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Author Merete Nordentoft

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The effect of flexible assertive community treatment in Denmark: a quasi-experimental controlled study.

Camilla Munch Nielsen, Carsten Hjorthøj, Helen Killaspy, Merete Nordentoft,

BACKGROUND:Flexible assertive community treatment (FACT) is a community-based treatment model for patients with severe mental illness that has been widely implemented despite little evidence for its effectiveness. We aimed to evaluate the effect of FACT on mental health care outcomes compared with treatment from standard community mental health teams (CMHTs) ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, :]

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Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis.

Thomas A Pollak, Matthew J Kempton, Conrad Iyegbe, Angela Vincent, Sarosh R Irani, Ester Coutinho, David A Menassa, Leslie Jacobson, Lieuwe de Haan, Stephan Ruhrmann, Gabriele Sachs, Anita Riecher-Rössler, Marie-Odile Krebs, Paul Amminger, Birte Glenthøj, Neus Barrantes-Vidal, Jim van Os, Bart P F Rutten, Rodrigo A Bressan, Mark van der Gaag, Robert Yolken, Matthew Hotopf, Lucia Valmaggia, James Stone, Anthony S David, , Philip McGuire,

Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case-control study, sera ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

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A large-scale genome-wide association study meta-analysis of cannabis use disorder.

Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke, Dongbing Lai, Gunnar W Reginsson, Hang Zhou, June He, David A A Baranger, Daniel F Gudbjartsson, Robbee Wedow, Daniel E Adkins, Amy E Adkins, Jeffry Alexander, Silviu-Alin Bacanu, Tim B Bigdeli, Joseph Boden, Sandra A Brown, Kathleen K Bucholz, Jonas Bybjerg-Grauholm, Robin P Corley, Louisa Degenhardt, Danielle M Dick, Benjamin W Domingue, Louis Fox, Alison M Goate, Scott D Gordon, Laura M Hack, Dana B Hancock, Sarah M Hartz, Ian B Hickie, David M Hougaard, Kenneth Krauter, Penelope A Lind, Jeanette N McClintick, Matthew B McQueen, Jacquelyn L Meyers, Grant W Montgomery, Ole Mors, Preben B Mortensen, Merete Nordentoft, John F Pearson, Roseann E Peterson, Maureen D Reynolds, John P Rice, Valgerdur Runarsdottir, Nancy L Saccone, Richard Sherva, Judy L Silberg, Ralph E Tarter, Thorarinn Tyrfingsson, Tamara L Wall, Bradley T Webb, Thomas Werge, Leah Wetherill, Margaret J Wright, Stephanie Zellers, Mark J Adams, Laura J Bierut, Jason D Boardman, William E Copeland, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Richard A Grucza, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William G Iacono, Eric O Johnson, Kenneth S Kendler, Martin A Kennedy, Henry R Kranzler, Pamela A F Madden, Hermine H Maes, Brion S Maher, Nicholas G Martin, Matthew McGue, Andrew M McIntosh, Sarah E Medland, Elliot C Nelson, Bernice Porjesz, Brien P Riley, Michael C Stallings, Michael M Vanyukov, Scott Vrieze, , Lea K Davis, Ryan Bogdan, Joel Gelernter, Howard J Edenberg, Kari Stefansson, Anders D Børglum, Arpana Agrawal,

BACKGROUND:Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, :]

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Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.

Ana Catalan, Stefania Tognin, Matthew J Kempton, Daniel Stahl, Gonzalo Salazar de Pablo, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rössler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P F Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, , Lucia R Valmaggia, Philip McGuire,

BACKGROUND:Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. METHODS:In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-9]

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Discontinuation of antipsychotic medication-time to rethink trial design.

Helene Speyer, Marieke Begemann, Nikolai Albert, Amber Weller, Merete Nordentoft, Wim Veling, Iris E Sommer, Kelly Allott, Eóin Killackey,

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(10):841-842]

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Association between neonatal homecare for preterm infants and incidence of severe postpartum depression in mothers.

Kristine Sarah Hedegaard Andersen, Kristina Garne Holm, Merete Nordentoft, Carsten Hjorthøj,

BACKGROUND:Understanding the association between neonatal homecare and postpartum depression could contribute to the design of evidence-based interventions to prevent postpartum depression. We aimed to determine whether the change from inpatient stays in neonatal intensive care units to offering neonatal homecare was associated with a reduced incidence rate of severe postpartum ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 278:453-459]

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Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls: The Danish High Risk and Resilience Study-VIA 7, a population-based cohort study.

