Full Text Journal Articles by
Author Menno J Oudhoff


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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

Cited: 0 times

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Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Robert N Judson, Marco Quarta, Menno J Oudhoff, Hesham Soliman, Lin Yi, Chih Kai Chang, Gloria Loi, Ryan Vander Werff, Alissa Cait, Mark Hamer, Justin Blonigan, Patrick Paine, Linda T N Doan, Elena Groppa, WenJun He, Le Su, Regan H Zhang, Peter Xu, Christine Eisner, Marcela Low, Ingrid Barta, Coral-Ann B Lewis, Colby Zaph, Mohammad M Karimi, Thomas A Rando, Fabio M Rossi,

The development of cell therapy for repairing damaged or diseased skeletal muscle has been hindered by the inability to significantly expand immature, transplantable myogenic stem cells (MuSCs) in culture. To overcome this limitation, a deeper understanding of the mechanisms regulating the transition between activated, proliferating MuSCs and differentiation-primed, poorly engrafting progenitors ... Read more >>

Cell Stem Cell (Cell stem cell)
[2018, 22(2):177-190.e7]

Cited: 11 times

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E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.

Jesús Gómez-Escudero, Vanessa Moreno, Mara Martín-Alonso, M Victoria Hernández-Riquer, Tamar Feinberg, Ángel Colmenar, Enrique Calvo, Emilio Camafeita, Fernando Martínez, Menno J Oudhoff, Stephen J Weiss, Alicia G Arroyo,

Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Here, we characterize an unexpected role for the membrane-anchored metalloproteinase MT2-MMP in regulating epithelial cell quiescence. Following co-immunoprecipitation and mass spectrometry, the MT2-MMP cytosolic tail was found to interact ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2017, 130(23):4013-4027]

Cited: 3 times

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Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

Menno J Oudhoff, Frann Antignano, Alistair L Chenery, Kyle Burrows, Stephen A Redpath, Mitchell J Braam, Georgia Perona-Wright, Colby Zaph,

The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases are part of a family of novel attractive targets for drug discovery. SETD7 is a member of ... Read more >>

PLoS Pathog (PLoS pathogens)
[2016, 12(9):e1005876]

Cited: 6 times

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G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

Frann Antignano, Mitchell Braam, Michael R Hughes, Alistair L Chenery, Kyle Burrows, Matthew J Gold, Menno J Oudhoff, David Rattray, Timotheus Y Halim, Alissa Cait, Fumio Takei, Fabio M Rossi, Kelly M McNagny, Colby Zaph,

Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and disease-associated immune processes. Despite recent advances in defining the molecular pathways that control development and function of ILCs, the epigenetic mechanisms that regulate ILC biology are unknown. Here, we identify a role for the lysine methyltransferase G9a in ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2016, 213(7):1153-1162]

Cited: 14 times

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SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Menno J Oudhoff, Mitchell J S Braam, Spencer A Freeman, Denise Wong, David G Rattray, Jia Wang, Frann Antignano, Kimberly Snyder, Ido Refaeli, Michael R Hughes, Kelly M McNagny, Michael R Gold, Cheryl H Arrowsmith, Toshiro Sato, Fabio M V Rossi, John H Tatlock, Dafydd R Owen, Peter J Brown, Colby Zaph,

Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal cancers, while dysregulation of the Hippo/Yes-Associated Protein (YAP) pathway is an emerging regulator of intestinal tumorigenesis. In addition, these closely related ... Read more >>

Dev Cell (Developmental cell)
[2016, 37(1):47-57]

Cited: 31 times

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Dalia Barsyte-Lovejoy, Fengling Li, Menno J Oudhoff, John H Tatlock, Aiping Dong, Hong Zeng, Hong Wu, Spencer A Freeman, Matthieu Schapira, Guillermo A Senisterra, Ekaterina Kuznetsova, Richard Marcellus, Abdellah Allali-Hassani, Steven Kennedy, Jean-Philippe Lambert, Amber L Couzens, Ahmed Aman, Anne-Claude Gingras, Rima Al-Awar, Paul V Fish, Brian S Gerstenberger, Lee Roberts, Caroline L Benn, Rachel L Grimley, Mitchell J S Braam, Fabio M V Rossi, Marius Sudol, Peter J Brown, Mark E Bunnage, Dafydd R Owen, Colby Zaph, Masoud Vedadi, Cheryl H Arrowsmith,

SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery of (R)-PFI-2-a first-in-class, potent (Ki (app) = 0.33 nM), selective, and cell-active inhibitor of the methyltransferase activity of human SETD7-and its 500-fold ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(35):12853-12858]

