Full Text Journal Articles by
Author Michael E Egger

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Role of Surgery in Stage IV Melanoma.

Conor H O'Neill, Kelly M McMasters, Michael E Egger,

Stage IV melanoma has a 5-year survival rate of 6%, but considerable advances have been made in systemic therapies. Systemic immunotherapy has achieved durable responses in up to 40% of patients, with similar improvements with targeted therapies. This has reshaped the landscape for surgery in stage IV melanoma. Metastasectomy can ... Read more >>

Surg. Oncol. Clin. N. Am. (Surgical oncology clinics of North America)
[2020, 29(3):485-495]

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A literature-based treatment algorithm for low-grade neuroendocrine liver metastases.

Neal Bhutiani, Elizabeth H Bruenderman, Jordan M Jones, John H Wehry, Michael E Egger, Prejesh Philips, Charles R Scoggins, Kelly M McMasters, Robert C G Martin,

BACKGROUND:The optimal timing of treatment of liver metastases from low-grade neuroendocrine tumors (LG-NELM) varies significantly due to numerous treatment modalities and the literature supporting various treatment(s). This study sought to create and validate a literature-based treatment algorithm for LG-NELM. METHODS:A treatment algorithm to maximize overall survival (OS) was designed using ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Identifying factors impacting the efficacy of postmastectomy radiotherapy in patients with early-stage breast cancer and one to two positive lymph nodes.

Neal Bhutiani, Michael E Egger, Arnold J Stromberg, Inder K Bhutiani, Nicolás Ajkay, Kelly M McMasters,

INTRODUCTION:In women with T1-2 breast cancer and one to two positive axillary lymph nodes (LN) at low risk for recurrence, postmastectomy radiation therapy (PMRT) may provide insufficient benefit to justify its toxicity. This study evaluated the interaction of factors associated with overall survival (OS) after PMRT in these patients. METHODS:The ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, :]

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Optimal perfusion chemotherapy: A prospective comparison of mitomycin C and oxaliplatin for hyperthermic intraperitoneal chemotherapy in metastatic colon cancer.

Matthew R Woeste, Prejesh Philips, Michael E Egger, Charles R Scoggins, Kelly M McMasters, Robert C G Martin,

BACKGROUND:Peritoneal carcinomatosis of colorectal adenocarcinoma (CRC) origin is common and is the second-most frequent cause of death in colorectal cancer. There is survival benefit to surgical resection plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with metastatic CRC. However, there remains controversy between oxaliplatin (Oxali) and mitomycin C (MMC), as the ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(8):1298-1305]

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Recidivism Rates Following Firearm Injury as Determined by a Collaborative Hospital and Law Enforcement Database.

William Aaron Marshall, Michael E Egger, Annabelle Pike, Matthew C Bozeman, Glen A Franklin, Nicholas A Nash, Jason W Smith, J David Richardson, Brian G Harbrecht, Matthew V Benns, Keith R Miller,

Recidivism is a key outcome measure for injury prevention programs. Firearm injury recidivism rates are difficult to determine due to poor longitudinal follow-up and incomplete, disparate databases. Reported recidivism rates from trauma registries are 2-3%. We created a collaborative database merging law enforcement, emergency department, and inpatient trauma registry data ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, :]

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Transarterial Chemoembolization vs Radioembolization for Neuroendocrine Liver Metastases: A Multi-Institutional Analysis.

Michael E Egger, Emily Armstrong, Robert Cg Martin, Charles R Scoggins, Prejesh Philips, Manisha Shah, Bhavana Konda, Mary Dillhoff, Timothy M Pawlik, Jordan M Cloyd,

BACKGROUND:Liver-directed hepatic arterial therapies are associated with improved survival and effective symptom control for patients with unresectable neuroendocrine liver metastases (NELM). Whether transarterial chemoembolization (TACE) or transarterial radioembolization (TARE) with yttrium-90 (y-90) are associated with improved short- or long-term outcomes is unknown. STUDY DESIGN:A retrospective review was performed of all ... Read more >>

J. Am. Coll. Surg. (Journal of the American College of Surgeons)
[2020, 230(4):363-370]

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Sexual Harassment during Residency Training: A Cross-Sectional Analysis.

