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Author Michael Gold

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

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Modified Design of Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-responders, Previously Untreatable and High-Risk Upgrade Patients (SOLVE-CRT) Trial.

Jagmeet P Singh, Mary Norine Walsh, Spencer H Kubo, Angelo Auricchio, Peter Paul Delnoy, Michael R Gold, Prashanthan Sanders, JoAnn Lindenfeld, Christopher A Rinaldi, Steven Ullery,

The WiSE system is a novel, leadless endocardial system that can provide cardiac resynchronization therapy in patients who cannot be treated with a conventional epicardial left ventricular lead. Safety and efficacy was being evaluated in the pivotal, randomized, double-blind SOLVE-CRT Trial (Stimulation of the Left Ventricular Endocardium for Cardiac Resynchronization ... Read more >>

Am Heart J (American heart journal)
[2021, :]

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Clascoterone cream (1%) topical androgen receptor inhibitor for the treatment of acne in patients 12 years and older.

Michael H Gold,

<h4>Introduction</h4>The efficacy of clascoterone cream was demonstrated in two phase three vehicle-controlled clinical trials that enrolled over 1,400 subjects. Its safety profile allowed it to be approved for treating patients as young as 12 years old. During clinical trials, the occurrence of local skin reactions (edema, erythema, pruritus, dryness) was ... Read more >>

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2021, :]

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Commentary on: A Randomized, Double-Blind, Split-Body, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Tolerability of a Topical Firming Moisturizer for Upper Arm Rejuvenation.

Michael H Gold,

Aesthet Surg J (Aesthetic surgery journal)
[2021, :]

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Redefining the Classifications of Response to Cardiac Resynchronization Therapy: Results From the REVERSE Study.

Michael R Gold, John Rickard, J Claude Daubert, Patrick Zimmerman, Cecilia Linde,

This study sought to assess the impact of a more detailed classification of response on survival. Cardiac resynchronization therapy (CRT) improves functional status and outcomes in selected populations with heart failure (HF). However, approximately 30% of patients do not improve with CRT by various metrics, and they are traditionally classified ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

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JCD Editorial-March 2021.

Michael H Gold,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(3):709-710]

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Current Models for Development of Disease-Modifying Osteoarthritis Drugs.

Meagan J Makarczyk, Qi Gao, Yuchen He, Zhong Li, Michael S Gold, Mark C Hochberg, Bruce A Bunnell, Rocky S Tuan, Stuart B Goodman, Hang Lin,

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy. Furthermore, there are currently no disease-modifying OA drugs (DMOADs) with demonstrated efficacy in OA patients, which is, in part, attributed to a lack of full understanding of the ... Read more >>

Tissue Eng Part C Methods (Tissue engineering. Part C, Methods)
[2021, 27(2):124-138]

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Commentary on: Bipolar Radio Frequency as an Adjunct to Face and Body Contouring: A 745-Patient Clinical Experience.

Michael H Gold,

Aesthet Surg J (Aesthetic surgery journal)
[2021, :]

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Outcomes of two versus three incision techniques: Results from the subcutaneous ICD post-approval study.

Mikhael El-Chami, Raul Weiss, Martin C Burke, Michael R Gold, Jordan M Prutkin, Gautham Kalahasty, Sharon Shen, Michael J Mirro, Nathan Carter, Johan D Aasbo,

<h4>Background</h4>Traditionally, implantation of the subcutaneous implantable cardioverter defibrillator (S-ICD) requires incisions near the lateral chest wall, the xyphoid, and the superior sternal region (three-incision technique [3IT]). A two-incision technique (2IT) avoids the superior incision and has been shown to be a viable alternative in small studies with limited follow-up.<h4>Objectives</h4>To report ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, :]

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Positive Psychotherapy Improves Cardiac Electrical Stability and Mood in ICD Patients: PAM-ICD Trial Results.

Eva R Serber, Lillian M Christon, Joseph L Fava, Richard L Verrier, Bruce D Nearing, Alfred E Buxton, Michael R Gold, James R Rodrigue, Michael B Frisch,

Psychosom Med (Psychosomatic medicine)
[2021, :]

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Predicting complete heart block after alcohol septal ablation for hypertrophic cardiomyopathy using a risk stratification model and clinical tool.

