Full Text Journal Articles by
Author Michael Klompas

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Likelihood of Bacterial Infection in Patients Treated With Broad-Spectrum IV Antibiotics in the Emergency Department.

Claire N Shappell, Michael Klompas, Aileen Ochoa, Chanu Rhee, ,

<h4>Objectives</h4>Best practice guidelines and quality metrics recommend immediate antibiotic treatment for all patients with suspected sepsis. However, little is known about how many patients given IV antibiotics in the emergency department are ultimately confirmed to have bacterial infection.<h4>Design, setting, and patients</h4>We performed a retrospective study of adult patients who presented ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):e1144-e1150]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Conducting Sepsis Surveillance by Applying Sepsis-3 Criteria to Electronic Health Record Data: Promises and Potential Pitfalls.

Chanu Rhee, Michael Klompas,

Crit Care Med (Critical care medicine)
[2021, 49(11):1983-1986]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Association between Airborne Infection Isolation Room Utilization Rates and Healthcare Worker COVID-19 Infections in Two Academic Hospitals.

Michael Klompas, Shangyuan Ye, Vineeta Vaidya, Aileen Ochoa, Meghan A Baker, Karen Hopcia, Dean Hashimoto, Rui Wang, Chanu Rhee,

We compared healthcare worker SARS-CoV-2 infection rates between March-August 2020 in two similar hospitals with high versus low airborne infection isolation room utilization rates but otherwise identical infection control policies. We found no difference in healthcare worker infection rates between the two hospitals nor between patient-facing vs non-patient-facing providers. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Genomic Determination of Relative Risks for Clostridioides difficile Infection From Asymptomatic Carriage in Intensive Care Unit Patients.

Jay Worley, Mary L Delaney, Christopher K Cummins, Andrea DuBois, Michael Klompas, Lynn Bry,

<h4>Background</h4>Clostridioides difficile infections (CDIs) are among the most prevalent hospital-associated infections (HAIs), particularly for intensive care unit (ICU) patients. The risks for developing active CDI from asymptomatic carriage of C. difficile are not well understood.<h4>Methods</h4>We identified asymptomatic C. difficile carriage among 1897 ICU patients using rectal swabs from an existing ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(7):e1727-e1736]

Cited: 1 time

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Reply to Cimolai.

Chanu Rhee, Sanjat Kanjilal, Meghan Baker, Michael Klompas,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(7):e1788-e1789]

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Low Risk of Coronavirus Disease 2019 (COVID-19) Among Patients Exposed to Infected Healthcare Workers.

Meghan A Baker, Karen Fiumara, Chanu Rhee, Sarah A Williams, Robert Tucker, Paige Wickner, Andrew Resnick, Michael Klompas,

Many patients are fearful of acquiring coronavirus disease 2019 (COVID-19) in hospitals and clinics. We characterized the risk of COVID-19 among 226 patients exposed to healthcare workers with confirmed COVID-19. One patient may have been infected, suggesting that the risk of COVID-19 transmission from healthcare workers to patients is generally ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(7):e1878-e1880]

Cited: 8 times

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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What Is the Utility of Measuring Lactate Levels in Patients with Sepsis and Septic Shock?

Jeremy Weinberger, Michael Klompas, Chanu Rhee,

Elevations in blood lactate concentrations have been studied in sepsis and other disease states for decades and are well known to be associated with increased mortality. Many studies have also demonstrated the prognostic accuracy of serial lactate levels, and some have suggested that lactate clearance may be a useful therapeutic ... Read more >>

Semin Respir Crit Care Med (Seminars in respiratory and critical care medicine)
[2021, 42(5):650-661]

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Observational bias within a hospital-wide hand hygiene program.

Amy E Badwaik, Robert P Tucker, Peggy Leung, Michael Klompas,

We assessed the extent to which healthcare workers report more favorable hand hygiene rates when observing members of their own professional group versus other groups' observations of them. Healthcare workers consistently reported higher compliance rates for their own group compared to others' observations of them (97 vs 92%; P ≤ ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2021, :1-3]

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Surveillance for Healthcare-Associated Infections: Hospital-Onset Adult Sepsis Events Versus Current Reportable Conditions.

