Full Text Journal Articles by
Author Michael D Shields

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Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review.

Lauren Alexandra Quinn, Michael D Shields, Ian Sinha, Helen E Groves,

<h4>Background</h4>Acute bronchiolitis caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and asthma. However, it is unclear whether this association is causal. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, but the longer-term follow-up has given conflicting evidence for ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):269]

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Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): a prospective, multicentre cohort study.

Thomas Waterfield, Juli-Ann Maney, Derek Fairley, Mark D Lyttle, James P McKenna, Damian Roland, Michael Corr, Lisa McFetridge, Hannah Mitchell, Kerry Woolfall, Fiona Lynn, Bethany Patenall, Michael D Shields, ,

<h4>Background</h4>No previous studies have validated current clinical practice guidelines for the management of non-blanching rashes in children who have received meningococcal B and C vaccinations. The aim of this study was to evaluate the performance of existing clinical practice guidelines in the diagnosis of invasive meningococcal disease in children presenting ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.

Thomas Waterfield, Julie-Ann Maney, Mark D Lyttle, James P McKenna, Damian Roland, Michael Corr, Bethany Patenall, Michael D Shields, Kerry Woolfall, Derek Fairley, ,

<h4>Background</h4>The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):487]

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Characteristics of Reported Pediatric Medication Errors in Northern Ireland and Use in Quality Improvement.

Richard L Conn, Mary P Tully, Michael D Shields, Angela Carrington, Tim Dornan,

BACKGROUND:To protect children from harm, clinicians, educators, and patient safety champions need information to direct improvement efforts. Critical incident data could provide this but are often disregarded as a source of evidence because under-reporting makes them an inaccurate measure of error rates. OBJECTIVE:Our aim was to identify key targets for ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(5):551-560]

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How we teach children with asthma to use their inhaler: a scoping review protocol.

Patrick McCrossan, Orla Mallon, Michael D Shields, Dara O'Donoghue,

BACKGROUND:One reason that asthma remains poorly controlled in children is poor inhaler technique. Current guidelines recommend checking inhaler technique at each clinical visit. However, they do not specify how best to train children to mastery of correct inhaler technique. Currently, many children are simply shown how to use inhalers (brief ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):178]

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Aerosol Therapy in Asthma-Why We Are Failing Our Patients and How We Can Do Better.

Robert W Morton, Heather E Elphick, Vanessa Craven, Michael D Shields, Lesley Kennedy,

In order for inhaled corticosteroids to be delivered adequately to the airways they require patients to take them regularly using an effective technique. Patients often have a poor inhaler technique, and this has been shown to result in sub-optimal asthma control. It is important for all clinicians prescribing inhaled medication ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:305]

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A protocol for a systematic review and meta-analysis of the diagnostic accuracy of mid-regional pro-adrenomedullin in predicting invasive bacterial infection in children.

Michael Corr, Thomas Waterfield, Derek Fairley, James McKenna, Michael D Shields,

<h4>Background</h4>The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limiting viral infection. These challenges mandate a cautious approach resulting in the overuse of antimicrobial drugs with resultant antimicrobial resistance. ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):69]

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Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media.

Lindsay Broadbent, Sheerien Manzoor, Maria C Zarcone, Judit Barabas, Michael D Shields, Sejal Saglani, Claire M Lloyd, Andrew Bush, Adnan Custovic, Peter Ghazal, Mindy Gore, Ben Marsland, Graham Roberts, Jurgen Schwarze, Steve Turner, Ultan F Power,

The culture of differentiated human airway epithelial cells allows the study of pathogen-host interactions and innate immune responses in a physiologically relevant in vitro model. As the use of primary cell culture has gained popularity the availability of the reagents needed to generate these cultures has increased. In this study ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0228229]

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Comparative Therapeutic Potential of ALX-0171 and Palivizumab against Respiratory Syncytial Virus Clinical Isolate Infection of Well-Differentiated Primary Pediatric Bronchial Epithelial Cell Cultures.

