Full Text Journal Articles by
Author Michael F Waters


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Trajectories of stroke recovery of impairment, function, and quality of life in response to 12-month mobility and fitness intervention.

Catherine Boissoneault, Dorian K Rose, Tyler Grimes, Michael F Waters, Anna Khanna, Somnath Datta, Janis J Daly,

<h4>Background</h4>Gait deficits and functional disability are persistent problems for many stroke survivors, even after standard neurorehabilitation. There is little quantified information regarding the trajectories of response to a long-dose, 12-month intervention.<h4>Objective</h4>We quantified treatment response to an intensive neurorehabilitation mobility and fitness program.<h4>Methods</h4>The 12-month neurorehabilitation program targeted impairments in balance, limb ... Read more >>

NeuroRehabilitation (NeuroRehabilitation)
[2021, 49(4):573-584]

Cited: 0 times

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Spatial Mechanisms for Segregation of Competing Sounds, and a Breakdown in Spatial Hearing.

John C Middlebrooks, Michael F Waters,

We live in complex auditory environments, in which we are confronted with multiple competing sounds, including the cacophony of talkers in busy markets, classrooms, offices, etc. The purpose of this article is to synthesize observations from a series of experiments that focused on how spatial hearing might aid in disentangling ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:571095]

Cited: 1 time

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Comparison of aspiration-first versus stentriever-first techniques in performing mechanical thrombectomy for large vessel occlusions.

Vance L Fredrickson, Phillip A Bonney, Shivani D Rangwala, Joshua S Catapano, Tyler S Cole, Daniel D Cavalcanti, Neil Majmundar, D Andrew Wilkinson, Luis San Roman, Michael F Waters, Felipe C Albuquerque, Andrew F Ducruet,

<h4>Background</h4>Both stentriever and direct-aspiration thrombectomy effectively treat large-vessel occlusions. However, data are limited comparing clinical outcomes after aspiration-first versus stentriever-assisted aspiration for thrombectomy.<h4>Methods</h4>A retrospective cohort study compared procedure times and radiographic outcomes after two mechanical thrombectomy techniques (aspiration first or stentriever). To minimize bias and variability inherent to multi-operator series, ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2021, 13(7):614-618]

Cited: 1 time

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Innovative Long-Dose Neurorehabilitation for Balance and Mobility in Chronic Stroke: A Preliminary Case Series.

Catherine Boissoneault, Tyler Grimes, Dorian K Rose, Michael F Waters, Anna Khanna, Somnath Datta, Janis J Daly,

(1) Objective: The objective was two-fold: (a) test a protocol of combined interventions; (b) administer this combined protocol within the framework of a six-month, intensive, long-duration program. The array of interventions was designed to target the treatment-resistant impairments underlying persistent mobility dysfunction: weakness, balance deficit, limb movement dyscoordination, and gait ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(8):]

Cited: 3 times

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Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury.

Kumar Vaibhav, Molly Braun, Katelyn Alverson, Hesam Khodadadi, Ammar Kutiyanawalla, Ayobami Ward, Christopher Banerjee, Tyler Sparks, Aneeq Malik, Mohammad H Rashid, Mohammad Badruzzaman Khan, Michael F Waters, David C Hess, Ali S Arbab, John R Vender, Nasrul Hoda, Babak Baban, Krishnan M Dhandapani,

Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Preventative measures reduce injury incidence and/or severity, yet one-third of hospitalized patients with TBI die from secondary pathological processes that develop during supervised care. Neutrophils, which orchestrate innate immune responses, worsen TBI outcomes via undefined mechanisms. We hypothesized ... Read more >>

Sci Adv (Science advances)
[2020, 6(22):eaax8847]

Cited: 15 times

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Spinocerebellar Ataxia Type 13

Michael F Waters,

<h4>Clinical characteristics</h4>Spinocerebellar ataxia type 13 (SCA13) is a phenotypic spectrum that includes both non-progressive infantile-onset ataxia and progressive childhood-onset and adult-onset cerebellar ataxia. Three phenotypes are seen: Cerebellar hypoplasia with non-progressive infantile-onset limb, truncal, and gait ataxia with mild-to-moderate intellectual disability and occasionally seizures and/or psychiatric manifestations. Cognition and motor ... Read more >>

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Cited: 0 times

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Surgical Approaches to Stroke Risk Reduction.

