Full Text Journal Articles by
Author Metin Karakok


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A detailed assessment of high infant death rates in Gaziantep in 2013.

Neriman Aydin, Birgul Ozcirpici, Senay Leyla Kuzu, Metin Karakok,

<h4>Objective</h4>To determine the causes of a relatively high infant mortality rate in a Turkish city compared to the nationwide rate.<h4>Methods</h4>The cross-sectional study was conducted at Gaziantep from January to March 2014, and comprised a representative sample of infant deaths that occurred between January and December 2013 in the city of ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(6):846-851]

Cited: 0 times

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Increased Expressions of ICAM-2 and ICAM-3 in Pterygium.

Seniz Demiryürek, Ahmet Saracaloglu, Sabit Kimyon, Alper Mete, Omer Eronat, Ebru Temiz, Gülper Nacarkahya, Zeynep Sav Tunca, Betül Düzen, Oguzhan Saygili, Kıvanc Güngör, Metin Karakök, Abdullah T Demiryürek,

<b>Purpose</b>: Pterygium, one of the most common ocular surface diseases, is characterized by inflammatory infiltrates, proliferation, angiogenesis, fibrosis, and extracellular matrix breakdown. The objective of this study was to elucidate the levels of the intercellular adhesion molecule (ICAM)-2, and ICAM-3 gene and protein expressions in pterygium. <b>Methods</b>: A total of ... Read more >>

Curr Eye Res (Current eye research)
[2019, 44(6):645-650]

Cited: 0 times

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The re-awakening of hCG expression. Its role in the diagnosis of cervical squamous cell carcinoma.

Zehra Bozdag, Aynur M Taslar, Neslihan B Tepe, Omer F Dizibuyuk, Huseyin C Ozcan, Metin Karakök,

<h4>Objectives</h4>To compare immunohistochemical detection of Human chorionic gonadotropin (hCG) expression in paraffin embedded tissue of squamous cell carcinomas (SCC) and high grade squamous intraepithelial lesions (HSIL).<h4>Methods</h4>The samples in this retrospective study were obtained from the archives of the Pathology Department at Gaziantep University, Gaziantep, Turkey, over the period from January ... Read more >>

Saudi Med J (Saudi medical journal)
[2018, 39(9):873-877]

Cited: 1 time

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Evaluation of EGFR, KRAS and BRAF gene mutations in renal cell carcinoma.

Omer Bayrak, Haluk Sen, Ersan Bulut, Beyhan Cengiz, Metin Karakok, Sakip Erturhan, Ilker Seckiner,

A subset of renal cell carcinoma (RCC) patients has been shown to respond to anti-EGFR therapy. As KRAS and BRAF mutations are associated with poor response to anti-EGFR therapy in some cancers, it has been suggested that screening for KRAS and BRAF mutations in RCC may be a promising strategy ... Read more >>

J Kidney Cancer VHL (Journal of kidney cancer and VHL)
[2014, 1(4):40-45]

Cited: 5 times

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Limitation of HIF-1α with pentoxifillyne on renal tubular ischemia result of hiperoxaluria and ESWL.

Sakip Erturhan, Omer Bayrak, Ilker Seckiner, Mehmet Celik, Metin Karakok,

To evaluate hypoxia-inducible factor 1 subunit α (HIF-1α) expression during the performance of extracorporeal shock wave lithotripsy (ESWL) and to investigate the effects of pentoxyphylline on HIF-1α expression.One hundred New Zealand Albino rabbit were used in the study divided in 5 groups. There were 20 rabbits in each group. The ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2014, 67(2):191-197]

Cited: 0 times

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Antitumoral effect of a selective Rho-kinase inhibitor Y-27632 against Ehrlich ascites carcinoma in mice.

