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Stepwise Oxidations Play Key Roles in the Structural and Functional Regulations of DJ-1

In-Kang Song, Mi-Sun Kim, James Ferrell, Dong-Hae Shin, Kong-Joo Lee,

DJ-1 is known to play neuroprotective roles by eliminating reactive oxygen species (ROS) as an antioxidant protein. However, the molecular mechanism of DJ-1 function has not been well elucidated. This study explored the structural and functional changes of DJ-1 in response to oxidative stress. We found that Cys46 is also ... Read more >>

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Inhibition of d-glycero-β-d-manno-heptose 1-phosphate adenylyltransferase from Burkholderia pseudomallei by epigallocatechin gallate and myricetin.

Suwon Kim, Seri Jo, Mi-Sun Kim, Heejin Kam, Dong Hae Shin,

Flavonoids play beneficial roles in various human diseases. In this study, a flavonoid library was employed to probe inhibitors of d-glycero-β-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei (BpHldC) and two flavonoids, epigallocatechin gallate (EGCG) and myricetin, have been discovered. BpHldC is one of the essential enzymes in the ADP-l-glycero-β-d-manno-heptose biosynthesis pathway constructing ... Read more >>

Biochem J (The Biochemical journal)
[2020, :]

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

Cited: 58 times

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A study of Rose Bengal against a 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase as an antibiotic candidate.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

Frequent occurrences of multi-drug resistance of pathogenic Gram-negative bacteria threaten human beings. The CMP-2-keto-3-deoxy-d-<i>manno</i>-octulosonic acid biosynthesis pathway is one of the new targets for antibiotic design. 2-Keto-3-deoxy-d-<i>manno</i>-octulosonate cytidylyltransferase (KdsB) is the key enzyme in this pathway. KdsB proteins from <i>Burkholderia pseudomallei</i> (<i>Bp</i>), <i>B. thailandensis</i> (<i>Bt</i>), <i>Pseudomonas aeruginosa</i> (<i>Pa</i>), and <i>Chlamydia ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1414-1421]

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Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro.

Seri Jo, Suwon Kim, Dae Yong Kim, Mi-Sun Kim, Dong Hae Shin,

Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease. Main protease (3CLpro) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the good targets ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1539-1544]

Cited: 1 time

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Crystal structure of pharmaceutical-grade human serum albumin.

Jimin Park, Mi-Sun Kim, Taeseong Park, Young Hwan Kim, Dong Hae Shin,

Human serum albumin (HSA) is the most abundant protein in human plasma and plays versatile biological role. HSA has been widely used to treat several diseases and develop biocompatible biomaterials for biomedical applications. However, pharmaceutical-grade HSA (p-HSA) showed the altered oxidative and ligand-binding properties compare to native HSA. To investigate ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 166:221-228]

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Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features.

Ji Hyae Lim, Yu-Jung Kang, Hye Jin Bak, Mi Sun Kim, Hyun Jung Lee, Dong Wook Kwak, You Jung Han, Moon Young Kim, Hyeyeon Boo, Shin Young Kim, Hyun Mee Ryu,

<h4>Background</h4>Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely remains unclear. Here, we performed DNA methylation profiling to determine whether differential patterns of DNA methylation correlate with PE and severe ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2020, 12(1):128]

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Feasibility of 3-Dimensional Visual Guides for Preparing Pediatric Zirconia Crowns: An In Vitro Study.

Ho Yeon Kang, Hyeonjong Lee, Yong Kwon Chae, Seoung-Jin Hong, Yun Yeong Jeong, Ko Eun Lee, Mi Sun Kim, Hyo-Seol Lee, Sung Chul Choi, Ok Hyung Nam,

This study evaluated the feasibility of a tooth preparation guide for prefabricated zirconia crowns (PZCs). Three-dimensional surface data for PZCs of the left maxillary primary first molar and left mandibular primary second molar were obtained using a model scanner. The tooth preparation data were digitally designed to harmonize with the ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(16):]

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Cognitive profile as a predictor of the long-term outcome after deep brain stimulation in Parkinson's disease.

Kye Won Park, Sungyang Jo, Mi Sun Kim, Nari Choi, Sang Ryong Jeon, Hee Kyung Park, Kyum-Yil Kwon, Chong S Lee, Sun Ju Chung,

BACKGROUND:Although dementia is a contraindication for deep brain stimulation (DBS) in patients with Parkinson's disease (PD), the concept is supported by little scientific evidence. Moreover, it is unclear whether PD with mild cognitive impairment (PD-MCI) or domain-specific cognitive impairments affect the outcome of DBS in non-demented PD patients. OBJECTIVE:To investigate ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 417:117063]

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Age-dependent efficacy of subthalamic nucleus deep brain stimulation in young- and late-onset Parkinson's disease based on a 10 year follow-up.