Ahmadreza Karimianpour, Justin Heizer, Davis Leaphart, Jeremy D Rier, Shawn Shaji, Viswanathan Ramakrishnan, Christopher D Nielsen, Valerian L Fernandes, Michael R Gold,

<h4>Background</h4>Alcohol septal ablation (ASA) is a proven method of septal reduction for patients with drug refractory, symptomatic hypertrophic obstructive cardiomyopathy (HOCM). This procedure is associated with a 6.5-11% risk of complete heart block (CHB).<h4>Objective</h4>The aim of this study is to determine factors that predict CHB and to develop a clinical ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2021, :]

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JCD - January 2021 Editorial.

Michael H Gold,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(1):5]

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JCD editorial-February 2021.

Michael H Gold,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(2):371]

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OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule.

Gladymar Perez Chacon, Marie J Estcourt, James Totterdell, Dianne E Campbell, Kirsten P Perrett, Julie A Marsh, Peter C Richmond, Nicholas Wood, Michael S Gold, Patrick G Holt, Claire S Waddington, Thomas L Snelling,

<h4>Introduction</h4>Combination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and 1999 and replaced by the less reactogenic acellular pertussis (aP) antigens. In a large case-control study of Australian children born during the transition period, those with allergist diagnosed IgE-mediated food allergy were ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e042838]

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Device-Detected Atrial Fibrillation Before and After Hospitalization for Non-cardiac Surgery or Medical Illness: Insights from ASSERT.

William F McIntyre, Jia Wang, Alexander P Benz, Emilie P Belley-Côté, David Conen, P J Devereaux, Jorge A Wong, Stefan H Hohnloser, Alessandro Capucci, Chu-Pak Lau, Michael R Gold, Carsten W Israel, Richard P Whitlock, Stuart J Connolly, Jeff S Healey,

<h4>Background</h4>Atrial fibrillation (AF) is often detected during hospitalization for surgery or medical illness and is often assumed to be due to the acute condition.<h4>Methods</h4>ASSERT enrolled patients >65 years old without AF. Pacemakers or implantable cardioverter defibrillators recorded device-detected AF. We identified participants who were hospitalized and compared the prevalence of ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, :]

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To click or not to click - The importance of understanding the layers of the forehead when injecting neuromodulators - A clinical, prospective, interventional, split-face study.

Kristina Davidovic, Dmitry V Melnikov, Konstantin Frank, Diana Gavril, Jeremy B Green, David L Freytag, Stephan Heisinger, Tatjana Pavicic, Michael H Gold, Sebastian Cotofana,

<h4>Background</h4>Differences in the effectiveness of neuromodulator treatments for horizontal forehead lines dependent on depth of product administration have been described. However, knowledge in respect to the fascial anatomy of the forehead still remains elusive.<h4>Aims</h4>To relate the fascial anatomy of the forehead to the effectiveness of neuromodulator treatments by conducting a ... Read more >>

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2020, :]

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JCD-Editorial for December, 2020.

Michael H Gold,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2020, 19(12):3157]

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Meta-analysis comparing outcomes of catheter ablation for ventricular arrhythmia in ischemic versus nonischemic cardiomyopathy.

Indranill Basu-Ray, Dibbendhu Khanra, Sumit K Shah, Anindya Mukherjee, Sudhanva V Char, Bhavna Jain, T Jared Bunch, Michael Gold, Adedayo A Adeboye, Mohammad Saeed,

<h4>Background</h4>Catheter ablation is an effective treatment for ventricular arrhythmia (VA) in ischemic cardiomyopathy (ICM). However, results in non-ICM (NICM) patients are not satisfactory, and studies comparing differences between NICM and ICM are limited. We conducted a meta-analysis of procedural characteristics and long-term outcomes of catheter ablation for VA, comparing results ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(1):54-62]

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Laser therapy in the treatment of cicatricial ectropion.