Lindsay Broadbent, Hong Guo Parke, Lyndsey J Ferguson, Andrena Millar, Michael D Shields, Laurent Detalle, Ultan F Power,

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in young infants. There are no RSV-specific treatments available. Ablynx has been developing an anti-RSV F-specific nanobody, ALX-0171. To characterize the therapeutic potential of ALX-0171, we exploited our well-differentiated primary pediatric bronchial epithelial cell (WD-PBEC)/RSV infection model, which replicates several ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(2):]

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Exposure and attitudes to adolescent health amongst Paediatric trainees in Northern Ireland: a mixed-methods study.

Stephen Mullen, Michael D Shields, Dara O'Donoghue,

Aims:To determine the exposure and attitudes of paediatric trainees towards adolescent medicine. Methods:All paediatric trainees in the Northern Ireland deanery (n=107) were invited to participate in an online survey in March 2016. The questionnaire was based on the 'Modified Perceptions of Adolescent Issues and Resources: Care of Adolescents' questionnaire. The ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2020, 4(1):e000563]

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Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a protocol for a systematic review.

Lauren Alexandra Quinn, Michael D Shields, Helen E Groves,

<h4>Background</h4>Lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and subsequent asthma. However, it is still unclear whether this association is causal or not. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, i.e. those ... Read more >>

Syst Rev (Systematic reviews)
[2019, 8(1):333]

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Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Fernando M de Benedictis, Ines Carloni, Pasquale Comberiati, Michael D Shields, Andrew Bush, Anne B Chang,

The causes of chronic cough in children are mainly dependent on the setting and age of the child. Protracted bacterial bronchitis is a frequent cause of morbidity in childhood, and antibiotic treatment is beneficial. Prompt recognition and early treatment is important both to prevent inappropriate use of asthma medications and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:459]

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Investigating the clinical use of structured light plethysmography to assess lung function in children with neuromuscular disorders.

Deborah Fleck, Chistopher Curry, Kate Donnan, Orla Logue, Kathryn Graham, Kate Jackson, Karen Keown, John Winder, Michael D Shields, Ciara M Hughes,

<h4>Background</h4>Children and young people with neuromuscular disorders (NMD), such as Duchenne Muscular Dystrophy (DMD), develop progressive respiratory muscles weakness and pulmonary restriction. Pulmonary function monitoring of the decline in lung function allows for timely intervention with cough assist techniques and nocturnal non-invasive ventilation (NIV). NMD may find the measurement of ... Read more >>

PLoS One (PloS one)
[2019, 14(8):e0221207]

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What causes prescribing errors in children? Scoping review.

Richard L Conn, Orla Kearney, Mary P Tully, Michael D Shields, Tim Dornan,

<h4>Objectives</h4>(1) Systematically assemble, analyse and synthesise published evidence on causes of prescribing error in children. (2) Present results to a multidisciplinary group of paediatric prescribing stakeholders to validate findings and establish how causative factors lead to errors in practice.<h4>Design</h4>Scoping review using Arksey and O'Malley's framework, including stakeholder consultation; qualitative evidence ... Read more >>

BMJ Open (BMJ open)
[2019, 9(8):e028680]

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Respiratory Syncytial Virus and Asthma Inception: Cause and Effect, or Shared Susceptibility?

Helen E Groves, Michael D Shields,

J Infect Dis (The Journal of infectious diseases)
[2019, 220(4):547-549]

Cited: 1 time

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Stress-strain data for aluminum 6061-T651 from 9 lots at 6 temperatures under uniaxial and plane strain tension.

B S Aakash, JohnPatrick Connors, Michael D Shields,

Stress-strain curves in steady-state tension of aluminum 6061-T651 sourced from 9 lots of material from several manufacturers at 6 temperatures (20,100,150,200,250,300 °C) are presented. A total of 100 stress-strain curves for uniaxial tension specimens and 54 stress-strain curves for plane strain tension specimens are shared. Strains are estimated through digital image ... Read more >>

Data Brief (Data in brief)
[2019, 25:104085]

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A systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in the diagnosis of invasive meningococcal disease in children.

