Full Text Journal Articles by
Author Melanie C Bois

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Anatomy and Pathology of the Cardiac Conduction System.

Roshan Karki, Anvi Raina, Fatima M Ezzeddine, Melanie C Bois, Samuel J Asirvatham,

The cardiac conduction system is formed of histologically and electrophysiologically distinct specialized tissues uniquely located in the human heart. Understanding the anatomy and pathology of the cardiac conduction system is imperative to an interventional electrophysiologist to perform safe ablation and device therapy for the management of cardiac arrhythmias and heart ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):569-584]

Cited: 0 times

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The 2021 WHO Classification of Tumors of the Heart.

Joseph J Maleszewski, Cristina Basso, Melanie C Bois, Carolyn Glass, Kyle W Klarich, Charles Leduc, Robert F Padera, Fabio Tavora,

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, :]

Cited: 0 times

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Left ventricular chord masquerading as an aortic valve papillary fibroelastoma.

Fatima M Ezzeddine, Melanie C Bois, Sorin V Pislaru, Hartzell V Schaff,

Eur Heart J Case Rep (European heart journal. Case reports)
[2021, 5(9):ytab369]

Cited: 0 times

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Correlation between computed tomography angiography and histology of carotid artery atherosclerosis: Can semi-automated imaging software predict a plaque's composition?

John C Benson, Valentina Nardi, Melanie C Bois, Luca Saba, Waleed Brinjikji, Luis Savastano, Giuseppe Lanzino, Amir Lerman,

<h4>Background</h4>Using computed tomography angiography to differentiate between components of carotid atherosclerotic lesions remains largely elusive. This study sought to validate a semi-automated software for computed tomography angiography plaque analysis using histologic comparisons.<h4>Materials and methods</h4>A retrospective review was performed of consecutive patients that underwent a carotid endarterectomy, with pre-procedural computed tomography ... Read more >>

Interv Neuroradiol (Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences)
[2021, :15910199211031093]

Cited: 0 times

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Carotid Plaques From Symptomatic Patients Are Characterized by Local Increase in Xanthine Oxidase Expression.

Morsaleh Ganji, Valentina Nardi, Megha Prasad, Kyra L Jordan, Melanie C Bois, Federico Franchi, Xiang Y Zhu, Hui Tang, Melissa D Young, Lilach O Lerman, Amir Lerman,

[Figure: see text]. ... Read more >>

Stroke (Stroke)
[2021, 52(9):2792-2801]

Cited: 1 time

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Recurrence of Pathologically Proven Papillary Fibroelastoma.

Ahmed A Sorour, Reto D Kurmann, Edward A El-Am, Melanie C Bois, Christopher G Scott, Alex T Lee, Joseph A Dearani, Joseph J Maleszewski, Kyle W Klarich,

<h4>Background</h4>Papillary fibroelastoma (PFE) is the most common primary benign cardiac tumor. Because PFEs have the potential to embolize, they often are surgically excised. Prior studies have suggested that postoperative recurrence of PFE is rare or does not occur. We aimed to determine the rate at which PFEs recurred after surgical ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

Cited: 0 times

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Three-Dimensional Surface Imaging and Printing in Anatomic Pathology.

Melanie C Bois, Jonathan M Morris, Jennifer M Boland, Nicole L Larson, Emily F Scharrer, Marie-Christine Aubry, Joseph J Maleszewski,

Three-dimensional (3D) imaging is increasingly being incorporated into a variety of medical specialties: surgery and radiology being but two prominent examples. Image-intensive disciplines, such as anatomic pathology (AP), represent excellent potential candidates for further exploration of this innovative technology. Multiple potential use cases exist within AP, involving patient care, education, ... Read more >>

J Pathol Inform (Journal of pathology informatics)
[2021, 12:22]

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Papillary Fibroelastoma Growth: A Retrospective Follow-Up Study of Patients With Pathology-Proven Papillary Fibroelastoma.

Reto D Kurmann, Edward A El-Am, Ahmed A Sorour, Ali Ahmad, Alexander T Lee, Christopher G Scott, Melanie C Bois, Joseph J Maleszewski, Kyle W Klarich,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(16):2154-2155]

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Outcomes on anti-VEGFR-2/paclitaxel treatment after progression on immune checkpoint inhibition in patients with metastatic gastroesophageal adenocarcinoma.