Derya Isler, Mehmet Ozaslan, Isik Didem Karagoz, Ibrahim Halil Kilic, Metin Karakok, Seyithan Taysi, Izzettin Guler, Ahmet Cakmak, Abdullah Tuncay Demiryurek,

<h4>Background</h4>The Rho proteins and Rho-kinase (ROCK) enzymes are responsible for signal transduction, and cause cell permeability, contractility, differentiation, migration, proliferation or apoptosis depending on cell types. All of these functions are vital for cancer initiation and progression. In this study, the preventive and protective effects of a selective ROCK inhibitor ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2014, 66(1):114-120]

Cited: 3 times

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Loss of heterozygosity of chromosome 13q33-34 region and molecular analysis of ING1 and p53 genes in bladder carcinoma.

Mehri Igci, Ahmet Arslan, Sakip Erturhan, Yusuf Ziya Igci, Elif Pala, Bulent Gogebakan, Metin Karakok, Ecir Ali Cakmak, Beyhan Cengiz,

Cancer is a consequence of accumulation of genetic and epigenetic alterations in the cell which can lead to activation of oncogenes or inactivation of tumor suppressor genes (TSG). Since members of ING family were discovered as TSGs in different cancer types, it was aimed to analyze the chromosome 13q33-34 region, ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2015, 42(2):507-516]

Cited: 0 times

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Chemical cystitis developed in experimental animals model: Topical effect of intravesical ozone application to bladder.

Omer Bayrak, Sakip Erturhan, Ilker Seckiner, Ahmet Erbagci, Abdulkerim Ustun, Metin Karakok,

<h4>Aims</h4>To demonstrate the effects of intravesical ozone treatment on inflammation and epithelial cell damage in chemical cystitis animal model.<h4>Materials and methods</h4>A total of 30 New Zealand rabbits were divided into six groups. Cystitis was conducted with transurethral intravesical hydrochloric acid instillation on the subjects in Groups IA, IB, IIA, and ... Read more >>

Urol Ann (Urology annals)
[2014, 6(2):122-126]

Cited: 3 times

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Investigation of intercellular adhesion molecules (ICAMs) gene expressions in patients with Barrett's esophagus.

Belgin Alasehirli, Elif Oğuz, Ebru Oksuzler, Irfan Koruk, Serdar Oztuzcu, Esma Ozkara, Metin Karakok, Ayse Binnur Erbagcı, Abdullah Tuncay Demiryurek,

The adhesion molecules play a major role in inflammation as well as in neoplastic diseases. The aim of this study is to evaluate the expressions of the adhesion molecules, intercellular adhesion molecule 1 (ICAM-1), ICAM-2, and ICAM-3, in Barrett's esophagus, recognized as a premalign lesion for esophageal cancer and related ... Read more >>

Tumour Biol (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(5):4907-4912]

Cited: 2 times

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Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model.

Omer Bayrak, Ilker Seckiner, Mehmet Solakhan, Metin Karakok, Sakip M Erturhan, Faruk Yagci,

<h4>Objective</h4>To demonstrate the effects of intravesical dexpanthenol use on bladder histology and lipid peroxidation in a chemical cystitis animal model.<h4>Methods</h4>Thirty-five New Zealand rabbits were divided into 3 groups. Cystitis was conducted with transurethral intravesical hydrochloric acid instillation on the subjects in groups I and II. Then, Group I subjects were ... Read more >>

Urology (Urology)
[2012, 79(5):1023-1026]

Cited: 6 times

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Can mycoplasma contribute to formation of prostate cancer?

Sakip M Erturhan, Omer Bayrak, Sacide Pehlivan, Hanifi Ozgul, Ilker Seckiner, Tugce Sever, Metin Karakök,

<h4>Purpose</h4>To reveal the possible role of mycoplasmas in the etiopathogenesis of prostate cancer.<h4>Methods</h4>In the study, prostate biopsy was performed on 62 patients with an abnormal digital rectal examination and/or elevated PSA. The patients' age was between 62 and 77 (mean 65.4 years) years. Thirty-one patients had adenocarcinoma of the prostate ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2013, 45(1):33-38]

Cited: 7 times

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Esophagus cancer and IgA deficiency in a patient with Dubowitz syndrome: a case report.

