Full Text Journal Articles by
Author Mervyn Singer

Advertisement

Find full text journal articles






Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.

Anoop D Shah, Niall S MacCallum, Steve Harris, David A Brealey, Edward Palmer, James Hetherington, Sinan Shi, David Perez-Suarez, Ari Ercole, Peter J Watkinson, Andrew Jones, Simon Ashworth, Richard Beale, Stephen J Brett, Mervyn Singer,

<h4>Objectives</h4>To describe the epidemiology of sepsis in critical care by applying the Sepsis-3 criteria to electronic health records.<h4>Design</h4>Retrospective cohort study using electronic health records.<h4>Setting</h4>Ten ICUs from four U.K. National Health Service hospital trusts contributing to the National Institute for Health Research Critical Care Health Informatics Collaborative.<h4>Patients</h4>A total of 28,456 critical ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1883-1894]

Cited: 0 times

View full text PDF listing >>



Reflections on Critical Care's Past, Present, and Future.

Manu Shankar-Hari, Hannah Wunsch, Kathy Rowan, Mervyn Singer, Gordon D Rubenfeld, Derek C Angus,

Crit Care Med (Critical care medicine)
[2021, 49(11):1855-1865]

Cited: 0 times

View full text PDF listing >>



Advertisement

International Critical Care-From an Indulgence of the Best-Funded Healthcare Systems to a Core Need for the Provision of Equitable Care.

Philip D Lumb, Diane C Adler, Hussain Al Rahma, Pravin Amin, Jan Bakker, Satish Bhagwanjee, Bin Du, Christopher W Bryan-Brown, Geoffrey Dobb, Bruce Gingles, Judith Jacobi, Younsuck Koh, Assem Abdel Razek, Carol Peden, Gentle S Shrestha, Khalid Shukri, Mervyn Singer, Phil Taylor, Ged Williams,

Crit Care Med (Critical care medicine)
[2021, 49(10):1589-1605]

Cited: 0 times

View full text PDF listing >>



Influence of IL-6 levels on patient survival in COVID-19.

Nishkantha Arulkumaran, Timothy A C Snow, Adarsh Kulkarni, David Brealey, Hannah M Rickman, Chloe Rees-Spear, Moira J Spyer, Judith Heaney, Edmund Garr, Bryan Williams, Peter Cherepanov, George Kassiotis, Michael P Lunn, Gareth Ambler, Catherine Houlihan, Laura E McCoy, Eleni Nastouli, Mervyn Singer,

J Crit Care (Journal of critical care)
[2021, 66:123-125]

Cited: 0 times

View full text PDF listing >>



Effect of Dexamethasone In Patients With ARDS And COVID-19 (REMED Trial) – Study Protocol For A Prospective, Multi-Centre, Open-Label, Parallel-Group, Randomized Controlled Trial

Jan Maláska, Jan Stašek, František Duška, Martin Balík, Jan Máca, Jan Hruda, Tomáš Vymazal, Olga Klementová, Jan Zatloukal, Tomáš Gabrhelík, Pavel Novotný, Regina Demlová, Jana Kubátová, Jana Vinklerová, Adam Svobodník, Milan Kratochvíl, Jozef Klučka, Roman Gál, Mervyn Singer,

<h4>Background: </h4> Since December 2019, SARS-Co-2 virus has infected millions of people worldwide. In patients with COVID-19 pneumonia in need for oxygen therapy or mechanical ventilation, dexamethasone 6 mg per day is currently recommended. However, the dose of 6 mg of dexamethasone is currently being reappraised and may miss important ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Risk factors associated with bloodstream infections among critically ill patients with COVID-19.

Tim McMillan, Conor Jones, Cavan J O'Connor, Daniel Nolan, Xin Hui S Chan, Jayne Ellis, Clare Thakker, Katharina Kranzer, Neil Rh Stone, Mervyn Singer, A Peter R Wilson, Nishkantha Arulkumaran,

J Infect (The Journal of infection)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression.

Timothy A C Snow, Naveed Saleem, Gareth Ambler, Eleni Nastouli, Laura E McCoy, Mervyn Singer, Nishkantha Arulkumaran,

<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies, particularly those preventing interaction between the viral spike receptor-binding domain and the host angiotensin-converting enzyme 2 receptor, may prevent viral entry into host cells and disease progression.<h4>Methods</h4>We performed a systematic review, meta-analysis, trial sequential analysis (TSA), and meta-regression of RCTs to evaluate ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Corticosteroids in adult respiratory distress syndrome - an inconvenient truth?

Rob Shulman, Cecilia Montanari, Inês Pinheiro, Alessia Longobardo, Suzanne Benhalm, Sara Polhill, Mervyn Singer, Geoff Bellingan, Nishkantha Arulkumaran,

<h4>Objectives</h4>Recent studies have demonstrated mortality benefits from corticosteroid use in COVID-19 patients requiring respiratory support. However, clinical practice may warrant the use of corticosteroids outside the context of a clinical trial. Such data are rarely, if ever, reported. We explored the use of corticosteroids for adult respiratory distress syndrome (ARDS) ... Read more >>

Int J Pharm Pract (The International journal of pharmacy practice)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Cholesterol and its association with muscle weakness in critical illness.

