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Author Mengzhu Zhao

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Core Outcome Set for Clinical Trials of COVID-19 based on Traditional Chinese and Western Medicine

Ruijin Qiu, Chen Zhao, Tengxiao Liang, Xuezeng Hao, Ya Huang, Xiaoyu Zhang, Zhao Chen, Xuxu Wei, Mengzhu Zhao, Changming Zhong, Jiayuan Hu, Min Li, Songjie Han, Tianmai He, Jing Chen, Hongcai Shang,

Background: Development of a core outcome set (COS) for clinical trials for COVID-19 is urgent because of the pandemic wreaking havoc worldwide and the heterogeneity of outcomes in clinical trials. Methods: A preliminary list of outcomes were developed after a systematic review of protocols of clinical trials for COVID-19. Then, ... Read more >>

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Outcome reporting from protocols of clinical trials of Coronavirus Disease 2019 (COVID-19): a review

Ruijin Qiu, Xuxu Wei, Mengzhu Zhao, Changming Zhong, Chen Zhao, Jiayuan Hu, Min Li, Ya Huang, Songjie Han, Tianmai He, Jing Chen, Hongcai Shang,

Objectives: To examine heterogeneity of outcomes in protocols of clinical trials of Coronavirus Disease 2019 (COVID-19) and to identify outcomes for prioritization in developing a core outcome set (COS) in this field. Design: This study is a review. Data sources: Databases of ICMJE-accepted clinical trial registry platform were searched on ... Read more >>

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Neurological manifestations of autoinflammatory diseases in Chinese adult patients.

Wenyi Qin, Di Wu, Yi Luo, Mengzhu Zhao, Yi Wang, Xiaochun Shi, Lixin Zhou, Weihong Yu, Yang Sun, Rongrong Wang, Wen Zhang, Mengqi Liu, Min Shen,

OBJECTIVE:Systemic autoinflammatory diseases (SAIDs) are a group of disorders characterized by a dysregulation of innate immune system leading to multi-systemic inflammation. We aim to assess the neurological manifestations of Chinese adult patients with SAIDs. METHODS:Eighty adult patients (≥16 years) were diagnosed as SAIDs from April 2015 to June 2019, at ... Read more >>

Semin. Arthritis Rheum. (Seminars in arthritis and rheumatism)
[2020, :]

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Effective treatment of TNFα inhibitors in Chinese patients with Blau syndrome.

Jing Chen, Yi Luo, Mengzhu Zhao, Di Wu, Yunjiao Yang, Wen Zhang, Min Shen,

OBJECTIVES:Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded diverse results. We aimed to evaluate clinical features and outcomes of Chinese patients with BS who were treated with tumor necrosis factor (TNF)α ... Read more >>

Arthritis Res. Ther. (Arthritis research & therapy)
[2019, 21(1):236]

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Clinical and genetic features of Chinese adult patients with tumour necrosis factor receptor-associated periodic fever syndrome.

Mengzhu Zhao, Yi Luo, Di Wu, Yunjiao Yang, Yang Sun, Rongrong Wang, Min Shen,

OBJECTIVES:TNF receptor-associated periodic fever syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease caused by mutations of TNF receptor superfamily member 1 A (TNFRSF1A) gene. TRAPS has hardly been reported in the Chinese population. We aimed to characterize the clinical and genetic features of Chinese adult patients with TRAPS. METHODS:Nine adult ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2019, :]

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Autophagosome closure by ESCRT: Vps21/RAB5-regulated ESCRT recruitment via an Atg17-Snf7 interaction.

Fan Zhou, Zulin Wu, Mengzhu Zhao, Nava Segev, Yongheng Liang,

The macroautophagy/autophagy pathway includes successive steps of phagophore assembly structure formation, phagophore expansion, autophagosome (AP) closure and AP fusion with the lysosome/vacuole. Although information about regulators, factors and molecular mechanisms important for early and late steps of autophagy is abundant, information about AP closure is scarce. In 2017, we reported ... Read more >>

Autophagy (Autophagy)
[2019, 15(9):1653-1654]

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