Michael F Waters,

<h4>Purpose of review</h4>Surgical vascular intervention is an important tool in reducing the risk of stroke. This article examines the evidence for using the available options.<h4>Recent findings</h4>Carotid endarterectomy is an effective treatment option for reducing the risk of stroke in appropriately selected patients. Patients should be stratified for future stroke risk ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(2):457-477]

Cited: 1 time

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C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke.

Saif Ahmad, Chirayu Pandya, Adam Kindelin, Kanchan Bhatia, Rafay Chaudhary, Alok Kumar Dwivedi, Jennifer M Eschbacher, Qiang Liu, Michael F Waters, Md Nasrul Hoda, Andrew F Ducruet,

<h4>Background and purpose</h4>Intravenous thrombolysis (IVT) after stroke enhances C3a generation, which may abrogate the benefits of reperfusion. The C3aR antagonist SB290157 is neuroprotective following transient but not permanent middle cerebral artery occlusion (MCAo). SB290157 remains untested in thromboembolic (TE) models, which better approximate human stroke and also facilitate testing in ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(11):2466-2477]

Cited: 5 times

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Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis.

Ashley M Wabnitz, Colin P Derdeyn, David J Fiorella, Michael J Lynn, George A Cotsonis, David S Liebeskind, Michael F Waters, Helmi Lutsep, Elena López-Cancio, Tanya N Turan, Jean Montgomery, L Scott Janis, Bethany Lane, Marc I Chimowitz, ,

Background and Purpose- Although aggressive medical therapy was superior to stenting in the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), the stroke rate in the medical arm was still high. The aim of this study was to determine the association between hemodynamic markers ... Read more >>

Stroke (Stroke)
[2018, :STROKEAHA118020840]

Cited: 9 times

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Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow.

De-Cai Tian, Kaibin Shi, Zilong Zhu, Jia Yao, Xiaoxia Yang, Lei Su, Sheng Zhang, Meixia Zhang, Rayna J Gonzales, Qiang Liu, DeRen Huang, Michael F Waters, Kevin N Sheth, Andrew F Ducruet, Ying Fu, Min Lou, Fu-Dong Shi,

<h4>Objective</h4>The present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window.<h4>Methods</h4>This was a prospective, randomized, open-label, blinded endpoint clinical trial, enrolling patients with internal carotid artery or middle cerebral artery proximal occlusion within 4.5 to 6 ... Read more >>

Ann Neurol (Annals of neurology)
[2018, 84(5):717-728]

Cited: 24 times

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C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity.

Swati Khare, Kira Galeano, Yalan Zhang, Jerelyn A Nick, Harry S Nick, S H Subramony, Jacinda Sampson, Leonard K Kaczmarek, Michael F Waters,

Mutations in the potassium channel gene KCNC3 (Kv3.3) cause the autosomal dominant neurological disease, spinocerebellar ataxia 13 (SCA13). In this study, we expand the genotype-phenotype repertoire of SCA13 by describing the novel KCNC3 deletion p.Pro583_Pro585del highlighting the allelic heterogeneity observed in SCA13 patients. We characterize adult-onset, progressive clinical symptoms of ... Read more >>

Cerebellum (Cerebellum (London, England))
[2018, 17(5):692-697]

Cited: 1 time

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Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach.

Douglas M Bennion, Chad H Jones, Alex N Dang, Jacob Isenberg, Justin T Graham, Lena Lindblad, Oliver Domenig, Michael F Waters, Marko Poglitsch, Colin Sumners, Ulrike Muscha Steckelings,

Significant neuroprotective effects of angiotensin II type 2 (AT2) receptor (AT2 receptor) agonists in ischemic stroke have been previously demonstrated in multiple studies. However, the routes of agonist application used in these pre-clinical studies, direct intracerebroventricular (ICV) and systemic administration, are unsuitable for translation into humans; in the latter case ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2018, 132(5):581-593]

Cited: 8 times

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Smoking cessation and outcome after ischemic stroke or TIA.

