Full Text Journal Articles by
Author Melissa Moore Clingenpeel

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Age-dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

<h4>Background</h4>Age-dependent differences in clinical presentation and viral loads in infants and young children with respiratory syncytial virus (RSV) infection, and their correlation with disease severity are poorly defined.<h4>Methods</h4>Previously healthy children <2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and viral loads measured by polymerase chain ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):116-122]

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Mental health history and social barriers impacting caregivers of infants with cystic fibrosis.

Michelle L Gillespie, Christopher J Nemastil, Melissa Moore-Clingenpeel, Diana Gilmore, Mary L Dell, Katelyn Krivchenia,

<h4>Objectives</h4>Caregivers of infants with cystic fibrosis (CF) carry a heavy treatment burden for their child along with the inherent difficulties of raising an infant. This study investigated the impact of self-reported caregiver mental health diagnoses and social barriers during the 1st year of life on clinical outcomes.<h4>Methods</h4>A retrospective chart review ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, :]

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Clinical Disease Severity Scores and Viral Loads in Children with RSV Infection.

Asuncion Mejias, Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Octavio Ramilo,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Electroencephalography Technologist Inter-rater Agreement and Interpretation of Pediatric Critical Care Electroencephalography.

Stephanie Ahrens, Jaime D Twanow, Jorge Vidaurre, Satyanarayana Gedela, Melissa Moore-Clingenpeel, Adam P Ostendorf,

<h4>Objectives</h4>Electroencephalography (EEG) technologists commonly screen continuous EEG. Until now, the inter-rater agreement or sensitivity for important EEG findings has been unknown in this group.<h4>Methods</h4>Twenty-nine EEG technologists and three clinical neurophysiologists interpreted 90 five-minute samples of pediatric critical care EEG. Inter-rater agreement was examined with Cohen's kappa and Fleiss' kappa for ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2021, 115:66-71]

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Optic nerve sheath diameter does not correlate with intracranial pressure in pediatric neurocritical care patients.

Austin Biggs, Marlina Lovett, Melissa Moore-Clingenpeel, Nicole O'Brien,

<h4>Purpose</h4>Intracranial pressure (ICP) > 20 mmHg is associated with worse outcomes in children. The gold standard for monitoring ICP is invasive, has complications such as bleeding and infection, and may not be available in resource limited areas. Ultrasound of the optic nerve sheath diameter (ONSD) has been studied as a noninvasive way ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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1465. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children with Respiratory Syncytial Virus Infection (RSV) Infection

Helena Brenes-Chacon, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Differences in clinical presentation and viral loads according to age in young children with RSV, and their correlation with disease severity are poorly defined. The aim of this study was to define age-dependent the differences in demographic, clinical factors and viral loads between children < 2 years of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S734-S735]

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131. The Protective Role of Mucosal Interferons in Infants with Respiratory Syncytial Virus (RSV) Infection

Jeanette Taveras, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Mark E Peeples, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Despite the high burden associated with RSV infection in young children the factors that determine disease severity are not well understood. The objective of this study was to assess the association of mucosal cytokine profiles, RSV loads (VL) and RSV disease severity. <h4>Methods</h4> Single-center, prospective study in previously ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S195-S196]

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Autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry.

Ohoud AlAhmed, Vidya Sivaraman, Melissa Moore-Clingenpeel, Stacy P Ardoin, Sharon Bout-Tabaku, ,

<h4>Objective</h4>Polyautoimmunity (PA) with systemic lupus erythematosus (SLE) is reported as a poor prognostic factor, but little is known about its effect in childhood-onset SLE (cSLE). We describe PA in cSLE within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry and evaluate its association to lupus disease outcomes.<h4>Methods</h4>CARRA Legacy ... Read more >>

Lupus (Lupus)
[2020, 29(14):1926-1936]

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Natural History of Steroid-Treated Young Boys With Duchenne Muscular Dystrophy Using the NSAA, 100m, and Timed Functional Tests.

Natalie F Miller, Lindsay N Alfano, Megan A Iammarino, Anne M Connolly, Melissa Moore-Clingenpeel, Brenna R Powers, Chang-Yong Tsao, Megan A Waldrop, Kevin M Flanigan, Jerry R Mendell, Linda P Lowes,

<h4>Introduction</h4>Clinical trials targeting younger cohorts of boys with Duchenne muscular dystrophy are necessary as earlier intervention may maximize treatment effect. Boys with Duchenne muscular dystrophy often have gross motor delays very early in life, and although they gain skills, they are on a lower trajectory than typical peers. Quantifying the ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2020, 113:15-20]

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Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis.

Katherine E Bline, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Jennifer A Muszynski, Octavio Ramilo, Mark W Hall,

<h4>Background</h4>Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydrocortisone in septic children based on their immune phenotype, but this has not been shown using a functional readout of the immune response. This study ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):545]

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Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome.

