Full Text Journal Articles by
Author Michael A Mazzeffi

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Racial disparities in catheter related urinary tract infections among elderly trauma patients in the US.

Ryan J Keneally, Jonathan H Chow, Raymond A Pla, Eric R Heinz, Michael A Mazzeffi,

<h4>Background</h4>Catheter associated urinary tract infections (CAUTIs) have become a focus for reducing healthcare costs. Reimbursement may be reduced to hospitals with higher rates. The implementation of bundles or other efforts to reduce infection numbers may not be as robust at hospitals caring for more diverse patient populations. This may lead ... Read more >>

Am J Infect Control (American journal of infection control)
[2022, 50(1):77-80]

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Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: An Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists-Part II, Intraoperative Management and Troubleshooting.

Michael A Mazzeffi, Vidya K Rao, Jeffrey Dodd-O, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M Bauer, Joseph S Meltzer, Sree Satyapriya, Raymond Rector, James G Ramsay, Jacob Gutsche,

In the second part of the Society of Cardiovascular Anesthesiologists Extracorporeal Membrane Oxygenation (ECMO) working group expert consensus statement, venoarterial (VA) and venovenous (VV) ECMO management and troubleshooting in the operating room are discussed. Expert consensus statements are provided about intraoperative monitoring, anesthetic drug dosing, and management of intraoperative problems ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(6):1478-1493]

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Association of Volume Status During Veno-Venous Extracorporeal Membrane Oxygenation with Outcome.

Aakash Shah, Jay Menaker, Michael A Mazzeffi, Samuel M Galvagno, Kristopher B Deatrick, Ronson J Madathil, Raymond Rector, James V O'Connor, Thomas M Scalea, Ali Tabatabai,

Fluid overload in acute respiratory distress syndrome is associated with increased mortality. The purpose of this study was to investigate the association of cumulative fluid balance (CFB) during the first 7 days of eno-venous extracorporeal membrane oxygenation (VV ECMO) and mortality. Adult patients on VV ECMO for greater than 168 ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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The 7 Pillars of Blood Conservation in Cardiac Surgery.

Rawn Salenger, Michael A Mazzeffi,

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(6):504-509]

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New-Onset Atrial Arrhythmias Are Independently Associated With In-Hospital Mortality in Veno-Venous Extracorporeal Membrane Oxygenation.

Cecilia Li, Mehrnaz Pajoumand, Kerry Lambert, Laila Najia, Allison L Bathula, Michael A Mazzeffi, Samuel M Galvagno, Ali Tabatabai, Alison Grazioli, Siamak Dahi, Eric S Hochberg, Michael E Plazak,

<h4>Objective</h4>To explore if atrial arrhythmias are associated with in-hospital mortality in veno-venous extracorporeal membrane oxygenation (VV-ECMO) patients.<h4>Design</h4>Retrospective observational cohort study.<h4>Setting</h4>Quaternary care academic medical center.<h4>Participants</h4>Patients with respiratory failure requiring VV-ECMO for >24 hours between January 1, 2016, and January 1, 2019.<h4>Interventions</h4>None, observational study.<h4>Measurements and main results</h4>Two hundred nineteen VV-ECMO patients were ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, :]

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Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: An Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists-Part I, Technical Aspects of Extracorporeal Membrane Oxygenation.

Michael A Mazzeffi, Vidya K Rao, Jeffrey Dodd-O, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M Bauer, Joseph S Meltzer, Sree Satyapriya, Raymond Rector, James G Ramsay, Jacob Gutsche,

Extracorporeal membrane oxygenation (ECMO) is used to support patients with refractory cardiopulmonary failure. Given ECMO's increased use in adults and the fact that many ECMO patients are cared for by anesthesiologists, the Society of Cardiovascular Anesthesiologists ECMO working group created an expert consensus statement that is intended to help anesthesiologists ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(6):1459-1477]

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Effects of a single bolus of hydroxocobalamin on hemodynamics in vasodilatory shock.

Lindsay A Ritter, Mary Maldarelli, Michael T McCurdy, David P Yamane, Danielle Davison, Christopher Parrino, David N Yim, Myounghee Lee, Michael A Mazzeffi, Jonathan H Chow,

<h4>Purpose</h4>Hydroxocobalamin has been observed to cause transient hypertension in healthy subjects, but rigorous studies examining its efficacy are lacking.<h4>Materials and methods</h4>Adults in shock who received hydroxocobalamin from 2017 to 2021 were analyzed retrospectively. Hourly hemodynamics from 24 h before and after treatment were collected, and the difference and hourly change of ... Read more >>

J Crit Care (Journal of critical care)
[2022, 67:66-71]

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In vitro effects of emicizumab on activated clotting time in blood samples from cardiac surgical patients.

