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Author Mentore Ribolsi

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Letter: is wireless oesophageal pH monitoring the best technique to evaluate night-time reflux?

Mentore Ribolsi, Edoardo Savarino,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):974-975]

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An update of pharmacology, efficacy, and safety of vonoprazan in acid-related disorders.

Vincenzo Savarino, Luca Antonioli, Matteo Fornai, Elisa Marabotto, Maria Giulia Demarzo, Fabiana Zingone, Matteo Ghisa, Brigida Barberio, Patrizia Zentilin, Mentore Ribolsi, Edoardo Savarino,

<h4>Introduction</h4>Patients with acid-related disorders (ARDs) of the upper digestive tract remain highly prevalent and need to be continuously investigated to improve their management.<h4>Areas covered</h4>This review provides a summary of the most recent advancements in the treatment of ARDs with particular focus on the new drugs available to overcome the unmet ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, :1-10]

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Patients With Definite and Inconclusive Evidence of Reflux According to Lyon Consensus Display Similar Motility and Esophagogastric Junction Characteristics.

Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, C Prakash Gyawali,

<h4>Background/aims</h4>The role of esophageal high-resolution manometry (HRM) within Lyon consensus phenotypes, especially patients with inconclusive gastroesophageal reflux disease (GERD) evidence, has not been fully investigated. In this multicenter, observational study we aim to compare HRM parameters in patients with GERD stratified according to the Lyon consensus.<h4>Methods</h4>Clinical and endoscopic data, HRM ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2021, 27(4):565-573]

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Application of Lyon Consensus criteria for GORD diagnosis: evaluation of conventional and new impedance-pH parameters.

Leonardo Frazzoni, Marzio Frazzoni, Nicola De Bortoli, Mentore Ribolsi, Salvatore Tolone, Salvatore Russo, Rita Luisa Conigliaro, Roberto Penagini, Lorenzo Fuccio, Rocco Maurizio Zagari, Edoardo Savarino,

<h4>Objective</h4>To validate Lyon Consensus criteria for diagnosing gastro-oesophageal reflux disease (GORD) by reflux monitoring.<h4>Design</h4>Manual review of impedance-pH tracings from patients with proton pump inhibitor (PPI)-dependent heartburn, evaluated off PPI. Acid exposure time (AET) thresholds defined by the Lyon Consensus and impedance parameters were investigated, namely, total refluxes (TRs), postreflux swallow-induced ... Read more >>

Gut (Gut)
[2021, :]

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Exploring the association between esophageal mucosal inflammation, impaired motility, and GERD severity.

Mentore Ribolsi, Edoardo Savarino,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(10):e14211]

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The Results From Up-Front Esophageal Testing Predict Proton Pump Inhibitor Response in Patients With Chronic Cough.

Mentore Ribolsi, Michele Pier Luca Guarino, Paola Balestrieri, Annamaria Altomare, Alessandro Tullio, Tommasangelo Petitti, Michele Cicala,

<h4>Introduction</h4>The clinical management of chronic cough patients is challenging, and their response to proton pump inhibitors (PPIs) is considered as unsatisfactory. Few data concerning the association between impedance-pH variables and PPI response in these patients are available. Mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave (PSPW) index increase ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, :]

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Editorial: inconclusive diagnosis of GERD: are new parameters in impedance-pHmetry ready for clinical use? Authors' reply.

Mentore Ribolsi, Marzio Frazzoni, Elisa Marabotto, Michele Cicala, Edoardo Savarino,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(4):498-499]

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Novel impedance-pH parameters are associated with proton pump inhibitor response in patients with inconclusive diagnosis of gastro-oesophageal reflux disease according to Lyon Consensus.

Mentore Ribolsi, Marzio Frazzoni, Elisa Marabotto, Giovanni De Carlo, Sebastiano Ziola, Daria Maniero, Paola Balestrieri, Michele Cicala, Edoardo Savarino,

<h4>Background</h4>The Lyon Consensus delineates impedance-pH parameters that can demonstrate/exclude gastro-oesophageal reflux disease (GERD). In patients with acid exposure time between 4% and 6%, GERD diagnosis has been considered inconclusive. In these cases, mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index may either confirm or refute GERD ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(4):412-418]

Cited: 1 time

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Reflux characteristics triggering post-reflux swallow-induced peristaltic wave (PSPW) in patients with GERD symptoms.

