Full Text Journal Articles by
Author Meltem Izzetoglu

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Evaluation of fNIRS signal components elicited by cognitive and hypercapnic stimuli.

Pratusha Reddy, Meltem Izzetoglu, Patricia A Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia, Kurtulus Izzetoglu,

Functional near infrared spectroscopy (fNIRS) measurements are confounded by signal components originating from multiple physiological causes, whose activities may vary temporally and spatially (across tissue layers, and regions of the cortex). Furthermore, the stimuli can induce evoked effects, which may lead to over or underestimation of the actual effect of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):23457]

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Cognitive Reserve Moderates the Efficiency of Prefrontal Cortex Activation Patterns of Gait in Older Adults.

Roee Holtzer, Daliah Ross, Catherine O'Brien, Meltem Izzetoglu, Mark E Wagshul,

<h4>Background</h4>Cognitive Reserve (CR) protects against cognitive decline, but whether CR influences the efficiency of cortical control of gait has not been reported. The current study addressed this important gap in the literature. Specifically, we determined the role of CR in moderating the efficiency of functional Near-Infrared-Spectroscopy (fNIRS)-derived HbO2 in the ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, :]

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Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions.

Daliah Ross, Mark E Wagshul, Meltem Izzetoglu, Roee Holtzer,

Dual tasking, a defined facet of executive control processes, is subserved, in part, by the prefrontal cortex (PFC). Previous functional near-infrared spectroscopy (fNIRS) studies revealed elevated PFC oxygenated hemoglobin (HbO<sub>2</sub>) under Dual-Task-Walk (DTW) compared to Single-Task Walk (STW) conditions. Based on the concept of neural inefficiency (i.e., greater activation coupled ... Read more >>

Geroscience (GeroScience)
[2021, 43(4):1959-1974]

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Evaluation of fNIRS Signal Components Elicited by Cognitive and Hypercapnic Stimuli

Pratusha Reddy, Meltem Izzetoglu, Patricia Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia, Kurtulus Izzetoglu,

Functional near infrared spectroscopy (fNIRS) measurements are confounded by signal components originating from multiple physiological causes, whose activities may vary temporally and spatially (across tissue layers, and regions of the cortex). Furthermore, the stimuli can induce evoked effects, which may lead to over or underestimation of the actual effect of ... Read more >>

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The Effects of Perceived Pain in the Past Month on Prefrontal Cortex Activation Patterns Assessed During Cognitive and Motor Performances in Older Adults.

Hannah Pakray, Elizabeth Seng, Meltem Izzetoglu, Roee Holtzer,

<h4>Objective</h4>Pain is prevalent and functionally impactful in older adults. The prefrontal cortex is involved in pain perception, attentional control, and cortical control of locomotion. Although pain is a known moderator of attentional capacity, its moderating effect on cortical control of locomotion has not been assessed. This study aimed to examine ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2021, 22(2):303-314]

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Intraindividual variability in neural activity in the prefrontal cortex during active walking in older adults.

Roee Holtzer, Daliah Ross, Meltem Izzetoglu,

Intraindividual variability in gait and cognitive performance is distinct from central-tendency measures and associated with clinical outcomes in aging. Knowledge concerning intraindividual variability in neural activity, however, has been relatively scarce, and no research to date has reported on such variability during active walking. The current study addressed this major ... Read more >>

Psychol Aging (Psychology and aging)
[2020, 35(8):1201-1214]

Cited: 1 time

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Short-Term Effects of Meditation on Sustained Attention as Measured by fNIRS.

Meltem Izzetoglu, Patricia A Shewokis, Kathryn Tsai, Phillip Dantoin, Kathryn Sparango, Katherine Min,

Cognitive abilities such as attention, memory, processing time, perception, and reasoning can be augmented using some type of intervention. Within the broad range of conventional and unconventional intervention methods used in cognitive enhancement, meditation is one of those that is safe, widely practiced by many since ancient times, and has ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(9):]

Cited: 2 times

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A consensus guide to using functional near-infrared spectroscopy in posture and gait research.

Jasmine C Menant, Inbal Maidan, Lisa Alcock, Emad Al-Yahya, Antonio Cerasa, David J Clark, Eling D de Bruin, Sarah Fraser, Vera Gramigna, Dennis Hamacher, Fabian Herold, Roee Holtzer, Meltem Izzetoglu, Shannon Lim, Annette Pantall, Paulo Pelicioni, Sue Peters, Andrea L Rosso, Rebecca St George, Samuel Stuart, Roberta Vasta, Rodrigo Vitorio, Anat Mirelman,

<h4>Background</h4>Functional near-infrared spectroscopy (fNIRS) is increasingly used in the field of posture and gait to investigate patterns of cortical brain activation while people move freely. fNIRS methods, analysis and reporting of data vary greatly across studies which in turn can limit the replication of research, interpretation of findings and comparison ... Read more >>

Gait Posture (Gait & posture)
[2020, 82:254-265]

Cited: 10 times

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Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults.