Cited: 67 times

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Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

Frann Antignano, Kyle Burrows, Michael R Hughes, Jonathan M Han, Ken J Kron, Nadia M Penrod, Menno J Oudhoff, Steven Kai Hao Wang, Paul H Min, Matthew J Gold, Alistair L Chenery, Mitchell J S Braam, Thomas C Fung, Fabio M V Rossi, Kelly M McNagny, Cheryl H Arrowsmith, Mathieu Lupien, Megan K Levings, Colby Zaph,

Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4⁺ Th cell responses, with intestinal homeostasis depending on the balance between IL-17-producing Th17 and Foxp3⁺ Tregs. Differentiation of naive T cells into Th17 and Treg subsets is associated with specific gene expression profiles; however, the contribution of epigenetic mechanisms to ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2014, 124(5):1945-1955]

Cited: 36 times

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Control of the hippo pathway by Set7-dependent methylation of Yap.

Menno J Oudhoff, Spencer A Freeman, Amber L Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H Min, Jeffrey P Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Hiroshi Nishina, Michael R Gold, Fabio M V Rossi, Anne-Claude Gingras, Colby Zaph,

Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates and alters function of a variety of proteins in vitro, but the in vivo relevance has not been established. We found that Set7 is a modifier of ... Read more >>

Dev. Cell (Developmental cell)
[2013, 26(2):188-194]

Cited: 64 times

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Requirement for core 2 O-glycans for optimal resistance to helminth infection.

Sarah C Mullaly, Menno J Oudhoff, Paul H Min, Kyle Burrows, Frann Antignano, David G Rattray, Alistair Chenery, Kelly M McNagny, Hermann J Ziltener, Colby Zaph,

The migration of lymphocytes to the small intestine is controlled by expression of the integrin α4β7 and the chemokine receptor CCR9. However, the molecules that specifically regulate migration to the large intestine remain unclear. Immunity to infection with the large intestinal helminth parasite Trichuris muris is dependent upon CD4(+) T ... Read more >>

PLoS One (PloS one)
[2013, 8(3):e60124]

Cited: 4 times

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Sortase A as a tool for high-yield histatin cyclization.

Jan G M Bolscher, Menno J Oudhoff, Kamran Nazmi, John M Antos, Carla P Guimaraes, Eric Spooner, Evan F Haney, Juan J Garcia Vallejo, Hans J Vogel, Wim van't Hof, Hidde L Ploegh, Enno C I Veerman,

Cyclic peptides are highly valued tools in biomedical research. In many cases, they show higher receptor affinity, enhanced biological activity, and improved serum stability. Technical difficulties in producing cyclic peptides, especially larger ones, in appreciable yields have precluded a prolific use in biomedical research. Here, we describe a novel and ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2011, 25(8):2650-2658]

Cited: 43 times

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The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity.

Menno J Oudhoff, Marjolein E Blaauboer, Kamran Nazmi, Nina Scheres, Jan G M Bolscher, Enno C I Veerman,

Antimicrobial peptides are multifunctional in innate immunity and wound repair of multicellular organisms. We were the first to discover that histatins, a family of salivary antimicrobial peptides, enhance epithelial cell migration, suggesting a role in oral wound healing. It is unknown whether histatins display innate-immunity activities, similar to other antimicrobial ... Read more >>

Biol Chem (Biological chemistry)
[2010, 391(5):541-548]

Cited: 24 times

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Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold.

Menno J Oudhoff, Kim L Kroeze, Kamran Nazmi, Petra A M van den Keijbus, Wim van 't Hof, Mar Fernandez-Borja, Peter L Hordijk, Susan Gibbs, Jan G M Bolscher, Enno C I Veerman,

Wounds in the mouth heal faster and with less scarification and inflammation than those in the skin. Saliva is thought to be essential for the superior oral wound healing, but the involved mechanism is still unclear. We have previously discovered that a human-specific peptide, histatin, might be implicated in the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2009, 23(11):3928-3935]

Cited: 32 times

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Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.

Menno J Oudhoff, Jan G M Bolscher, Kamran Nazmi, Hakan Kalay, Wim van 't Hof, Arie V Nieuw Amerongen, Enno C I Veerman,

Wounds in the oral cavity heal much faster than skin lesions. Among other factors, saliva is generally assumed to be of relevance to this feature. Rodent saliva contains large amounts of growth factors such as epidermal growth factor (EGF) and nerve growth factor (NGF). In humans, however, the identity of ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2008, 22(11):3805-3812]

Cited: 84 times

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