Mi Sun Kim, Ho-Sung Ryu, Kye Won Park, Nari Choi, Sooyeoun You, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Sun Ju Chung,

<b>Introduction: </b>Long-term efficacy and safety of subthalamic nucleus deep brain stimulation (STN DBS) in patients with young-onset Parkinson's disease (YOPD) and late-onset PD (LOPD) (i.e. motor symptom initial appearance at ages ≤40 and > 40 years, respectively) was compared to identify relationships between PD onset age and the efficacy of DBS.<br><br><b>Methods: </b>Statistical analyses ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 416:117004]

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Application of magnetic resonance computer-aided diagnosis for preoperatively determining invasive disease in ultrasonography-guided core needle biopsy-proven ductal carcinoma in situ.

Hye Shin Ahn, Sun Mi Kim, Mi Sun Kim, Mijung Jang, Bo La Yun, Eunyoung Kang, Eun-Kyu Kim, So Yeon Park, Bohyoung Kim,

The aim of this study was to analyze kinetic and morphologic features using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with computer-aided diagnosis (CAD) to predict occult invasive components in cases of biopsy-proven ductal carcinoma in situ (DCIS).We enrolled 138 patients with 141 breasts who underwent preoperative breast MRI and were ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(31):e21257]

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Transabdominal fetal reduction: a report of 124 cases.

Mi Sun Kim, Sukho Kang, Youngri Kim, Ji Yeon Kang, Myoung Jin Moon, Min Jung Baek,

To prevent fetal loss, preterm delivery, and perinatal morbidity of multifetal pregnancies (MPs), fetal reduction (FR) is offered to some patients. We retrospectively analysed the data of 124 MPs that underwent transabdominal FR to twin (<i>n</i> = 63) and singleton (<i>n</i> = 61) pregnancies at a mean gestational age of 12 + 6 weeks between December 2006 ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, :1-6]

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A Tryptophan-based Assay Method to Search Regulatory Compounds for TCTP

Seri Jo, Eun-Wha Jang, Mi-Sun Kim, Suwon Kim, Kyunglim Lee, Dong Hae Shin,

Transcriptionally controlled tumor protein (TCTP) is a highly conserved protein performing a large number of cellular functions by binding with various partner proteins. The importance of its roles in many diseases requires an assay method to find regulatory compounds. However, the molecular characteristics of TCTP made it difficult to search ... Read more >>

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Treatment of superimposed preeclampsia on chronic hypertension in a twin pregnancy with automatic continuous positive airway pressure: a case report.

Mi Sun Kim, Myoung Jin Moon, Yoon Hee Lee, Kyu Young Chae, Eun Hee Ahn,

BACKGROUND:Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CPAP) in adverse obstetric outcomes. CASE PRESENTATION:We introduce a case of 34 year old twin pregnant woman diagnosed with superimposed preeclampsia on chronic hypertension ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):157]

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The association between mastication and mild cognitive impairment in Korean adults.

Mi-Sun Kim, Bumjo Oh, Ji Won Yoo, Dong-Hun Han,

Currently, a few of studies revealed that there is an association between mastication and cognitive impairment. There is no study of Korean adult representative samples in relation to mastication and cognitive decline. This study was to investigate the relationship between mastication and mild cognitive impairment in Korean adults.A population-based cross-sectional ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(23):e20653]

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Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson's Disease.

Hae-Won Shin, Mi Sun Kim, Sung Reul Kim, Sang Ryong Jeon, Sun Ju Chung,

OBJECTIVE:The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson's disease (PD) remain unclear. In this study, we aimed to evaluate the longterm effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. METHODS:This study included ... Read more >>

J Mov Disord (Journal of movement disorders)
[2020, 13(2):127-132]

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Production of Flavonoids in Callus Cultures of Sophora flavescens Aiton.

Ji-Sun Park, Zuh-Kyung Seong, Mi-Sun Kim, Jang-Ho Ha, Ki-Beom Moon, Hyo-Jun Lee, Hyeong-Kyu Lee, Jae-Heung Jeon, Sang Un Park, Hyun-Soon Kim,

Flavonoids, including maackiain (Maac) from Sophora flavescens Aiton roots, have many pharmacological properties, such as antitumor, antimicrobial, and antifungal activities. This research aimed to develop an in vitro plant and callus culture system for S. flavescens for the purpose of generating an alternative production system for enhancing Maac production, as ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(6):]

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Parkinson Disease-Related Pattern of Glucose Metabolism Associated With the Potential for Motor Improvement After Deep Brain Stimulation.