Daniel A Hofmaenner, Anna Kleyman, Mervyn Singer,

Crit Care (Critical care (London, England))
[2021, 25(1):296]

Cited: 0 times

View full text PDF listing >>



Sepsis in severe COVID-19 is rarely septic shock: a retrospective single-centre cohort study.

Pietro Arina, Valeria Moro, Beatrice Baso, Christopher Baxter-Derrington, Mervyn Singer,

Br J Anaesth (British journal of anaesthesia)
[2021, 127(5):e182-e185]

Cited: 0 times

View full text PDF listing >>



"L'histoire se répète", one size does not fit all. Author's reply.

Timothy Arthur Chandos Snow, Naveed Saleem, Mervyn Singer, Nishkantha Arulkumaran,

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1171-1172]

Cited: 0 times

View full text PDF listing >>



Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release

Shivalee Duduskar, Mohamed Ghait, Martin Westermann, Huijuan Guo, Anuradha Ramoji, Christoph Sponholz, Bianca Göhrig, Tony Bruns, Ute Neugebauer, Jurgen Popp, Lorena Tuchscherr, Bettina Löffler, Nico Ueberschaar, Christine Beemelmanns, Mervyn Singer, Michael Bauer, Sachin Deshmukh,

<h4>ABSTRACT</h4> Molecular mechanisms through which Gram-positive bacteria induce the canonical inflammasome are poorly understood. Here, we studied the effects of Group B streptococci (GBS) and Staphylococcus aureus (SA) on inflammasome activation in human macrophages. Dinucleotide binding small RNA aptamers released by SA and GBS were shown to trigger increased IL-1β ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats.

Nishkantha Arulkumaran, Sean J Pollen, Robert Tidswell, Charlotte Gaupp, Vera B M Peters, Giacomo Stanzani, Timothy A C Snow, Michael R Duchen, Mervyn Singer,

<h4>Background</h4>Excess mitochondrial reactive oxygen species (mROS) in sepsis is associated with organ failure, in part by generating inflammation through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. We determined the impact of a mitochondrial-targeted antioxidant (MitoTEMPO) on mitochondrial dysfunction in renal proximal tubular epithelial cells, peritoneal immune cell ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 127(4):577-586]

Cited: 0 times

View full text PDF listing >>



Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort.

Nishkantha Arulkumaran, Timothy Arthur Chandos Snow, Adarsh Kulkarni, David Brealey, Hannah Rickman, Chloe Rees-Spear, Moira J Spyer, Judith Heaney, Edmund Garr, Bryan Williams, Peter Cherepanov, George Kassiotis, Michael Lunn, Catherine Houlihan, Laura E McCoy, Eleni Nastouli, Mervyn Singer,

<h4>Objectives</h4>Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus disease 2019 therapeutic targets discriminated between patients with mild or severe disease.<h4>Design</h4>A search of ClinicalTrials.gov identified ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(8):e0488]

Cited: 0 times

View full text PDF listing >>



Comparison of renal replacement therapy and renal recovery before and during the COVID-19 pandemic. A single centre observational study.

Rebecca Ryan, Isabel Taylor, Chris Laing, Mervyn Singer, Dereck Gondongwe, Niall MacCALLUM, Nishkantha Arulkumaran,

<h4>Background</h4>Our objective was to the describe indications, management, complications and outcomes of renal replacement therapy (RRT) in COVID-19 critically ill patients. To contextualise these findings, comparisons were made against 36 non-COVID-19 consecutive patients requiring RRT on ICU.<h4>Methods</h4>We conducted a retrospective single centre observational cohort study of patients requiring acute RRT ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study.

Vincenzo De Santis, Alberto Corona, Domenico Vitale, Cecilia Nencini, Antonella Potalivo, Anna Prete, Gianluca Zani, Anna Malfatto, Luigi Tritapepe, Stefania Taddei, Alessandro Locatelli, Vittorio Sambri, Maurizio Fusari, Mervyn Singer,

<h4>Purpose</h4>To investigate the prevalence, incidence and characteristics of bacterial infections and their impact on outcome in critically ill patients infected with COVID-19.<h4>Methods</h4>We conducted a prospective observational study in eight Italian ICUs from February to May 2020; data were collected through an interactive electronic database. Kaplan-Meier analysis (limit product method) was ... Read more >>

Infection (Infection)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.

Mervyn Singer, Andre Kalil,

Intensive Care Med (Intensive care medicine)
[2021, 47(8):896-898]

Cited: 1 time

View full text PDF listing >>



Feasibility of Noninvasive Positive Pressure Ventilation in the Treatment of Oxygen-Dependent COVID-19 Patients in Peru.