Roee Holtzer, Meltem Izzetoglu,

The presence of Mild Cognitive Impairments (MCI) is associated with worse gait performance. However, the effect of MCI on cortical control of gait, as assessed during active walking, is unknown. We hypothesized that MCI would be associated with attenuated activations and limited improvement in efficiency in the Prefrontal cortex (PFC) ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(7):]

Cited: 5 times

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Effects of Processing Methods on fNIRS Signals Assessed During Active Walking Tasks in Older Adults.

Meltem Izzetoglu, Roee Holtzer,

Functional near infrared spectroscopy (fNIRS) is a noninvasive optics-based neuroimaging modality successfully applied to real-life settings. The technology uses light in the near infrared range (650-950nm) to track changes in oxygenated (HbO2) and deoxygenated hemoglobin (Hb) obtained from measured light intensity using light-tissue interaction principles. fNIRS data processing involves artifact ... Read more >>

IEEE Trans Neural Syst Rehabil Eng (IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society)
[2020, 28(3):699-709]

Cited: 10 times

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Assessment of fNIRS Processing Methods on Active Walking Data: Findings and Implications for Future Research

Meltem Izzetoglu, Roee Holtzer,

Abstract Functional near infrared spectroscopy (fNIRS) studies utilized a limited and inconsistent number of processing algorithms to assess the prefrontal activity during active walking. To address this critical limitation, we have reanalyzed our large dataset of older adults (n=83) who underwent single and dual-task walking (STW and DTW) protocol by ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):791-792]

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Neural Inefficiency During Dual-Task Walking in Older Adults: The Moderating Effect of Brain Morphology

Daliah Ross, Mark Wagshul, Meltem Izzetoglu, Roee Holtzer,

Abstract Aging is accompanied by changes in cognitive, physical, and brain function. Research has found increased activation in the prefrontal cortex (PFC) in dual-task-walk (DTW) as compared to single-task walk (STW) due to increased cognitive demands in the former condition. Older adults have more difficulty with DTW than younger adults, ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):288-288]

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Effects of fNIRS Processing Methods on Prefrontal Hemodynamics During Single and Dual Task Walking in Older Adults

Meltem Izzetoglu, Roee Holtzer,

Abstract functional near infrared spectroscopy (fNIRS) has been increasingly used to assess changes in the hemodynamic response during active walking in aging and disease populations. Key findings revealed that HbO2 in the prefrontal cortex (PFC) increased from single-task-walk (STW) to dual-task-walk (DTW) due to the greater cognitive demands inherent in ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):288-288]

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The Effects of Pain on Brain and Behavior During Cognitive and Motor Performances in Older Adults

Hannah Pakray, Elizabeth Seng, Meltem Izzetoglu, Roee Holtzer,

Abstract Pain is prevalent and associated with adverse outcomes in older adults. The moderating effect of pain on cortical control of locomotion has not been assessed. This study examined the effects of subjective pain on changes in fNIRS-derived oxygenated hemoglobin (HbO2), gait velocity, and cognitive accuracy from single to dual-task ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):288-289]

Cited: 0 times

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Investigation of the source-detector separation in near infrared spectroscopy for healthy and clinical applications.

Lei Wang, Hasan Ayaz, Meltem Izzetoglu,

Understanding near infrared light propagation in tissue is vital for designing next generation optical brain imaging devices. Monte Carlo (MC) simulations provide a controlled mechanism to characterize and evaluate contributions of diverse near infrared spectroscopy (NIRS) sensor configurations and parameters. In this study, we developed a multilayer adult digital head ... Read more >>

J Biophotonics (Journal of biophotonics)
[2019, 12(11):e201900175]

Cited: 7 times

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Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults.

Mark E Wagshul, Melanie Lucas, Kenny Ye, Meltem Izzetoglu, Roee Holtzer,

It has been well established over the last two decades that walking is not merely an automatic, motoric activity; it also utilizes executive function circuits, which play an increasingly important role in walking for older people and those with mobility and cognitive deficits. Dual-task walking, such as walking while performing ... Read more >>

Neuroimage (NeuroImage)
[2019, 189:745-754]

Cited: 13 times

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Distinct fNIRS-Derived HbO2 Trajectories During the Course and Over Repeated Walking Trials Under Single- and Dual-Task Conditions: Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults.

Roee Holtzer, Meltem Izzetoglu, Michelle Chen, Cuiling Wang,

<h4>Background</h4>Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2019, 74(7):1076-1083]

Cited: 10 times

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Brain Activation Changes During Balance- and Attention-Demanding Tasks in Middle- and Older-Aged Adults With Multiple Sclerosis.

