Full Text Journal Articles by
Author Michael Eisenhut

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Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view.

Andreas Kronbichler, Maria Effenberger, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin,

Now COVID-19 is causing a severe public health emergency and the mortality is rapidly increasing all over the world. In the current pandemic era, although there have been many efforts to diagnose a number of patients with symptoms or close contacts in the world to prevent the spread in the ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, :102570]

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Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review.

Jae Hyon Park, Keum Hwa Lee, Bokyoung Jeon, Hans D Ochs, Joon Suk Lee, Heon Yung Gee, Seeun Seo, Dongil Geum, Ciriaco A Piccirillo, Michael Eisenhut, Hans J van der Vliet, Jiwon M Lee, Andreas Kronbichler, Younhee Ko, Jae Il Shin,

BACKGROUND:Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder characterized by early onset fatal multi-system autoimmunity due to loss-of-function mutations in the gene encoding the forkhead box P3 (FOXP3) transcription factor which is crucial for the development, maturation, and maintenance of CD4+ regulatory T (T-reg) cells. Various autoimmune ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, 19(6):102526]

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Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis.

Jae Hyon Park, Gwang Hun Jeong, Kwang Seob Lee, Keum Hwa Lee, Jin-Soon Suh, Michael Eisenhut, Hans J van der Vliet, Andreas Kronbichler, Brendon Stubbs, Marco Solmi, Elena Dragioti, Ai Koyanagi, Jae Il Shin, Gabriele Gamerith,

BACKGROUND:Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. METHOD:We searched PubMed and investigated the results of ... Read more >>

Eur. J. Clin. Invest. (European journal of clinical investigation)
[2020, 50(4):e13203]

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Statin and Cancer Mortality and Survival: An Umbrella Systematic Review and Meta-Analysis.

Gwang Hun Jeong, Keum Hwa Lee, Jong Yeob Kim, Michael Eisenhut, Andreas Kronbichler, Hans J van der Vliet, Jae Il Shin, Gabriele Gamerith,

The aim of this study is to provide an overview and understand the strength of evidence and the extent of potential biases and the validity of claimed associations between the use of statins and cancer mortality or survival. We performed a comprehensive umbrella review of meta-analyses and systematically appraised the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Treatment of Refractory Henoch-Schonlein Purpura (HSP) with Dapsone: A Systematic Review.

Keum Hwa Lee, Sung Hwi Hong, Jinhae Jun, Youngheun Jo, Woogyeong Jo, Dayeon Choi, Jeongho Joo, Guhyun Jung, Sunghee Ahn, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin,

Henoch-Schonlein Purpura (HSP) is a systemic IgA-mediated vasculitis of small vessels common in children. The natural history of HSP is generally self-limiting, however, one third of patients experience recurrence of symptoms showing refractory courses. Our objective was to generate a systematic review of the use of dapsone in refractory HSP. ... Read more >>

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, :]

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Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.

Jong Yeob Kim, Andreas Kronbichler, Michael Eisenhut, Sung Hwi Hong, Hans J van der Vliet, Jeonghyun Kang, Jae Il Shin, Gabriele Gamerith,

Tumor mutational burden (TMB) is a genomic biomarker that predicts favorable responses to immune checkpoint inhibitors (ICIs). Here, we set out to assess the predictive value of TMB on long-term survival outcomes in patients undergoing ICIs. We systematically searched PubMed, Embase, CENTRAL and clinicaltrials.gov from inception to 6 August 2019. ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

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Efficacy of Cancer Immunotherapy: An Umbrella Review of Meta-analyses of Randomized Controlled Trials.

Jong Yeob Kim, Keum Hwa Lee, Michael Eisenhut, Hans J van der Vliet, Andreas Kronbichler, Gwang Hun Jeong, Jae Il Shin, Gabriele Gamerith,

We conducted a systematic review for evidence of the clinical efficacy of cancer immunotherapies. We searched PubMed from inception to 14 February 2018 for meta-analyses of randomized controlled trials (RCTs) of cancer immunotherapies. Re-analyses were performed to estimate the summary effect size under random-effects, the 95% confidence interval (CI), heterogeneity, ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(11):]

Cited: 1 time

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Environmental risk factors and biomarkers for autism spectrum disorder: an umbrella review of the evidence.

