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Clinical Characteristics and Survival Associations of Pancreatic Neuroendocrine Tumor: Does Age Matter?

Mengqi Liu, Xiaoyan Sun, Zheng Zhang, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo, Shunrong Ji,

Abstract Background: Pancreatic neuroendocrine tumor (pNET) is the second most common epithelial neoplasm of pancreas. As in pancreatic adenocarcinoma, patients with different onset ages display different clinical features and prognosis, we divided pNET patients into early-onset pancreatic neuroendocrine tumor (EOpNET) and typical age-at-onset pancreatic neuroendocrine tumor (TOpNET) to investigate the ... Read more >>

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Clinical Characteristics and Survival Associations of Pancreatic Neuroendocrine Tumor: Does Age Matter?

Mengqi Liu, Xiaoyan Sun, Zheng Zhang, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo, Shunrong Ji,

Abstract Background Pancreatic neuroendocrine tumor (pNET) is the second most common epithelial neoplasm of pancreas. As in pancreatic adenocarcinoma, patients with different onset ages display different clinical features and prognosis, we divided pNET patients into early-onset pancreatic neuroendocrine tumor (EOpNET) and typical age-at-onset pancreatic neuroendocrine tumor (TOpNET) to investigate the ... Read more >>

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COVID-19 pneumonia: CT findings of 122 patients and differentiation from influenza pneumonia.

Mengqi Liu, Wenbin Zeng, Yun Wen, Yineng Zheng, Fajin Lv, Kaihu Xiao,

OBJECTIVES:To investigate the clinical and chest CT characteristics of COVID-19 pneumonia and explore the radiological differences between COVID-19 and influenza. MATERIALS AND METHODS:A total of 122 patients (61 men and 61 women, 48 ± 15 years) confirmed with COVID-19 and 48 patients (23 men and 25 women, 47 ± 19 years) confirmed with influenza were enrolled ... Read more >>

Eur Radiol (European Radiology)
[2020, :]

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High-Resolution Computed Tomography Manifestations of 5 Pediatric Patients With 2019 Novel Coronavirus.

Mengqi Liu, Zongbiao Song, Kaihu Xiao,

We present clinical and chest computed tomography (CT) features of 5 cases of pediatric patients with 2019 novel coronavirus. Two patients had fever and dry cough, whereas the rest of 3 patients were asymptomatic. Three patients had unilateral ground glass opacities with or without consolidation in the subpleural region on ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2020, 44(3):311-313]

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Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.

Qiqing Sun, Guixiong Fan, Qifeng Zhuo, Weixing Dai, Zeng Ye, Shunrong Ji, Wenyan Xu, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu, Xiaowu Xu, Yi Qin,

OBJECTIVES:Accumulated evidence suggests that Pin1 contributes to oncogenesis of diverse cancers. However, the underlying mechanism of oncogenic function of Pin1 in PDAC requires further exploration. MATERIALS AND METHODS:IHC was performed using PDAC tissues. Western blot, PCR, immunofluorescence and transwell were performed using cell lines. GSEA were applied for possible downstream ... Read more >>

Cell Prolif. (Cell proliferation)
[2020, 53(5):e12816]

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Ferroptosis: Final destination for cancer?

Zeng Ye, Wensheng Liu, Qifeng Zhuo, Qiangsheng Hu, Mengqi Liu, Qiqing Sun, Zheng Zhang, Guixiong Fan, Wenyan Xu, Shunrong Ji, Xianjun Yu, Yi Qin, Xiaowu Xu,

Ferroptosis is a recently defined, non-apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron-containing enzymes. In this process, a variety of inducers destroy the cell redox balance and produce a large number of lipid peroxidation products, eventually triggering cell ... Read more >>

Cell Prolif. (Cell proliferation)
[2020, 53(3):e12761]

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Management of Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An analysis of the US SEER Database and a Chinese Single-center Cohort

Shunrong Ji, Mengqi Liu, Zeng Ye, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo,