Lindsay F Arnold, Shiva R Zargham, Camille E Gordon, William I McKinley, Elizabeth H Bruenderman, Jessica L Weaver, Matthew V Benns, Michael E Egger, Amirreza T Motameni,

The reality of sexual harassment is unmasking in many fields, and medical trainees constitute a vulnerable and at-risk group. We report the prevalence of sexual harassment among GI, internal medicine, and pediatric residents, with a focus on identifying underlying reasons for lack of victim reporting. A modified previously validated Department ... Read more >>

Am Surg (The American surgeon)
[2020, 86(1):65-72]

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Vertical Growth Phase and Sentinel Lymph Node Metastases: In reply to Roncati and Piscioli.

Michael E Egger, Kelly M McMasters,

J. Am. Coll. Surg. (Journal of the American College of Surgeons)
[2019, 229(3):325-326]

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The Sunbelt Melanoma Trial.

Michael E Egger, Charles R Scoggins, Kelly M McMasters,

The Sunbelt Melanoma Trial, a multicenter, prospective randomized clinical study, evaluated the role of high-dose interferon alfa-2b (HDI) therapy for patients with a single positive sentinel lymph node (SLN) metastasis treated with a completion lymph node dissection (CLND). A second protocol in the trial evaluated the prognostic significance of using ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(1):28-34]

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Age and Lymphovascular Invasion Accurately Predict Sentinel Lymph Node Metastasis in T2 Melanoma Patients.

Michael E Egger, Megan Stevenson, Neal Bhutiani, Adrienne C Jordan, Charles R Scoggins, Prejesh Philips, Robert C G Martin, Kelly M McMasters,

BACKGROUND:The risk of sentinel lymph node (SLN) metastasis in melanoma is related directly to tumor thickness and inversely to age. The authors hypothesized that for T2 (thickness 1.1-2.0 mm) melanoma, age, and other factors may be able to identify a cohort of patients with a low risk of SLN metastases. METHODS:The ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(12):3955-3961]

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Evaluating patterns of utilization of gene signature panels and impact on treatment patterns in patients with ductal carcinoma in situ of the breast.

Neal Bhutiani, Brooke Vuong, Michael E Egger, Harriet Eldredge-Hindy, Kelly M McMasters, Nicolás Ajkay,

BACKGROUND:Broad patterns of use of the gene signature panel Oncotype DX DCIS and its large-scale impact on postoperative administration of radiation therapy in women with ductal carcinoma in situ of the breast remain unclear. This study sought to evaluate the patterns of use of this gene signature panel in women ... Read more >>

Surgery (Surgery)
[2019, 166(4):509-514]

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Identifying risk factor for development of perioperative venous thromboembolism in patients with gastrointestinal malignancy.

Neal Bhutiani, Seth A Quinn, Megan K Mercer, Young K Hong, Megan Stevenson, Michael E Egger, Prejesh Philips, Kelly M McMasters, Robert C G Martin, Charles R Scoggins,

BACKGROUND:Current data suggests that decreasing VTE incidence may require focus on other factors. This study aimed to identify perioperative risk factors for VTE in patients undergoing surgery for gastrointestinal (GI) malignancy. METHODS:Patients undergoing surgery for GI malignancy from 2013 to 2016 were grouped according to whether or not they developed ... Read more >>

Am. J. Surg. (American journal of surgery)
[2019, 218(2):311-314]

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Should Sentinel Lymph Node Biopsy Be Performed for All T1b Melanomas in the New 8th Edition American Joint Committee on Cancer Staging System?