Jong Yeob Kim, Min Ji Son, Chei Yun Son, Joaquim Radua, Michael Eisenhut, Florence Gressier, Ai Koyanagi, Andre F Carvalho, Brendon Stubbs, Marco Solmi, Theodor B Rais, Keum Hwa Lee, Andreas Kronbichler, Elena Dragioti, Jae Il Shin, Paolo Fusar-Poli,

BACKGROUND:Numerous studies have identified potential risk factors and biomarkers for autism spectrum disorder. We aimed to study the strength and validity of the suggested environmental risk factors or biomarkers of autism spectrum disorder. METHODS:We did an umbrella review and systematically appraised the relevant meta-analyses of observational studies. We searched PubMed, ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2019, 6(7):590-600]

Cited: 1 time

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Stimulation of Nucleotide Oligomerization Domain and Toll-Like Receptors 2 to Enhance the Effect of Bacillus Calmette Guerin Immunization for Prevention of Mycobacterium Tuberculosis Infection: Protocol for a Series of Preclinical Randomized Controlled Trials.

Michael Eisenhut,

BACKGROUND:Bacillus calmette guerin (BCG) immunization has been associated with a reduction in Mycobacterium tuberculosis (MTB) infection. BCG immunization has been shown to enhance innate immunity. This effect of BCG can be explained by an enhancing effect on innate immunity. OBJECTIVE:This study aimed to test the following hypotheses: (1) BCG immunization ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2019, 8(6):e13045]

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Neurodisability with Severe Restriction of Mobility Is Associated with Reduced Serum Creatinine Values.

Chun Lim, Marianne Phillips, Liam Watson, Michael Eisenhut,

Introduction:We investigated whether reduced mobility is associated with a reduction in serum creatinine in otherwise well children with neurodisability. Materials and Methods:This was a record based retrospective study and creatinine levels of children in groups with Gross Motor Function Classification System (GMFCS) category 1, 2, or 3 (group I); GMFCS ... Read more >>

Int J Pediatr (International journal of pediatrics)
[2019, 2019:3598123]

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Effect of Statin on Cancer Incidence: An Umbrella Systematic Review and Meta-Analysis.

Gwang Hun Jeong, Keum Hwa Lee, Jong Yeob Kim, Michael Eisenhut, Andreas Kronbichler, Hans J van der Vliet, Sung Hwi Hong, Jae Il Shin, Gabriele Gamerith,

Statins are reported to reduce the risk of cancer, but the results of various published studies have been contradictory. We carried out an umbrella review to provide an overview and understand the strength of evidence, extent of potential biases, and validity of claimed associations between the use of statins and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(6):]

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Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation.

Nicholas J A Webb, Rebecca L Woolley, Tosin Lambe, Emma Frew, Elizabeth A Brettell, Emma N Barsoum, Richard S Trompeter, Carole Cummins, Jonathan J Deeks, Keith Wheatley, Natalie J Ives, ,

OBJECTIVE:To determine whether extending initial prednisolone treatment from eight to 16 weeks in children with idiopathic steroid sensitive nephrotic syndrome improves the pattern of disease relapse. DESIGN:Double blind, parallel group, phase III randomised placebo controlled trial, including a cost effectiveness analysis. SETTING:125 UK National Health Service district general hospitals and ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2019, 365:l1800]

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Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis.

Jiwon M Lee, Jae Won Yang, Andreas Kronbichler, Michael Eisenhut, Gaeun Kim, Keum Hwa Lee, Jae Il Shin,

Introduction:The soluble urokinase-type plasminogen activator receptor (suPAR) has been found to be elevated in primary focal segmental glomerulosclerosis (pFSGS). However, its usefulness as a biomarker for FSGS remains controversial. We conducted a meta-analysis aiming at investigating the significance of suPAR in diagnosing pFSGS. Methods:Electronic databases (PubMed and EMBASE) were searched ... Read more >>

J Immunol Res (Journal of immunology research)
[2019, 2019:5679518]

Cited: 3 times

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Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.

Kwang Seob Lee, Andreas Kronbichler, Daniel Fernando Pereira Vasconcelos, Felipe Rodolfo Pereira da Silva, Younhee Ko, Yeon Su Oh, Michael Eisenhut, Peter A Merkel, David Jayne, Christopher I Amos, Katherine A Siminovitch, Chinar Rahmattulla, Keum Hwa Lee, Jae Il Shin,

A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(2):]

Cited: 2 times

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Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis.

Gwang Hun Jeong, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet, Omar Abdel-Rahman, Brendon Stubbs, Marco Solmi, Nicola Veronese, Elena Dragioti, Ai Koyanagi, Joaquim Radua, Jae Il Shin,

Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(2):]

Cited: 1 time

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Cerebral tuberculomas in a 6-year-old girl causing central diabetes insipidus.