Mentore Ribolsi, Marzio Frazzoni, Nicola De Bortoli, Salvatore Tolone, Elena Arsiè, Lucia Mariani, Giovanni De Carlo, Daria Maniero, Roberto Penagini, Michele Cicala, Edoardo Savarino,

<h4>Background</h4>Esophageal chemical clearance has been evaluated with the post-reflux swallow-induced peristaltic wave (PSPW) index. The factors triggering PSPW in Gastro-esophageal reflux disease (GERD) have not yet been investigated. This multicenter study was aimed at evaluating the characteristics of reflux episodes associated with PSPW occurrence in patients with typical GERD symptoms.<h4>Methods</h4>Impedance-pH ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14183]

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Modern Diagnosis of Early Esophageal Cancer: From Blood Biomarkers to Advanced Endoscopy and Artificial Intelligence.

Pierfrancesco Visaggi, Brigida Barberio, Matteo Ghisa, Mentore Ribolsi, Vincenzo Savarino, Matteo Fassan, Michele Valmasoni, Santino Marchi, Nicola de Bortoli, Edoardo Savarino,

Esophageal cancer (EC) is the seventh most common cancer and the sixth cause of cancer death worldwide. Histologically, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) account for up to 90% and 20% of all ECs, respectively. Clinical symptoms such as dysphagia, odynophagia, and bolus impaction occur late in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Diagnostic delay and misdiagnosis in eosinophilic oesophagitis.

Marco Vincenzo Lenti, Edoardo Savarino, Aurelio Mauro, Roberto Penagini, Francesca Racca, Matteo Ghisa, Giorgio Laserra, Stefania Merli, Elena Arsiè, Valeria Longoni, Nicola de Bortoli, Andrea Sostilio, Elisa Marabotto, Sebastiano Ziola, Alessandro Vanoli, Fabiana Zingone, Brigida Barberio, Salvatore Tolone, Ludovico Docimo, Gaia Pellegatta, Giovanni Paoletti, Mentore Ribolsi, Alessandro Repici, Catherine Klersy, Antonio Di Sabatino,

<h4>Background</h4>Eosinophilic oesophagitis (EoE) may lead to severe complications if not promptly recognised.<h4>Aims</h4>To assess the diagnostic delay in patients with EoE and to explore its risk factors.<h4>Methods</h4>EoE patients followed-up at eight clinics were included via retrospective chart review. Diagnostic delay was estimated as the time lapse occurring between the appearance of ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, :]

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Association between Dietary Habits and Fecal Microbiota Composition in Irritable Bowel Syndrome Patients: A Pilot Study.

Annamaria Altomare, Federica Del Chierico, Giulia Rocchi, Sara Emerenziani, Chiara Nuglio, Lorenza Putignani, Silvia Angeletti, Alessandra Lo Presti, Massimo Ciccozzi, Alessandra Russo, Silvia Cocca, Mentore Ribolsi, Maurizio Muscaritoli, Michele Cicala, Michele Pier Luca Guarino,

Intestinal dysbiosis seems to play a role in the pathophysiology of irritable bowel syndrome (IBS). The present pilot study aimed to elucidate the association between nutrient intake and Mediterranean diet (MD) adherence with IBS symptoms and gut microbiota in IBS patients. The nutrient intake of 28 IBS patients and 21 ... Read more >>

Nutrients (Nutrients)
[2021, 13(5):]

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Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease.

Annamaria Altomare, Manuele Gori, Silvia Cocca, Simone Carotti, Maria Francesconi, Mentore Ribolsi, Sara Emerenziani, Giuseppe Perrone, Sergio Morini, Michele Cicala, Michele P L Guarino,

<h4>Background/aims</h4>Impaired intestinal motility seems to play a crucial role in symptomatic uncomplicated diverticular disease (SUDD), although the mechanism is not clear. The aim of the present study is to explore the contractility patterns of colonic smooth muscle strips (MS) and smooth muscle cells (SMCs) and to assess mucosal integrity in ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2021, 27(2):292-301]

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Esophageal pH increments associated with post-reflux swallow-induced peristaltic waves show the occurrence and relevance of esophago-salivary reflex in clinical setting.