Thomas Waterfield, Derek Fairley, Bronagh Blackwood, James McKenna, Michael D Shields,

BACKGROUND:The early recognition of meningococcal disease in children is vital. During the prodrome however, meningococcal infection presents similarly to many self-limiting viral infections. This mandates a cautious approach with many children receiving unnecessary broad-spectrum parenteral antibiotics. Advances in nucleic acid amplification techniques mean that it is now possible to test ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):49]

Cited: 2 times

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Correction: Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year.

Helen E Groves, Hong Guo-Parke, Lindsay Broadbent, Michael D Shields, Ultan F Power,

[This corrects the article DOI: 10.1371/journal.pone.0201328.]. ... Read more >>

PLoS One (PloS one)
[2019, 14(1):e0211611]

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Point-of-care testing for procalcitonin in identifying bacterial infections in young infants: a diagnostic accuracy study.

Thomas Waterfield, Julie-Ann Maney, Martin Hanna, Derek Fairley, Michael D Shields,

<h4>Background</h4>The primary objective of this study was to report on the diagnostic accuracy of point-of-care testing (POCT) for procalcitonin (PCT) in identifying invasive bacterial infections in young infants. Invasive bacterial infection was defined as the isolation of a bacterial pathogen in blood or cerebrospinal fluid culture.<h4>Methods</h4>This was a prospective observational ... Read more >>

BMC Pediatr (BMC pediatrics)
[2018, 18(1):387]

Cited: 1 time

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Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year.

Helen E Groves, Hong Guo-Parke, Lindsay Broadbent, Michael D Shields, Ultan F Power,

<h4>Background</h4>Innate immune responses of airway epithelium are important defences against respiratory pathogens and allergens. Newborn infants are at greater risk of severe respiratory infections compared to older infants, while premature infants are at greater risk than full term infants. However, very little is known regarding human neonatal airway epithelium immune ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0201328]

Cited: 4 times

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The "Petechiae in children" (PiC) study: evaluating potential clinical decision rules for the management of feverish children with non-blanching rashes, including the role of point of care testing for Procalcitonin & Neisseria meningitidis DNA - a study protocol.

Thomas Waterfield, Mark D Lyttle, Derek Fairley, James Mckenna, Kerry Woolfall, Fiona Lynn, Julie-Ann Maney, Damian Roland, Aoife Weir, Michael D Shields, ,

<h4>Background</h4>Children commonly present to Emergency Departments (ED) with a non-blanching rash in the context of a feverish illness. While most have a self-limiting viral illness, this combination of features potentially represents invasive serious bacterial infection, including meningococcal septicaemia. A paucity of definitive diagnostic testing creates diagnostic uncertainty for clinicians; a ... Read more >>

BMC Pediatr (BMC pediatrics)
[2018, 18(1):246]

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The child with an incessant dry cough.

Niamh C Galway, Michael D Shields,

Cough is a forced expulsive manoeuvre, usually against a closed glottis and is associated with a characteristic sound that is easily recognised. It is a protective reflex against aspiration and to clear airway secretions. In children cough is extremely common and when prolonged it is often a cause for concern ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2019, 30:58-64]

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The impact of fetal umbilical artery Doppler pulsatility index on childhood respiratory function and atopy: a prospective case-control study.

Fionnuala Mone, Andrew Thompson, Moira C Stewart, Ricardo Segurado, Jennifer Curry, James C Dornan, Fionnuala M McAuliffe, Michael D Shields,

<b>Objective:</b> To determine if an elevated fetal umbilical artery Doppler pulsatility index is associated with abnormal respiratory function and atopy in children aged 12 years.<b>Methods:</b> This prospective case-control study compared children that had an elevated fetal umbilical artery Doppler pulsatility index (>90th centile) to those with a normal pulsatility index (<90th ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, 33(5):707-711]

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A protocol for a systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in diagnosis of invasive meningococcal disease in children.

Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood, Michael D Shields,

BACKGROUND:Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis and initial management of suspected MD with many children receiving precautionary broad-spectrum intravenous antibiotics. Despite this approach, some children are ... Read more >>

Syst Rev (Systematic reviews)
[2018, 7(1):86]

Cited: 3 times

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Annual Out of Town Conference: 25th - 26th September 2015, Ballymascanlon House Hotel, Carlingford.

Ulster Med J (The Ulster medical journal)
[2018, 87(2):140-142]

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