Brady Page, Michael Klompas, Christina Chan, Michael R Filbin, Sayon Dutta, Dustin S McEvoy, Roger Clark, Matthew Leibowitz, Chanu Rhee,

<h4>Background</h4>US hospitals are required by the Centers for Medicare and Medicaid Services to publicly report central line-associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), Clostridioidesdiffficile, methicillin-resistant Staphylococcus aureus bacteremia, and selected surgical site infections for benchmarking and pay-for-performance programs. It is unclear, however, to what extent these conditions capture ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(6):1013-1019]

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Annals On Call - The Case for Mandating COVID-19 Vaccines for Health Care Workers.

Robert M Centor, Michael Klompas, Madelyn Pearson, Charles Morris,

Ann Intern Med (Annals of internal medicine)
[2021, 174(9):OC1]

Cited: 0 times

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Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China: A Nested Case-Control Study.

Wen Wang, Shichao Zhu, Qiao He, Mingqi Wang, Yan Kang, Rui Zhang, Peng Ji, Kang Zou, Michael Klompas, Zhiyong Zong, Xin Sun,

<h4>Objectives</h4>Fluid therapy is an important component of intensive care management, however, optimal fluid management is unknown. The relationship between fluid balance and ventilator-associated events has not been well established. This study investigated the dose-response relationship between fluid balance and ventilator-associated events.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>The study was based on a well-established, research-oriented ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Suspected SARS-CoV-2 Reinfections: Incidence, Predictors, and Healthcare Use among Patients at 238 U.S. Healthcare Facilities, June 1, 2020- February 28, 2021.

Alexander Lawandi, Sarah Warner, Junfeng Sun, Cumhur Y Demirkale, Robert L Danner, Michael Klompas, Adi Gundlapalli, Deblina Datta, Aaron M Harris, Sapna Bamrah Morris, Pavithra Natarajan, Sameer S Kadri,

In a retrospective cohort study, among 131,773 patients with previous COVID19, reinfection with SARS-CoV-2 was suspected in 253(0.2%) patients at 238 U.S. healthcare facilities between June 1, 2020- February 28, 2021. Women displayed a higher cumulative reinfection risk. Healthcare burden and illness severity were similar between index and reinfection encounters. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 0 times

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Absence of long-range severe acute respiratory coronavirus virus 2 (SARS-CoV-2) transmission from a highly infectious patient with undiagnosed coronavirus disease 2019 (COVID-19) in a positive-pressure room.

Chanu Rhee, Meghan A Baker, Robert Tucker, Michael Klompas,

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2021, :1-2]

Cited: 0 times

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Prospective genomic surveillance reveals cryptic MRSA outbreaks with local to international origins among NICU patients

Jay Worley, Jessica Crothers, William Wolfgang, Sai Laxmi Gubbala Venkata, Maria Hoffmann, Victor Jayeola, Michael Klompas, Marc Allard, Lynn Bry,

MRSA infections cause significant morbidity and mortality in neonates. Clinical testing and routine surveillance screening identified an increase in neonates with MRSA colonization and infection which triggered prospective genomic surveillance. Here we show the complex transmission dynamics of MRSA in a NICU setting. Analyses revealed concurrent transmission chains affecting 16 ... Read more >>

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Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond.

Claire N Shappell, Michael Klompas, Chanu Rhee,

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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The Case for Mandating COVID-19 Vaccines for Health Care Workers.

Michael Klompas, Madelyn Pearson, Charles Morris,

Ann Intern Med (Annals of internal medicine)
[2021, 174(9):1305-1307]

Cited: 1 time

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Association Between Caseload Surge and COVID-19 Survival in 558 U.S. Hospitals, March to August 2020.