Katrine Søborg Spang, Ditte Ellersgaard, Nicoline Hemager, Camilla Jerlang Christiani, Birgitte Klee Burton, Aja Neergaard Greve, Ditte Gantriis, Jessica Ohland, Marianne Giørtz Pedersen, Ole Mors, Merete Nordentoft, Kerstin J Plessen, Carsten Obel, Jens Richardt Møllegaard Jepsen, Anne A E Thorup,

Cognitive impairments are strongly associated with schizophrenia (SZ) and bipolar disorder (BP) with executive functions (EF) impairments as a likely key feature. Studies of everyday behavior rated EF in young children at familial high risk of SZ (FHR-SZ) are scarce and, to our knowledge, non-existent in young children at familial ... Read more >>

Eur Child Adolesc Psychiatry (European child & adolescent psychiatry)
[2020, :]

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Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Tarjinder Singh, Timothy Poterba, David Curtis, Huda Akil, Mariam Al Eissa, Jack Barchas, Nicholas Bass, Tim Bigdeli, Gerome Breen, Evelyn Bromet, Peter Buckley, William Bunney, Jonas Bybjerg-Grauholm, William Byerley, Sinead Chapman, Wei Chen, Claire Churchhouse, Nicholas Craddock, Charles Curtis, Caroline Cusick, Lynn DeLisi, Sheila Dodge, Michael Escamilla, Saana Eskelinen, Ayman Fanous, Stephen Faraone, Alessia Fiorentino, Laurent Francioli, Stacey Gabriel, Diane Gage, Sarah Gagliano Taliun, Andrea Ganna, Giulio Genovese, David Glahn, Jakob Grove, Mei-Hua Hall, Eija Hamalainen, Henrike Heyne, Matti Holi, David Hougaard, Daniel Howrigan, Hailiang Huang, Hai-Gwo Hwu, Rene Kahn, Hyun Min Kang, Konrad Karczewski, George Kirov, James Knowles, Francis Lee, Douglas Lehrer, Francesco Lescai, Dolores Malaspina, Stephen Marder, Steven McCarroll, Helena Medeiros, Lili Milani, Christopher Morley, Derek Morris, Preben Bo Mortensen, Richard Myers, Merete Nordentoft, Niamh O'Brien, Ana Maria Olivares, Dost Ongur, Willem Hendrik Ouwehand, Duncan Palmer, Tiina Paunio, Digby Quested, Mark Rapaport, Elliott Rees, Brandi Rollins, Kyle Satterstrom, Alan Schatzberg, Edward Scolnick, Laura Scott, Sally Sharp, Pamela Sklar, Jordan Smoller, Janet Sobell, Matthew Solomonson, Christine Stevens, Jaana Suvisaari, Grace Tiao, Stanley Watson, Nicholas Watts, Douglas Blackwood, Anders Borglum, Bruce Cohen, Aiden Corvin, Tonu Esko, Nelson Freimer, Stephen Glatt, Christina Hultman, Andrew McQuillin, Aarno Palotie, Carlos Pato, Michele Pato, Ann Pulver, David St. Clair, Ming Tsuang, Marquis Vawter, James Walters, Thomas Werge, Roel Ophoff, Patrick Sullivan, Michael Owen, Michael Boehnke, Michael O'Donovan, Benjamin Neale, Mark Daly,

By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for schizophrenia (odds ratios 3 - 50, P < 2.14 x 10^-6), and 32 genes at a FDR < 5%. These genes have the greatest expression in ... Read more >>

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Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder.

Søren D Østergaard, Betina B Trabjerg, Thomas D Als, Clara Albiñana Climent, Florian Privé, Bjarni Jóhann Vilhjálmsson, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, David M Hougaard, Merete Nordentoft, Thomas Werge, Ditte Demontis, Preben B Mortensen, Anders D Børglum, Ole Mors, Esben Agerbo,

The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):335]

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Gestational age-dependent development of the neonatal metabolome.

Madeleine Ernst, Simon Rogers, Ulrik Lausten-Thomsen, Anders Björkbom, Susan Svane Laursen, Julie Courraud, Anders Børglum, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, David M Hougaard, Arieh S Cohen,

BACKGROUND:Prematurity is a severe pathophysiological condition, however, little is known about the gestational age-dependent development of the neonatal metabolome. METHODS:Using an untargeted liquid chromatography-tandem mass spectrometry metabolomics protocol, we measured over 9000 metabolites in 298 neonatal residual heel prick dried blood spots retrieved from the Danish Neonatal Screening Biobank. By ... Read more >>

Pediatr Res (Pediatric research)
[2020, :]

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The Duffy-null genotype and risk of infection.

Sophie E Legge, Rune H Christensen, Liselotte Petersen, Antonio F Pardiñas, Matthew Bracher-Smith, Steven Knapper, Jonas Bybjerg-Grauholm, Marie Baekvad-Hansen, David M Hougaard, Thomas Werge, Merete Nordentoft, Preben Bo Mortensen, Michael J Owen, Michael C O'Donovan, Michael E Benros, James T R Walters,

Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimise risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, :]

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Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders - A comprehensive systematic review and meta-analysis.