Marzio Frazzoni, Leonardo Frazzoni, Mentore Ribolsi, Nicola De Bortoli, Salvatore Tolone, Rita Conigliaro, Elena Arsiè, Roberto Penagini, Michele Cicala, Edoardo Savarino,

<h4>Background</h4>Following acid perfusion, esophageal pH is restored by swallowed bicarbonate-containing saliva secreted in response to a vagal esophago-salivary reflex. At impedance-pH monitoring, the post-reflux swallow-induced peristaltic wave (PSPW) index puts into relationship timely post-reflux swallows with the number of reflux events: Low values typify reflux-related heartburn (RRH) and lack of ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(7):e14085]

Cited: 1 time

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Normal values and regional differences in oesophageal impedance-pH metrics: a consensus analysis of impedance-pH studies from around the world.

Daniel Sifrim, Sabine Roman, Edoardo Savarino, Serhat Bor, Albert J Bredenoord, Donald Castell, Michele Cicala, Nicola de Bortoli, Marzio Frazzoni, Sutep Gonlachanvit, Katsuhiko Iwakiri, Osamu Kawamura, Anne Krarup, Yeong Yeh Lee, Chai Soon Ngiu, Eugene Ndebia, Tanisa Patcharatraku, Ans Pauwels, Julio Pérez de la Serna, Rosa Ramos, Jose Maria Remes-Troche, Mentore Ribolsi, Alastair Sammon, Magnus Simren, Jan Tack, Radu Tutuian, Miguel Valdovinos, Yinglian Xiao, Frank Zerbib, C Prakash Gyawali,

<h4>Objective</h4>Limitations of existing impedance-pH thresholds include small sample size of normative studies, inclusion of artefactual pH drops and incorrect identification of impedance reflux events. We aimed to obtain new impedance-pH thresholds from expert consensus analysis of tracings from a large number of healthy subjects.<h4>Design</h4>Of 541 studies performed worldwide using two ... Read more >>

Gut (Gut)
[2020, :]

Cited: 3 times

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Postreflux swallow-induced peristaltic wave index from pH-impedance monitoring associates with esophageal body motility and esophageal acid burden.

Benjamin D Rogers, Arvind Rengarajan, Mentore Ribolsi, Matteo Ghisa, Farhan Quader, Roberto Penagini, Nicola de Bortoli, Aurelio Mauro, Michele Cicala, Edoardo Savarino, C Prakash Gyawali,

<h4>Background</h4>Postreflux swallow-induced peristaltic wave (PSPW) on pH-impedance monitoring and contraction vigor on high-resolution manometry (HRM) both assess esophageal peristaltic response. We aimed to evaluate relationships between PSPW and esophageal peristalsis on HRM in the context of reflux disease in this multicenter cohort study.<h4>Methods</h4>pH-impedance and HRM studies performed on patients with ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(2):e13973]

Cited: 1 time

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High-resolution Manometry Determinants of Refractoriness of Reflux Symptoms to Proton Pump Inhibitor Therapy.

Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, C Prakash Gyawali,

Background/Aims:Impaired esophageal motility and disrupted esophagogastric junction (EGJ) on high-resolution manometry (HRM) have been associated with increased reflux severity in gastroesophageal reflux disease (GERD) patients. However, there are limited data evaluating HRM parameters in proton pump inhibitors (PPI) non-responders. Methods:Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH studies performed ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2020, 26(4):447-454]

Cited: 1 time

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Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro.

Manuele Gori, Annamaria Altomare, Silvia Cocca, Eleonora Solida, Mentore Ribolsi, Simone Carotti, Alberto Rainer, Maria Francesconi, Sergio Morini, Michele Cicala, Michele Pier Luca Guarino,

Palmitic acid (PA), a long-chain saturated fatty acid, might activate innate immune cells. PA plays a role in chronic liver disease, diabetes and Crohn's disease, all of which are associated with impaired intestinal permeability. We investigated the effect of PA, at physiological postprandial intestinal concentrations, on gut epithelium as compared ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(5):]

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The Lyon Consensus: Does It Differ From the Previous Ones?

