Full Text Journal Articles by
Author Metztli Cisneros Aguirre

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To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining.

Metztli Cisneros-Aguirre, Xiaoli Ping, Jeremy M Stark,

Chromosomal DNA double-strand breaks (DSBs) are the effective lesion of radiotherapy and other clastogenic cancer therapeutics, and are also the initiating event of many approaches to gene editing. Ligation of the DSBs by end joining (EJ) pathways can restore the broken chromosome, but the repair junctions can have insertion/deletion (indel) ... Read more >>

DNA Repair (Amst) (DNA repair)
[2022, 118:103380]

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The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened.

Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Linda Jillianne Tsai, Ragini Bhargava, Jeremy M Stark,

Canonical non-homologous end joining (C-NHEJ) factors can assemble into a long-range (LR) complex with DNA ends relatively far apart that contains DNAPKcs, XLF, XRCC4, LIG4, and the KU heterodimer and a short-range (SR) complex lacking DNAPKcs that has the ends positioned for ligation. Since the SR complex can form de ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):3662]

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