Kenichi A Tanaka, Reney Henderson, Kiruphagaran Thangaraju, Yoshihisa Morita, Michael A Mazzeffi, Erik Strauss, Upendra Katneni, Paul W Buehler,

<h4>Background</h4>Heparin management in hemophilia A (HA) patients with a factor VIII (FVIII) inhibitor can be challenging due to severe activated clotting time (ACT) prolongations. It is important to better understand the impact of emicizumab, a FVIII mimetic on ACT, and tissue factor (TF)-based coagulation assays.<h4>Methods</h4>Whole blood from 18 patients undergoing ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2022, 28(1):183-190]

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Bivalirudin Superior to Heparin for Extracorporeal Membrane Oxygenation: Not So Fast.

Michael A Mazzeffi, Michael Plazak, Heidi Dalton,

Crit Care Med (Critical care medicine)
[2021, 49(10):e1057-e1058]

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Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: an Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists- Part II, Intraoperative Management and Troubleshooting.

Michael A Mazzeffi, Vidya K Rao, Jeffrey Dodd-O, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M Bauer, Joseph S Meltzer, Sree Satyapriya, Raymond Rector, James G Ramsay, Jacob Gutsche,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, 35(12):3513-3527]

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Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: an Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists-Part I, Technical Aspects of Extracorporeal Membrane Oxygenation.

Michael A Mazzeffi, Vidya K Rao, Jeffrey Dodd-O, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M Bauer, Joseph S Meltzer, Sree Satyapriya, Raymond Rector, James G Ramsay, Jacob Gutsche,

Extracorporeal membrane oxygenation (ECMO) is used to support patients with refractory cardiopulmonary failure. Given ECMO's increased use in adults and the fact that many ECMO patients are cared for by anesthesiologists, the Society of Cardiovascular Anesthesiologists ECMO working group created an expert consensus statement that is intended to help anesthesiologists ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, 35(12):3496-3512]

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The Algorithm Examining the Risk of Massive Transfusion (ALERT) Score Accurately Predicts Massive Transfusion at the Scene of Injury and on Arrival to the Trauma Bay: A Retrospective Analysis.

Jonathan H Chow, Justin E Richards, Samuel M Galvagno, Patrick J Coleman, Allison S Lankford, Cheralyn Hendrix, Jackson Dunitz, Ikeoluwapo Ibrahim, Mira Ghneim, Kenichi A Tanaka, Thomas M Scalea, Michael A Mazzeffi, Peter Hu,

<h4>Background</h4>Massive transfusion (MT) is required to resuscitate traumatically injured patients with complex derangements. Scoring systems for MT typically require laboratory values and radiological imaging that may delay the prediction of MT.<h4>Study design</h4>The Trauma ALgorithm Examining the Risk of massive Transfusion (Trauma ALERT) study was an observational cohort study. Prehospital and ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(4):529-536]

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Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis.

Jonathan H Chow, Ying Yin, David P Yamane, Danielle Davison, Ryan J Keneally, Katrina Hawkins, K Gage Parr, Mustafa Al-Mashat, Jeffery S Berger, Reamer L Bushardt, Michael A Mazzeffi, Stuart J Nelson,

<h4>Purpose</h4>Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk. The impact of prehospital antiplatelet therapy on in-hospital mortality is uncertain.<h4>Methods</h4>This was an observational cohort study of 34 675 patients ≥50 years old from 90 health systems in the United States. Patients were hospitalized with laboratory-confirmed COVID-19 between February 2020 and ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2021, 19(11):2814-2824]

Cited: 2 times

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A Comparison of Anticoagulation Strategies in Veno-venous Extracorporeal Membrane Oxygenation.

Aakash Shah, Chetan Pasrija, Anthony Kronfli, Eno-Obong Essien, Ya Zhou, Francis Brigante, Gregory Bittle, Jay Menaker, Daniel Herr, Michael A Mazzeffi, Kristopher B Deatrick, Zachary N Kon,

Bleeding remains a major source of morbidity associated with veno-venous extracorporeal membrane oxygenation (VV-ECMO). Moreover, there remains significant controversy, and a paucity of data regarding the ideal anticoagulation strategy for VV-ECMO patients. All patients undergoing isolated, peripheral VV-ECMO between January 2009 and December 2014 at our institution were retrospectively reviewed. ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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A descriptive evaluation of causes of death in venovenous extracorporeal membrane oxygenation.

Sagar B Dave, Kristopher B Deatrick, Samuel M Galvagno, Michael A Mazzeffi, David J Kaczorowski, Ronson J Madathil, Raymond Rector, Ali Tabatabai, Daniel J Haase, Daniel Herr, Thomas M Scalea, Jay Menaker,

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become an important support modality for patients with acute respiratory failure refractory to optimal medical therapy, such as low tidal volume mechanical ventilator support, early paralytic infusion, and early prone positioning. The objective of this cohort study was to investigate the causes and ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211035938]

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The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma.

Justin E Richards, Michael A Mazzeffi, Michael S Massey, Peter Rock, Samuel M Galvagno, Thomas M Scalea,

<h4>Background</h4>Hyperglycemia is associated with mortality after trauma; however, few studies have simultaneously investigated the association of depth of shock and acute hyperglycemia. We evaluated lactate, as a surrogate measure for depth of shock, and glucose levels on mortality following severe blunt trauma. We hypothesize that measurements of both lactate and ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(2):455-461]

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Precannulation International Normalized Ratio is Independently Associated With Mortality in Veno-Arterial Extracorporeal Membrane Oxygenation.