Hua-Wei Ouyang, Michael H Gold, Ying Lei, Jun Tan,

<h4>Introduction</h4>The objective of this study was to investigate the clinical effects of laser therapy in treating cicatricial ectropion.<h4>Methods</h4>Seven patients with cicatricial ectropion were entered into this clinical study. The ectropions were pretreated with the 595-nm pulsed dye laser if the scar color was red. If there was no red, the ... Read more >>

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(1):84-92]

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Effects of Tazarotene 0.045% Lotion on Quality of Life in Patients With Moderate-to-Severe Acne.

Leon H Kircik, Edward Lain, Michael Gold, Bruce Katz, Hilary Baldwin, Eric Guenin, Anya Loncaric, Radhakrishnan Pillai,

<h4>Background</h4>In two phase 3 trials (NCT03168334, NCT03168321), participants with moderate-to-severe acne had significant symptom improvements after 12 weeks of treatment with tazarotene 0.045% lotion. Given the negative psychosocial effects of acne on patients, data from these studies were analyzed to evaluate quality of life in various subgroups.<h4>Methods</h4>Mean changes from baseline ... Read more >>

J Drugs Dermatol (Journal of drugs in dermatology : JDD)
[2020, 19(11):1086-1092]

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JCD Editorial-November 2020.

Michael H Gold,

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2020, 19(11):2777]

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Economic implications of adding a novel algorithm to optimize cardiac resynchronization therapy: rationale and design of economic analysis for the AdaptResponse trial.

Gerasimos Filippatos, Xiaoxiao Lu, Stelios I Tsintzos, Michael R Gold, Wilfried Mullens, David Birnie, Ahmad S Hersi, Kengo Kusano, Christophe Leclercq, Dedra H Fagan, Bruce L Wilkoff,

<h4>Aims</h4>Although cardiac resynchronization therapy (CRT) has proven beneficial in several randomized trials, a subset of patients have limited clinical improvement. The AdaptivCRT algorithm provides automated selection between synchronized left ventricular or biventricular pacing with optimization of atrioventricular delays. The rationale and design of the economic analysis of the AdaptResponse clinical ... Read more >>

J Med Econ (Journal of medical economics)
[2020, :1-8]

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Retraction Note to: Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial.

Robert Boyle, Nick Brown, Wen Chin Chiang, Chua Mei Chien, Michael Gold, Jonathan Hourihane, Jane Peake, Patrick Quinn, Raj Rao, Peter Smith, Mimi Tang, John Ziegler, John Warner,

[This retracts the article DOI: 10.1186/2045-7022-5-S3-P30.]. ... Read more >>

Clin Transl Allergy (Clinical and translational allergy)
[2020, 10:48]

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Healthcare utilization and cost in patients with atrial fibrillation and heart failure undergoing catheter ablation.

Michael E Field, Michael R Gold, Motiur Rahman, Laura Goldstein, Sonia Maccioni, Abhishek Srivastava, Rahul Khanna, Jonathan P Piccini, Daniel J Friedman,

<h4>Background</h4>Catheter ablation is an effective treatment for patients with atrial fibrillation (AF) and heart failure (HF). However, little is known about how healthcare utilization and cost change after ablation in this population. We sought to determine healthcare utilization and cost patterns among patients with AF and HF undergoing ablation.<h4>Methods</h4>Using a ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(12):3166-3175]

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Primary Results From the Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction (UNTOUCHED) Trial.

Michael R Gold, Pier D Lambiase, Mikhael F El-Chami, Reinoud E Knops, Johan D Aasbo, Maria Grazia Bongiorni, Andrea M Russo, Jean-Claude Deharo, Martin C Burke, Jay Dinerman, Craig S Barr, Naushad Shaik, Nathan Carter, Thomas Stoltz, Kenneth M Stein, Amy J Brisben, Lucas V A Boersma, ,

<h4>Background</h4>The subcutaneous (S) implantable cardioverter-defibrillator (ICD) is safe and effective for sudden cardiac death prevention. However, patients in previous S-ICD studies had fewer comorbidities, had less left ventricular dysfunction, and received more inappropriate shocks (IAS) than in typical transvenous ICD trials. The UNTOUCHED trial (Understanding Outcomes With the S-ICD in ... Read more >>

Circulation (Circulation)
[2021, 143(1):7-17]

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