Sameer S Kadri, Junfeng Sun, Alexander Lawandi, Jeffrey R Strich, Lindsay M Busch, Michael Keller, Ahmed Babiker, Christina Yek, Seidu Malik, Janell Krack, John P Dekker, Alicen B Spaulding, Emily Ricotta, John H Powers, Chanu Rhee, Michael Klompas, Janhavi Athale, Tegan K Boehmer, Adi V Gundlapalli, William Bentley, S Deblina Datta, Robert L Danner, Cumhur Y Demirkale, Sarah Warner,

<h4>Background</h4>Several U.S. hospitals had surges in COVID-19 caseload, but their effect on COVID-19 survival rates remains unclear, especially independent of temporal changes in survival.<h4>Objective</h4>To determine the association between hospitals' severity-weighted COVID-19 caseload and COVID-19 mortality risk and identify effect modifiers of this relationship.<h4>Design</h4>Retrospective cohort study. (ClinicalTrials.gov: NCT04688372).<h4>Setting</h4>558 U.S. hospitals in ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(9):1240-1251]

Cited: 2 times

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Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals.

Mohammad Alrawashdeh, Michael Klompas, Simeon Kimmel, Marc R Larochelle, Runa H Gokhale, Raymund B Dantes, Brooke Hoots, Kelly M Hatfield, Sujan C Reddy, Anthony E Fiore, Edward J Septimus, Sameer S Kadri, Russell Poland, Kenneth Sands, Chanu Rhee, ,

<h4>Objectives</h4>Widespread use and misuse of prescription and illicit opioids have exposed millions to health risks including serious infectious complications. Little is known, however, about the association between opioid use and sepsis.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>About 373 U.S. hospitals.<h4>Patients</h4>Adults hospitalized between January 2009 and September 2015.<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Sepsis was identified by clinical ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Incidence, Characteristics, and Outcomes of Ventilator-Associated Events during the COVID-19 Pandemic.

Jeremy Weinberger, Chanu Rhee, Michael Klompas, ,

<h4>Rationale</h4>Ventilator-associated event (VAE) surveillance provides an objective means to measure and compare complications that develop during mechanical ventilation by identifying patients with sustained increases in ventilator settings after a period of stable or decreasing ventilator settings. The impact of the Covid-19 pandemic on VAE rates and characteristics is unknown.<h4>Objectives</h4>To compare ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, :]

Cited: 0 times

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The Risk of SARS-CoV-2 Transmission from Patients with Undiagnosed Covid-19 to Roommates in a Large Academic Medical Center.

Abraar Karan, Michael Klompas, Robert Tucker, Meghan Baker, Vineeta Vaidya, Chanu Rhee, ,

We assessed SARS-CoV-2 transmission between patients in shared rooms in an academic hospital between September 2020-April 2021. 11,290 patients were admitted to shared rooms, of whom 25 tested positive. Among 31 exposed roommates, 12 (39%) tested positive within 14 days. Transmission was associated with PCR cycle thresholds ≤21. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 2 times

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Nonventilator hospital-acquired pneumonia: A call to action.

Shannon C Munro, Dian Baker, Karen K Giuliano, Sheila C Sullivan, Judith Haber, Barbara E Jones, Matthew B Crist, Richard E Nelson, Evan Carey, Olivia Lounsbury, Michelle Lucatorto, Ryan Miller, Brian Pauley, Michael Klompas,

In 2020 a group of U.S. healthcare leaders formed the National Organization to Prevent Hospital-Acquired Pneumonia (NOHAP) to issue a call to action to address non-ventilator-associated hospital-acquired pneumonia (NVHAP). NVHAP is one of the most common and morbid healthcare-associated infections, but it is not tracked, reported, or actively prevented by ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2021, 42(8):991-996]

Cited: 0 times

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Universal Use of N95s in Healthcare Settings when Community Covid-19 Rates are High.

Michael Klompas, Chanu Rhee, Meghan Baker,

CDC now recommends N95 respirators for all providers seeing patients with possible or confirmed Covid-19. We suggest, however, that N95s may be just as important for the care of patients without suspected Covid-19 when community incidence rates are high. This is because SARS-CoV-2 is most contagious before symptom onset. Ironically, ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 0 times

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