Rose Jeppesen, Rune H B Christensen, Emilie M J Pedersen, Merete Nordentoft, Carsten Hjorthøj, Ole Köhler-Forsberg, Michael E Benros,

OBJECTIVE:Antipsychotic effects of immunomodulating drugs have been suggested; however, a thorough, comprehensive meta-analysis on the effect and safety of anti-inflammatory add-on treatment on psychotic disorders is lacking. METHOD:Multiple databases were searched up until February 2020. Only double-blinded, randomized, placebo-controlled clinical trials (RCTs) were included. Primary outcomes were change in total ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2020, 90:364-380]

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Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis.

Alison McLaverty, Kelly A Allott, Maximus Berger, Rob Hester, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger,

BACKGROUND:Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations. METHOD:Erythrocyte levels of total omega-3-and ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial.

Tina D Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, René C W Mandl, Jayachandra M Raghava, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

Background:Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods:In a randomized, clinical trial, UHR individuals aged ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:873]

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Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population. ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence.

David Mongan, Melanie Föcking, Colm Healy, Subash Raj Susai, Meike Heurich, Kieran Wynne, Barnaby Nelson, Patrick D McGorry, G Paul Amminger, Merete Nordentoft, Marie-Odile Krebs, Anita Riecher-Rössler, Rodrigo A Bressan, Neus Barrantes-Vidal, Stefan Borgwardt, Stephan Ruhrmann, Gabriele Sachs, Christos Pantelis, Mark van der Gaag, Lieuwe de Haan, Lucia Valmaggia, Thomas A Pollak, Matthew J Kempton, Bart P F Rutten, Robert Whelan, Mary Cannon, Stan Zammit, Gerard Cagney, David R Cotter, Philip McGuire, ,

Importance:Biomarkers that are predictive of outcomes in individuals at risk of psychosis would facilitate individualized prognosis and stratification strategies. Objective:To investigate whether proteomic biomarkers may aid prediction of transition to psychotic disorder in the clinical high-risk (CHR) state and adolescent psychotic experiences (PEs) in the general population. Design, Setting, and ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Parental mental illness, attendance at preventive child healthcare and dental caries in the offspring: a nation-wide population-based cohort study.

Kirstine A Davidsen, Erik Christiansen, Dorte Haubek, Jette Asmussen, Anne Ranning, Anne A E Thorup, Merete Nordentoft, Susanne Harder, Niels Bilenberg,

PURPOSE:Severe mental illness (SMI) may interfere with parental caregiving practices and offspring development. Adhering to preventive well-child visits and maintaining good oral hygiene during early childhood requires parental involvement. Whether these activities are affected by parental SMI is unclear. The purpose of the present study was to determine whether children ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2020, :]

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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

Gabriëlla Blokland, Jakob Grove, Chia-Yen Chen, Chris Cotsapas, Stuart Tobet, Robert Handa, David St Clair, Todd Lencz, Bryan Mowry, Sathish Periyasamy, Murray Cairns, Paul Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick Sullivan, Aiden Corvin, Brien Riley, Tõnu Esko, Lili Milani, Erik Jönsson, Aarno Palotie, Hannelore Ehrenreich, Martin Begemann, Agnes Steixner-Kumar, Pak Sham, Nakao Iwata, Daniel Weinberger, Pablo Gejman, Alan Sanders, Joseph Buxbaum, Dan Rujescu, Ina Giegling, Bettina Konte, Annette Hartmann, Elvira Bramon, Robin Murray, Michele Pato, Jimmy Lee, Ingrid Melle, Espen Molden, Roel Ophoff, Andrew McQuillin, Nicholas Bass, Rolf Adolfsson, Anil Malhotra, Nicholas Martin, Janice Fullerton, Philip Mitchell, Peter Schofield, Andreas Forstner, Franziska Degenhardt, Sabrina Schaupp, Ashley Comes, Manolis Kogevinas, José Guzman-Parra, Andreas Reif, Fabian Streit, Lea Sirignano, Sven Cichon, Maria Grigoroiu-Serbanescu, Joanna Hauser, Jolanta Lissowska, Fermin Mayoral, Bertram Müller-Myhsok, Beata Świątkowska, Thomas Schulze, Markus Nöthen, Marcella Rietschel, John Kelsoe, Marion Leboyer, Stéphane Jamain, Bruno Etain, Frank Bellivier, John Vincent, Martin Alda, Claire O’Donovan, Pablo Cervantes, Joanna Biernacka, Mark Frye, Susan McElroy, Laura Scott, Eli Stahl, Mikael Landén, Marian Hamshere, Olav Smeland, Srdjan Djurovic, Arne Vaaler, Ole Andreassen, Bernhard Baune, Tracy Air, Martin Preisig, Rudolf Uher, Douglas Levinson, Myrna Weissman, James Potash, Jianxin Shi, James Knowles, Roy Perlis, Susanne Lucae, Dorret Boomsma, Brenda Penninx, Jouke-Jan Hottenga, Eco de Geus, Gonneke Willemsen, Yuri Milaneschi, Henning Tiemeier, Hans Grabe, Alexander Teumer, Sandra Van der Auwera, Uwe Völker, Steven Hamilton, Patrik Magnusson, Alexander Viktorin, Divya Mehta, Niamh Mullins, Mark Adams, Gerome Breen, Andrew McIntosh, Cathryn Lewis, David Hougaard, Merete Nordentoft, Ole Mors, Preben Mortensen, Thomas Werge, Thomas Als, Anders Børglum, Tracey Petryshen, Jordan Smoller, Jill Goldstein, , , , , ,