Manuel E Hernandez, Erin O'Donnell, Gioella Chaparro, Roee Holtzer, Meltem Izzetoglu, Brian M Sandroff, Robert W Motl,

Functional near-infrared spectroscopy was used to evaluate prefrontal cortex activation differences between older adults with multiple sclerosis (MS) and healthy older adults (HOA) during the performance of a balance- and attention-demanding motor task. Ten older adults with MS and 12 HOA underwent functional near-infrared spectroscopy recording while talking, virtual beam ... Read more >>

Motor Control (Motor control)
[2019, :1-20]

Cited: 4 times

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Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults.

Melanie Lucas, Mark E Wagshul, Meltem Izzetoglu, Roee Holtzer,

Using multimodal neuroimaging methods, the current study was designed to examine the relationship between white matter microstructural integrity (WMI) and changes in prefrontal cortex (PFC) oxygenated hemoglobin (HbO2) during active walking in older adults. Consistent with neural inefficiency, we hypothesized that worse WMI would be associated with a greater increase ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2019, 74(4):435-441]

Cited: 10 times

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The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults.

Roee Holtzer, Rebecca Kraut, Meltem Izzetoglu, Kenny Ye,

Neural inefficiency is inferred when higher brain activations are associated with similar or worse performance. Improved neural efficiency is achieved when task-related brain activations are reduced after practice. No information is available on the effect of fear-of-falling (FOF) on brain activation during walking. We hypothesized that the presence of FOF ... Read more >>

Geroscience (GeroScience)
[2019, 41(1):89-100]

Cited: 11 times

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Early diagnosis of traumatic intracranial hematomas.

Hasan Ayaz, Meltem Izzetoglu, Kurtulus Izzetoglu, Banu Onaral, Baruch Ben Dor,

Timing of the intervention for intracranial hematomas is critical for its success, specifically since expansion of the hemorrhage can result in debilitating and sometimes fatal outcomes. Led by Britton Chance, we and an extended team from University of Pennsylvania, Baylor and Drexel universities developed a handheld brain hematoma detector for ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2019, 24(5):1-10]

Cited: 3 times

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The effect of polypharmacy on prefrontal cortex activation during single and dual task walking in community dwelling older adults.

Claudene J George, Joe Verghese, Meltem Izzetoglu, Cuiling Wang, Roee Holtzer,

<h4>Introduction</h4>Polypharmacy, defined as the use of 5 or more medications is associated with multiple adverse outcomes in older adults, including falls and slow gait velocity. However, the relationship between polypharmacy and cortical control of locomotion has not been reported. The purpose of this study was to examine the relationship between ... Read more >>

Pharmacol Res (Pharmacological research)
[2019, 139:113-119]

Cited: 3 times

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Erratum to: The relationship between dorsolateral prefrontal activation and speech performance-based social anxiety using functional near infrared spectroscopy.

Lisa H Glassman, Anootnara T Kuster, Jena A Shaw, Evan M Forman, Meltem Izzetoglu, Alyssa Matteucci, James D Herbert,

Brain Imaging Behav (Brain imaging and behavior)
[2018, 12(3):917]

Cited: 0 times

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The effect of diabetes on prefrontal cortex activation patterns during active walking in older adults.

Roee Holtzer, Claudene J George, Meltem Izzetoglu, Cuiling Wang,

<h4>Background</h4>Gait alterations were documented in diabetic patients. However, the effect of diabetes on cortical control of gait has not been reported. We evaluated the effect of diabetes on prefrontal cortex (PFC) Oxygenated Hemoglobin (HbO<sub>2</sub>) levels during active walking in older adults.<h4>Methods</h4>Of the total sample (n = 315; mean age = 76.84 ± 6.71ys; % female = 56.5) 43 ... Read more >>

Brain Cogn (Brain and cognition)
[2018, 125:14-22]

Cited: 11 times

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Effects of Methylphenidate on Reaction Time in Children with Attention Deficit / Hyperactivity Disorder.

Ayşegül Güven, Miray Altinkaynak, Nazan Dolu, Esra Demirci, Sevgi Özmen, Meltem İzzetoğlu, Ferhat Pektaş,

Introduction:Attention-deficit/hyperactivity disorder (ADHD) is associated with a broad range of neuropsychological impairments that are attenuated with methylphenidate (MPH) treatment. The aim of this study was to determine how MPH effects attentional functioning in terms of reaction time (RT) in ADHD. Methods:Eighteen pre-medicated ADHD children (7 to 12 years old) and ... Read more >>

Noro Psikiyatr Ars (Noro psikiyatri arsivi)
[2019, 56(1):27-31]

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