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross-talk and redox-mediated activation of the tyrosine kinase FYN.

Carmen Veith, Milena Hristova, Karamatullah Danyal, Aida Habibovic, Christopher M Dustin, John E McDonough, Bart M Vanaudenaerde, Michael Kreuter, Marc A Schneider, Nicolas Kahn, Frederik Jan van Schooten, Agnes W Boots, Albert van der Vliet,

Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed redox balance and increased production of reactive oxygen species (ROS), which is believed to contribute to epithelial injury and fibrotic lung scarring. The main pulmonary sources of ROS include mitochondria and NADPH oxidases (NOXs), of which the NOX4 isoform has been ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, :]

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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicentre trial.

Jürgen Hetzel, Athol U Wells, Ulrich Costabel, Thomas V Colby, Simon L F Walsh, Johny Verschakelen, Alberto Cavazza, Sara Tomassetti, Claudia Ravaglia, Michael Böckeler, Werner Spengler, Michael Kreuter, Ralf Eberhardt, Kaid Darwiche, Alfons Torrego, Virginia Pajares, Rainer Muche, Regina Musterle, Marius Horger, Falko Fend, Arne Warth, Claus Peter Heußel, Sara Piciucchi, Alessandra Dubini, Dirk Theegarten, Tomas Franquet, Enrique Lerma, Venerino Poletti, Maik Häntschel,

<h4>Introduction</h4>The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a diagnosis cannot be made after multidisciplinary team discussion (MDTD), surgical lung biopsy is the current recommended tissue sampling technique according to the most recent guidelines. Transbronchial lung cryobiopsy ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(6):]

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Osteoprotegerin is elevated in pulmonary fibrosis and associates with IPF progression

Habibie, Kurnia S.S. Putri, Carian Boorsma, David Brass, Peter Heukels, Marlies Wijsenbeek, Mirjam Kool, Maarten van den Berge, Theo Borghuis, Corry-Anke Brandsma, Tji Gan, Peter Olinga, Wim Timens, Nicolas Kahn, Michael Kreuter, Janette Burgess, Barbro Melgert,

<h4>ABSTRACT</h4> Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-kB ligand (RANKL), is used as a biomarker for assessing severity of liver fibrosis. However, its expression and role in pulmonary fibrosis are unknown. We hypothesized that OPG also has a role in pulmonary fibrosis. Human and mouse control and ... Read more >>

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Idiopathic Pulmonary Fibrosis in Elderly Patients: Analysis of the INSIGHTS-IPF Observational Study.

Gabriela Leuschner, Jens Klotsche, Michael Kreuter, Antje Prasse, Hubert Wirtz, David Pittrow, Marion Frankenberger, Jürgen Behr, Nikolaus Kneidinger, ,

<b>Background:</b> An association between idiopathic pulmonary fibrosis (IPF) and advancing age is suspected since IPF occurs primarily in patients over 60 years of age. Though, little is known about the disease in the elderly. The aim of this study was to characterize elderly IPF patients using data from the longitudinal, ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:601279]

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Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study.

Thomas M Drake, Annemarie B Docherty, Ewen M Harrison, Jennifer K Quint, Huzaifa Adamali, Sarah Agnew, Suresh Babu, Christopher M Barber, Shaney Barratt, Elisabeth Bendstrup, Stephen Bianchi, Diego Castillo Villegas, Nazia Chaudhuri, Felix Chua, Robina Coker, William Chang, Anjali Crawshaw, Louise E Crowley, Davinder Dosanjh, Christine A Fiddler, Ian A Forrest, Peter M George, Michael A Gibbons, Katherine Groom, Sarah Haney, Simon P Hart, Emily Heiden, Michael Henry, Ling-Pei Ho, Rachel K Hoyles, John Hutchinson, Killian Hurley, Mark Jones, Steve Jones, Maria Kokosi, Michael Kreuter, Laura S MacKay, Siva Mahendran, George Margaritopoulos, Maria Molina-Molina, Philip L Molyneaux, Aiden O'Brien, Katherine O'Reilly, Alice Packham, Helen Parfrey, Venerino Poletti, Joanna C Porter, Elisabetta Renzoni, Pilar Rivera-Ortega, Anne-Marie Russell, Gauri Saini, Lisa G Spencer, Giulia M Stella, Helen Stone, Sharon Sturney, David Thickett, Muhunthan Thillai, Tim Wallis, Katie Ward, Athol U Wells, Alex West, Melissa Wickremasinghe, Felix Woodhead, Glenn Hearson, Lucy Howard, J Kenneth Baillie, Peter J M Openshaw, Malcolm G Semple, Iain Stewart, R Gisli Jenkins, ,