Katherine A Epstein, Catherine M Viscoli, J David Spence, Lawrence H Young, Silvio E Inzucchi, Mark Gorman, Brett Gerstenhaber, Peter D Guarino, Anand Dixit, Karen L Furie, Walter N Kernan, ,

<h4>Objective</h4>To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking.<h4>Methods</h4>We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized to pioglitazone or placebo within 180 days of ... Read more >>

Neurology (Neurology)
[2017, 89(16):1723-1729]

Cited: 13 times

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Stroke Hospital Characteristics in the Florida-Puerto Rico Collaboration to Reduce Stroke Disparities Study.

Maria A Ciliberti-Vargas, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Li Yi, Jose G Romano, Mary Robichaux, Salina P Waddy, Ulises Nobo, Sandra Diaz-Acosta, Tatjana Rundek, Michael F Waters, Ralph L Sacco,

<h4>Objectives</h4>Although disparities in stroke care and outcomes have been well documented nationally, state-based registries to monitor acute stroke care in Florida (FL) and Puerto Rico (PR) have not been established. The FL-PR Collaboration to Reduce Stroke Disparities (CReSD) was developed to evaluate race-ethnicity and regional disparities in stroke care performance. ... Read more >>

South Med J (Southern medical journal)
[2017, 110(7):466-474]

Cited: 4 times

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A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.

Swati Khare, Jerelyn A Nick, Yalan Zhang, Kira Galeano, Brittany Butler, Habibeh Khoshbouei, Sruti Rayaprolu, Tyisha Hathorn, Laura P W Ranum, Lisa Smithson, Todd E Golde, Martin Paucar, Richard Morse, Michael Raff, Julie Simon, Magnus Nordenskjöld, Karin Wirdefeldt, Diego E Rincon-Limas, Jada Lewis, Leonard K Kaczmarek, Pedro Fernandez-Funez, Harry S Nick, Michael F Waters,

The autosomal dominant spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders anchored by the phenotypes of motor incoordination and cerebellar atrophy. Disease heterogeneity is appreciated through varying comorbidities: dysarthria, dysphagia, oculomotor and/or retinal abnormalities, motor neuron pathology, epilepsy, cognitive impairment, autonomic dysfunction, and psychiatric manifestations. Our study focuses ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0173565]

Cited: 11 times

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Racial-Ethnic Disparities in Acute Stroke Care in the Florida-Puerto Rico Collaboration to Reduce Stroke Disparities Study.

Ralph L Sacco, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Maria A Ciliberti-Vargas, Carolina M Gutierrez, Negar Asdaghi, W Scott Burgin, Olveen Carrasquillo, Enid J Garcia-Rivera, Ulises Nobo, Sofia Oluwole, David Z Rose, Michael F Waters, Juan Carlos Zevallos, Mary Robichaux, Salina P Waddy, Jose G Romano, Tatjana Rundek, ,

<h4>Background</h4>Racial-ethnic disparities in acute stroke care can contribute to inequality in stroke outcomes. We examined race-ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines-Stroke hospitals.<h4>Methods and results</h4>Seventy-five sites in the Florida Puerto Rico Stroke Registry (66 Florida and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(2):]

Cited: 15 times

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Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.

Douglas M Bennion, Christian A Rosado, Emily A Haltigan, Robert W Regenhardt, Colin Sumners, Michael F Waters,

Levels of angiotensin converting enzyme 2 (ACE2), a cardio and neuro-protective carboxypeptidase, are dynamically altered after stroke in preclinical models. We sought to characterize the previously unexplored changes in serum ACE2 activity of stroke patients and the mechanism of these changes. Serum samples were obtained from patients during acute ischemic ... Read more >>

J Renin Angiotensin Aldosterone Syst (Journal of the renin-angiotensin-aldosterone system : JRAAS)
[2016, 17(3):]

Cited: 12 times

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Thoracoscopic Ablation With Appendage Ligation Versus Medical Therapy for Stroke Prevention: A Proof-of-Concept Randomized Trial.

Thomas M Beaver, Vishnumurthy Shushrutha Hedna, Anna Y Khanna, William M Miles, Catherine C Price, Ilona M Schmalfuss, Seyed Hossein Aalaei-Andabili, Michael F Waters,

<h4>Objective</h4>Atrial fibrillation (AF) has a demonstrable effect on quality of life (QOL). Recurrent stroke occurs in 10% of patients with AF. The objective of this study was to demonstrate proof of concept that thoracoscopic pulmonary vein isolation and atrial appendage ligation (TPVIAL) could prevent recurrent stroke and could potentially improve ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2016, 11(2):99-105]

Cited: 4 times

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Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial.