Kristen L Benninger, Teresa Borghese, Jason B Kovalcik, Melissa Moore-Clingenpeel, Cherie Isler, Elizabeth M Bonachea, Ann R Stark, Stephen W Patrick, Nathalie L Maitre,

<b>Aim:</b> To define a developmental trajectory in infants with neonatal opioid withdrawal syndrome (NOWS) and determine whether the impacted developmental domain varies with the type of antenatal exposure. <b>Methods:</b> We performed a retrospective cohort study of infants treated pharmacologically for NOWS and assessed using a standardized schedule for follow-up visits. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:462]

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Caregiver perception of hand function in infants with cerebral palsy: psychometric properties of the Infant Motor Activity Log.

Helen Carey, Krystal Hay, Mary Ann Nelin, Brianna Sowers, Dennis J Lewandowski, Melissa Moore-Clingenpeel, Nathalie L Maitre,

<h4>Aim</h4>To evaluate the properties of the Infant Motor Activity Log (IMAL), a caregiver-report for frequency and quality of use of more affected upper extremity in infants with neurological and functional impairments.<h4>Method</h4>This was a prospective cohort study of 66 children (34 females, 32 males) aged 6 to 24 months (mean age [SD] ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2020, 62(11):1266-1273]

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Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children.

Lara S Srouji, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Kathleen Nicol, Mark W Hall, Octavio Ramilo, Jennifer A Muszynski,

<h4>Objective</h4>To test the hypothesis that early RBC transfusion is associated with duration of organ dysfunction in critically ill septic children.<h4>Design</h4>Secondary analysis of a single-center prospective observational study. Multivariable negative binomial regression was used to determine relationships between RBC transfusion within 48 hours of sepsis onset and number of days in ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(8):e475-e484]

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Nosocomial Infection Following Severe Traumatic Injury in Children.

Eric A Sribnick, Josey Hensley, Melissa Moore-Clingenpeel, Jennifer A Muszynski, Rajan K Thakkar, Mark W Hall,

<h4>Objectives</h4>Nosocomial infection is a common source of morbidity in critically injured children including those with traumatic brain injury. Risk factors for nosocomial infection in this population, however, are poorly understood. We hypothesized that critically ill pediatric trauma patients with traumatic brain injury would demonstrate higher rates of nosocomial infection than ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(5):443-450]

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Network Implementation of Guideline for Early Detection Decreases Age at Cerebral Palsy Diagnosis.

Nathalie L Maitre, Vera J Burton, Andrea F Duncan, Sai Iyer, Betsy Ostrander, Sarah Winter, Lauren Ayala, Stephanie Burkhardt, Gwendolyn Gerner, Ruth Getachew, Kelsey Jiang, Laurie Lesher, Carrie M Perez, Melissa Moore-Clingenpeel, Rebecca Lam, Dennis J Lewandowski, Rachel Byrne,

BACKGROUND AND OBJECTIVES:Early diagnosis of cerebral palsy (CP) is critical in obtaining evidence-based interventions when plasticity is greatest. In 2017, international guidelines for early detection of CP were published on the basis of a systematic review of evidence. Our study aim was to reduce the age at CP diagnosis throughout ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(5):]

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Caregiver Characteristics Associated With Quality of Cardiac Compressions on an Adult Mannequin With Real-Time Visual Feedback: A Simulation-Based Multicenter Study.

David O Kessler, Daniel S Lemke, Priti Jani, Maya L Dewan, Melissa Moore-Clingenpeel, Todd P Chang, Jonathan Pirie, Marlina E Lovett, Ilana Harwayne-Gidansky, Heather A Wolfe, ,

INTRODUCTION:Chest compression (CC) quality directly impacts cardiac arrest outcomes. Provider body type can influence the quality of cardiopulmonary resuscitation (CPR); however, the magnitude of this impact while using visual feedback is not well described. The aim of the study was to determine the association between provider anthropometric variables on fatigue ... Read more >>

Simul Healthc (Simulation in healthcare : journal of the Society for Simulation in Healthcare)
[2020, 15(2):82-88]

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Immune profiles provide insights into respiratory syncytial virus disease severity in young children.

Santtu Heinonen, Victoria M Velazquez, Fang Ye, Sara Mertz, Santiago Acero-Bedoya, Bennett Smith, Eleonora Bunsow, Cristina Garcia-Mauriño, Silvia Oliva, Daniel M Cohen, Melissa Moore-Clingenpeel, Mark E Peeples, Octavio Ramilo, Asuncion Mejias,

Respiratory syncytial virus (RSV) is associated with major morbidity in infants, although most cases result in mild disease. The pathogenesis of the disease is incompletely understood, especially the determining factors of disease severity. A better characterization of these factors may help with development of RSV vaccines and antivirals. Hence, identification ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(540):]

Cited: 6 times

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Burnout in Pediatric Critical Care Medicine Fellows.

