Full Text Journal Articles by
Author Mengdi He

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The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer.

Mengdi He, Yiying Wang, Guodong Zhang, Kankan Cao, Moran Yang, Haiou Liu,

<h4>Objective</h4>To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker.<h4>Methods</h4>We employed CIBERSORT and xCell method to evaluate the abundances of 23 cells types in tumor microenvironment. Five specific cell types were filtrated to determine different immunotypes by applying ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e32]

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The immune landscape during the tumorigenesis of cervical cancer.

Yiying Wang, Mengdi He, Guodong Zhang, Kankan Cao, Moran Yang, Hongwei Zhang, Haiou Liu,

<h4>Objective</h4>Deciphering the determinants of the intralesional immune reaction in cervical carcinogenesis may be conducive to improving the understanding of the disease and then improve outcomes.<h4>Methods</h4>Public gene-expression data and full clinical annotation were searched in Gene Expression Omnibus in the joint analysis of the array-based four eligible cohorts. The infiltrating estimation ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(7):2380-2395]

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Biochemical characterization of specific Alanine Decarboxylase (AlaDC) and its ancestral enzyme Serine Decarboxylase (SDC) in tea plants (Camellia sinensis).

Peixian Bai, Liyuan Wang, Kang Wei, Li Ruan, Liyun Wu, Mengdi He, Dejiang Ni, Hao Cheng,

<h4>Background</h4>Alanine decarboxylase (AlaDC), specifically present in tea plants, is crucial for theanine biosynthesis. Serine decarboxylase (SDC), found in many plants, is a protein most closely related to AlaDC. To investigate whether the new gene AlaDC originate from gene SDC and to determine the biochemical properties of the two proteins from ... Read more >>

BMC Biotechnol (BMC biotechnology)
[2021, 21(1):17]

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Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.

Moran Yang, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Jiaqi Lu, Haiou Liu, Congjian Xu,

<h4>Background</h4>Tumour associated neutrophils (TANs) play a controversial role in regulating immune surveillance and immune evasion in various malignancies. Here, we investigated the relevance of TANs with the prognosis and immune microenvironment of epithelial ovarian cancer (EOC).<h4>Methods</h4>We characterised TANs using flow cytometric analysis and immunofluorescence analysis. The prognostic merit of TANs ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 123(9):1404-1416]

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