Ibrahim Halil Turkbeyler, Yavuz Pehlivan, Gazi Comez, Davut Pehlivan, Alper Sevinc, Mehmet Emin Kalender, Metin Karakok, Celalettin Camci,

Dubowitz syndrome was first described in 1965 by the English physician Dr. Victor Dubowitz. This genetic disorder causes growth retardation both before and after birth. It is primarily diagnosed through the distinctive facial features of affected individuals, including a small triangular-shaped face with a high forehead and wide-set, slitted eyes. ... Read more >>

Tokai J Exp Clin Med (The Tokai journal of experimental and clinical medicine)
[2011, 36(2):29-30]

Cited: 3 times

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A rare cause of intestinal obstruction: neonatal gastrointestinal stromal tumor.

Bilge Tanyeri, Naim Koku, Mustafa Demirci, Metin Karakök, Elvan Caglar Citak,

Gastrointestinal stromal tumors (GISTs) are rare in the childhood period. The authors reported a case who was admitted to the neonatal intensive care unit (NICU) on a suspicion of intestinal obstruction. She was operated and a mass in a size of 6 x 4.5 x 4 cm was resected from ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2011, 28(2):155-158]

Cited: 1 time

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Widespread metastases in small cell carcinoma of the prostate on FDG PET/CT.

Mustafa Yilmaz, Zeki Celen, Alper Sevinc, Metin Karakok,

A 72-year-old man recently diagnosed with a small cell carcinoma of the prostate was referred for staging of the primary malignancy. F-18-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed tomography (PET/CT) revealed extensive hypermetabolic metastatic involvement of the liver, multiple small metastatic nodules in the lungs, and a solitary bone metastasis ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2009, 34(9):598-600]

Cited: 7 times

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Immunohistochemical prognostic criteria in xeroderma pigmentosum.

Metin Karakok, Arif Turkmen, Mehmet Bekerecioglu, N Emrah Koçer,

Xeroderma pigmentosum (XP) is a rare inheritable disease characterized by severe sun sensitivity and early development of skin cancers. We compared the expression of cell proliferation markers and cell cycle checkpoint regulators in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) from patients with and without XP. Immunostaining for ... Read more >>

Int J Dermatol (International journal of dermatology)
[2010, 49(11):1266-1271]

Cited: 1 time

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Successful treatment of refractory adult Still's disease and membranous glomerulonephritis with infliximab.

Taner Babacan, Ahmet Mesut Onat, Yavuz Pehlivan, Gazi Comez, Metin Karakök,

Adult onset Still's Disease (ASD) is a systemic inflammatory disorder of unknown etiology characterized by chronic and fluctuant fever with accompanying rash, polyarthritis and involvement of multiple organs, especially lymphoid tissues. Although kidney involvement may appear in some cases of adult Still's disease, membranous glomerulonephyritis has not been described before. ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2010, 29(4):423-426]

Cited: 3 times

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Evaluation of relationship between HIF-1alpha immunoreactivity and stage, grade, angiogenic profile and proliferative index in bladder urothelial carcinomas.

Hale Deniz, Metin Karakök, Faruk Yagci, Muhammet Emin Güldür,

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a critical regulatory protein of cellular response to hypoxia. In this study, we evaluated the relationship of HIF-1alpha with clinicopathologic parameters such as tumor stage and grade, as well as angiogenic profile and proliferation index. The immunoreactivity of HIF-1alpha was assessed in 70 cases of primary ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2010, 42(1):103-107]

Cited: 21 times

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Hyperoxaluria-induced tubular ischemia: the effect of verapamil on the limitation of tissue HIF-1 alpha levels in renal parenchyma.

Faruk Yencilek, Kemal Sarica, Bilal Eryildirim, Sakip Erturhan, Metin Karakok, Ugur Kuyumcuoglu,

<h4>Objectives</h4>The effect of verapamil on tubular ischemia that is demonstrated by HIF-1alpha positivity in tubular cells following hyperoxaluria was evaluated in a rabbit model.<h4>Methods</h4>Thirty-six healthy male rabbits were randomly divided into three groups. Animals in the hyperoxaluric group were fed with 0.75% ethylene glycol. The verapamil group was fed identically ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2010, 42(2):361-367]

Cited: 3 times

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A case of metachronous triple primary urogenital cancer: urinary bladder, prostate, and renal cancer.