Paloma M Cárcamo, Manuel Laca-Barrera, Diana Cabanillas-Silva, Germán Málaga-Rodríguez, Patricia Mallma-Salazar, David Moore, Rebecca Shipley, Mervyn Singer, Patricia J Garcia,

Intensive care is expensive, and availability is limited. Low- and middle-income countries in particular have struggled to cope with the large influx of critically ill patients during the COVID-19 pandemic. Noninvasive respiratory support devices delivering continuous positive airways pressure (CPAP) require less resource and staff expertise compared with invasive mechanical ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2021, 105(3):727-730]

Cited: 0 times

View full text PDF listing >>



Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study

Alexandre Xerri, Frédéric Gallardo, Frank Kober, Calypso Mathieu, Natacha Fourny, Thi Thom Tran, Jean-Louis Mege, Mervyn Singer, Nathalie Lalevée, Monique Bernard, Marc Leone,

<h4>Introduction: </h4> Although epidemiologic research has demonstrated significant differences in incidence and outcomes of sepsis according to gender, their underlying biological mechanisms are poorly understood. Here, we studied the influence of hormonal status by comparing in vivo cardiac performances measured by MRI in non-ovariectomized and ovariectomized septic female rats. <h4>Methods: ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



The future of acute and emergency care.

Virginia Newcombe, Timothy Coats, Paul Dark, Anthony Gordon, Steve Harris, Danny F McAuley, David K Menon, Susanna Price, Zudin Puthucheary, Mervyn Singer,

Improved outcomes for acutely unwell patients are predicated on early identification of deterioration, accelerating the time to accurate diagnosis of the underlying condition, selection and titration of treatments that target biological phenotypes, and personalised endpoints to achieve optimal benefit yet minimise iatrogenic harm. Technological developments entering routine clinical practice over ... Read more >>

Future Healthc J (Future healthcare journal)
[2021, 8(2):e230-e236]

Cited: 0 times

View full text PDF listing >>



Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort.

Nishkantha Arulkumaran, Timothy A C Snow, Adarsh Kulkarni, David Brealey, Hannah M Rickman, Chloe Rees-Spear, Moira J Spyer, Judith Heaney, Edmund Garr, Bryan Williams, Peter Cherepanov, George Kassiotis, Michael P Lunn, Catherine Houlihan, Laura E McCoy, Eleni Nastouli, Mervyn Singer,

Br J Anaesth (British journal of anaesthesia)
[2021, 127(2):e75-e78]

Cited: 0 times

View full text PDF listing >>



Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials.

Timothy Arthur Chandos Snow, Naveed Saleem, Gareth Ambler, Eleni Nastouli, Mervyn Singer, Nishkantha Arulkumaran,

<h4>Purpose</h4>Interleukin-6 (IL-6) levels discriminate between patients with mild and severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a systematic review, meta-analysis, trial sequential analysis (TSA), and meta-regression of randomized-controlled trials to ascertain the benefit of IL-6 blockade with tocilizumab for COVID-19.<h4>Methods</h4>We included randomized-controlled trials (RCTs) allocating patients ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(6):641-652]

Cited: 8 times

View full text PDF listing >>



Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study.

Dan Frampton, Tommy Rampling, Aidan Cross, Heather Bailey, Judith Heaney, Matthew Byott, Rebecca Scott, Rebecca Sconza, Joseph Price, Marios Margaritis, Malin Bergstrom, Moira J Spyer, Patricia B Miralhes, Paul Grant, Stuart Kirk, Chris Valerio, Zaheer Mangera, Thaventhran Prabhahar, Jeronimo Moreno-Cuesta, Nish Arulkumaran, Mervyn Singer, Gee Yen Shin, Emilie Sanchez, Stavroula M Paraskevopoulou, Deenan Pillay, Rachel A McKendry, Mariyam Mirfenderesky, Catherine F Houlihan, Eleni Nastouli,

<h4>Background</h4>Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of concern (VOC), including virological characteristics and clinical severity in contemporaneous patients with ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, 21(9):1246-1256]

Cited: 69 times

View full text PDF listing >>



The Pharmacology and Therapeutic Utility of Sodium Hydroselenide.

Kavitej Samra, Mathun Kuganesan, William Smith, Anna Kleyman, Robert Tidswell, Nishkantha Arulkumaran, Mervyn Singer, Alex Dyson,

Metabolically active gasotransmitters (nitric oxide, carbon monoxide and hydrogen sulfide) are important signalling molecules that show therapeutic utility in oxidative pathologies. The reduced form of selenium, hydrogen selenide (HSe<sup>-</sup>/H<sub>2</sub>Se), shares some characteristics with these molecules. The simple selenide salt, sodium hydroselenide (NaHSe) showed significant metabolic activity, dose-dependently decreasing ex vivo ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

Cited: 0 times

View full text PDF listing >>



Pathophysiology of sepsis.

Pietro Arina, Mervyn Singer,

<h4>Purpose of review</h4>To provide a current overview of sepsis pathophysiology.<h4>Recent findings</h4>The emphasis on sepsis pathophysiology has moved away from the pathogen - the initiating factor - and instead is focussed upon the abnormal and exaggerated host response. Instead of targeted eradication of the infection, the host response activates or suppresses ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(2):77-84]

Cited: 1 time

View full text PDF listing >>



Advertisement


Disclaimer

1.1213 s