Markita L Suttle, Margaret A Chase, William C Sasser, Melissa Moore-Clingenpeel, Tensing Maa, Jason A Werner, Meredith F Bone, Donald L Boyer, Karen J Marcdante, Katherine E Mason, Megan E McCabe, Richard B Mink, Felice Su, David A Turner, ,

OBJECTIVES:Assess the overall level of burnout in pediatric critical care medicine fellows and examine factors that may contribute to or protect against its development. DESIGN:Cross-sectional observational study. SETTING:Accreditation Council for Graduate Medical Education-accredited pediatric critical care medicine fellowship programs across the United States. SUBJECTS:Pediatric critical care medicine fellows and program ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(6):872-880]

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CD4+ T cell restoration and control of hepatitis C virus replication after childbirth.

Samantha L Coss, Almudena Torres-Cornejo, Mona R Prasad, Melissa Moore-Clingenpeel, Arash Grakoui, Georg M Lauer, Christopher M Walker, Jonathan R Honegger,

Chronic hepatitis C virus (HCV) infection is characterized by persistent high-level viremia and defective cellular immunity, including a lack of functional HCV-specific CD4+ T cells. We previously described an exceptional period of viral control that occurs in some chronically infected women after childbirth. Here, we investigated whether reduced HCV replication ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(2):748-753]

Cited: 1 time

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Transcranial Doppler ultrasound findings in children with moderate-to-severe traumatic brain injury following abusive head trauma.

Marlina E Lovett, Tensing Maa, Melissa Moore-Clingenpeel, Nicole F O'Brien,

PURPOSE:Abusive head trauma (AHT) is the leading cause of fatal head injuries for children under 2 years. The objective was to evaluate, using transcranial Doppler ultrasound (TCD), whether children with AHT have a similar neurovascular response to injury compared with children without AHT. METHODS:Retrospective sub-analysis of previously prospectively acquired data in ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, 36(5):993-1000]

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2623. Bacterial Co-detection and Outcomes for Infants with Bronchiolitis Requiring Emergency Department Intubation for Respiratory Failure

Manzilat Akande, Melissa Moore-Clingenpeel, Nathan Jamieson, Sandra Spencer, Todd Karsies,

Abstract <h4>Background</h4> Viral bronchiolitis is a common cause of respiratory failure requiring intubation and ICU admission for infants. Bacterial codetection from respiratory cultures is common but its association with outcomes is unclear. <h4>Methods</h4> We conducted a retrospective cohort study over 5 years of infants <1 year with suspected bronchiolitis who ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S914-S914]

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Validation of a risk screening tool for pediatric type 1 diabetes patients: a predictor of increased acute health care utilization.

Bethany A Glick, K Ming Chan Hong, Don Buckingham, Melissa Moore-Clingenpeel, Ann Salvator, Manmohan K Kamboj,

Background Both psychosocial and socioeconomic risk factors contribute to poor glycemic control (GC). Previous research has identified that diabetes care behaviors are generally 'set' by late childhood, further highlighting the importance of psychosocial screening and intervention in the early course of disease management. The purpose of the current study was ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(10):1155-1162]

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Gastroesophageal reflux in cystic fibrosis across the age spectrum.

Frederick W Woodley, Don Hayes, Benjamin T Kopp, Melissa Moore-Clingenpeel, Rodrigo Strehl Machado, Christopher J Nemastil, Sudarshan Jadcherla, Carlo Di Lorenzo, Ajay Kaul, Hayat Mousa,

Background:Scientific advances have improved longevity in cystic fibrosis (CF) patients and many of these patients can expect to experience age-related gastrointestinal co-morbidities. We aimed to assess the extent to which age might impact gastroesophageal reflux (GER) in patients with CF. Methods:Our esophageal pH-multichannel intraluminal impedance monitoring database was searched for ... Read more >>

Transl Gastroenterol Hepatol (Translational gastroenterology and hepatology)
[2019, 4:69]

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Young Becker Muscular Dystrophy Patients Demonstrate Fibrosis Associated With Abnormal Left Ventricular Ejection Fraction on Cardiac Magnetic Resonance Imaging.

T Pace Johnston, Linda H Cripe, May Ling Mah, Melissa Moore-Clingenpeel, Cody Young, Kevin M Flanigan, Jerry Mendell, Kan N Hor,

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2019, 12(7):e008919]

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Risk factors with epinephrine use: 5-year review of in clinic pediatric allergic reactions.

Monica T Kraft, Rebecca Scherzer, Kasey Strothman, Melissa Moore-Clingenpeel, Mitchell H Grayson,

Ann Allergy Asthma Immunol (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 123(4):406-407]

Cited: 1 time

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