Michael E Egger, Megan Stevenson, Neal Bhutiani, Adrienne C Jordan, Charles R Scoggins, Prejesh Philips, Robert Cg Martin, Kelly M McMasters,

BACKGROUND:In the 8th edition of the American Joint Committee on Cancer melanoma staging system, the T1b category has been redefined based solely on thickness and ulceration. National Comprehensive Cancer Network guidelines recommend consideration of sentinel lymph node biopsy (SLNB) for all patients with T1b melanomas (0.8 to 1.0 mm thick). ... Read more >>

J. Am. Coll. Surg. (Journal of the American College of Surgeons)
[2019, 228(4):466-472]

Cited: 1 time

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A model for predicting low probability of nonsentinel lymph node positivity in melanoma patients with a single positive sentinel lymph node.

Neal Bhutiani, Michael E Egger, Arnold J Stromberg, Jeffrey E Gershenwald, Merrick I Ross, Prejesh Philips, Robert C G Martin, Charles R Scoggins, Kelly M McMasters,

BACKGROUND:Identifying factors associated with nonsentinel lymph node (NSN) metastases in melanoma patients with a single positive sentinel lymph node (SLN) could aid decision making regarding adjuvant therapy. We describe a model for identifying patients with a single positive SLN at low risk for NSN metastasis. METHODS:Factors associated with NSN metastasis ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2018, 118(6):922-927]

Cited: 0 times

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ASO Author Reflections: The Sentinel Lymph Node in Melanoma: Now More Important Than Ever.

Michael E Egger, Kelly M McMasters,

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(Suppl 3):906-907]

Cited: 0 times

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Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines.

Jingjing Xiao, Michael E Egger, Kelly M McMasters, Hongying Hao,

BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specific mutation V600E in the BRAF protein. Initial response ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):675]

Cited: 3 times

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Safety and efficacy of irreversible electroporation in the treatment of obstructive jaundice in advanced hilar cholangiocarcinoma.

Emily K Martin, Neal Bhutiani, Michael E Egger, Prejesh Philips, Charles R Scoggins, Kelly M McMasters, Lawrence R Kelly, Gary C Vitale, Robert C G Martin,

BACKGROUND:Irreversible electroporation (IRE) has successfully been used for palliation of pancreatic and liver cancers due to its ability to ablate tumors without destroying nearby vital structures. To date, it has not been evaluated in patients with advanced hilar cholangiocarcinoma (AHC). This study presents a single-institution experience with IRE for management ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2018, 20(11):1092-1097]

Cited: 1 time

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Ductal carcinoma in situ current trends, controversies, and review of literature.

Young K Hong, Kelly M McMasters, Michael E Egger, Nicolas Ajkay,

Ductal carcinoma in situ (DCIS) is a non-obligate precursor, non-invasive malignancy confined within the basement membrane of the breast ductal system. There is a wide variation in the natural history of DCIS with an estimated incidence of progression to invasive ductal carcinoma being at least 13%-50% over a range of ... Read more >>

Am. J. Surg. (American journal of surgery)
[2018, 216(5):998-1003]

Cited: 1 time

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Unique Genes in Tumor-Positive Sentinel Lymph Nodes Associated with Nonsentinel Lymph Node Metastases in Melanoma.

Michael E Egger, Deyi Xiao, Hongying Hao, Charles W Kimbrough, Jianmin Pan, Shesh N Rai, Alexander C Cambon, Sabine J Waigel, Wolfgang Zacharias, Kelly M McMasters,

BACKGROUND:Current risk assessment tools to estimate the risk of nonsentinel lymph node metastases after completion lymphadenectomy for a positive sentinel lymph node (SLN) biopsy in cutaneous melanoma are based on clinical and pathologic factors. We identified a novel genetic signature that can predict non-SLN metastases in patients with cutaneous melanoma ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(5):1296-1303]

Cited: 2 times

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Multigene Signature Panels and Breast Cancer Therapy: Patterns of Use and Impact on Clinical Decision Making.