Eun Jung Lee, Jungsu S Oh, Hyojeong Moon, Min-Ju Kim, Mi Sun Kim, Sun Ju Chung, Jae Seung Kim, Sang Ryong Jeon,

<h4>Background</h4>Motor dysfunctions in Parkinson disease (PD) patients are not completely normalized by deep brain stimulation (DBS), and there is an obvious difference in the degree of symptom improvement after DBS for each patient.<h4>Objective</h4>To test our hypothesis that each patient has their own restoration capacity for motor improvement after DBS, and ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):492-499]

Cited: 1 time

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Re-Irradiation and Its Contribution to Good Prognosis in Recurrent Glioblastoma Patients.

Mi Sun Kim, Jaejoon Lim, Hyun Soo Shin, Kyung Gi Cho,

BACKGROUND:Radiation therapy, one of the strongest anti-cancer treatments, is already performed to treat primary glioblastoma; however, the effect of repeated radiation therapy for recurrent tumors has not been fully explored. The aim of this study was to determine the efficacy of re-irradiation in treating recurrent glioblastoma. METHODS:The study included 36 ... Read more >>

Brain Tumor Res Treat (Brain tumor research and treatment)
[2020, 8(1):29-35]

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Age-dependent facial subcutaneous fat thickness by high-frequency medical diagnostic ultrasound system.

Mi-Sun Kim, Yong Yeon Jeong, Sun Gyoo Park, Nae-Gyu Kang,

Skin Res Technol (Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI))
[2020, 26(5):769-771]

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Assessing the Presence of Post-Traumatic Stress and Turnover Intention Among Nurses Post-Middle East Respiratory Syndrome Outbreak: The Importance of Supervisor Support.

Heeja Jung, Sun Young Jung, Mi Hyang Lee, Mi Sun Kim,

<i>Background:</i> South Korea faced the Middle East Respiratory Syndrome (MERS) outbreak for the first time in 2015, which resulted in 186 infected patients and 39 deaths. This study investigated the level of post-traumatic stress disorder (PTSD) and turnover intention, the relationship between PTSD and turnover intention, and the buffering effect ... Read more >>

Workplace Health Saf (Workplace health & safety)
[2020, 68(7):337-345]

Cited: 5 times

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The Use of Histidine-tryptophan-ketoglutarate Solution as a New Storage Medium for the Avulsed Tooth.

Tae Jun Oh, Ok Hyung Nam, Mi Sun Kim, Hyo-Seol Lee, Yu-Shik Hwang, Sung Chul Choi,

<h4>Introduction</h4>Histidine-tryptophan-ketoglutarate (HTK) is a preservation solution used for organ transplantation. The physiological pH and osmolality of this solution are known to facilitate cell proliferation and cell membrane stabilization. The purpose of the present study was to investigate the efficacy of several concentrations of HTK solution as a storage medium for ... Read more >>

J Endod (Journal of endodontics)
[2020, 46(1):74-80]

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GTP Preference of d-Glycero-α-d-manno-Heptose-1-Phosphate Guanylyltransferase from Yersinia pseudotuberculosis.

Suwon Kim, Mi-Sun Kim, Seri Jo, Dong Hae Shin,

d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme synthesizing a building component of lipopolysaccharide (LPS) of Gram-negative bacteria. Since HddC is a potential new target to develop antibiotics, the analysis of the structural and functional relationship of the complex structure will lead to a better idea to design inhibitory compounds. X-ray ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 21(1):]

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Factors influencing self-management in Parkinson's disease: A cross-sectional study.

Kyeung Eun Lim, Sung Reul Kim, Young Hee Sung, Sun-Young Oh, Mi Sun Kim, Sun Ju Chung,

This study aimed to identify factors influencing self-management in patients with Parkinson's disease (PD) based on social cognitive theory. A cross-sectional design was used; data were collected at three tertiary medical centers in Korea from a convenience sample of 356 PD patients. Higher self-management scores were associated with higher education ... Read more >>

Geriatr Nurs (Geriatric nursing (New York, N.Y.))
[2020, 41(3):254-260]

Cited: 1 time

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A Study of a Potent Inhibitor Against a GDP-6-Deoxy-α-d-Manno-Heptose Biosynthesis Pathway as Antibiotic Candidates.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

The GDP-6-deoxy-α-d-<i>manno</i>-heptose is a key building block molecule in constructing lipopolysaccharide of Gram-negative bacteria. Therefore, blockage of the biosynthesis pathway of GDP-6-deoxy-α-d-<i>manno</i>-heptose is lethal or increases antibiotics susceptibility to pathogens. In this study, we assayed d-<i>glycero</i>-α-d-<i>manno</i>-heptose-1-phosphate guanylyltransferase (HddC) from <i>Yersinia pseudotuberculosis</i> (<i>Yp</i>) using an efficient assay method supplying its natural ... Read more >>

Microb Drug Resist (Microbial drug resistance (Larchmont, N.Y.))
[2020, 26(4):385-390]

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