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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(10):4411-4419]

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Artificial intelligence in medical imaging: implications for patient radiation safety.

Jarrel Seah, Zoe Brady, Kyle Ewert, Meng Law,

Artificial intelligence, including deep learning, is currently revolutionising the field of medical imaging, with far reaching implications for almost every facet of diagnostic imaging, including patient radiation safety. This paper introduces basic concepts in deep learning and provides an overview of its recent history and its application in tomographic reconstruction ... Read more >>

Br J Radiol (The British journal of radiology)
[2021, 94(1126):20210406]

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Artificial intelligence and medical imaging: applications, challenges and solutions.

Meng Law, Jarrel Seah, George Shih,

Med J Aust (The Medical journal of Australia)
[2021, 214(10):450-452.e1]

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Topographic divergence of atypical cortical asymmetry and regional atrophy patterns in temporal lobe epilepsy: a worldwide enigma study

Bo-yong Park, Sara Lariviere, Raul Rodriguez-Cruces, Jessica Royer, Shahin Tavakol, Yezhou Wang, Lorenzo Caciagli, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon Keller, Fernando Cendes, Marina KM Alvim, Clarissa Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels Focke, Barbara AK Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Michael Rebsamen, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence O'Brien, Meng Law, Benjamin Sinclair, Lucy Vivash, Patricia Desmond, Charles Malpas, Elaine Lui, Saud Alhusaini, Colin Doherty, Gianpiero Cavalleri, Norman Delanty, Reetta Kalviainen, Graeme Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Bernd Weber, Chantal Depondt, Julie Absil, Sarah JA Carr, Eugenio Abela, Mark Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Costanza Parodi, Domenico Tortora, Sean Hatton, Sjoerd Vos, John Duncan, Marian Galovic, Christopher Whelan, Nuria Bargallo, Jose Pariente, Estefania Conde, Anna Elisabetta Vaudano, Manuela Tondelli, Stefano Meletti, Xiang-Zhen Kong, Clyde Francks, Simon Fisher, Angelo Labate, Sanjay Sisodiya, Paul Thompson, Carrie McDonald, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt,

Temporal lobe epilepsy (TLE), a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter pathology in TLE relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry or (ii) regional ... Read more >>

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The RSNA Pulmonary Embolism CT Dataset.

Errol Colak, Felipe C Kitamura, Stephen B Hobbs, Carol C Wu, Matthew P Lungren, Luciano M Prevedello, Jayashree Kalpathy-Cramer, Robyn L Ball, George Shih, Anouk Stein, Safwan S Halabi, Emre Altinmakas, Meng Law, Parveen Kumar, Karam A Manzalawi, Dennis Charles Nelson Rubio, Jacob W Sechrist, Pauline Germaine, Eva Castro Lopez, Tomas Amerio, Pushpender Gupta, Manoj Jain, Fernando U Kay, Cheng Ting Lin, Saugata Sen, Jonathan Wesley Revels, Carola C Brussaard, John Mongan, ,

<i>Supplemental material is available for this article.</i> ... Read more >>

Radiol Artif Intell (Radiology. Artificial intelligence)
[2021, 3(2):e200254]

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Neuroimaging at 3T vs 7T: Is It Really Worth It?

Stephen E Jones, Jonathan Lee, Meng Law,

Food and Drug Administration approval of 7T MR imaging allows ultrahigh-field neuroimaging to extend from the research realm into the clinical realm. Increased signal is clinically advantageous for smaller voxels and thereby high spatial resolution imaging, with additional advantages of increased tissue contrast. Susceptibility, time-of-flight signal, and blood oxygen level-dependent ... Read more >>

Magn Reson Imaging Clin N Am (Magnetic resonance imaging clinics of North America)
[2021, 29(1):1-12]

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Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV.

