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Author Mengdie Wang

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Data-driven respiratory gating based on localized diaphragm sensing in TOF PET.

Kyungsang Kim, Mengdie Wang, Ning Guo, Joshua Schaefferkoetter, Quanzheng Li,

It is important to measure the respiratory cycle in positron emission tomography (PET) to enhance the contrast of the tumor as well as the accuracy of its localization in organs such as the lung and liver. Several types of data-driven respiratory gating methods, such as center of mass and principal ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, 65(16):165007]

Cited: 0 times

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Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study.

Yanan Li, Man Li, Mengdie Wang, Yifan Zhou, Jiang Chang, Ying Xian, David Wang, Ling Mao, Huijuan Jin, Bo Hu,

BACKGROUND AND PURPOSE:COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Apart from respiratory complications, acute cerebrovascular disease (CVD) has been observed in some patients with COVID-19. Therefore, we described the clinical characteristics, laboratory features, treatment and outcomes of CVD complicating SARS-CoV-2 infection. MATERIALS AND ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2020, :]

Cited: 8 times

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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, Bo Hu,

Importance:The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(6):683-690]

Cited: 227 times

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Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management.

Yifan Zhou, Wei Li, David Wang, Ling Mao, Huijuan Jin, Yanan Li, Candong Hong, Shengcai Chen, Jiang Chang, Quanwei He, Mengdie Wang, Bo Hu,

Coronavirus disease-2019 (COVID-19) has become a global pandemic. COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. At the later clinical symptomatic phase, the immune system ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2020, 5(2):177-179]

Cited: 1 time

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Upconversion Nanoparticles-Based Multiplex Protein Activation to Neuron Ablation for Locomotion Regulation.

Yan Zhang, Wanmei Zhang, Kanghua Zeng, Yanxiao Ao, Mengdie Wang, Zhongzheng Yu, Fukang Qi, Weiwei Yu, Heng Mao, Louis Tao, Cuntai Zhang, Timothy Thatt Yang Tan, Xiangliang Yang, Kanyi Pu, Shangbang Gao,

The optogenetic neuron ablation approach enables noninvasive remote decoding of specific neuron function within a complex living organism in high spatiotemporal resolution. However, it suffers from shallow tissue penetration of visible light with low ablation efficiency. This study reports a upconversion nanoparticle (UCNP)-based multiplex proteins activation tool to ablate deep-tissue ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(8):e1906797]

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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study

Ling Mao, Mengdie Wang, Shanghai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Yanan Li, Huijuan Jin, Bo Hu,

OBJECTIVE: To study the neurological manifestations of patients with coronavirus disease 2019 (COVID-19). DESIGN: Retrospective case series SETTING: Three designated COVID-19 care hospitals of the Union Hospital of Huazhong University of Science and Technology in Wuhan, China. PARTICIPANTS: Two hundred fourteen hospitalized patients with laboratory confirmed diagnosis of severe acute ... Read more >>

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Cited: 17 times

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The sale of antihypertensive drugs by online pharmacies in China: A nationwide cross-sectional survey.

Nan Jiang, Xiaoxv Yin, Zhenyuan Chen, Hui Li, Jing Wang, Jia Zhang, Xing Xu, Wei Liu, Mengdie Wang, Yanhong Gong,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487319896678]

Cited: 0 times

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Centrosome loss results in an unstable genome and malignant prostate tumors.

Mengdie Wang, Raymond B Nagle, Beatrice S Knudsen, Anne E Cress, Gregory C Rogers,

Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis in various mouse models. Therefore, we developed a single-cell assay for ... Read more >>

Oncogene (Oncogene)
[2020, 39(2):399-413]

Cited: 1 time

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Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers

Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu, Zuxun Lu,

Abstract Background Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei province, China, to assess neurologists’ experiences of the treatment, and to identify barriers against the treatment from ... Read more >>

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Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers.

Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu, Zuxun Lu,

BACKGROUND:Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei province, China, to assess neurologists' experiences of the treatment, and to identify barriers against the treatment from perspective of AIS ... Read more >>

BMC Neurol (BMC neurology)
[2019, 19(1):202]

Cited: 0 times

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Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing.

Ameer L Elaimy, Mengdie Wang, Ankur Sheel, Caitlin W Brown, Melanie R Walker, John J Amante, Wen Xue, Amanda Chan, Christina E Baer, Hira Lal Goel, Arthur M Mercurio,

The ability to monitor changes in the expression and localization of integrins is essential for understanding their contribution to development, tissue homeostasis and disease. Here, we pioneered the use of Crispr/Cas9 genome editing to tag an allele of the β4 subunit of the α6β4 integrin. A tdTomato tag was inserted ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2019, 132(15):]

Cited: 0 times

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Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.

Cynthia S Rubenstein, Jaime M C Gard, Mengdie Wang, Julie E McGrath, Nadia Ingabire, James P Hinton, Kendra D Marr, Skyler J Simpson, Raymond B Nagle, Cindy K Miranti, Noel A Warfel, Joe G N Garcia, Hina Arif-Tiwari, Anne E Cress,

Human prostate cancer confined to the gland is indolent (low-risk), but tumors outside the capsule are aggressive (high-risk). Extracapsular extension requires invasion within and through a smooth muscle-structured environment. Because integrins respond to biomechanical cues, we used a gene editing approach to determine if a specific region of laminin-binding α6β1 ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(18):4703-4714]

Cited: 0 times

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The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.