<b>Rationale:</b> The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.<b>Objectives:</b> To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population.<b>Methods:</b> An international multicenter audit of patients with a prior diagnosis ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(12):1656-1665]

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Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis.

Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma, Vincent Cottin,

<h4>Background</h4>Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight loss over 52 weeks was ... Read more >>

Respir Res (Respiratory research)
[2020, 21(1):312]

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Effect of nintedanib on lung function in patients with systemic sclerosis-associated interstitial lung disease: further analyses of the SENSCIS trial.

Toby M Maher, Maureen D Mayes, Michael Kreuter, Elizabeth R Volkmann, Martin Aringer, Ivan Castellvi, Maurizio Cutolo, Christian Stock, Nils Schoof, Margarida Alves, Ganesh Raghu, ,

<h4>Objective</h4>In the SENSCIS trial in subjects with systemic sclerosis-associated ILD (SSc-ILD), nintedanib reduced the rate of decline in forced vital capacity (FVC) over 52 weeks by 44% versus placebo. We investigated the effects of nintedanib on categorical changes in FVC and other measures of ILD progression.<h4>Methods</h4>In post-hoc analyses, we assessed ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, :]

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ERS International Congress, Madrid, 2019: highlights from the Interstitial Lung Diseases Assembly.

Clairelyne Dupin, Vânia Fernandes, Fernanda Hernandez-Gonzalez, Sebastiano Emanuele Torrisi, Tiago M Alfaro, Michael Kreuter, Marlies S Wijsenbeek, Elisabetta A Renzoni, Elena Bargagli, Hilario Nunes, Paolo Spagnolo, Francesco Bonella, Maria Molina-Molina, Katerina Antoniou, Venerino Poletti,

This article discusses a selection of the scientific presentations in the field of interstitial lung diseases (ILDs) that took place at the 2019 European Respiratory Society International Congress in Madrid, Spain. There were sessions from all four groups within Assembly 12: group 12.01 "Idiopathic interstitial pneumonias", group 12.02 "ILDs/diffuse parenchymal ... Read more >>

ERJ Open Res (ERJ open research)
[2020, 6(4):]

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Tobacco Use, Knowledge about Smoking-Associated Risks, and Cessation Programs among Dental Students in Germany - ToDent.

Claudia Bauer-Kemeny, Ilona Verena Lis, Tobias Raupach, Michael Kreuter,

<h4>Background</h4>Professional and consistent smoking prevention and cessation may avoid many smoking-associated deaths worldwide. Dentists can exert a decisive influence on smoking behavior, as most people regularly visit a dentist. However, only if dentists have been trained sufficiently about the consequences of smoking and of smoking cessation methods might they fulfill ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2020, 99(9):764-770]

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Determinants of health-related quality of life decline in interstitial lung disease.