Michael F Waters, Brian L Hoh, Michael J Lynn, Hyung-Min Kwon, Tanya N Turan, Colin P Derdeyn, David Fiorella, Anna Khanna, Tiffany O Sheehan, Bethany F Lane, Scott Janis, Jean Montgomery, Marc I Chimowitz, ,

<h4>Importance</h4>The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial showed that aggressive medical therapy was more effective than stenting for preventing stroke in patients with symptomatic intracranial stenosis. However, 15% of patients in the medical group still experienced a primary end point during a ... Read more >>

JAMA Neurol (JAMA neurology)
[2016, 73(3):308-315]

Cited: 16 times

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Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.

Yalan Zhang, Xiao-Feng Zhang, Matthew R Fleming, Anahita Amiri, Lynda El-Hassar, Alexei A Surguchev, Callen Hyland, David P Jenkins, Rooma Desai, Maile R Brown, Valeswara-Rao Gazula, Michael F Waters, Charles H Large, Tamas L Horvath, Dhasakumar Navaratnam, Flora M Vaccarino, Paul Forscher, Leonard K Kaczmarek,

Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3. We found that Kv3.3 recruits Arp2/3 to the plasma membrane, resulting in formation of a relatively stable ... Read more >>

Cell (Cell)
[2016, 165(2):434-448]

Cited: 28 times

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Rare neurological channelopathies--networks to study patients, pathogenesis and treatment.

Joanna C Jen, Tetsuo Ashizawa, Robert C Griggs, Michael F Waters,

Each of the thousands of rare neurological diseases requires a widely distributed network of centres, investigators and patients, so as to foster multidisciplinary investigations and involve sufficient numbers of patients in the discovery of disease pathogenesis and novel treatment. In this Review, we highlight the value of this collaborative approach ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2016, 12(4):195-203]

Cited: 5 times

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CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

Brian L Hoh, Yan Gong, Caitrin W McDonough, Michael F Waters, Adrienne J Royster, Tiffany O Sheehan, Ben Burkley, Taimour Y Langaee, J Mocco, Scott L Zuckerman, Nishit Mummareddy, Marcus L Stephens, Christie Ingram, Christian M Shaffer, Joshua C Denny, Murray H Brilliant, Terrie E Kitchner, James G Linneman, Dan M Roden, Julie A Johnson,

OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but have not been studied in ICAD. The authors studied CYP2C19 and CES1 single-nucleotide polymorphisms (SNPs) in symptomatic ICAD patients. METHODS Genotype testing ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2016, 124(6):1746-1751]

Cited: 11 times

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Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage.

Jenna L Leclerc, Spiros Blackburn, Dan Neal, Nicholas V Mendez, Jeffrey A Wharton, Michael F Waters, Sylvain Doré,

Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Free hemoglobin (Hb) within the subarachnoid space has been implicated in the pathogenesis of CV. Haptoglobin (Hp) binds free pro-oxidant Hb, thereby modulating its harmful effects. Humans can be of ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2015, 112(4):1155-1160]

Cited: 24 times

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Vagus nerve stimulation in ischemic stroke: old wine in a new bottle.

Peter Y Cai, Aakash Bodhit, Roselle Derequito, Saeed Ansari, Fawzi Abukhalil, Spandana Thenkabail, Sarah Ganji, Pradeepan Saravanapavan, Chandana C Shekar, Sharatchandra Bidari, Michael F Waters, Vishnumurthy Shushrutha Hedna,

Vagus nerve stimulation (VNS) is currently Food and Drug Administration-approved for treatment of both medically refractory partial-onset seizures and severe, recurrent refractory depression, which has failed to respond to medical interventions. Because of its ability to regulate mechanisms well-studied in neuroscience, such as norepinephrine and serotonin release, the vagus nerve ... Read more >>

Front Neurol (Frontiers in neurology)
[2014, 5:107]

Cited: 30 times

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Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism.

Justin S Bickford, Narjis F Ali, Jerelyn A Nick, Musab Al-Yahia, Dawn E Beachy, Sylvain Doré, Harry S Nick, Michael F Waters,

Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm, ischemia, reperfusion and the activation of various pathways. Given the ... Read more >>

Brain Res (Brain research)
[2014, 1588:25-36]

Cited: 6 times

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