Talia M Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau M Ances, Jasmina Boban, Bruce J Brew, Joga R Chaganti, Linda Chang, Christopher R K Ching, Lucette A Cysique, Thomas Ernst, Joshua Faskowitz, Vikash Gupta, Jaroslaw Harezlak, Jodi M Heaps-Woodruff, Charles H Hinkin, Jacqueline Hoare, John A Joska, Kalpana J Kallianpur, Taylor Kuhn, Hei Y Lam, Meng Law, Christine Lebrun-Frénay, Andrew J Levine, Lydiane Mondot, Beau K Nakamoto, Bradford A Navia, Xavier Pennec, Eric C Porges, Lauren E Salminen, Cecilia M Shikuma, Wesley Surento, April D Thames, Victor Valcour, Matteo Vassallo, Adam J Woods, Paul M Thompson, Ronald A Cohen, Robert Paul, Dan J Stein, Neda Jahanshad,

<h4>Importance</h4>Despite more widely accessible combination antiretroviral therapy (cART), HIV-1 infection remains a global public health challenge. Even in treated patients with chronic HIV infection, neurocognitive impairment often persists, affecting quality of life. Identifying the neuroanatomical pathways associated with infection in vivo may delineate the neuropathologic processes underlying these deficits. However, ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2031190]

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Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial.

Gerson D Hernandez, Christine M Solinsky, Wendy J Mack, Naoko Kono, Kathleen E Rodgers, Chun-Yi Wu, Ana R Mollo, Claudia M Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A Rogawski, Lon S Schneider, Roberta D Brinton,

<h4>Introduction</h4>Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well-established preclinical safety efficacy make it a viable candidate.<h4>Methods</h4>A randomized, double-blinded, placebo-controlled, single and multiple ascending dose trial was conducted. Intravenous allopregnanolone or placebo was administered once-per-week ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12107]

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Perivascular Space Imaging at Ultrahigh Field MR Imaging.

Giuseppe Barisano, Meng Law, Rachel M Custer, Arthur W Toga, Farshid Sepehrband,

The recent Food and Drug Administration approval of 7 T MR imaging scanners for clinical use has introduced the possibility to study the brain not only in physiologic but also in pathologic conditions at ultrahigh field (UHF). Because UHF MR imaging offers higher signal-to-noise ratio and spatial resolution compared with lower ... Read more >>

Magn Reson Imaging Clin N Am (Magnetic resonance imaging clinics of North America)
[2021, 29(1):67-75]

Cited: 1 time

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Clinical utility of deep learning motion correction for T1 weighted MPRAGE MR images.

Kamlesh Pawar, Zhaolin Chen, Jarrel Seah, Meng Law, Tom Close, Gary Egan,

<h4>Purpose</h4>To evaluate the clinical utility of the application of a deep learning motion correction technique on 3D MPRAGE magnetic resonance images acquired in routine clinical practice.<h4>Methods</h4>An encoder-decoder deep learning network inspired by InceptionResnet was trained on public datasets. The clinical utility of the trained network was evaluated retrospectively on 27 ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 133:109384]

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Ultrahigh Field 7 T MR Imaging: Bridging the Gap Between Microscopic and Systems Level Macroscopic Imaging.

Meng Law,

Magn Reson Imaging Clin N Am (Magnetic resonance imaging clinics of North America)
[2021, 29(1):xv-xvi]

Cited: 1 time

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Body mass index, time of day and genetics affect perivascular spaces in the white matter.

Giuseppe Barisano, Nasim Sheikh-Bahaei, Meng Law, Arthur W Toga, Farshid Sepehrband,

The analysis of cerebral perivascular spaces (PVS) using magnetic resonance imaging (MRI) allows to explore <i>in vivo</i> their contributions to neurological disorders. To date the normal amount and distribution of PVS in healthy human brains are not known, thus hampering our ability to define with confidence pathogenic alterations. Furthermore, it ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2021, 41(7):1563-1578]

Cited: 2 times

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Artificial intelligence for clinical decision support in neurology.

Mangor Pedersen, Karin Verspoor, Mark Jenkinson, Meng Law, David F Abbott, Graeme D Jackson,

Artificial intelligence is one of the most exciting methodological shifts in our era. It holds the potential to transform healthcare as we know it, to a system where humans and machines work together to provide better treatment for our patients. It is now clear that cutting edge artificial intelligence models ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa096]

Cited: 2 times

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Body mass index, time of day, and genetics affect perivascular spaces in the white matter

Giuseppe Barisano, Farshid Sepehrband, Nasim Sheikh-Bahaei, Meng Law, Arthur Toga,

The analysis of cerebral perivascular spaces (PVS) using magnetic resonance imaging (MRI) allows to explore in vivo their contributions to neurological disorders. To date the normal amount and distribution of PVS in healthy human brains are not known, thus hampering our ability to define with confidence pathogenic alterations. Furthermore, it ... Read more >>

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Technique, radiation safety and image quality for chest X-ray imaging through glass and in mobile settings during the COVID-19 pandemic.