Matteo Ghisa, Brigida Barberio, Vincenzo Savarino, Elisa Marabotto, Mentore Ribolsi, Giorgia Bodini, Fabiana Zingone, Marzio Frazzoni, Edoardo Savarino,

Gastroesophageal reflux disease (GERD) is a complex disorder with heterogeneous symptoms and a multifaceted pathogenetic basis, which prevent a simple diagnostic algorithm or any categorical classification. Clinical history, questionnaires and response to proton pump inhibitor (PPI) therapy are insufficient tools to make a conclusive diagnosis of GERD and further investigations ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2020, 26(3):311-321]

Cited: 2 times

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Understanding the relationship between esophageal motor disorders and reflux disease.

Mentore Ribolsi, Giovanni de Carlo, Paola Balestrieri, Michele Pier Luca Guarino, Michele Cicala,

<h4>Introduction</h4>The management of gastro-esophageal reflux disease (GERD) patients is often complex as the clinical presentation is heterogeneous and the mechanisms underlying symptoms are multifactorial. In the past decades, investigations conducted with conventional manometry and, above all, the more accurate high resolution manometry (HRM), helped us in exploring the field of ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2020, 14(10):933-940]

Cited: 0 times

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Clinical impact of proton pump inhibitor response and dependence.

Mentore Ribolsi, Michele Cicala,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(6):e13846]

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Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults.

Michele Pier Luca Guarino, Annamaria Altomare, Sara Emerenziani, Claudia Di Rosa, Mentore Ribolsi, Paola Balestrieri, Paola Iovino, Giulia Rocchi, Michele Cicala,

In recent years, research has focused on the use of dietary fibers and prebiotics, since many of these polysaccharides can be metabolized by intestinal microbiota, leading to the production of short-chain fatty acids. The metabolites of prebiotic fermentation also show anti-inflammatory and immunomodulatory capabilities, suggesting an interesting role in the ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

Cited: 11 times

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Role of Overweight and Obesity in Gastrointestinal Disease.

Sara Emerenziani, Michele Pier Luca Guarino, Laura Maria Trillo Asensio, Annamaria Altomare, Mentore Ribolsi, Paola Balestrieri, Michele Cicala,

The prevalence of obesity is increasing worldwide, leading to a severe impairment of overall health. Actually, obesity has been associated with several pathological conditions, causing an excess overall mortality. In particular, overweight and obesity are well known risk factors for a variety of gastrointestinal (GI) disorders i.e., functional GI disorders ... Read more >>

Nutrients (Nutrients)
[2019, 12(1):]

Cited: 5 times

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Nutritional Aspects in Inflammatory Bowel Diseases.

Paola Balestrieri, Mentore Ribolsi, Michele Pier Luca Guarino, Sara Emerenziani, Annamaria Altomare, Michele Cicala,

Crohn's disease (CD) and ulcerative colitis (UC) are chronic, relapsing, inflammatory disorders of the digestive tract that characteristically develop in adolescence and early adulthood. The reported prevalence of malnutrition in inflammatory bowel disease (IBD) patients ranges between 20% and 85%. Several factors, including reduced oral food intake, malabsorption, chronic blood ... Read more >>

Nutrients (Nutrients)
[2020, 12(2):]

Cited: 14 times

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Fragmented and failed swallows on esophageal high-resolution manometry associate with abnormal reflux burden better than weak swallows.

Benjamin D Rogers, Arvind Rengarajan, Aurelio Mauro, Matteo Ghisa, Nicola De Bortoli, Michele Cicala, Mentore Ribolsi, Roberto Penagini, Edoardo Savarino, C Prakash Gyawali,

<h4>Background</h4>Association between proportions of hypomotile swallows on esophageal high-resolution manometry (HRM) and esophageal reflux burden remains incompletely understood. We investigated relationships between hypomotility, acid exposure time (AET), and mean nocturnal baseline impedance (MNBI) on ambulatory reflux monitoring.<h4>Methods</h4>Clinical data, HRM, and ambulatory pH-impedance studies (performed off acid suppression) from patients with ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(2):e13736]

Cited: 3 times

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