Michael E Plazak, Alison Grazioli, Elizabeth K Powell, Ashley R Menne, Allison L Bathula, Ronson J Madathil, Eric M Krause, Kristopher B Deatrick, Michael A Mazzeffi,

<h4>Objectives</h4>To explore whether precannulation international normalized ratio (INR) is associated with in-hospital mortality in venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients.<h4>Design</h4>A retrospective, observational cohort study.<h4>Setting</h4>A quaternary care academic medical center.<h4>Participants</h4>Patients with cardiogenic shock on VA-ECMO for >24 hours.<h4>Interventions</h4>None, observational study.<h4>Measurements and main results</h4>A total of 188 patients who were on VA-ECMO ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, :]

Cited: 0 times

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Pro-Con Debate: Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patients.

Nadia B Hensley, Michael A Mazzeffi,

Cryoprecipitate has been the gold standard for treating acquired hypofibrinogenemia in cardiac surgery for nearly 50 years. More recently, fibrinogen concentrate has been used off-label in the United States and is the standard in European countries and Canada to treat the acquired hypofibrinogenemia during cardiac surgery. Fibrinogen concentrate has multiple ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(1):19-28]

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 1 time

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In Response.

Jonathan H Chow, Michael A Mazzeffi,

Anesth Analg (Anesthesia and analgesia)
[2021, 132(5):e90]

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Ultrasound-assisted catheter directed thrombolysis for pulmonary embolus during extracorporeal membrane oxygenation.

Douglas Tran, Nicole Hays, Aakash Shah, Chetan Pasrija, Rafael S Cires-Drouet, Shahab A Toursavadkohi, Michael A Mazzeffi, Daniel L Herr, Ronson J Madathil, James S Gammie, Bartley P Griffith, Kristopher B Deatrick, David J Kaczorowski,

<h4>Background</h4>Acute pulmonary embolism (PE) is the third most common cause of cardiovascular death. For patients who are hemodynamically unstable, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support has been shown to provide hemodynamic stability, and allow time for definitive treatment and recovery. Ultrasound-assisted catheter directed thrombolysis (USAT) has the potential to be ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(8):2685-2691]

Cited: 1 time

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Reasons for discontinuation of acute postoperative pain ketamine infusions: A retrospective case-control study.

Laura V Gil, Michael A Mazzeffi, Yi Cai, Whitney W McLeod, Steven B Porter,

<h4>Purpose</h4>The purpose of the study was to investigate factors associated with early discontinuation of low-dose ketamine infusions due to adverse drug events (ADEs).<h4>Methods</h4>A retrospective, matched case-control study of surgical patients who received low-dose ketamine infusions for postoperative pain over 6 years was conducted. Forty-seven study patients, who required early discontinuation of ... Read more >>

Pain Pract (Pain practice : the official journal of World Institute of Pain)
[2021, 21(7):759-765]

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 104 times

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COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management.

Michael A Mazzeffi, Jonathan H Chow, Kenichi Tanaka,

<h4>Abstract</h4>Patients with severe coronavirus disease-2019 (COVID-19) frequently have hypercoagulability caused by the immune response to the severe acute respiratory syndrome coronavirus-2 infection. The pathophysiology of COVID-19 associated hypercoagulability is not fully understood, but characteristic changes include: increased fibrinogen concentration, increased Factor VIII activity, increased circulating von Willebrand factor, and exhausted ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(4):465-471]

Cited: 10 times

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SARS-CoV-2 infection of the oral cavity and saliva.

Ni Huang, Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda, Rodney C Gilmore, Cecilia Domínguez Conde, Billel Gasmi, Sydney Stein, Margaret Beach, Eileen Pelayo, Jose O Maldonado, Bernard A Lafont, Shyh-Ing Jang, Nadia Nasir, Ricardo J Padilla, Valerie A Murrah, Robert Maile, William Lovell, Shannon M Wallet, Natalie M Bowman, Suzanne L Meinig, Matthew C Wolfgang, Saibyasachi N Choudhury, Mark Novotny, Brian D Aevermann, Richard H Scheuermann, Gabrielle Cannon, Carlton W Anderson, Rhianna E Lee, Julie T Marchesan, Mandy Bush, Marcelo Freire, Adam J Kimple, Daniel L Herr, Joseph Rabin, Alison Grazioli, Sanchita Das, Benjamin N French, Thomas Pranzatelli, John A Chiorini, David E Kleiner, Stefania Pittaluga, Stephen M Hewitt, Peter D Burbelo, Daniel Chertow, , , Karen Frank, Janice Lee, Richard C Boucher, Sarah A Teichmann, Blake M Warner, Kevin M Byrd,

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets of the human minor salivary glands and gingiva ... Read more >>

Nat Med (Nature medicine)
[2021, 27(5):892-903]

Cited: 66 times

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