Abstract Background. Nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) are often small, slow growing, clinically silent neoplasms. Currently, ‘wait-and-see’ policy is recommended by the European Neuroendocrine Tumor Society (ENETS) for NF-pNETs (<2 cm). But the scientific basis for such recommendation is scarce. Methods. Data of NF-pNETs cases were reviewed retrospectively from the ... Read more >>

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Enzymatic degradation of algal 1,3-xylan: from synergism of lytic polysaccharide monooxygenases with β-1,3-xylanases to their intelligent immobilization on biomimetic silica nanoparticles.

Lixi Cai, Xin Liu, Yue Qiu, Mengqi Liu, Guangya Zhang,

Lytic polysaccharide monooxygenases (LPMOs) with synergistic effect on polysaccharide hydrolase represent a revolution in biotechnology, which may accelerate the conversion of biomass to the second-generation biofuels. Discovering more hydrolases that have synergism with LPMOs will considerably expand the knowledge and application of biomass degradation. The LPMOs named CgAA9 were verified ... Read more >>

Appl. Microbiol. Biotechnol. (Applied microbiology and biotechnology)
[2020, :]

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Neurological manifestations of autoinflammatory diseases in Chinese adult patients.

Wenyi Qin, Di Wu, Yi Luo, Mengzhu Zhao, Yi Wang, Xiaochun Shi, Lixin Zhou, Weihong Yu, Yang Sun, Rongrong Wang, Wen Zhang, Mengqi Liu, Min Shen,

OBJECTIVE:Systemic autoinflammatory diseases (SAIDs) are a group of disorders characterized by a dysregulation of innate immune system leading to multi-systemic inflammation. We aim to assess the neurological manifestations of Chinese adult patients with SAIDs. METHODS:Eighty adult patients (≥16 years) were diagnosed as SAIDs from April 2015 to June 2019, at ... Read more >>

Semin. Arthritis Rheum. (Seminars in arthritis and rheumatism)
[2020, :]

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Prognostic Value and Clinical Predictors of Lymph Node Metastases in Pancreatic Neuroendocrine Tumors.

Zheng Zhang, Mengqi Liu, Shunrong Ji, Guopei Luo, Wenyan Xu, Wensheng Liu, Qiangsheng Hu, Qiqing Sun, Zeng Ye, Yi Qin, Guixiong Fan, Xianjun Yu, Xiaowu Xu,

OBJECTIVES:To investigate the correlation between lymph node metastasis (LNM) and various clinicopathological features of pancreatic neuroendocrine tumors (pNETs) and its impact on prognosis. METHODS:We searched the Surveillance Epidemiology and End Results database (2004-2015) for patients with surgically treated pNETs. Factors correlated with LNMs were analyzed by logistic regression and by ... Read more >>

Pancreas (Pancreas)
[2020, 49(3):381-386]

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Autophagy Triggered by Oxidative Stress Appears to Be Mediated by the AKT/mTOR Signaling Pathway in the Liver of Sleep-Deprived Rats.

Yongmei Li, Yuan Zhang, Guang Ji, Yiwei Shen, Nan Zhao, Yuhan Liang, Zihan Wang, Mengqi Liu, Laixiang Lin,

Sleep deprivation adversely affects the digestive system. Multiple studies have suggested sleep deprivation and oxidative stress are closely related. Autophagy can be triggered by oxidative stress as a self-defense strategy to promote survival. In this study, we investigated the effects of sleep deprivation on liver functions, oxidative stress, and concomitant ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:6181630]

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Evaluating the temporomandibular joint disc using calcium-suppressed technique in dual-layer detector computed tomography.

Xiaohuan Zhang, Mengqi Liu, Yanyi Wang, Weiwei Deng, Houmin Tan, Wenping Fan, Zhiye Chen,

J. Int. Med. Res. (The Journal of international medical research)
[2019, :300060519891332]

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FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer.