Zoe Brady, Heather Scoullar, Ben Grinsted, Kyle Ewert, Helen Kavnoudias, Alexander Jarema, James Crocker, Rob Wills, Gillian Houston, Meng Law, Dinesh Varma,

The COVID-19 pandemic in 2020 has led to preparations within our hospital for an expected surge of patients. This included developing a technique to perform mobile chest X-ray imaging through glass, allowing the X-ray unit to remain outside of the patient's room, effectively reducing the cleaning time associated with disinfecting ... Read more >>

Phys Eng Sci Med (Physical and engineering sciences in medicine)
[2020, 43(3):765-779]

Cited: 7 times

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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Axel Montagne, Daniel A Nation, Abhay P Sagare, Giuseppe Barisano, Melanie D Sweeney, Ararat Chakhoyan, Maricarmen Pachicano, Elizabeth Joe, Amy R Nelson, Lina M D'Orazio, David P Buennagel, Michael G Harrington, Tammie L S Benzinger, Anne M Fagan, John M Ringman, Lon S Schneider, John C Morris, Eric M Reiman, Richard J Caselli, Helena C Chui, Julia Tcw, Yining Chen, Judy Pa, Peter S Conti, Meng Law, Arthur W Toga, Berislav V Zlokovic,

Vascular contributions to dementia and Alzheimer's disease are increasingly recognized<sup>1-6</sup>. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction<sup>7</sup>, including the early clinical stages of Alzheimer's disease<sup>5,8-10</sup>. The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer's ... Read more >>

Nature (Nature)
[2020, 581(7806):71-76]

Cited: 120 times

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Microstructural correlates of 23Na relaxation in human brain at 7 Tesla.

Scott C Kolbe, Warda Syeda, Yasmin Blunck, Rebecca Glarin, Meng Law, Leigh A Johnston, Jon O Cleary,

<sup>23</sup>Na provides the second strongest MR-observable signal in biological tissue and exhibits bi-exponential T<sub>2</sub><sup>∗</sup> relaxation in micro-environments such as the brain. There is significant interest in developing <sup>23</sup>Na biomarkers for neurological diseases that are associated with sodium channel dysfunction such as multiple sclerosis and epilepsy. We have previously reported methods ... Read more >>

Neuroimage (NeuroImage)
[2020, 211:116609]

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Treatment of symptomatic fibroid disease using uterine fibroid embolisation: An Australian perspective.

Warren Clements, W Catarina Ang, Meng Law, Gerard S Goh,

Uterine leiomyomata (fibroids) are symptomatic in up to 35% of women and treatment can be a costly burden to the individual and society. Options for treatment range from non-hormonal, hormonal, minimally invasive, to surgery. While symptoms from smaller fibroids may respond to simple treatment, those with larger fibroids or with ... Read more >>

Aust N Z J Obstet Gynaecol (The Australian & New Zealand journal of obstetrics & gynaecology)
[2020, 60(3):324-329]

Cited: 3 times

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Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment.

Axel Montagne, Mikko T Huuskonen, Gautham Rajagopal, Melanie D Sweeney, Daniel A Nation, Farshid Sepehrband, Lina M D'Orazio, Michael G Harrington, Helena C Chui, Meng Law, Arthur W Toga, Berislav V Zlokovic,

<h4>Introduction</h4>Blood-brain barrier (BBB) breakdown is an early independent biomarker of human cognitive dysfunction, as found using gadolinium (Gd) as a contrast agent. Whether Gd accumulates in brains of individuals with an age-dependent BBB breakdown and/or mild cognitive impairment remains unclear.<h4>Methods</h4>We analyzed T1-weighted magnetic resonance imaging (MRI) scans from 52 older ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2019, 15(12):1568-1575]

Cited: 2 times

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Tracer kinetic models as temporal constraints during brain tumor DCE-MRI reconstruction.