Shavindra Chellen, Elizabeth Whittaker, Michael Eisenhut, Louis Grandjean,

A 6-year-old girl presented acutely with worsening frontal headaches. She had a 3-month history of lethargy, reduced appetite, weight loss, cough and intermittent fevers. A chest X-ray showed a left upper lobe consolidation, and a CT head showed multiple enhancing lesions with significant surrounding oedema in both cerebral hemispheres. Due ... Read more >>

BMJ Case Rep (BMJ case reports)
[2018, 2018:]

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Hyponatremia in children with respiratory infections: a cross-sectional analysis of a cohort of 3938 patients.

Sung Won Park, Son Moon Shin, Moonsun Jeong, Dong-Hee Cho, Keum Hwa Lee, Michael Eisenhut, Andreas Kronbichler, Michael Moritz, Jae Il Shin,

Hyponatremia can be a life-threatening illness among hospitalized children. The aims of this study were to evaluate the incidence and risk factors of hyponatremia in 3938 children who were admitted to the Cheil General Hospital and Women's Health Care Center with respiratory infections. Clinical data were collected, and multiplex RT-PCR analyses ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):16494]

Cited: 2 times

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Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review.

Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet,

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(11):]

Cited: 1 time

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Bayesian statistical methods in genetic association studies: Empirical examination of statistically non-significant Genome Wide Association Study (GWAS) meta-analyses in cancers: A systematic review.

Jae Hyon Park, Dong Il Geum, Michael Eisenhut, Hans J van der Vliet, Jae Il Shin,

A Bayesian statistical method was developed to assess the noteworthiness of a single nucleotide polymorphism (SNP)-phenotype association that shows statistical significance in various observational studies, but it has seldom been applied to GWAS meta-analyses in cancers. Data (i.e. allelic frequency, odds ratio, 95% confidence interval, etc.) on various SNP-cancer associations ... Read more >>

Gene (Gene)
[2019, 685:170-178]

Cited: 1 time

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In diabetic ketoacidosis brain injury including cerebral oedema and infarction is caused by interleukin-1.

Michael Eisenhut,

BACKGROUND:Brain injury in diabetic ketoacidosis (DKA) is common but under recognized and affects up to 54% of patients with this complication. It's manifestations include cerebral oedema (CE) and cerebral infarction (CI). The etiology of CE in DKA has up to the present time been uncertain. Practical management had been guided ... Read more >>

Med. Hypotheses (Medical hypotheses)
[2018, 121:44-46]

Cited: 2 times

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The Potential Role of Steroid-Induced Cerebral Vasospasm in the Pathogenesis of Delayed Cerebral Injury in Bacterial Meningitis.

Michael Eisenhut,

Crit. Care Med. (Critical care medicine)
[2018, 46(8):1383-1384]

Cited: 0 times

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Adherence to biologic therapy - Does it vary with ethnicity?

Muhammad K Nisar, Waqas Mirza, Aneesa Rafiq, Michael Eisenhut,

BackgroundPoor adherence to therapy remains a significant barrier to improving clinical outcomes in rheumatic diseases and carries a major financial burden. It has been linked to medication related patient beliefs, which were reported to differ between ethnic groups. Little is known about these variations in biologic therapies cohorts. The purpose ... Read more >>

Biologicals (Biologicals : journal of the International Association of Biological Standardization)
[2018, 54:28-32]

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Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis.

Dong Yeon Jeong, Sang Woo Lee, Young Ha Park, Ji Hoon Choi, Young Wook Kwon, Gabin Moon, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin,

Systemic lupus erythematosus (SLE) is a multi-systemic severe autoimmune disease which results from the irreversible loss of self-tolerance and impaired molecular responses, especially an altered interferon signature. We synthesized all meta-analyses reporting a genetic association of SLE, and further investigated their validity to discover false positive results under Bayesian methods. ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2018, 17(6):553-566]

Cited: 1 time

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Cerebrospinal fluid protein and glucose levels in neonates with a systemic inflammatory response without meningitis.

Mona Noureldein, Roxana Mardare, Jack Pickard, Hoi Lun Shing, Michael Eisenhut,

It has been estimated that paediatric meningitis without elevated CSF white cell count (pleocytosis) accounts for 0.5-12% of all cases of bacterial meningitis. CSF protein and glucose measurements are therefore essential in management but may be neglected in clinical practice. In order to improve recognition of bacterial meningitis in neonates ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2018, 15(1):8]

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Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians.

Kwang Seob Lee, Andreas Kronbichler, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin,

Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to increased mortality. In general, underlying chronic inflammation leads ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2018, 17(3):201-214]

Cited: 7 times

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