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Author Michael Camilleri

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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

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Correction to: Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases.

Priya Vijayvargiya, Daniel Gonzalez Izundegui, Gerardo Calderon, Sarah Tawfic, Sarah Batbold, Hiba Saifuddin, Patrick Duggan, Valeria Melo, Taylor Thomas, Megan Heeney, Adrian Beyde, James Miller, Kenneth Valles, Kafayat Oyemade, Joseph F Brant, Jessica Atieh, Leslie J Donato, Michael Camilleri,

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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Severity of dysphagia is associated with hospitalizations and mortality in patients with Parkinson's disease.

Saam Dilmaghani, Jessica Atieh, Lehar Khanna, Emily A Hosfield, Michael Camilleri, David A Katzka,

<h4>Background</h4>Aspiration pneumonia is the commonest cause of hospitalizations and death in patients with Parkinson's disease (PD). Among these patients, the relationships between severity of dysphagia, hospitalizations for related complications, and death are not robustly defined. Our aim was to characterize the relationship between PD-related oropharyngeal dysfunction and clinically relevant outcomes.<h4>Methods</h4>Retrospective ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14280]

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Beyond Metoclopramide for Gastroparesis.

Michael Camilleri,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Development of a Score to Predict Positive Colonic Histology in Chronic Diarrhea Assessed in Open-access Colonoscopy.

Jessica Atieh, Victor Chedid, Katayoun Khoshbin, Sunanda Kane, Michael Camilleri,

<h4>Goals</h4>To evaluate the diagnostic yield of colonoscopy and esophagogastroduodenoscopy with biopsies and to identify predictors of positive colonic histology in patients with chronic diarrhea.<h4>Background</h4>Colonoscopy with biopsies is performed in chronic diarrhea with negative initial work-up.<h4>Study</h4>We reviewed electronic medical records of 1022 consecutive patients with chronic diarrhea referred for a first ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, 55(8):694-701]

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What to do about the leaky gut.

Michael Camilleri, Adrian Vella,

Gut (Gut)
[2021, :]

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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New Developments in Prokinetic Therapy for Gastric Motility Disorders.

Michael Camilleri, Jessica Atieh,

Prokinetic agents amplify and coordinate the gastrointestinal muscular contractions to facilitate the transit of intra-luminal content. Following the institution of dietary recommendations, prokinetics are the first medications whose goal is to improve gastric emptying and relieve symptoms of gastroparesis. The recommended use of metoclopramide, the only currently approved medication for ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:711500]

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What is the leaky gut? Clinical considerations in humans.

Michael Camilleri,

<h4>Purpose of review</h4>To review the components of the intestinal barrier, the practical measurements of intestinal permeability, and the clinical conditions associated with altered intestinal barrier function, and to summarize the effects of dietary substances that fortify or weaken the intestinal barrier.<h4>Recent findings</h4>The intestinal barrier includes surface mucus, epithelial layer, and ... Read more >>

Curr Opin Clin Nutr Metab Care (Current opinion in clinical nutrition and metabolic care)
[2021, 24(5):473-482]

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Bile Acid Malabsorption in Patients with Neuroendocrine Tumors.

Lehar Khanna, Thorvardur R Halfdanarson, Mohamad B Sonbol, Rachel Eiring, Teresa Prond, Michael Camilleri,

<h4>Background</h4>Chronic diarrhea in patients with neuroendocrine tumors (NET) may be caused by bioactive products of NET, bile acid malabsorption (BAM), ileal resection (IR) or steatorrhea.<h4>Aim</h4>To quantitate BA and fat malabsorption in NET with diarrhea.<h4>Methods</h4>Part of evaluation in medical oncology clinical practice, 67 patients [42F, 25 M; median age 64.0 y (17.0 ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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Cohort Study in Parkinsonism: Delayed Transit, Accelerated Gastric Emptying, and Prodromal Dysmotility.

Katayoun Khoshbin, Anhar Hassan, Michael Camilleri,

<h4>Objective</h4>To evaluate gastric emptying (GE) and colonic transit in a cohort of patients with Parkinson disease and other parkinsonism disorders and to determine whether abnormal gut transit precedes motor onset of parkinsonism.<h4>Methods</h4>Medical record review of 84 patients with parkinsonism who underwent clinically indicated transit studies at Mayo Clinic (2001-2019) and ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2021, 11(4):e407-e413]

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Turning Purple with Pain.

Thomas W Fredrick, Manuel B Braga Neto, Daniel O Johnsrud, Michael Camilleri, Victor G Chedid,

N Engl J Med (The New England journal of medicine)
[2021, 385(6):549-554]

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Association of gastric emptying with postprandial appetite and satiety sensations in obesity.

Daniel Gonzalez-Izundegui, Alejandro Campos, Gerardo Calderon, Maria L Ricardo-Silgado, Lizeth Cifuentes, Paul A Decker, Eric J Vargas, Linh Tran, Duane Burton, Barham Abu Dayyeh, Michael Camilleri, Jeanette E Eckel-Passow, Andres Acosta,

<h4>Objective</h4>Satiety, defined as the duration of the sensation of fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, the association between gastric emptying (GE) and VAS appetite is unknown.<h4>Methods</h4>In this cross-sectional study, 134 participants (mean [SEM] ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(9):1497-1507]

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Establishing Minimal Clinically Important Differences in Quality of Life Measures in Opioid-Induced Constipation.