Zheng Zhang, Mengqi Liu, Qiangsheng Hu, Wenyan Xu, Wensheng Liu, Qiqing Sun, Zeng Ye, Guixiong Fan, Xiaowu Xu, Xianjun Yu, Shunrong Ji, Yi Qin,

The secreted fibroblast growth factor (FGF) binding protein (FGF-BP), which is an extracellular chaperone molecule for FGFs, has been demonstrated to enhance the biological and biochemical activities of FGFs and to be closely related to the growth of several cancers. However, the role of FGFBP1 in pancreatic adenocarcinoma (PDAC) has ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2019, 9(12):2650-2664]

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Prognostic and diagnostic significance of galectins in pancreatic cancer: a systematic review and meta-analysis.

Qiqing Sun, Yiyin Zhang, Mengqi Liu, Zeng Ye, Xianjun Yu, Xiaowu Xu, Yi Qin,

Background:Galectins constitute a family of β-galactoside-binding proteins, which influence various hallmarks of pancreatic cancer, including cell proliferation, invasion and migration; immune escape; and angiogenesis. Although many studies have concentrated on the role of galectins in pancreatic cancer, the results remain controversial. Hence, we performed a comprehensive meta-analysis to clarify the ... Read more >>

Cancer Cell Int. (Cancer Cell International)
[2019, 19:309]

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ABO Blood Group and the Risk of Pancreatic Neoplasms in Chinese Han Population: A Study at Shanghai Pancreatic Cancer Institute.

Mengqi Liu, Shunrong Ji, Wenyan Xu, Wensheng Liu, Yi Qin, Jinfeng Xiang, Qiangsheng Hu, Qiqing Sun, Zheng Zhang, Xiaowu Xu, Xianjun Yu,

Pancreas (Pancreas)
[2019, 48(9):e65-e66]

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Expression of stilbene synthase VqSTS6 from wild Chinese Vitis quinquangularis in grapevine enhances resveratrol production and powdery mildew resistance.

Mengqi Liu, Fuli Ma, Fengying Wu, Changyue Jiang, Yuejin Wang,

MAIN CONCLUSION:In grape (Vitis), stilbene phytoalexins can either be in situ synthesized or transported to the site of response during powdery mildew infection, enhancing disease resistance. Resveratrol is a phytoprotective stilbenoid compound that is synthesized by stilbene synthase (STS) in response to biotic and abiotic stresses, and is also known ... Read more >>

Planta (Planta)
[2019, 250(6):1997-2007]

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Management of solid pseudopapillary neoplasms of pancreas: A single center experience of 243 consecutive patients.

Mengqi Liu, Jiang Liu, Qiangsheng Hu, Wenyan Xu, Wensheng Liu, Zheng Zhang, Qiqing Sun, Yi Qin, Xianjun Yu, Shunrong Ji, Xiaowu Xu,

BACKGROUND:Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare neoplasm, which mainly affects young women. The aim of this study was to investigate the clinicopathological features and surgical management of SPNs in our institution. METHODS:Patients who underwent surgery for a pathologically confirmed SPN in our institution between January 2008 ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2019, 19(5):681-685]

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Volume of Hypothalamus as a Diagnostic Biomarker of Chronic Migraine.

Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Lin Ma, Shengyuan Yu,

It is believed than hypothalamus (HTH) might be involved in generation of migraine, and evidence from high resolution fMRI reported that the more anterior part of HTH seemed to play an important role in migraine chronification. The current study was aimed to identify the alteration of morphology and resting-state functional ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:606]

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Laparoscopic pancreaticoduodenectomy: are the best times coming?

Mengqi Liu, Shunrong Ji, Wenyan Xu, Wensheng Liu, Yi Qin, Qiangsheng Hu, Qiqing Sun, Zheng Zhang, Xianjun Yu, Xiaowu Xu,

BACKGROUND:The introduction of laparoscopic technology has greatly promoted the development of surgery, and the trend of minimally invasive surgery is becoming more and more obvious. However, there is no consensus as to whether laparoscopic pancreaticoduodenectomy (LPD) should be performed routinely. MAIN BODY:We summarized the development of laparoscopic pancreaticoduodenectomy (LPD) in ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2019, 17(1):81]

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UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.