Phillen Nozibuyiso Maqhuzu, Boglarka L Szentes, Michael Kreuter, Thomas Bahmer, Nicolas Kahn, Martin Claussen, Rolf Holle, Larissa Schwarzkopf,

<h4>Background</h4>Health-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period.<h4>Methods</h4>We analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King's Brief Interstitial Lung Disease questionnaire ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2020, 18(1):334]

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Determinants of health-related quality of life decline in interstitial lung disease

Phillen Nozibuyiso Maqhuzu, Boglárka Lilla Szentes, Michael Kreuter, Thomas Bahmer, Nicolas Kahn, Martin Claussen, Rolf Holle, Larissa Schwarzkopf,

<h4>Background: </h4> Health-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period. <h4>Methods: </h4> We analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King’s ... Read more >>

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Progressive fibrosing interstitial lung disease: clinical uncertainties, consensus recommendations, and research priorities.

Peter M George, Paolo Spagnolo, Michael Kreuter, Goksel Altinisik, Martina Bonifazi, Fernando J Martinez, Philip L Molyneaux, Elisabetta A Renzoni, Luca Richeldi, Sara Tomassetti, Claudia Valenzuela, Carlo Vancheri, Francesco Varone, Vincent Cottin, Ulrich Costabel, ,

Within the spectrum of fibrosing interstitial lung diseases (ILDs) is a subset of patients who have inexorable progression of pulmonary fibrosis despite treatment, which is known as the progressive fibrotic phenotype. Although the concept of progressive fibrosing ILD has been applied largely to patients with idiopathic pulmonary fibrosis (IPF), there ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(9):925-934]

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Updates in using a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples.

Andrea Crespo, Tiago Alfaro, Vivien Somogyi, Michael Kreuter,

<b>A molecular classifier using a machine-learning algorithm based on genomic data could provide an objective method to aid clinicians and multidisciplinary teams to establish the diagnosis of IPF in less-invasive transbronchial lung biopsy samples</b> https://bit.ly/2QLdWim. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(3):200067]

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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis.

Bruce C Trapnell, Yoshikazu Inoue, Francesco Bonella, Cliff Morgan, Stéphane Jouneau, Elisabeth Bendstrup, Ilaria Campo, Spyros A Papiris, Etsuro Yamaguchi, Erdogan Cetinkaya, Mikhail M Ilkovich, Mordechai R Kramer, Marcel Veltkamp, Michael Kreuter, Tomohisa Baba, Cecilia Ganslandt, Inge Tarnow, Grant Waterer, Taneli Jouhikainen, ,

<h4>Background</h4>Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It is caused by disruption of granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which pulmonary alveolar macrophages require to clear surfactant. Recently, inhaled GM-CSF was shown to improve the partial pressure of arterial oxygen in patients ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(17):1635-1644]

Cited: 1 time

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Effects of Vibration Training in Interstitial Lung Diseases: A Randomized Controlled Trial.

Andreas Rembert Koczulla, Tobias Boeselt, Janina Koelpin, Fabian Kaufhold, Martina Veith, Christoph Nell, Inga Jarosch, Marc Spielmanns, Peter Alter, Christian Kähler, Timm Greulich, Claus F Vogelmeier, Rainer Glöckl, Tessa Schneeberger, Klaus Kenn, Nicolas Carlos Kahn, Felix J F Herth, Michael Kreuter,

<h4>Background</h4>Numerous studies have reported positive effects of exercise training in patients with interstitial lung disease (ILD) on physical capacity and quality of life. However, evidence is rare on the effects of specific forms of training and further pathophysiological mechanisms in these patients.<h4>Objectives</h4>In this multicenter study we aimed to explore the ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2020, 99(8):658-666]

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Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry.

Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Nicolas Kahn, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Thomas Bahmer, Tim Oqueka, Marion Frankenberger, Michael Kreuter,

<h4>Objective</h4>There is a paucity of observational data on antifibrotic therapy for idiopathic pulmonary fibrosis (IPF). We aimed to assess the course of disease of IPF patients with and without antifibrotic therapy under real-life conditions.<h4>Methods</h4>We analysed data from a non-interventional, prospective cohort study of consecutively enrolled IPF patients from 20 interstitial ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(2):]

Cited: 1 time

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