Jan Tack, Michael Camilleri, Martin Hale, Bart Morlion, Srinivas Nalamachu, Lynn Webster, James Wild,

<h4>Background & aims</h4>Opioids have a role in chronic pain management. However, opioid-induced constipation may cause patients to skip or reduce opioid doses, leading to inadequate pain relief and negatively impacting quality of life. We sought to establish a minimal clinically important difference to understand whether changes in quality of life ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 1 time

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Correction to: Gastroparesis Following Immune Checkpoint Inhibitor Therapy: A Case Series.

Jessica Atieh, Jordan Sack, Richard Thomas, Osama E Rahma, Michael Camilleri, Shilpa Grover,

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(8):2843-2844]

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Naldemedine Improves Patient-Reported Outcomes of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain in the COMPOSE Phase 3 Studies.

Michael Camilleri, Martin Hale, Bart Morlion, Jan Tack, Lynn Webster, James Wild,

<h4>Objective</h4>Opioid-induced constipation is among the most common side effects associated with opioid use in patients with chronic non-cancer pain, and it can have a significant negative impact on health-related quality of life (QOL). This analysis evaluated the effect of naldemedine 0.2 mg on patient-reported outcomes in three phase 3 clinical ... Read more >>

J Pain Res (Journal of pain research)
[2021, 14:2179-2189]

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Editorial: finding the ideal prokinetic for gastroparesis-we are not there yet. Authors' reply.

Michael Camilleri, Braden Kuo,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(2):212-213]

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A Review of Irritable Bowel Syndrome-Reply.

Michael Camilleri,

JAMA (JAMA)
[2021, 326(2):189-190]

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Retrospective analysis of 450 emergency department dermatology consultations: An analysis of in-person and teledermatology consultations from 2015 to 2019.

Alexander S Hines, Jacqueline Zayas, David A Wetter, Alina G Bridges, Michael J Camilleri, Marian T McEvoy, Rokea A El-Azhary, Deepi G Goyal, Mark Dp Davis, Julio C Sartori-Valinotti,

<h4>Introduction</h4>Dermatologic complaints are a common reason for emergency department visits.<h4>Methods</h4>Retrospective chart review from 1 January 2015 to 31 December 2019. Patients in the Mayo Clinic Emergency Department receiving dermatology consultation were included.<h4>Results</h4>Dermatitis (24.7%, <i>n</i> = 113), infection (20.4%, <i>n</i> = 93), and drug reaction (10.3%, <i>n</i> = 47) accounted for the majority of diagnoses. Emergency department ... Read more >>

J Telemed Telecare (Journal of telemedicine and telecare)
[2021, :1357633X211024844]

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Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis.

Braden Kuo, Cecilia Scimia, George Dukes, Wenwen Zhang, Saurabh Gupta, Chunlin Chen, Emil Chuang, Michael Camilleri,

<h4>Background</h4>Gastroparesis is a chronic gastric motility disorder. Dopamine D<sub>2</sub> /D<sub>3</sub> receptor antagonists metoclopramide and domperidone are current treatment options but are associated with central nervous system and cardiovascular safety concerns, respectively, precluding chronic use. Trazpiroben (TAK-906), a dopamine D<sub>2</sub> /D<sub>3</sub> receptor antagonist, is under development for chronic treatment of moderate-to-severe ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(3):267-280]

Cited: 1 time

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Markers of Bile Acid Metabolism in Pediatric Diarrhea Predominant Irritable Bowel Syndrome and Healthy Controls.

Beate C Beinvogl, Mhd Louai Manini, Michael Camilleri, Leslie J Donato, William Scott Harmsen, Imad Absah, Elizabeth Burch, Neil L Schechter, Samuel Nurko,

<h4>Objectives</h4>Excessive fecal bile acids in adults have been associated with diarrhea-predominant irritable bowel syndrome (IBS-D), but their role in pediatric IBS-D is unknown. Serum markers including 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor-19 (FGF-19) were validated in adults to detect bile acid diarrhea (BAD) compared to 48-hour fecal bile acid collection ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2021, 72(6):859-865]

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A North American perspective on the ESNM consensus statement on gastroparesis.

Michael Camilleri, Saam Dilmaghani, Kia Vosoughi, Ting Zheng,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(8):e14174]

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BAD on the Runs: Improved Diagnosis of Idiopathic Bile Acid Diarrhea.

Michael Camilleri,

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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New Drugs on the Horizon for Functional and Motility Gastrointestinal Disorders.

Michael Camilleri,

Gastroenterology (Gastroenterology)
[2021, 161(3):761-764]

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Retrospective analysis of 578 inpatient dermatology consultations in hematology and hematopoietic stem cell transplant patients.

Alexander Hines, Antonious Hazim, David A Wetter, Alina G Bridges, Michael J Camilleri, Marian T McEvoy, Rokea A El-Azhary, Mark D P Davis, Julio C Sartori-Valinotti,

<h4>Background</h4>Hospitalized patients with hematologic malignancies are medically complex and commonly affected by dermatologic conditions.<h4>Methods</h4>Retrospective chart review from January 1, 2014, to December 31, 2018, at Rochester Methodist Hospital (Rochester, Minnesota, USA). Patients hospitalized on hematology and BMT services receiving dermatology consultation were included.<h4>Results</h4>In all, 578 consultations (63% male, median age ... Read more >>

Int J Dermatol (International journal of dermatology)
[2021, :]

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