Neal Bhutiani, Michael E Egger, Nicolás Ajkay, Charles R Scoggins, Robert Cg Martin, Kelly M McMasters,

BACKGROUND:A growing body of evidence supports the use of multigene signature panels (MSPs) in predicting recurrence risk in patients with invasive breast cancer. This study aimed to evaluate trends in MSP use over time and the effect of MSPs on administration of postoperative chemotherapy. STUDY DESIGN:The National Cancer Database was ... Read more >>

J. Am. Coll. Surg. (Journal of the American College of Surgeons)
[2018, 226(4):406-412.e1]

Cited: 7 times

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Association of Clinical Factors With a Major Pathologic Response Following Preoperative Therapy for Pancreatic Ductal Adenocarcinoma.

Jordan M Cloyd, Huamin Wang, Michael E Egger, Ching-Wei D Tzeng, Laura R Prakash, Anirban Maitra, Gauri R Varadhachary, Rachna Shroff, Milind Javle, David Fogelman, Robert A Wolff, Michael J Overman, Eugene J Koay, Prajnan Das, Joseph M Herman, Michael P Kim, Jean-Nicolas Vauthey, Thomas A Aloia, Jason B Fleming, Jeffrey E Lee, Matthew H G Katz,

Importance:We previously demonstrated that a major pathologic response to preoperative therapy, defined histopathologically by the presence of less than 5% viable cancer cells in the surgical specimen, is an important prognostic factor for patients with pancreatic ductal adenocarcinoma. However, to our knowledge, the patients most likely to experience a significant ... Read more >>

JAMA Surg (JAMA surgery)
[2017, 152(11):1048-1056]

Cited: 12 times

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Optimizing Follow-up Assessment of Patients with Cutaneous Melanoma.

Neal Bhutiani, Michael E Egger, Kelly M McMasters,

Ann. Surg. Oncol. (Annals of surgical oncology)
[2017, 24(4):861-863]

Cited: 3 times

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Laparoscopic hepatectomy significantly shortens the time to postoperative chemotherapy in patients undergoing major hepatectomies.

Nsehniitooh Mbah, Steven C Agle, Prejesh Philips, Michael E Egger, Charles R Scoggins, Kelly M McMasters, Robert C G Martin,

The benefit of adjuvant chemotherapy occurs with early initiation, but is commonly delayed due to postoperative complications. Minimally invasive surgery is proven to significantly reduce complications and hospital length of stay. This study compares open versus laparoscopic liver resection in patients requiring adjuvant chemotherapy.120 consecutive patients with metastatic colorectal liver ... Read more >>

Am. J. Surg. (American journal of surgery)
[2017, 213(6):1060-1064]

Cited: 4 times

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Intrapancreatic accessory spleen (IPAS): A single-institution experience and review of the literature.

Neal Bhutiani, Michael E Egger, Catherine A Doughtie, Elizabeth S Burkardt, Charles R Scoggins, Robert C G Martin, Kelly M McMasters,

Accessory spleens located within the pancreatic parenchyma (intrapancreatic accessory spleen, IPAS) pose a unique clinical challenge. In many cases, despite imaging and other diagnostic studies, malignancy cannot be excluded and patients are subjected to pancreatic resection. We review our experience with the presentation, diagnosis, and treatment of patients with IPAS ... Read more >>

Am. J. Surg. (American journal of surgery)
[2017, 213(4):816-820]

Cited: 5 times

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Anesthetic and operative considerations for laparoscopic liver resection.

Michael E Egger, Vijaya Gottumukkala, Jonathan A Wilks, Jose Soliz, Matthias Ilmer, Jean Nicolas Vauthey, Claudius Conrad,

We enumerate the broad range of anesthetic considerations that affect the outcome of patients undergoing laparoscopic liver resection. Key elements for excellent outcomes after laparoscopic liver resection are careful patient selection and risk stratification, appropriate monitoring, techniques to reduce blood loss and transfusion, and active recovery management. Although some of ... Read more >>

Surgery (Surgery)
[2017, 161(5):1191-1202]

Cited: 3 times

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