Abstract BACKGROUND Sex differences in the incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across these disorders suggest possible shared sex-dependent genetic risk. METHODS We conducted the largest to date ... Read more >>

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Genetic liability to major depression and risk of childhood asthma.

Xiaoqin Liu, Trine Munk-Olsen, Clara Albiñana, Bjarni J Vilhjálmsson, Emil M Pedersen, Vivi Schlünssen, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, Merete Nordentoft, Anders D Børglum, Thomas Werge, David M Hougaard, Preben B Mortensen, Esben Agerbo,

OBJECTIVE:Major depression and asthma frequently co-occur, suggesting shared genetic vulnerability between these two disorders. We aimed to determine whether a higher genetic liability to major depression was associated with increased childhood asthma risk, and if so, whether such an association differed by sex of the child. METHODS:We conducted a population-based ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2020, 89:433-439]

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Polygenic Risk and Progression to Bipolar or Psychotic Disorders Among Individuals Diagnosed With Unipolar Depression in Early Life.

Katherine L Musliner, Morten D Krebs, Clara Albiñana, Bjarni Vilhjalmsson, Esben Agerbo, Peter P Zandi, David M Hougaard, Merete Nordentoft, Anders D Børglum, Thomas Werge, Preben B Mortensen, Søren D Østergaard,

OBJECTIVE:The authors investigated the associations between polygenic liability and progression to bipolar disorder or psychotic disorders among individuals diagnosed with unipolar depression in early life. METHODS:A cohort comprising 16,949 individuals (69% female, 10-35 years old at the first depression diagnosis) from the iPSYCH Danish case-cohort study (iPSYCH2012) who were diagnosed ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, 177(10):936-943]

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Dysregulated Lipid Metabolism Precedes Onset of Psychosis.

Alex M Dickens, Partho Sen, Matthew J Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rössler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyötyläinen, , Matej Orešič, Philip McGuire,

BACKGROUND:A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. METHODS:Serum lipidomic analysis was ... Read more >>

Biol. Psychiatry (Biological psychiatry)
[2020, :]

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Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

Ron Nudel, Camilla A J Christiani, Jessica Ohland, Md Jamal Uddin, Nicoline Hemager, Ditte Ellersgaard, Katrine S Spang, Birgitte K Burton, Aja N Greve, Ditte L Gantriis, Jonas Bybjerg-Grauholm, Jens Richardt M Jepsen, Anne A E Thorup, Ole Mors, Thomas Werge, Merete Nordentoft,

BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies ... Read more >>

BMC Neurosci (BMC neuroscience)
[2020, 21(1):30]

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How mental health care should change as a consequence of the COVID-19 pandemic.

Carmen Moreno, Til Wykes, Silvana Galderisi, Merete Nordentoft, Nicolas Crossley, Nev Jones, Mary Cannon, Christoph U Correll, Louise Byrne, Sarah Carr, Eric Y H Chen, Philip Gorwood, Sonia Johnson, Hilkka Kärkkäinen, John H Krystal, Jimmy Lee, Jeffrey Lieberman, Carlos López-Jaramillo, Miia Männikkö, Michael R Phillips, Hiroyuki Uchida, Eduard Vieta, Antonio Vita, Celso Arango,

The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health effects in previously healthy people and especially in people with ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(9):813-824]

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Co-occurring Hydrocephalus and Polygenic Risk in Autism Spectrum Disorder: A Danish Population-based Cohort Study

Tina Nørgaard Munch, Paula Hedley, Christian Munch Hagen, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, Jakob Grove, Merete Nordentoft, Anders Børglum, Preben Mortensen, Thomas Werge, Mads Melbye, David Hougaard, Michael Christiansen,

Abstract Background The association between autism spectrum disorder and hydrocephalus is not well understood, despite demonstrated links between autism spectrum disorder and cerebrospinal fluid abnormalities. Based on the hypothesis that autism spectrum disorder and hydrocephalus may, at least in some cases, be two manifestations of a shared congenital brain ... Read more >>

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