Sajan Goud Lingala, Yi Guo, Yannick Bliesener, Yinghua Zhu, R Marc Lebel, Meng Law, Krishna S Nayak,

<h4>Purpose</h4>To apply tracer kinetic models as temporal constraints during reconstruction of under-sampled brain tumor dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI).<h4>Methods</h4>A library of concentration vs time profiles is simulated for a range of physiological kinetic parameters. The library is reduced to a dictionary of temporal bases, where each profile ... Read more >>

Med Phys (Medical physics)
[2020, 47(1):37-51]

Cited: 3 times

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Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. Clinical management of mTBI is challenging due to the heterogeneous, subjective and transient nature of symptoms, and thus would be aided by objective biomarkers. Promising biomarkers ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14626]

Cited: 5 times

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Image processing approaches to enhance perivascular space visibility and quantification using MRI.

Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Ryan P Cabeen, Jeiran Choupan, Meng Law, Arthur W Toga,

Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the PVS. Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12351]

Cited: 6 times

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The LONI QC System: A Semi-Automated, Web-Based and Freely-Available Environment for the Comprehensive Quality Control of Neuroimaging Data.

Hosung Kim, Andrei Irimia, Samuel M Hobel, Mher Pogosyan, Haoteng Tang, Petros Petrosyan, Rita Esquivel Castelo Blanco, Ben A Duffy, Lu Zhao, Karen L Crawford, Sook-Lei Liew, Kristi Clark, Meng Law, Pratik Mukherjee, Geoffrey T Manley, John D Van Horn, Arthur W Toga,

Quantifying, controlling, and monitoring image quality is an essential prerequisite for ensuring the validity and reproducibility of many types of neuroimaging data analyses. Implementation of quality control (QC) procedures is the key to ensuring that neuroimaging data are of high-quality and their validity in the subsequent analyses. We introduce the ... Read more >>

Front Neuroinform (Frontiers in neuroinformatics)
[2019, 13:60]

Cited: 5 times

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Multicenter study demonstrates radiomic features derived from magnetic resonance perfusion images identify pseudoprogression in glioblastoma.

Nabil Elshafeey, Aikaterini Kotrotsou, Ahmed Hassan, Nancy Elshafei, Islam Hassan, Sara Ahmed, Srishti Abrol, Anand Agarwal, Kamel El Salek, Samuel Bergamaschi, Jay Acharya, Fanny E Moron, Meng Law, Gregory N Fuller, Jason T Huse, Pascal O Zinn, Rivka R Colen,

Pseudoprogression (PsP) is a diagnostic clinical dilemma in cancer. In this study, we retrospectively analyse glioblastoma patients, and using their dynamic susceptibility contrast and dynamic contrast-enhanced perfusion MRI images we build a classifier using radiomic features obtained from both Ktrans and rCBV maps coupled with support vector machines. We achieve ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3170]

Cited: 22 times

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Smaller limbic structures are associated with greater immunosuppression in over 1000 HIV-infected adults across five continents: Findings from the ENIGMA-HIV Working Group

Talia Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau Ances, Jasmina Boban, Bruce Brew, Linda Chang, Joga Chaganti, Christopher R.K. Ching, Lucette Cysique, Thomas Ernst, Joshua Faskowitz, Vikash Gupta, Jaroslaw Harezlak, Jodi Heaps-Woodruff, Charles Hinkin, Jacqueline Hoare, John Joska, Kalpana Kallianpur, Taylor Kuhn, Hei Lam, Meng Law, Christine Lebrun-Frenay, Andrew Levine, Lydiane Mondot, Beau Nakamoto, Bradford Navia, Xavier Pennec, Eric Porges, Cecilia Shikuma, April Thames, Victor Valcour, Matteo Vassallo, Adam Woods, Paul Thompson, Ronald Cohen, Robert Paul, Dan Stein, Neda Jahanshad, ,

<h4>Background</h4> Human immunodeficiency virus type-1 (HIV) infection can be controlled with combination antiretroviral therapy (cART), but neurocognitive impairment remains common even in chronic and treated HIV-infected (HIV+) cohorts. Identifying the neuroanatomical pathways associated with infection has the potential to delineate novel neuropathological processes underlying persisting deficits, yet individual neuroimaging studies ... Read more >>

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