Lionel A Kankeu Fonkoua, Sakti Chakrabarti, Mohamad B Sonbol, Pashtoon M Kasi, Jason S Starr, Alex J Liu, Wendy K Nevala, Rachel L Maus, Melanie C Bois, Henry C Pitot, Chandrikha Chandrasekharan, Helen J Ross, Tsung-Teh Wu, Rondell P Graham, Jose C Villasboas, Matthias Weiss, Nathan R Foster, Svetomir N Markovic, Haidong Dong, Harry H Yoon,

Through our involvement in KEYNOTE-059, we unexpectedly observed durable responses in two patients with metastatic gastroesophageal adenocarcinoma (mGEA) who received ramucirumab (anti-VEGFR-2)/paclitaxel after immune checkpoint inhibition (ICI). To assess the reproducibility of this observation, we piloted an approach to administer ramucirumab/paclitaxel after ICI in more patients, and explored changes in ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(2):378-386]

Cited: 1 time

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Age-related histologic features of the sinoatrial node from normal human hearts during the first 10 decades of life: a study of 200 cases.

Melanie C Bois, Cecilia W Wu, Christine M Martinez, Mathieu C Castonguay, Sarah M Jenkins, Joseph J Maleszewski,

Knowledge of the histologic constituency of the sinoatrial (SA) node is based on small studies with unevenly distributed ages and subjective assessments of nodal composition, leading to difficulties in interpreting what constitutes true pathology of the SA node. SA nodes from two-hundred normal hearts (10 male and 10 female from ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2021, 52:107327]

Cited: 0 times

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The Spectrum of Histopathologic Findings in Lungs of Patients With Fatal Coronavirus Disease 2019 (COVID-19) Infection.

Anja C Roden, Melanie C Bois, Tucker F Johnson, Marie Christine Aubry, Mariam P Alexander, Catherine E Hagen, Peter T Lin, Reade A Quinton, Joseph J Maleszewski, Jennifer M Boland,

<h4>Context.—</h4>Respiratory failure appears to be the ultimate mechanism of death in most patients with severe coronavirus disease 2019 (COVID-19) infection. Studies of postmortem COVID-19 lungs largely report diffuse alveolar damage and capillary fibrin thrombi, but we have also observed other patterns.<h4>Objective.—</h4>To report demographic and radiographic features along with macroscopic, microscopic, ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2021, 145(1):11-21]

Cited: 12 times

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Impact of Sirolimus as a Primary Immunosuppressant on Myocardial Fibrosis and Diastolic Function Following Heart Transplantation.

Hilmi Alnsasra, Rabea Asleh, Jae K Oh, Joseph J Maleszewski, Amir Lerman, Takumi Toya, Krishnaswamy Chandrasekaran, Melanie C Bois, Sudhir S Kushwaha,

Background Myocardial fibrosis is an important contributor for development of diastolic dysfunction. We investigated the impact of sirolimus as primary immunosuppression on diastolic dysfunction and fibrosis progression among heart transplantation recipients. Methods and Results In 100 heart transplantation recipients who were either treated with a calcineurin inhibitor (CNI) (n=51) or ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(1):e018186]

Cited: 1 time

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Thromboembolic Complications of Annuloplasty Rings.

Ratnasari Padang, Yehia Z Ali, Rekha Mankad, Melanie C Bois, Joseph F Maalouf, Lawrence J Sinak, Sorin V Pislaru, Vuyisile T Nkomo, Hector I Michelena, Sushil A Luis,

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, 14(8):1659-1665]

Cited: 0 times

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Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study.

Cristina Basso, Ornella Leone, Stefania Rizzo, Monica De Gaspari, Allard C van der Wal, Marie-Christine Aubry, Melanie C Bois, Peter T Lin, Joseph J Maleszewski, James R Stone,

<h4>Aims</h4>Coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been associated with cardiovascular features of myocardial involvement including elevated serum troponin levels and acute heart failure with reduced ejection fraction. The cardiac pathological changes in these patients with COVID-19 have yet to be well described.<h4>Methods and ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(39):3827-3835]

Cited: 102 times

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KRAS Mutations in Papillary Fibroelastomas: A Study of 50 Cases With Etiologic and Diagnostic Implications.

Melanie C Bois, Dragana Milosevic, Benjamin R Kipp, Joseph J Maleszewski,

Papillary fibroelastoma (PFE) is an increasingly recognized cardiac tumor. Despite its prevalence, controversy exists as to whether it represents a reactive or neoplastic process due to histopathologic similarities with Lambl excrescences (LEs), an accepted reactive phenomenon. Recently, KRAS mutations were reported in a small collection of PFEs, but the incidence ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(5):626-632]

Cited: 1 time

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Case Report: A Rare Case of Right-Sided Papillary Fibroelastoma in a 1-Year-Old With Congenital Heart Disease.

Ali Ahmad, Edward A El-Am, Reto D Kurmann, Donald J Hagler, Melanie C Bois, Joseph J Maleszewski, Kyle W Klarich,

<b>Introduction:</b> Cardiac papillary fibroelastomas (PFEs) are the most common primary benign cardiac tumors, although they are somewhat unusual in children and typically seen on the left-sided cardiac valves. <b>Case summary:</b> A 10-week-old patient was found to have a partial atrioventricular canal defect, with associated tricuspid and mitral regurgitation. He was ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:624219]

Cited: 0 times

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Amyloidosis in surgically resected atrial appendages: a study of 345 consecutive cases with clinical implications.