Ameer L Elaimy, John J Amante, Lihua Julie Zhu, Mengdie Wang, Charlotte S Walmsley, Thomas J FitzGerald, Hira Lal Goel, Arthur M Mercurio,

Vascular endothelial growth factor (VEGF) signaling in tumor cells mediated by neuropilins (NRPs) contributes to the aggressive nature of several cancers, including triple-negative breast cancer (TNBC), independently of its role in angiogenesis. Understanding the mechanisms by which VEGF-NRP signaling contributes to the phenotype of such cancers is a significant and ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(28):14174-14180]

Cited: 0 times

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Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.

Mengdie Wang, James P Hinton, Jaime M C Gard, Joe G N Garcia, Beatrice S Knudsen, Raymond B Nagle, Anne E Cress,

Integrin α6β4 is an essential, dynamic adhesion receptor for laminin 332 found on epithelial cells, required for formation of strong cell-extracellular matrix (ECM) adhesion and induced migration, and coordinated by regions of the β4C cytoplasmic domain. β4E, a unique splice variant of β4 expressed in normal tissue, contains a cytoplasmic ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2019, 30(7):838-850]

Cited: 1 time

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A method of quantifying centrosomes at the single-cell level in human normal and cancer tissue.

Mengdie Wang, Beatrice S Knudsen, Raymond B Nagle, Gregory C Rogers, Anne E Cress,

Centrosome abnormalities are emerging hallmarks of cancer. The overproduction of centrosomes (known as centrosome amplification) has been reported in a variety of cancers and is currently being explored as a promising target for therapy. However, to understand different types of centrosome abnormalities and their impact on centrosome function during tumor ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2019, 30(7):811-819]

Cited: 0 times

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LncRNA TUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia.

Shengcai Chen, Mengdie Wang, Hang Yang, Ling Mao, Quanwei He, Huijuan Jin, Zi-Ming Ye, Xue-Ying Luo, Yuan-Peng Xia, Bo Hu,

Emerging studies have illustrated that LncRNAs TUG1 play critical roles in multiple biologic processes. However, the LncRNA TUG1 expression and function in ischemic stroke have not been reported yet. In this study, we found that LncRNA TUG1 expression was significantly up-regulated in brain ischemic penumbra from rat middle carotid artery ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2017, 485(1):167-173]

Cited: 34 times

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A basal cell defect promotes budding of prostatic intraepithelial neoplasia.

Mengdie Wang, Raymond B Nagle, Beatrice S Knudsen, Gregory C Rogers, Anne E Cress,

Basal cells in a simple secretory epithelium adhere to the extracellular matrix (ECM), providing contextual cues for ordered repopulation of the luminal cell layer. Early high-grade prostatic intraepithelial neoplasia (HG-PIN) tissue has enlarged nuclei and nucleoli, luminal layer expansion and genomic instability. Additional HG-PIN markers include loss of α6β4 integrin ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2017, 130(1):104-110]

Cited: 4 times

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Determinants of Emergency Medical Services Utilization Among Acute Ischemic Stroke Patients in Hubei Province in China.

Xiaoxv Yin, Tingting Yang, Yanhong Gong, Yanfeng Zhou, Wenzhen Li, Xingyue Song, Mengdie Wang, Bo Hu, Zuxun Lu,

Emergency medical services (EMS) can effectively shorten the prehospital delay for patients with acute ischemic stroke. This study aimed to investigate EMS utilization and its associated factors in patients with acute ischemic stroke in China.A cross-sectional study was conducted from October 1, 2014, to January 31, 2015, which included 2096 ... Read more >>

Stroke (Stroke)
[2016, 47(3):891-894]

Cited: 7 times

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TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Amit Dipak Amin, Lingxiao Li, Soumya S Rajan, Vijay Gokhale, Matthew J Groysman, Praechompoo Pongtornpipat, Edgar O Tapia, Mengdie Wang, Jonathan H Schatz,

The anaplastic lymphoma kinase (ALK) protein drives tumorigenesis in subsets of several tumors through chromosomal rearrangements that express and activate its C-terminal kinase domain. In addition, germline predisposition alleles and acquired mutations are found in the full-length protein in the pediatric tumor neuroblastoma. ALK-specific tyrosine kinase inhibitors (TKIs) have become ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(17):23715-23729]

Cited: 5 times

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Pre-hospital Delay after Acute Ischemic Stroke in Central Urban China: Prevalence and Risk Factors.

Yanfeng Zhou, Tingting Yang, Yanhong Gong, Wenzhen Li, Yawen Chen, Jing Li, Mengdie Wang, Xiaoxv Yin, Bo Hu, Zuxun Lu,

Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals in 13 major cities across ... Read more >>

Mol. Neurobiol. (Molecular neurobiology)
[2017, 54(4):3007-3016]

Cited: 7 times

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A novel approach to assess the treatment response using Gaussian random field in PET.

Mengdie Wang, Ning Guo, Guangshu Hu, Georges El Fakhri, Hui Zhang, Quanzheng Li,

The assessment of early therapeutic response to anticancer therapy is vital for treatment planning and patient management in clinic. With the development of personal treatment plan, the early treatment response, especially before any anatomically apparent changes after treatment, becomes urgent need in clinic. Positron emission tomography (PET) imaging serves an ... Read more >>

Med Phys (Medical physics)
[2016, 43(2):833-842]

Cited: 1 time

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Retrospective data-driven respiratory gating for PET using TOF information.

Mengdie Wang, Ning Guo, Hui Zhang, Georges Elfhakri, Guangshu Hu, Quanzheng Li,

Traditional data-driven respiratory gating method is capable of detecting breathing cycles directly from positron emission tomography (PET) data, but usually fails at low SNR, particularly at low dose PET/CT study. Time-of-flight (TOF) PET has the potential to improve the SNR. In order for TOF information to reduce the statistical noise ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2015, 2015:4520-4523]

Cited: 2 times

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