Cemile Arikan-Sengul, Yavuz Pehlivan, Alper Sevinc, Metin Karakok, Mehmet Emin Kalender, Celalettin Camci,

<h4>Background</h4>Multiple primary malignant tumors are rarely seen. Tobacco is one of the factors in their etiology. We report the case of a heavy smoker with metachronous triple primary cancer occurring in the prostate, kidney and urinary bladder.<h4>Case report</h4>A 70-year-old man with prostate cancer presented with the complaint of hematuria. Computed ... Read more >>

Onkologie (Onkologie)
[2009, 32(3):122-124]

Cited: 3 times

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Local defense systems in the prepuce.

Ayse Balat, Metin Karakök, Elif Güler, Nevzat Uçaner, Yasemin Kibar,

<h4>Objective</h4>Urinary tract infection (UTI) is a common bacterial infection in children. Circumcision reduces the incidence of UTI, and prevents preputial colonization with uropathic bacteria in childhood. However, there is insufficient information about the reason(s) why such colonization tends to occur in prepucium skin.<h4>Material and methods</h4>We evaluated some of the humoral ... Read more >>

Scand J Urol Nephrol (Scandinavian journal of urology and nephrology)
[2008, 42(1):63-65]

Cited: 4 times

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The association between silicone implants and both antibodies and autoimmune diseases.

Mehmet Bekerecioglu, Ahmet Mesut Onat, Mustafa Tercan, Hakan Buyukhatipoglu, Metin Karakok, Daghan Isik, Omer Bulut,

Silicones are widely used materials in many fields of medicine and largely are believed to be biologically inert. However, some investigators have reported that silicone implants are associated with an increased incidence of autoimmune disorders. In this study, we evaluated the capsular tissue of silicone implants and the sera of ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2008, 27(2):147-150]

Cited: 9 times

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Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.

M Emin Kalender, Alper Sevinc, Celalettin Camci, H Mehmet Turk, Metin Karakok, Bulent Akgul,

<h4>Objective</h4>Anastrozole is a selective aromatase inhibitor and is used for the hormonal treatment of postmenopausal breast cancer. There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and ... Read more >>

Oncology (Oncology)
[2007, 73(5-6):415-418]

Cited: 3 times

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Brown tumor with atypical localization in a normocalcemic patient.

Oguz Cebesoy, Metin Karakok, Omer Arpacioglu, Enver Taner Baltaci,

Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. It is frequently seen in the head and neck region. Brown tumor presents itself on foot very rarely. Hyperparathyroidism is usually associated with high levels of calcium. Being normocalcemic and having the tumor on foot only without any ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2007, 127(7):577-580]

Cited: 10 times

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Urotensin-II immunoreactivity in children with chronic glomerulonephritis.

Ayse Balat, Metin Karakök, Kutluhan Yilmaz, Yasemin Kibar,

<h4>Background</h4>Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases.<h4>Methods</h4>Normal human kidneys were obtained from postmortem biopsies ... Read more >>

Ren Fail (Renal failure)
[2007, 29(5):573-578]

Cited: 17 times

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Primary synovial sarcoma of the kidney: use of PET/CT in diagnosis and follow-up.

Sakip Erturhan, Ilker Seçkiner, Sabri Zincirkeser, Ahmet Erbagci, Mehmet Celik, Faruk Yagci, Metin Karakok,

Primary renal synovial sarcoma is a rarely seen renal neoplasm. An experienced uropathologist is needed to make the pathological diagnosis. A patient, operated on with a prediagnosis of renal cell carcinoma, the pathology of which was reported as synovial sarcoma, is presented in this article. 18F-fluoro-deoxyglucose positron emission tomography and ... Read more >>

Ann Nucl Med (Annals of nuclear medicine)
[2008, 22(3):225-229]

Cited: 6 times

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