Ahmed U Fayyaz, Melanie C Bois, Surendra Dasari, Deepak Padmanabhan, Julie A Vrana, John M Stulak, William D Edwards, Paul J Kurtin, Samuel J Asirvatham, Martha Grogan, Joseph J Maleszewski,

Histomorphologic parameters of atrial appendages removed during the Cox-Maze procedure have been shown to correlate with recurrence of atrial fibrillation. While amyloid deposition has been noted within atrial appendages, the incidence and significance remains incompletely understood. More accurate amyloid typing methodologies and targeted pharmacotherapeutics have recently been developed, prompting pathologists ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(5):764-774]

Cited: 0 times

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Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report.

Nazanin Yeganeh Kazemi, Christopher Jain, Melanie C Bois, Atta Behfar, Kenneth Olivier, Svetomir N Markovic,

Merkel cell carcinoma (MCC) is a rare, rapidly proliferating skin cancer that commonly metastasizes to regional lymph nodes. We present the case of a 73-year-old woman with a history of MCC and non-Hodgkin B-cell lymphoma who presented with second-degree heart block (Mobitz type II) caused by an interatrial mass. Temporary ... Read more >>

Mayo Clin Proc Innov Qual Outcomes (Mayo Clinic proceedings. Innovations, quality & outcomes)
[2019, 3(4):510-516]

Cited: 0 times

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Pathology of Vaping-Associated Lung Injury.

Yasmeen M Butt, Maxwell L Smith, Henry D Tazelaar, Laszlo T Vaszar, Karen L Swanson, Matthew J Cecchini, Jennifer M Boland, Melanie C Bois, James H Boyum, Adam T Froemming, Andras Khoor, Isabel Mira-Avendano, Aiyub Patel, Brandon T Larsen,

N Engl J Med (The New England journal of medicine)
[2019, 381(18):1780-1781]

Cited: 80 times

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Primary Malignant Pericardial Mesothelioma: A Clinical Case Series Illustrating the Necessity of a Multidisciplinary Approach.

Andrew N Rosenbaum, Melanie C Bois, Xin Zhang, Wil L Santivasi, William K Freeman,

Primary malignant pericardial mesothelioma is a rare cardiac neoplasm. The authors evaluated risk factors, clinical presentation, and outcomes by reviewing all biopsy-confirmed cases at one institution. The use of multimodality imaging, detailed hemodynamic assessment for the presence of an effusive-constrictive profile, and cytology evaluation can support the diagnosis. (<b>Level of ... Read more >>

JACC Case Rep (JACC. Case reports)
[2019, 1(2):202-207]

Cited: 0 times

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Computed tomographically guided transthoracic biopsy of a cardiac mass in the right ventricular outflow tract.

Brian J Burkett, Arman Arghami, Melanie C Bois, Jerome F Breen, Jason R Young,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2020, 159(2):e115-e118]

Cited: 0 times

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Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy.

Catherine S Morris, Melanie C Bois, Charles H Aust, Ryan Thomas, Sanjeev Sethi, Joseph J Maleszewski,

Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2019, 42:6-9]

Cited: 1 time

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Transseptal Biopsy of Left Atrial Mass Using Side-Cutting Biopsy Needle.

Abdallah El Sabbagh, Gautam Reddy, Mohammed Al-Hijji, Melanie C Bois, John F Bresnahan,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(12):e103-e105]

Cited: 0 times

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Morphometric Study of Pulmonary Arterial Changes in Pulmonary Langerhans Cell Histiocytosis.

Melanie C Bois, Adam M May, Robert Vassallo, Sarah M Jenkins, Eunhee S Yi, Anja C Roden,

<h4>Context</h4>- Pulmonary hypertension (PHT) is a complication of pulmonary Langerhans cell histiocytosis (PLCH); however, the pathogenesis remains largely unknown. Few studies have evaluated histopathologic changes in pulmonary arteries (PAs) of patients with PLCH; systematic quantification of arterial remodeling has yet to be undertaken.<h4>Objective</h4>- To quantify the extent of arterial remodeling ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2018, 142(8):929-937]

Cited: 2 times

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Neoplasia and the Heart: Pathological Review of Effects With Clinical and Radiological Correlation.

Joseph J Maleszewski, Melanie C Bois, John P Bois, Philip M Young, John M Stulak, Kyle W Klarich,

The intersection of oncological and cardiovascular diseases is an increasingly recognized phenomenon. This recognition has led to the emergence of cardio-oncology as a true subspecialty. This field is not simply limited to primary cardiac tumors or complications of chemotherapeutic medications. Rather, it also encompasses metastatic cardiovascular complications and secondary cardiovascular effects ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2018, 72(2):202-227]

Cited: 23 times

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