Full Text Journal Articles by
Author Meriem Khiari

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Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Abdelmajid B Hmida, Saadia Bouraoui,

Recent studies suggest that SDF-1 and CXCR4 are expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in colorectal cancer (CRC) tissue has not been fully elucidated.The purpose of this study was to assess ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2015, 15(6):869-879]

Cited: 12 times

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Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Abdelmajid B Hmida, Sabeh Regaya Mzabi, Saadia Bouraoui,

The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from ... Read more >>

J Immunoassay Immunochem (Journal of immunoassay & immunochemistry)
[2015, 36(2):182-194]

Cited: 4 times

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Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia.

Souraya Sammoud, Meriem Khiari, Amara Semeh, Lounis Amine, Chaar Ines, Arfaoui Amira, Kriaa Lilia, Khalfallah Taher, Mzabi Sabeh, Bouraoui Saadia,

The K-ras proto-oncogene encodes a protein (p21-ras) belonging to the family of GTP/GDP-binding proteins with GTPase activity. The activation of ras family genes plays an important role in colorectal tumorigenesis. Frequency of K-ras mutations and overexpression of the protein in colorectal cancer (CRC) vary between 14% and 50% and between ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2012, 20(2):146-152]

Cited: 7 times

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The prognostic value of the immunohistochemical expression and mutational pattern of the key mediator of Wnt signaling: beta-catenin in Tunisian patients with colorectal carcinoma.

Meriem Khiari, Amira Arfaoui, Lilia Kriaa, Inés Chaar, Sameh Amara, Med Amine Lounis, Souraya Sammoud, Monia Dhraeif, Lassaad Gharbi, Sabeh Mzabi-Regaya, Saadia Bouraoui,

Beta-catenin plays a critical role with E-cadherin in cell-cell adhesion and is also a key molecule of the highly conserved Wnt signaling pathway that regulates cell proliferation and differentiation. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The objective of this study was ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2012, 20(1):62-70]

Cited: 5 times

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[Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)].

Amira Arfaoui Toumi, Lilia Kriaa Ben Mahmoud, Meriem Khiari, Ahlem Lahmer, Lasaad Gharbi, Monia Dhraïef, Tahar Khalfallah, Sabeh Regaya Mzabi, Saadia Bouraoui,

BACKGROUND: Colorectal carcinoma is one of the main causes of cancer death in the worldwide with a decrease survival rate in relationship with a later diagnosis of advanced disease. AIMS: This study highlights the particular epidemiological, clinicopathological and immunohistochemical colorectal cancer profile. Indeed, our results differ markedly from that reported ... Read more >>

Tunis Med (La Tunisie medicale)
[2010, 88(1):12-17]

Cited: 1 time

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