Qiangsheng Hu, Yi Qin, Shunrong Ji, Wenyan Xu, Wensheng Liu, Qiqing Sun, Zheng Zhang, Mengqi Liu, Quanxing Ni, Xianjun Yu, Xiaowu Xu,

UHRF1 (ubiquitin like with plant homeodomain and ring finger domains 1) is an epigenetic modifier that is overexpressed in some cancers, including pancreatic cancer, and mediates silencing of tumor suppressor genes. However, the role of UHRF1 in regulating pancreatic cancer metabolism and metastasis is not clear. In the present study, ... Read more >>

Cancer Lett. (Cancer letters)
[2019, 452:226-236]

Cited: 2 times

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Associations of PIK3CA mutations with clinical features and prognosis in gastric cancer.

Xiaobing Shen, Ying Zhao, Xiaowei Chen, Haixiang Sun, Mengqi Liu, Wenwen Zhang, Fei Jiang, Pengfei Li,

Aim: The clinical implications of PIK3CA mutations in gastric cancer (GC) are not conclusive. Materials & methods: A systematic searching of the previous publications and related studies in The Cancer Genome Atlas (TCGA) database were performed to investigate the clinical implications of PIK3CA mutations in GC.  Results: Twenty-six independent cohort ... Read more >>

Future Oncol (Future Oncology)
[2019, 15(16):1873-1894]

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Involuntary choreiform movements in a diabetic patient.

Fei Xiao, Mengqi Liu, Xue-Feng Wang,

Lancet (Lancet (London, England))
[2019, 393(10175):1033]

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Effects of ketamine use on psychotic disorders and symptoms in male, methamphetamine-dependent subjects.

Huixi Dong, Cheng Yang, Yidong Shen, Liang Liu, Mengqi Liu, Wei Hao,

BACKGROUND:Repeated and extensive methamphetamine or ketamine use may cause psychotic symptoms. Whether the chronic and combined use of these substances has a greater psychotic effect is still unknown. OBJECTIVES:To examine the effect of different levels of ketamine use on psychotic disorders and symptoms in male methamphetamine-dependent subjects. METHODS:A cross-sectional, structured, ... Read more >>

Am J Drug Alcohol Abuse (The American journal of drug and alcohol abuse)
[2019, 45(3):276-284]

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Comparison of Failure and Complication Risks of Porcelain Laminate and Indirect Resin Veneer Restorations: A Meta-Analysis.

Mengqi Liu, Kuo Gai, Junyu Chen, Li Jiang,

PURPOSE:To evaluate and compare the failure and complication risks of porcelain laminate and indirect resin veneer restorations (VRs) by means of a meta-analysis. METHODS:An electronic database search was performed in MEDLINE (PubMed), EMBASE (Ovid), and the Cochrane Central Register of Controlled Trials (CENTRAL) databases, and a gray literature search was ... Read more >>

Int J Prosthodont (The International journal of prosthodontics)
[2019, 32(1):59-65]

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Metal-Free Graphitic Carbon Nitride Photocatalyst Goes Into Two-Dimensional Time.

Gang Zhao, Hongcen Yang, Mengqi Liu, Xijin Xu,

Graphitic carbon nitride (g-C3N4) is always a research hotspot as a metal-free visible-light-responsive photocatalyst, in the field of solar energy conversion (hydrogen-production by water splitting). This critical review summarizes the recent progress in the design and syntheses of two-dimensional (2D) g-C3N4 and g-C3N4-based nanocomposites, covering (1) the modifications of organic ... Read more >>

Front Chem (Frontiers in chemistry)
[2018, 6:551]

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